GO:0032703

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Name negative regulation of interleukin-2 production
Categary Process
Go Slim No
Go Link GO:0032703
Unique Molecular Interactions 112
Total Molecular Interactions 139
Total Single Events 2107
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-2 production. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of interleukin-2 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
2 INT261461 Positive_regulation of Akr1d1 Regulation of Sftpd 1 0.01 0 0.86
3 INT261458 Akr1d1 Regulation of Sftpd 1 0.01 0 0.82
4 INT261447 Sftpd Positive_regulation of Akr1d1 1 0.01 0 0.77
5 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
6 INT261457 Sftpd Positive_regulation of Vta1 1 0.10 0 0.63
7 INT261450 Binding of Sftpd and Ptgdr 1 0.08 0.19 0.47
8 INT261451 Sftpd Positive_regulation of Ptgdr 1 0.09 0.05 0.45
9 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
10 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
11 INT261464 Sftpd Regulation of Regulation of Ptgdr 1 0.08 0.07 0.41
12 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
13 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
14 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
15 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
16 INT246435 Xcl1 Positive_regulation of Gene_expression of Cd79a 1 0.07 0.83 0.27
17 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25
18 INT261455 Sftpd Regulation of Ptgdr 1 0.11 0.09 0.23
19 INT318174 Binding of Crp and Xcl1 1 0.03 1.9 0.22
20 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
21 INT226335 Binding of IL20 and IL20RB 1 0.03 0.29 0.19
22 INT226370 Binding of IL24 and IL20RB 1 0.03 0.28 0.19
23 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
24 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
25 INT261459 Sftpd Negative_regulation of Ldha 1 0.08 0.63 0.18
26 INT296081 Binding of FOXP3 and Gtf3a 1 0.00 1.16 0.16
27 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16
28 INT261460 Binding of Sftpd and Akr1d1 1 0.01 0.43 0.16
29 INT204791 Binding of Spg7 and Nod2 1 0.03 0.5 0.16
30 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
31 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
32 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
33 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
34 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
35 INT296082 Binding of Rel and FOXP3 1 0.35 1.14 0.15
36 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
37 INT322265 Binding of MPZ and VSIG4 1 0.29 1.63 0.14
38 INT134698 Regulation of Prnp Positive_regulation of Nup214 1 0.26 1.18 0.14
39 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
40 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
41 INT145830 Mdp1 Positive_regulation of Nod2 1 0.34 0.52 0.13
42 INT134697 Prnp Positive_regulation of Nup214 1 0.44 1.18 0.13
43 INT261448 Sftpd Positive_regulation of Phospho1 1 0.01 0.58 0.12
44 INT261449 Sftpd Positive_regulation of Gene_expression of Phospho1 1 0.01 0.58 0.12
45 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12
46 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
47 INT286969 IL2 Regulation of Gene_expression of FOXP3 1 0.04 1.05 0.1
48 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08
49 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
50 INT296039 Binding of FOXP3 and IL17RB 1 0.01 0.63 0.08
51 INT296034 FOXP3 Negative_regulation of Gene_expression of IL7R 1 0.10 0.63 0.08
52 INT350708 Foxp3 Regulation of Socs1 1 0.08 0.21 0.07
53 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
54 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
55 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
56 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
57 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05
58 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05
59 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05
60 INT286967 Positive_regulation of STAT3 Regulation of Gene_expression of FOXP3 1 0.35 0.44 0.04
61 INT350704 Foxp3 Negative_regulation of Gene_expression of Mir142 1 0.02 0.13 0.04
62 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03
63 INT350696 Mir31 Regulation of Gene_expression of Foxp3 1 0.04 0 0.03
64 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03
65 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03
66 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0
67 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
68 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0
69 INT268183 Gene_expression of Rab22a Negative_regulation of Gene_expression of Prnp 1 0.28 0.1 0
70 INT97562 Sftpd Regulation of Gene_expression of Fos 1 0.13 0 0
71 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
72 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0
73 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0
74 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
75 INT268192 Gene_expression of Rab22a Positive_regulation of Protein_catabolism of Prnp 1 0.30 0.08 0
76 INT260561 Binding of AFM and PRNP 1 0.22 0 0
77 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
78 INT268191 Rab4a Regulation of Gene_expression of Prnp 1 0.23 0.22 0
79 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0
80 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0
81 INT97563 Sftpd Positive_regulation of Gene_expression of Fos 1 0.22 0 0
82 INT268197 Gene_expression of Rab22a Regulation of Prnp 1 0.29 0.08 0
83 INT268184 Prnp Regulation of Gene_expression of Rab22a 1 0.34 0.17 0
84 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 0.03 0 0
85 INT339977 Positive_regulation of Binding of HDAC3 and HDAC7 1 0.23 0.52 0
86 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0
87 INT268201 Tg(CAG-EGFP)D4Nagy Regulation of Prnp 1 0.01 0.22 0
88 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
89 INT97561 Sftpd Regulation of Fos 1 0.13 0 0
90 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
91 INT344000 PROC Positive_regulation of PRNP 1 0.00 0.07 0
92 INT268190 Gene_expression of Rab22a Negative_regulation of Prnp 1 0.32 0.08 0
93 INT339978 Binding of HDAC3 and HDAC7 1 0.17 1.04 0
94 INT256385 Foxp3 Positive_regulation of Cd4 1 0.32 0.15 0
95 INT268177 Rab4a Regulation of Prnp 1 0.14 0.22 0
96 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
97 INT339980 Binding of MEF2D and HDAC7 1 0.19 0.78 0
98 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
99 INT268185 Rab22a Negative_regulation of Gene_expression of Prnp 1 0.32 0.08 0
100 INT268195 Rab22a Negative_regulation of Prnp 1 0.44 0.09 0
101 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0
102 INT268176 Positive_regulation of Erc1 Positive_regulation of Gene_expression of Prnp 1 0.06 0.2 0
103 INT287034 Pgp Regulation of Positive_regulation of Prnp 1 0.13 0.09 0
104 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0
105 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-2 production. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of interleukin-2 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
2 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
3 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
4 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
5 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
6 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
7 INT69572 Localization of Prnp 96 0.81 38.11 5.45
8 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
9 INT69570 Binding of Prnp 75 0.48 44.26 4.37
10 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
11 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
12 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
13 INT175449 Gene_expression of Sftpd 30 0.55 25.7 3.15
14 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
15 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
16 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
17 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
18 INT175458 Positive_regulation of Gene_expression of Sftpd 1 0.49 17.86 2.36
19 INT97558 Gene_expression of Sftpd 6 0.47 3.35 2.07
20 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98
21 INT167203 Binding of PRNP 25 0.48 20.09 1.84
22 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72
23 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
24 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46
25 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
26 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
27 INT116008 Binding of Gata3 2 0.34 1.37 1.41
28 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
29 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
30 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
31 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
32 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
33 INT229562 Negative_regulation of Foxp3 6 0.36 3.7 1.14
34 INT175462 Positive_regulation of Sftpd 1 0.49 6.62 1.04
35 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
36 INT261436 Binding of Sftpd 1 0.29 0.18 1.02
37 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
38 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
39 INT136634 Transcription of Prnp 9 0.72 3.34 0.83
40 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83
41 INT157492 Transcription of Foxp3 4 0.61 1.69 0.81
42 INT150251 Transcription of FOXP3 7 0.61 0.43 0.76
43 INT100601 Localization of PRNP 17 0.66 13.61 0.71
44 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
45 INT190662 Regulation of Positive_regulation of Prnp 4 0.24 1.15 0.7
46 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
47 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
48 INT221428 Negative_regulation of Negative_regulation of FOXP3 1 0.35 1.97 0.7
49 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67
50 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
51 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
52 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
53 INT297286 Positive_regulation of Foxp3 7 0.58 3.05 0.63
54 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
55 INT157490 Regulation of Gene_expression of Foxp3 5 0.37 2.4 0.47
56 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46
57 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44
58 INT312270 Positive_regulation of Xcl1 4 0.31 3.32 0.44
59 INT188345 Regulation of Foxp3 3 0.18 1.59 0.42
60 INT260115 Regulation of FOXP3 3 0.29 0.75 0.34
61 INT175456 Regulation of Gene_expression of Sftpd 1 0.32 1.92 0.34
62 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3
63 INT260120 Regulation of Gene_expression of FOXP3 4 0.31 2.74 0.29
64 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29
65 INT339992 Positive_regulation of Transcription of HDAC7 1 0.45 1.56 0.28
66 INT346895 Positive_regulation of Gene_expression of Nod2 1 0.33 0.74 0.28
67 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27
68 INT340001 Transcription of HDAC7 1 0.61 1.5 0.27
69 INT331055 Positive_regulation of Phosphorylation of Prnp 1 0.07 0.24 0.27
70 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26
71 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26
72 INT346896 Binding of Nod2 1 0.21 0.72 0.26
73 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25
74 INT220604 Binding of Kat5 2 0.11 0.7 0.25
75 INT325072 Gene_expression of Xcl1 1 0.33 0.88 0.24
76 INT346899 Regulation of Positive_regulation of Nod2 1 0.18 0.75 0.22
77 INT150203 Positive_regulation of Xcl1 2 0.40 2.47 0.21
78 INT261438 Negative_regulation of Sftpd 1 0.30 0.1 0.21
79 INT318169 Regulation of Xcl1 1 0.15 1.14 0.19
80 INT277393 Gene_expression of HDAC7 2 0.65 4.71 0.18
81 INT188346 Binding of Foxp3 1 0.27 0.4 0.18
82 INT226496 Localization of IL20RB 1 0.34 0.23 0.18
83 INT15734 Negative_regulation of Xcl1 2 0.18 0 0.16
84 INT276372 Negative_regulation of Gene_expression of FOXP3 2 0.38 1.49 0.16
85 INT339984 Positive_regulation of HDAC7 1 0.45 1.07 0.16
86 INT15735 Positive_regulation of Negative_regulation of Xcl1 1 0.02 0 0.16
87 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16
88 INT175453 Binding of Sftpd 2 0.23 2.04 0.15
89 INT150253 Positive_regulation of Transcription of FOXP3 2 0.39 0 0.15
90 INT335788 Localization of FOXP3 1 0.34 0.42 0.15
91 INT322279 Binding of VSIG4 1 0.29 1.63 0.14
92 INT335812 Regulation of Transcription of FOXP3 1 0.21 0.34 0.14
93 INT286970 Binding of FOXP3 1 0.24 1.04 0.13
94 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
95 INT276923 Localization of Foxp3 1 0.38 0.52 0.12
96 INT175445 Transcription of Sftpd 1 0.51 1.78 0.12
97 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1
98 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09
99 INT204777 Negative_regulation of Localization of Nod2 1 0.28 0.61 0.09
100 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09
101 INT286971 Positive_regulation of Positive_regulation of FOXP3 1 0.32 0.57 0.09
102 INT303459 Transcription of PRNP 4 0.69 1.44 0.08
103 INT204779 Localization of Nod2 1 0.48 0.6 0.08
104 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08
105 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08
106 INT204770 Regulation of Nod2 1 0.29 0.66 0.07
107 INT207302 Positive_regulation of Transcription of Prnp 1 0.47 0.71 0.06
108 INT335179 Negative_regulation of Sftpd 1 0.21 2.61 0.06
109 INT296074 Regulation of Positive_regulation of FOXP3 1 0.18 0.28 0.06
110 INT261445 Regulation of Sftpd 1 0.10 0.69 0.05
111 INT322696 Localization of Sftpd 1 0.09 0.62 0.05
112 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04
113 INT260113 Positive_regulation of Regulation of FOXP3 1 0.32 0.15 0.04
114 INT322697 Positive_regulation of Gene_expression of Sftpd 1 0.07 1.22 0.04
115 INT325069 Regulation of Gene_expression of Xcl1 1 0.19 0 0.04
116 INT346893 Negative_regulation of Gene_expression of Nod2 1 0.28 0.13 0.04
117 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03
118 INT336900 Positive_regulation of Sftpd 1 0.01 1.39 0.03
119 INT175446 Negative_regulation of Positive_regulation of Sftpd 1 0.26 0.43 0.03
120 INT325073 Positive_regulation of Gene_expression of Xcl1 1 0.19 0 0.03
121 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03
122 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03
123 INT333755 Negative_regulation of Positive_regulation of Foxp3 1 0.49 0.18 0.03
124 INT268144 Negative_regulation of Localization of Prnp 3 0.37 0.71 0
125 INT217333 Positive_regulation of TNFAIP3 3 0.23 2.65 0
126 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0
127 INT277405 Negative_regulation of Gene_expression of HDAC7 2 0.41 1.52 0
128 INT268161 Regulation of Negative_regulation of Prnp 2 0.39 0.33 0
129 INT157493 Positive_regulation of Transcription of Foxp3 1 0.59 0.06 0
130 INT229517 Regulation of Phosphorylation of Prnp 1 0.39 0.26 0
131 INT348456 Protein_catabolism of TNFAIP3 1 0.22 1.13 0
132 INT325070 Negative_regulation of Positive_regulation of Xcl1 1 0.18 0 0
133 INT348453 Positive_regulation of Positive_regulation of TNFAIP3 1 0.17 1.06 0
134 INT339999 Positive_regulation of Gene_expression of HDAC7 1 0.45 1.97 0
135 INT284053 Positive_regulation of Positive_regulation of Nod2 1 0.25 0.08 0
136 INT188131 Negative_regulation of Regulation of PRNP 1 0.41 0.06 0
137 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0
138 INT97559 Negative_regulation of Gene_expression of Sftpd 1 0.28 0 0
139 INT344005 Regulation of Positive_regulation of PRNP 1 0.20 0.08 0
140 INT240690 Positive_regulation of Binding of PRNP 1 0.07 0.53 0
141 INT325068 Negative_regulation of Gene_expression of Xcl1 1 0.16 0.09 0
142 INT340003 Localization of HDAC7 1 0.67 1.61 0
143 INT175441 Positive_regulation of Positive_regulation of Sftpd 1 0.33 0.31 0
144 INT315417 Negative_regulation of Transcription of Prnp 1 0.43 0.14 0
145 INT268173 Negative_regulation of Negative_regulation of Prnp 1 0.37 0 0
146 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0
147 INT268148 Regulation of Protein_catabolism of Prnp 1 0.45 0 0
148 INT325071 Binding of Xcl1 1 0.13 0 0
149 INT277377 Phosphorylation of HDAC7 1 0.79 0.36 0
150 INT277399 Binding of HDAC7 1 0.36 1.67 0
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