GO:0032715

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Name negative regulation of interleukin-6 production
Categary Process
Go Slim No
Go Link GO:0032715
Unique Molecular Interactions 1973
Total Molecular Interactions 2746
Total Single Events 24811
Pain Genes Associated 30

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-6 production. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of interleukin-6 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
5 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
6 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
7 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
8 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
9 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
10 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
11 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
12 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
13 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
14 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
15 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
16 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
17 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
18 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
19 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
20 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
21 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
22 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
23 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
24 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
25 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
26 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
27 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
28 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
29 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
30 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
31 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
32 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
33 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
34 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
35 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
36 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
37 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
38 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
39 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
40 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
41 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
42 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
43 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
44 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
45 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
46 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
47 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
48 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
49 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
50 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
51 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
52 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
53 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
54 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
55 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
56 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
57 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
58 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
59 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
60 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
61 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
62 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
63 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
64 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
65 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
66 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
67 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
68 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
69 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
70 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
71 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
72 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
73 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
74 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
75 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
76 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
77 INT70036 LTA Regulation of Negative_regulation of IL10 1 0.03 1.42 1.21
78 INT70046 IL12A Regulation of IL10 1 0.07 1.42 1.21
79 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
80 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
81 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
82 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
83 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
84 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
85 INT70041 LTA Regulation of IL10 1 0.03 1.42 1.21
86 INT70034 IL12A Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
87 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
88 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
89 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
90 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
91 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
92 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
93 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
94 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
95 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
96 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
97 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
98 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
99 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
100 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
101 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
102 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
103 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
104 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
105 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
106 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
107 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
108 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
109 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
110 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
111 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
112 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
113 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
114 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
115 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
116 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
117 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
118 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
119 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
120 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
121 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
122 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
123 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
124 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
125 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
126 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
127 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
128 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
129 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
130 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99
131 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
132 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
133 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
134 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
135 INT129215 RYBP Positive_regulation of Il10 1 0.01 1.24 0.98
136 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
137 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
138 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
139 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
140 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
141 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
142 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
143 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
144 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
145 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
146 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
147 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
148 INT129213 RYBP Positive_regulation of Gene_expression of Il10 1 0.01 1.04 0.94
149 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
150 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
151 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
152 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
153 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
154 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
155 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
156 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
157 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
158 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
159 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
160 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
161 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
162 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
163 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
164 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
165 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
166 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
167 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
168 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
169 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
170 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
171 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
172 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
173 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
174 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
175 INT226337 Binding of IL10 and IL10RA 2 0.24 2.51 0.85
176 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
177 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
178 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
179 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
180 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
181 INT113237 Il10 Negative_regulation of Gene_expression of Tacr1 1 0.35 0.81 0.84
182 INT221034 IL10 Positive_regulation of Localization of CCL18 1 0.19 1.3 0.84
183 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
184 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
185 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
186 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
187 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
188 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
189 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
190 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82
191 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
192 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
193 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
194 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
195 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
196 INT187232 Vip Positive_regulation of Gene_expression of Il10 1 0.16 0.95 0.81
197 INT113239 Il10 Regulation of Transcription of Tacr1 1 0.45 0.79 0.81
198 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
199 INT228054 Fpr3 Positive_regulation of Il10 1 0.05 0.9 0.79
200 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-6 production. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of interleukin-6 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
8 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
9 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
10 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52
13 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
14 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
15 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84
16 INT10166 Localization of Tnf 237 0.81 153.95 88.64
17 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
18 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
19 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
20 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
21 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
22 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
23 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72
24 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
25 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69
26 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
27 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
28 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
29 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
30 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5
31 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
32 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07
33 INT13354 Transcription of TNF 108 0.72 85.81 42.32
34 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
35 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5
36 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
37 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
38 INT35406 Localization of Tnf 94 0.81 64.63 31.65
39 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
40 INT90792 Localization of Il10 144 0.80 87.88 30.03
41 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
42 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
43 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
44 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66
45 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
46 INT134651 Binding of TLR4 89 0.48 66.96 23.19
47 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
48 INT74423 Localization of IL10 91 0.80 61.6 22.95
49 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
50 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
51 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
52 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
53 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
54 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
55 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51
56 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79
57 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
58 INT74286 Regulation of Il10 42 0.44 28.06 19.44
59 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
60 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
61 INT72564 Localization of Il10 41 0.78 28.62 17.6
62 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
63 INT48892 Transcription of Il10 31 0.71 27.26 16.77
64 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
65 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
66 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
67 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
68 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
69 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
70 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
71 INT10173 Binding of Tnf 45 0.48 35.6 14.32
72 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
73 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
74 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
75 INT86950 Negative_regulation of Gene_expression of Il10 26 0.42 18.92 12.73
76 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
77 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39
78 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
79 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
80 INT79835 Regulation of Il10 28 0.61 21.22 11.29
81 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
82 INT71766 Transcription of Il10 31 0.69 24.66 10.78
83 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
84 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
85 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
86 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4
87 INT71769 Negative_regulation of Gene_expression of Il10 40 0.57 22.53 10.37
88 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87
89 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
90 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
91 INT73497 Regulation of IL10 33 0.45 22.6 9.19
92 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
93 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
94 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
95 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
96 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
97 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
98 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
99 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
100 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
101 INT68299 Binding of Tnf 17 0.39 12.55 7.49
102 INT103289 Binding of Il10 15 0.35 13.67 7.42
103 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
104 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
105 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
106 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
107 INT91906 Regulation of Gene_expression of Il10 13 0.58 8.92 7.06
108 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
109 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
110 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
111 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
112 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
113 INT60527 Transcription of IL10 16 0.56 13.57 6.42
114 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
115 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
116 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
117 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
118 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
119 INT97797 Localization of TLR4 18 0.77 13.78 6
120 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 8 0.48 6.44 5.97
121 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
122 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93
123 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
124 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87
125 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81
126 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
127 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
128 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61
129 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
130 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
131 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41
132 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
133 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
134 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22
135 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
136 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
137 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
138 INT142162 Binding of IL10 30 0.37 21.9 4.84
139 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75
140 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
141 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
142 INT71767 Positive_regulation of Transcription of Il10 10 0.67 5.55 4.66
143 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
144 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44
145 INT118230 Binding of Tnfrsf1a 15 0.42 7.63 4.39
146 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
147 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33
148 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
149 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
150 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
151 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
152 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
153 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
154 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
155 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
156 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
157 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
158 INT194846 Positive_regulation of Positive_regulation of Il10 9 0.57 5.07 3.71
159 INT77786 Negative_regulation of Tnfrsf1a 5 0.56 5.03 3.58
160 INT74157 Negative_regulation of Positive_regulation of Il10 5 0.43 5.83 3.56
161 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
162 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53
163 INT89521 Positive_regulation of Localization of Il10 8 0.44 6.45 3.51
164 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
165 INT96700 Positive_regulation of Positive_regulation of Tnfrsf1a 6 0.69 3.93 3.42
166 INT194848 Negative_regulation of Localization of Il10 11 0.36 8.29 3.38
167 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34
168 INT48893 Positive_regulation of Transcription of Il10 3 0.69 4.29 3.29
169 INT250581 Gene_expression of SELS 4 0.78 47.37 3.27
170 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
171 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
172 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
173 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
174 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
175 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
176 INT115579 Positive_regulation of Positive_regulation of Il10 7 0.68 4.82 2.91
177 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
178 INT204524 Binding of TLR9 17 0.43 11.69 2.76
179 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
180 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
181 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
182 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
183 INT90791 Regulation of Localization of Il10 6 0.44 2.94 2.5
184 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
185 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
186 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
187 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
188 INT48894 Negative_regulation of Transcription of Il10 5 0.26 2.79 2.22
189 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
190 INT127740 Regulation of Localization of Il10 3 0.60 0.65 2.18
191 INT275279 Positive_regulation of Localization of Tnfrsf1a 3 0.48 1.13 2.17
192 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
193 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
194 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
195 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
196 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
197 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98
198 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
199 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
200 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
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