GO:0032717

From wiki-pain
Jump to: navigation, search
Name negative regulation of interleukin-8 production
Categary Process
Go Slim No
Go Link GO:0032717
Unique Molecular Interactions 60
Total Molecular Interactions 93
Total Single Events 708
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-8 production. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of interleukin-8 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
2 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
3 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
4 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
5 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
6 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
7 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
8 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
9 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
10 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
11 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
12 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
13 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
14 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
15 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
16 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
17 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
18 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
19 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
20 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
21 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
22 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
23 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
24 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
25 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
26 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
27 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
28 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29
29 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29
30 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
31 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27
32 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
33 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
34 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24
35 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
36 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
37 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21
38 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2
39 INT329068 Tlr9 Positive_regulation of Localization of IFNA1 1 0.03 1.54 0.19
40 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
41 INT333271 Tlr9 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
42 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
43 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11
44 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
45 INT294773 IRF6 Positive_regulation of TLR9 1 0.06 0.17 0.1
46 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
47 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08
48 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05
49 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05
50 INT290165 Tlr9 Positive_regulation of Gene_expression of IFNA1 1 0.10 1.2 0.04
51 INT290161 Tlr9 Positive_regulation of Gene_expression of Pdc 1 0.21 1.2 0.04
52 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03
53 INT285396 Binding of Adam17 and R3hcc1 1 0.15 0.93 0
54 INT324814 Binding of Ighm and Tlr9 1 0.06 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-8 production. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of interleukin-8 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
2 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
3 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
4 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
5 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
6 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
7 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
8 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
9 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
10 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
11 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
12 INT174816 Binding of IL6R 14 0.09 11.26 3.63
13 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
14 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
15 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
16 INT204524 Binding of TLR9 17 0.43 11.69 2.76
17 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
18 INT333961 Binding of Il6r 1 0.07 3.67 2.29
19 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
20 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
21 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
22 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
23 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
24 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
25 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
26 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
27 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
28 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
29 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
30 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
31 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
32 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
33 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
34 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
35 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
36 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
37 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
38 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
39 INT333963 Localization of Il6r 1 0.10 0.75 0.83
40 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
41 INT294787 Localization of TLR9 2 0.67 2.35 0.75
42 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
43 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
44 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
45 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
46 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
47 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
48 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
49 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
50 INT288490 Binding of Tlr9 1 0.25 1.88 0.51
51 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
52 INT188677 Positive_regulation of Positive_regulation of Tlr9 2 0.29 1.22 0.49
53 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
54 INT204533 Regulation of Gene_expression of TLR9 8 0.55 2.81 0.4
55 INT251556 Localization of Adam17 2 0.38 2 0.39
56 INT219171 Negative_regulation of Positive_regulation of TLR9 1 0.18 1.3 0.39
57 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
58 INT156120 Localization of Arrb1 1 0.00 0 0.38
59 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
60 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
61 INT182134 Transcription of TLR9 2 0.72 1.21 0.37
62 INT284455 Regulation of Gene_expression of Tlr9 1 0.30 1.19 0.37
63 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
64 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
65 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
66 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
67 INT329061 Positive_regulation of Tlr9 1 0.47 2.05 0.29
68 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28
69 INT204528 Negative_regulation of Gene_expression of TLR9 5 0.52 4.47 0.27
70 INT236357 Negative_regulation of Positive_regulation of Tlr9 2 0.33 3.1 0.27
71 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
72 INT142864 Positive_regulation of Phosphorylation of ARRB1 1 0.01 0 0.25
73 INT204531 Negative_regulation of TLR9 1 0.43 1.29 0.25
74 INT142865 Phosphorylation of ARRB1 1 0.01 0 0.25
75 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
76 INT78865 Localization of Adam17 1 0.43 0.34 0.23
77 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
78 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
79 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
80 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
81 INT350779 Positive_regulation of Positive_regulation of TLR9 1 0.08 0.8 0.15
82 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
83 INT204527 Regulation of TLR9 7 0.40 2.88 0.12
84 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
85 INT151569 Transcription of Tlr9 3 0.69 0.75 0.11
86 INT151566 Positive_regulation of Transcription of Tlr9 2 0.47 0.67 0.11
87 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
88 INT187285 Protein_catabolism of Adam17 1 0.12 0.94 0.09
89 INT280015 Positive_regulation of Binding of TLR9 1 0.12 1.11 0.09
90 INT356064 Regulation of Negative_regulation of Adam17 1 0.23 0.24 0.08
91 INT356054 Regulation of Phosphorylation of Adam17 1 0.20 0.25 0.08
92 INT180096 Positive_regulation of Phosphorylation of Adam17 1 0.07 0 0.08
93 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
94 INT280648 Negative_regulation of Transcription of Il6r 1 0.38 0 0.05
95 INT280667 Transcription of Il6r 1 0.62 0 0.05
96 INT180094 Binding of Adam17 1 0.06 0 0.05
97 INT204526 Positive_regulation of Transcription of TLR9 1 0.50 0.06 0.03
98 INT294790 Regulation of Localization of TLR9 1 0.40 0 0
99 INT285438 Regulation of Regulation of TLR9 1 0.40 0 0
100 INT161253 Regulation of Gene_expression of Tlr9 1 0.09 0.18 0
101 INT324755 Positive_regulation of Binding of Tlr9 1 0.26 0.17 0
102 INT161254 Regulation of Tlr9 1 0.09 0.18 0
103 INT329056 Positive_regulation of Gene_expression of Tlr9 1 0.43 0.09 0
104 INT151568 Negative_regulation of Transcription of Tlr9 1 0.41 0.08 0
105 INT341498 Negative_regulation of Gene_expression of Tlr9 1 0.11 0.38 0
106 INT285394 Binding of Adam17 1 0.31 0.93 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox