GO:0032720

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Name negative regulation of tumor necrosis factor production
Categary Process
Go Slim No
Go Link GO:0032720
Unique Molecular Interactions 2053
Total Molecular Interactions 3221
Total Single Events 28177
Pain Genes Associated 48

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of tumor necrosis factor production. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of tumor necrosis factor production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
4 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
5 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
6 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
7 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
8 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
9 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
10 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
11 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
12 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
13 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
14 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
15 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
16 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
17 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
18 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
19 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
20 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
21 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
22 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
23 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
24 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
25 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
26 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
27 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
28 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
29 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
30 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
31 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
32 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
33 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
34 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
35 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
36 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
37 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
38 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
39 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
40 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
41 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
42 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
43 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
44 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
45 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
46 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
47 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
48 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
49 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
50 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
51 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
52 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
53 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
54 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
55 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
56 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
57 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
58 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
59 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
60 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
61 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
62 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
63 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
64 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
65 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
66 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
67 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
68 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
69 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
70 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
71 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
72 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
73 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
74 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
75 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
76 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
77 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
78 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
79 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
80 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
81 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
82 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
83 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
84 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
85 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
86 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
87 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
88 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
89 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
90 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
91 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
92 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
93 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
94 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
95 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
96 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
97 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
98 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
99 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
100 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
101 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
102 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
103 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
104 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
105 INT28992 Tmpo Positive_regulation of Pomc 1 0.36 3.18 1.41
106 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
107 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
108 INT27123 Binding of Pomc and Cck 2 0.31 0 1.38
109 INT66569 Pomc Positive_regulation of Atxn2l 1 0.03 0 1.36
110 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
111 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
112 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
113 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
114 INT59446 Rbm39 Positive_regulation of Negative_regulation of Pomc 1 0.03 0.19 1.32
115 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
116 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
117 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
118 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
119 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
120 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
121 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
122 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
123 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
124 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
125 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
126 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
127 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
128 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
129 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
130 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
131 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
132 INT34471 Negative_regulation of Pomc Regulation of Slc3a1 1 0.05 0.12 1.24
133 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
134 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
135 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
136 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
137 INT50385 Bdnf Positive_regulation of Pomc 1 0.22 0.47 1.23
138 INT34473 Pomc Regulation of Slc3a1 1 0.03 0.07 1.23
139 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
140 INT70036 LTA Regulation of Negative_regulation of IL10 1 0.03 1.42 1.21
141 INT70046 IL12A Regulation of IL10 1 0.07 1.42 1.21
142 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
143 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
144 INT82754 Cck Positive_regulation of Positive_regulation of Pomc 1 0.39 0.3 1.21
145 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
146 INT70041 LTA Regulation of IL10 1 0.03 1.42 1.21
147 INT70034 IL12A Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
148 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
149 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
150 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
151 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
152 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 0.45 0 1.19
153 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
154 INT34661 Abat Positive_regulation of Localization of Pomc 1 0.04 0 1.18
155 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
156 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
157 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
158 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
159 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
160 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
161 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
162 INT30359 Pomc Regulation of Localization of Oxt 1 0.03 0 1.13
163 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
164 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
165 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
166 INT59606 Binding of Tspo and Penk 1 0.04 0 1.12
167 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
168 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
169 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
170 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
171 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
172 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
173 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
174 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
175 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
176 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
177 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06
178 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
179 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
180 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05
181 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05
182 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
183 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
184 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
185 INT58807 Pomc Negative_regulation of Localization of LH 2 0.06 0 1.02
186 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
187 INT19494 Pomc Positive_regulation of Localization of Ins1 2 0.62 0.38 1.02
188 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
189 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02
190 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
191 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
192 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
193 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
194 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
195 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
196 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
197 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
198 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99
199 INT22109 Positive_regulation of Pomc Positive_regulation of Penk 1 0.35 0 0.99
200 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of tumor necrosis factor production. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of tumor necrosis factor production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
5 INT738 Regulation of POMC 459 0.62 111.19 243.74
6 INT1308 Localization of Pomc 457 0.81 66.83 217.5
7 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
8 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
9 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
10 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
11 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
12 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69
13 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52
14 INT695 Binding of POMC 304 0.48 56.66 126.85
15 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
16 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
17 INT1026 Binding of Lbp 207 0.48 150.96 119.16
18 INT1438 Localization of Pomc 360 0.81 101.26 116.47
19 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84
20 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
21 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
22 INT462 Regulation of Pomc 157 0.62 41.67 67.27
23 INT9664 Binding of LBP 127 0.48 94.9 63.42
24 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
25 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
26 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
27 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72
28 INT21737 Binding of MC1R 129 0.48 45.45 56.54
29 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
30 INT1463 Binding of Pomc 129 0.48 15.89 56.27
31 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69
32 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
33 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
34 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
35 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
36 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
37 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
38 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5
39 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07
40 INT1295 Binding of Pomc 85 0.48 12.92 42.8
41 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
42 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
43 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
44 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
45 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5
46 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
47 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
48 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
49 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
50 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
51 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
52 INT90792 Localization of Il10 144 0.80 87.88 30.03
53 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
54 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
55 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
56 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
57 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
58 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
59 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
60 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
61 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66
62 INT1030 Localization of Lbp 52 0.74 38.92 24.91
63 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
64 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
65 INT134651 Binding of TLR4 89 0.48 66.96 23.19
66 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
67 INT74423 Localization of IL10 91 0.80 61.6 22.95
68 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
69 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
70 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51
71 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79
72 INT74286 Regulation of Il10 42 0.44 28.06 19.44
73 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
74 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
75 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
76 INT72564 Localization of Il10 41 0.78 28.62 17.6
77 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
78 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
79 INT48892 Transcription of Il10 31 0.71 27.26 16.77
80 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
81 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
82 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
83 INT1416 Transcription of POMC 40 0.72 10.71 15.38
84 INT15643 Positive_regulation of Positive_regulation of Pomc 30 0.65 4.59 15.34
85 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8
86 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
87 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59
88 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
89 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
90 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
91 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
92 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
93 INT86950 Negative_regulation of Gene_expression of Il10 26 0.42 18.92 12.73
94 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39
95 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39
96 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
97 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
98 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
99 INT5515 Negative_regulation of Positive_regulation of Pomc 25 0.58 8.73 11.88
100 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
101 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
102 INT79835 Regulation of Il10 28 0.61 21.22 11.29
103 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26
104 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
105 INT71766 Transcription of Il10 31 0.69 24.66 10.78
106 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
107 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4
108 INT71769 Negative_regulation of Gene_expression of Il10 40 0.57 22.53 10.37
109 INT18088 Binding of Tspo 26 0.48 9.12 10.2
110 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
111 INT57000 Localization of LBP 21 0.78 11.01 10.01
112 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87
113 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
114 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
115 INT73497 Regulation of IL10 33 0.45 22.6 9.19
116 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
117 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97
118 INT32624 Regulation of LBP 15 0.60 11.48 8.71
119 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
120 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57
121 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
122 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
123 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
124 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
125 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
126 INT6335 Binding of TSPO 39 0.44 10.88 7.66
127 INT103289 Binding of Il10 15 0.35 13.67 7.42
128 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
129 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
130 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
131 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
132 INT91906 Regulation of Gene_expression of Il10 13 0.58 8.92 7.06
133 INT11839 Protein_catabolism of Pomc 15 0.98 0.77 6.99
134 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
135 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
136 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
137 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
138 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
139 INT60527 Transcription of IL10 16 0.56 13.57 6.42
140 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
141 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
142 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
143 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
144 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15
145 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
146 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
147 INT97797 Localization of TLR4 18 0.77 13.78 6
148 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
149 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
150 INT32532 Regulation of Positive_regulation of Pomc 11 0.61 3.2 5.93
151 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
152 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87
153 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
154 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
155 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
156 INT6276 Negative_regulation of Positive_regulation of Pomc 12 0.57 3.65 5.49
157 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
158 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
159 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
160 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
161 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22
162 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18
163 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
164 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
165 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
166 INT16051 Regulation of Tspo 6 0.45 2.81 4.95
167 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
168 INT142162 Binding of IL10 30 0.37 21.9 4.84
169 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75
170 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
171 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
172 INT71767 Positive_regulation of Transcription of Il10 10 0.67 5.55 4.66
173 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
174 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
175 INT7575 Regulation of Transcription of Pomc 8 0.60 1.57 4.59
176 INT10806 Positive_regulation of Transcription of Pomc 13 0.50 1.74 4.58
177 INT24420 Transcription of Pomc 13 0.69 3.32 4.54
178 INT29809 Gene_expression of Tspo 8 0.75 4.12 4.54
179 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
180 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
181 INT11106 Gene_expression of Lbp 10 0.67 10.29 4.52
182 INT7841 Gene_expression of Tspo 10 0.75 7.63 4.45
183 INT6881 Binding of Tspo 12 0.46 5.03 4.38
184 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
185 INT22337 Negative_regulation of Transcription of Pomc 12 0.59 2.17 4.32
186 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
187 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
188 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
189 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
190 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14
191 INT14499 Regulation of Regulation of Pomc 7 0.61 0.15 4.06
192 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
193 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
194 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
195 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74
196 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
197 INT194846 Positive_regulation of Positive_regulation of Il10 9 0.57 5.07 3.71
198 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
199 INT133733 Positive_regulation of Localization of Lbp 6 0.43 9.19 3.61
200 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
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