GO:0032743

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Name positive regulation of interleukin-2 production
Categary Process
Go Slim No
Go Link GO:0032743
Unique Molecular Interactions 95
Total Molecular Interactions 115
Total Single Events 785
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-2 production. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of interleukin-2 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
2 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
3 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
4 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
5 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
6 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
7 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
8 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
9 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
10 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
11 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
12 INT281126 Binding of Ccr2 and Cxcr4 1 0.30 0.32 0.44
13 INT181448 Eae1 Positive_regulation of Gene_expression of Ccr2 1 0.04 4.98 0.42
14 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
15 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
16 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
17 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
18 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
19 INT163906 CCL2 Positive_regulation of CCR2 1 0.18 0.2 0.35
20 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
21 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
22 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
23 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
24 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
25 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
26 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
27 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
28 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
29 INT329530 Malt1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.48 0.22
30 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22
31 INT213970 Vip Positive_regulation of Localization of Cd83 1 0.15 0.41 0.21
32 INT158222 Positive_regulation of Binding of MAPK1 and CCR2 1 0.26 0.3 0.2
33 INT158207 Positive_regulation of Binding of TNFSF14 and CCR2 1 0.07 0.3 0.2
34 INT158224 TNFSF14 Positive_regulation of CCR2 1 0.07 0.3 0.2
35 INT158204 Negative_regulation of Binding of MAPK1 and CCR2 1 0.22 0.3 0.2
36 INT158198 Negative_regulation of Binding of AHSA1 and CCR2 1 0.21 0.3 0.2
37 INT158206 Binding of TNFSF14 and CCR2 1 0.05 0.3 0.2
38 INT158216 Negative_regulation of Binding of TNFSF14 and CCR2 1 0.06 0.3 0.2
39 INT158217 Binding of AHSA1 and CCR2 1 0.18 0.3 0.2
40 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
41 INT158234 Binding of MAPK1 and CCR2 1 0.19 0.3 0.2
42 INT158235 Positive_regulation of Binding of AHSA1 and CCR2 1 0.24 0.3 0.2
43 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
44 INT181440 Binding of Ccr2 and Eae1 1 0.03 1.3 0.19
45 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18
46 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
47 INT337180 CD40 Positive_regulation of Gene_expression of CD83 1 0.17 1.07 0.17
48 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
49 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
50 INT352416 Ccl2 Positive_regulation of Ccr2 1 0.23 0.26 0.14
51 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12
52 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
53 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
54 INT204890 Cd83 Positive_regulation of Tlr4 1 0.25 0.1 0.1
55 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
56 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
57 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
58 INT337178 CCR2 Regulation of Gene_expression of CCR6 1 0.14 0.72 0.08
59 INT337173 PTGER2 Positive_regulation of Gene_expression of CD83 1 0.02 0.63 0.08
60 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
61 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
62 INT186183 Binding of SCARB2 and SASH3 1 0.00 0.49 0.04
63 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
64 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
65 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
66 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04
67 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
68 INT274577 Binding of MEFV and SASH3 1 0.01 0.45 0.04
69 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04
70 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
71 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
72 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03
73 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03
74 INT337167 Binding of TLR3 and Positive_regulation of CD83 1 0.13 0.31 0.03
75 INT292553 Binding of TRAF2 and TRADD 1 0.09 0.1 0
76 INT274591 Binding of PSTPIP1 and SASH3 1 0.01 0 0
77 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
78 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
79 INT348018 Map3k7 Positive_regulation of Chuk 1 0.19 0.06 0
80 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
81 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
82 INT348020 Binding of Traf6 and Irak2 1 0.13 0.05 0
83 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0
84 INT348037 Irak2 Positive_regulation of Binding of Traf6 1 0.18 0.05 0
85 INT348035 Map3k7 Positive_regulation of Binding of Chuk 1 0.20 0.06 0
86 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0
87 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
88 INT274590 Positive_regulation of Binding of MEFV and SASH3 1 0.01 0.27 0
89 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-2 production. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of interleukin-2 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
2 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
3 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
4 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75
5 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89
6 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
7 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
8 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22
9 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
10 INT20459 Regulation of Ripk2 5 0.44 0 4.53
11 INT161221 Positive_regulation of Positive_regulation of Ccr2 3 0.50 4.55 3.98
12 INT97139 Gene_expression of CD83 43 0.70 22.05 3.91
13 INT222241 Binding of Ccr2 5 0.42 4.09 3.71
14 INT281144 Regulation of Gene_expression of Ccr2 2 0.44 2.38 3.29
15 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02
16 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91
17 INT151436 Regulation of Ccr2 4 0.44 2.81 2.82
18 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
19 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
20 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
21 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
22 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66
23 INT146504 Regulation of Ccr2 5 0.39 3.58 2.21
24 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
25 INT209890 Positive_regulation of Gene_expression of CD83 11 0.62 9.04 1.88
26 INT181341 Binding of Ccr2 8 0.32 6.47 1.77
27 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
28 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
29 INT102550 Positive_regulation of Gene_expression of Ccr2 6 0.69 4.53 1.67
30 INT97133 Positive_regulation of CD83 3 0.42 11.97 1.61
31 INT181373 Negative_regulation of Gene_expression of Ccr2 5 0.59 5.92 1.44
32 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
33 INT190067 Binding of Traf2 5 0.20 3.28 1.27
34 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
35 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
36 INT281139 Phosphorylation of Ccr2 2 0.79 1.2 1.18
37 INT281141 Positive_regulation of Phosphorylation of Ccr2 2 0.49 1.2 1.18
38 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
39 INT62959 Positive_regulation of CCR2 4 0.61 1.47 1.13
40 INT222235 Localization of Ccr2 7 0.73 5.32 1.12
41 INT158242 Negative_regulation of Gene_expression of CCR2 3 0.37 2.13 1.12
42 INT151435 Negative_regulation of Positive_regulation of Ccr2 1 0.53 0.7 1.08
43 INT194657 Negative_regulation of CCR2 2 0.29 2.3 1.07
44 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
45 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
46 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
47 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
48 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
49 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
50 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
51 INT161223 Negative_regulation of Positive_regulation of Ccr2 1 0.43 0.83 0.81
52 INT204852 Gene_expression of Cd83 7 0.48 3.15 0.76
53 INT148839 Regulation of Gene_expression of CCR2 2 0.26 1.78 0.76
54 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
55 INT222239 Transcription of Ccr2 2 0.61 1.15 0.73
56 INT136269 Transcription of CCR2 2 0.61 1.27 0.69
57 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
58 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
59 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
60 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
61 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
62 INT97144 Negative_regulation of CD83 5 0.39 2.28 0.54
63 INT174797 Regulation of Tnfsf4 1 0.03 4.05 0.54
64 INT239551 Binding of CCR2 2 0.39 0 0.52
65 INT222242 Positive_regulation of Transcription of Ccr2 1 0.44 0.66 0.52
66 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
67 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
68 INT236350 Transcription of Ccr2 2 0.72 3.59 0.49
69 INT272877 Localization of Ccr2 2 0.75 1.68 0.46
70 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46
71 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
72 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
73 INT172800 Binding of Tnfsf4 2 0.04 4.58 0.45
74 INT172801 Positive_regulation of Tnfsf4 4 0.08 7.95 0.44
75 INT44600 Gene_expression of MALT1 6 0.75 6.14 0.42
76 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
77 INT97141 Regulation of Gene_expression of CD83 6 0.55 2.66 0.4
78 INT163905 Positive_regulation of Positive_regulation of Ccr2 1 0.13 0.16 0.37
79 INT217464 Binding of Traf6 5 0.29 1.28 0.35
80 INT340642 Regulation of Gene_expression of Ccr2 1 0.62 2.26 0.35
81 INT298355 Regulation of CD83 5 0.24 2.98 0.32
82 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
83 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
84 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
85 INT174805 Gene_expression of Tnfsf4 1 0.04 3.49 0.28
86 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
87 INT222841 Phosphorylation of Map3k7 1 0.16 0.55 0.25
88 INT65739 Gene_expression of Map3k7 1 0.54 1.41 0.25
89 INT204848 Localization of Cd83 2 0.47 0.5 0.24
90 INT213966 Positive_regulation of Localization of Cd83 1 0.20 0.42 0.23
91 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
92 INT136270 Positive_regulation of Transcription of CCR2 1 0.09 0.82 0.22
93 INT158246 Phosphorylation of CCR2 1 0.55 0.32 0.21
94 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
95 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
96 INT204853 Positive_regulation of Cd83 3 0.29 0.29 0.2
97 INT213963 Positive_regulation of Gene_expression of Cd83 1 0.18 0.4 0.2
98 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
99 INT288669 Negative_regulation of Gene_expression of CD83 2 0.38 2.35 0.18
100 INT276401 Localization of MALT1 1 0.60 3.62 0.18
101 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
102 INT158245 Negative_regulation of Positive_regulation of CCR2 1 0.37 0.26 0.17
103 INT252702 Binding of TRAF2 3 0.23 2.21 0.16
104 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
105 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
106 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
107 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
108 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
109 INT172790 Negative_regulation of Tnfsf4 1 0.05 2.43 0.14
110 INT251559 Binding of Traf2 1 0.23 1.68 0.13
111 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
112 INT172785 Positive_regulation of Binding of Tnfsf4 1 0.05 2.89 0.12
113 INT347994 Positive_regulation of Gene_expression of Map3k7 1 0.26 1.27 0.11
114 INT347985 Gene_expression of Map3k7 1 0.35 1.26 0.11
115 INT229187 Binding of MALT1 2 0.31 1.48 0.09
116 INT144094 Negative_regulation of Localization of Ripk2 1 0.42 0.49 0.09
117 INT337246 Regulation of CCR2 1 0.35 0.75 0.09
118 INT236358 Regulation of Transcription of Ccr2 1 0.24 1 0.09
119 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
120 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
121 INT181172 Positive_regulation of MALT1 1 0.01 0.27 0.08
122 INT352409 Regulation of Positive_regulation of Ccr2 1 0.44 0.15 0.07
123 INT190543 Localization of Map3k7 1 0.33 0.74 0.07
124 INT174802 Positive_regulation of Regulation of Tnfsf4 1 0.03 0.92 0.06
125 INT276397 Positive_regulation of Localization of MALT1 1 0.37 1.17 0.04
126 INT186196 Binding of SASH3 1 0.01 0.49 0.04
127 INT276400 Positive_regulation of Binding of MALT1 1 0.37 1.09 0.04
128 INT174799 Regulation of Binding of Tnfsf4 1 0.03 0.92 0.04
129 INT276403 Regulation of MALT1 3 0.34 3.37 0.03
130 INT204865 Transcription of Cd83 1 0.43 0.08 0.03
131 INT337203 Binding of CD83 1 0.21 0.6 0.03
132 INT337243 Positive_regulation of Binding of CD83 1 0.29 0.6 0.03
133 INT266482 Phosphorylation of Map3k7 1 0.18 0.26 0
134 INT298986 Positive_regulation of Gene_expression of Traf6 1 0.23 0.4 0
135 INT222849 Gene_expression of Traf2 1 0.12 0.38 0
136 INT298982 Positive_regulation of Positive_regulation of Traf6 1 0.23 0.4 0
137 INT252712 Phosphorylation of TRAF2 1 0.28 1.38 0
138 INT347996 Binding of Map3k7 1 0.19 0.06 0
139 INT348474 Regulation of Gene_expression of TRAF2 1 0.23 0.41 0
140 INT337231 Transcription of CD83 1 0.39 0.63 0
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