GO:0032753

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Name positive regulation of interleukin-4 production
Categary Process
Go Slim No
Go Link GO:0032753
Unique Molecular Interactions 134
Total Molecular Interactions 183
Total Single Events 1091
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-4 production. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of interleukin-4 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
3 INT69307 Prkcq Negative_regulation of TH1L 1 0.00 0.98 0.98
4 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
5 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
6 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
7 INT237204 Binding of LGALS4 and Cd3e 1 0.15 2.61 0.8
8 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
9 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
10 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
11 INT325263 Il33 Positive_regulation of Gene_expression of Il5 1 0.16 1.59 0.69
12 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
13 INT73073 Binding of Cd3e and Oprk1 1 0.28 0.06 0.59
14 INT182348 Binding of Cd3e and Crp 1 0.15 2.33 0.56
15 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53
16 INT325259 Il33 Positive_regulation of Gene_expression of Spg21 1 0.07 1.23 0.53
17 INT325269 Il33 Positive_regulation of Spg21 1 0.05 1.11 0.48
18 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
19 INT164890 Binding of IL1RAP and IL33 1 0.09 0.2 0.36
20 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
21 INT94473 Binding of Cd3e and Trav6-3 2 0.05 0 0.34
22 INT94474 Binding of Cd3e and Il27ra 1 0.02 0 0.34
23 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34
24 INT329954 Binding of PRKCQ and SNRNP70 1 0.07 0.65 0.33
25 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
26 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33
27 INT325266 Positive_regulation of Spg21 Positive_regulation of Il33 1 0.05 0.75 0.32
28 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
29 INT325265 Il33 Positive_regulation of Gene_expression of Ik 1 0.01 0.67 0.32
30 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
31 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
32 INT311046 Binding of CSF2 and IL33 1 0.00 1.86 0.26
33 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
34 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
35 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
36 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
37 INT351143 Binding of Cd3e and Ighg2a 1 0.00 1.56 0.25
38 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
39 INT325276 Il33 Positive_regulation of Gene_expression of TNF 1 0.04 0.82 0.23
40 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
41 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22
42 INT237201 Cd3e Positive_regulation of KIT 1 0.03 0 0.21
43 INT202809 Cd3e Positive_regulation of Positive_regulation of Cxcl5 1 0.00 0.5 0.21
44 INT226335 Binding of IL20 and IL20RB 1 0.03 0.29 0.19
45 INT226370 Binding of IL24 and IL20RB 1 0.03 0.28 0.19
46 INT169567 IL33 Regulation of Pscs 1 0.03 0.46 0.19
47 INT164892 IL33 Regulation of Gene_expression of IL1RAP 1 0.06 0.2 0.18
48 INT316072 Binding of Cd3e and Ncam1 1 0.01 0.4 0.18
49 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18
50 INT316074 Binding of Cd19 and Cd3e 1 0.02 0.39 0.17
51 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
52 INT277990 Binding of Cd3e and Hand1 1 0.01 0.5 0.16
53 INT302381 Il33 Regulation of Gene_expression of Il4 1 0.01 0.76 0.16
54 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
55 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
56 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
57 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
58 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
59 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
60 INT169562 PDGFD Positive_regulation of Gene_expression of IL33 1 0.03 0.35 0.13
61 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
62 INT211313 Binding of Cd3e and Cd8a 1 0.02 0.19 0.13
63 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
64 INT194814 Cd3e Positive_regulation of Gene_expression of Il4 1 0.05 0 0.12
65 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12
66 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
67 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
68 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
69 INT350708 Foxp3 Regulation of Socs1 1 0.08 0.21 0.07
70 INT351142 Binding of Cd3e and Ighg2b 1 0.03 0.6 0.07
71 INT293220 Cd3e Regulation of Gene_expression of CNR2 1 0.03 0.06 0.06
72 INT293221 Cd3e Regulation of Gene_expression of CNR1 1 0.03 0.06 0.06
73 INT237190 Cd3e Positive_regulation of LPT 1 0.00 0.15 0.06
74 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
75 INT325255 Chchd8 Regulation of Il33 1 0.00 0.33 0.05
76 INT325261 Ralbp1 Positive_regulation of Gene_expression of Il33 1 0.01 0 0.05
77 INT178574 IL2RA Positive_regulation of Gene_expression of Cd3e 1 0.04 0.16 0.05
78 INT235640 Binding of GATA3 and Mrgpre 1 0.01 0.8 0.04
79 INT186183 Binding of SCARB2 and SASH3 1 0.00 0.49 0.04
80 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04
81 INT274577 Binding of MEFV and SASH3 1 0.01 0.45 0.04
82 INT350704 Foxp3 Negative_regulation of Gene_expression of Mir142 1 0.02 0.13 0.04
83 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
84 INT350696 Mir31 Regulation of Gene_expression of Foxp3 1 0.04 0 0.03
85 INT336404 Binding of Cd3e and ALPK1 1 0.01 0.55 0.03
86 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
87 INT182918 Binding of DR1 and RARA 2 0.08 0 0
88 INT182949 Binding of RARA and VDR 1 0.20 0 0
89 INT274591 Binding of PSTPIP1 and SASH3 1 0.01 0 0
90 INT164899 IL33 Positive_regulation of IFNG 1 0.25 0.05 0
91 INT331089 Binding of Cd3e and Itga2 1 0.09 0.2 0
92 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0
93 INT164895 IL33 Positive_regulation of Gene_expression of CCL2 1 0.16 0.05 0
94 INT164901 IL33 Positive_regulation of Gene_expression of CXCL10 1 0.16 0.05 0
95 INT164906 IL33 Positive_regulation of Gene_expression of IL4 1 0.43 0.05 0
96 INT321642 Binding of Cd3e and Spn 1 0.00 1.08 0
97 INT164910 IL33 Positive_regulation of Gene_expression of CXCL1 1 0.12 0.05 0
98 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
99 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 0.03 0 0
100 INT276606 Binding of DBT and IL33 1 0.01 0 0
101 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0
102 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
103 INT182961 Binding of RARA and KCNIP3 1 0.21 0.76 0
104 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0
105 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0
106 INT256385 Foxp3 Positive_regulation of Cd4 1 0.32 0.15 0
107 INT234440 Binding of PROC and RARA 1 0.00 0.73 0
108 INT325271 Positive_regulation of Il33 Regulation of Gene_expression of Il1rl1 1 0.22 0 0
109 INT164912 IL33 Positive_regulation of Gene_expression of IL8 1 0.45 0.05 0
110 INT164903 IL33 Positive_regulation of Gene_expression of CXCL2 1 0.12 0.05 0
111 INT164889 IL33 Positive_regulation of Gene_expression of IFNG 1 0.25 0.05 0
112 INT355309 Positive_regulation of Binding of Cd3e and Cd5 1 0.03 2 0
113 INT164909 IL33 Positive_regulation of Phosphorylation of NFKBIA 1 0.53 0.05 0
114 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
115 INT274590 Positive_regulation of Binding of MEFV and SASH3 1 0.01 0.27 0
116 INT313481 Binding of Cd3e and Epcam 1 0.19 0.81 0
117 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
118 INT225504 Binding of gr and Rara 1 0.02 0 0
119 INT355314 Binding of Cd3e and Cd5 1 0.02 1.99 0
120 INT182948 KCNIP3 Regulation of Transcription of RARA 1 0.23 0.55 0
121 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0
122 INT164893 IL33 Positive_regulation of Gene_expression of IL6 1 0.46 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-4 production. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of interleukin-4 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
2 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21
3 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
4 INT226402 Gene_expression of Il33 60 0.77 23.82 8.67
5 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
6 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
7 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
8 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
9 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
10 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
11 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41
12 INT36286 Binding of Cd3e 33 0.36 10.11 3.21
13 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16
14 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
15 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
16 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
17 INT63846 Gene_expression of Prkcq 1 0.73 1.11 2.58
18 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
19 INT172078 Localization of Cd3e 22 0.37 9.88 2.27
20 INT325254 Positive_regulation of Il33 19 0.69 6.56 2.09
21 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
22 INT325244 Localization of Il33 1 0.80 4.17 1.8
23 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
24 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
25 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
26 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46
27 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
28 INT67457 Binding of Rara 12 0.24 8.28 1.45
29 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
30 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
31 INT116008 Binding of Gata3 2 0.34 1.37 1.41
32 INT70954 Negative_regulation of Cd3e 11 0.41 4.22 1.31
33 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
34 INT81400 Binding of RARA 25 0.36 12.93 1.27
35 INT63849 Regulation of Gene_expression of Prkcq 1 0.58 0.62 1.24
36 INT63847 Regulation of Prkcq 1 0.42 0.5 1.23
37 INT63856 Positive_regulation of Gene_expression of Prkcq 1 0.47 0.53 1.16
38 INT229562 Negative_regulation of Foxp3 6 0.36 3.7 1.14
39 INT182985 Transcription of RARA 9 0.60 3.52 1.12
40 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
41 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
42 INT192090 Localization of Rara 6 0.46 4.15 0.89
43 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
44 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
45 INT89669 Negative_regulation of Positive_regulation of Prkcq 1 0.08 0.23 0.87
46 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
47 INT89668 Positive_regulation of Prkcq 1 0.09 0.22 0.86
48 INT48250 Regulation of Rara 3 0.29 2.47 0.83
49 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
50 INT325230 Positive_regulation of Gene_expression of Il33 1 0.50 1.47 0.83
51 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
52 INT157492 Transcription of Foxp3 4 0.61 1.69 0.81
53 INT212109 Localization of RARA 5 0.65 3.17 0.79
54 INT174492 Positive_regulation of Gene_expression of Cd3e 8 0.39 5.08 0.77
55 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
56 INT204929 Binding of IL33 18 0.08 4.74 0.7
57 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
58 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
59 INT226421 Regulation of Il33 2 0.45 2.7 0.68
60 INT91398 Regulation of RARA 7 0.59 5.84 0.67
61 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
62 INT297286 Positive_regulation of Foxp3 7 0.58 3.05 0.63
63 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
64 INT226403 Regulation of Gene_expression of Il33 2 0.61 1.94 0.63
65 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
66 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
67 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
68 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
69 INT273000 Localization of IL33 5 0.45 1.77 0.56
70 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
71 INT174797 Regulation of Tnfsf4 1 0.03 4.05 0.54
72 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
73 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49
74 INT157490 Regulation of Gene_expression of Foxp3 5 0.37 2.4 0.47
75 INT172077 Positive_regulation of Localization of Cd3e 3 0.09 3.18 0.47
76 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
77 INT155265 Regulation of Cd3e 7 0.17 2.62 0.46
78 INT63850 Negative_regulation of Prkcq 1 0.40 0 0.46
79 INT172800 Binding of Tnfsf4 2 0.04 4.58 0.45
80 INT110477 Positive_regulation of Localization of PRKCZ 1 0.20 0.07 0.45
81 INT325251 Positive_regulation of Localization of Il33 1 0.69 1.03 0.45
82 INT172801 Positive_regulation of Tnfsf4 4 0.08 7.95 0.44
83 INT110479 Localization of PRKCZ 1 0.35 0.07 0.43
84 INT188345 Regulation of Foxp3 3 0.18 1.59 0.42
85 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
86 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
87 INT325250 Regulation of Positive_regulation of Il33 2 0.45 1.16 0.39
88 INT273005 Negative_regulation of IL33 4 0.07 2.4 0.38
89 INT325234 Negative_regulation of Il33 1 0.43 0.67 0.37
90 INT110478 Regulation of PRKCZ 1 0.20 0.1 0.37
91 INT325231 Negative_regulation of Negative_regulation of Il33 1 0.43 0.67 0.34
92 INT174805 Gene_expression of Tnfsf4 1 0.04 3.49 0.28
93 INT278687 Regulation of Positive_regulation of Cd3e 1 0.10 0.51 0.23
94 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
95 INT188346 Binding of Foxp3 1 0.27 0.4 0.18
96 INT226496 Localization of IL20RB 1 0.34 0.23 0.18
97 INT325246 Regulation of Localization of Il33 1 0.27 0.23 0.16
98 INT169566 Positive_regulation of Gene_expression of IL33 1 0.41 0.38 0.14
99 INT172790 Negative_regulation of Tnfsf4 1 0.05 2.43 0.14
100 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
101 INT325249 Binding of Il33 1 0.37 0.72 0.13
102 INT319432 Positive_regulation of Localization of IL33 1 0.26 1.02 0.13
103 INT164918 Regulation of Gene_expression of IL33 2 0.44 1.09 0.12
104 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
105 INT172785 Positive_regulation of Binding of Tnfsf4 1 0.05 2.89 0.12
106 INT276923 Localization of Foxp3 1 0.38 0.52 0.12
107 INT211285 Positive_regulation of Positive_regulation of Cd3e 1 0.25 0.35 0.11
108 INT169564 Negative_regulation of Gene_expression of IL33 1 0.38 0.3 0.11
109 INT211299 Regulation of Gene_expression of Cd3e 3 0.23 0.79 0.1
110 INT70955 Negative_regulation of Negative_regulation of Cd3e 1 0.41 0.47 0.09
111 INT312847 Regulation of Localization of Cd3e 1 0.06 1.61 0.09
112 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
113 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
114 INT180504 Phosphorylation of Cd3e 2 0.49 0.38 0.07
115 INT180505 Positive_regulation of Phosphorylation of Cd3e 1 0.06 0.38 0.07
116 INT174802 Positive_regulation of Regulation of Tnfsf4 1 0.03 0.92 0.06
117 INT197017 Binding of GATA3 2 0.36 0.94 0.04
118 INT260808 Negative_regulation of Gene_expression of Cd3e 2 0.21 0.81 0.04
119 INT186196 Binding of SASH3 1 0.01 0.49 0.04
120 INT174799 Regulation of Binding of Tnfsf4 1 0.03 0.92 0.04
121 INT330788 Protein_catabolism of Cd3e 1 0.07 0 0.04
122 INT265385 Negative_regulation of Binding of Cd3e 1 0.04 0.23 0.03
123 INT325253 Negative_regulation of Positive_regulation of Il33 1 0.42 0 0.03
124 INT325247 Negative_regulation of Gene_expression of Il33 1 0.42 0 0.03
125 INT333755 Negative_regulation of Positive_regulation of Foxp3 1 0.49 0.18 0.03
126 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
127 INT211290 Regulation of Binding of Cd3e 2 0.23 0 0
128 INT157493 Positive_regulation of Transcription of Foxp3 1 0.59 0.06 0
129 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
130 INT325237 Transcription of Il33 1 0.68 0.15 0
131 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
132 INT294502 Transcription of Cd3e 1 0.27 0 0
133 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
134 INT276617 Negative_regulation of Localization of IL33 1 0.03 0.28 0
135 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
136 INT235637 Localization of GATA3 1 0.73 0.55 0
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