GO:0032792

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Name negative regulation of CREB transcription factor activity
Categary Process
Go Slim No
Go Link GO:0032792
Unique Molecular Interactions 52
Total Molecular Interactions 70
Total Single Events 577
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of CREB transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of CREB transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118568 Binding of Ddit3 and Atf6 1 0.33 0.85 0.66
2 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
3 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
4 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
5 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
6 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
7 INT318680 Binding of Cebpg and Ddit3 1 0.39 1.73 0.18
8 INT296081 Binding of FOXP3 and Gtf3a 1 0.00 1.16 0.16
9 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16
10 INT296082 Binding of Rel and FOXP3 1 0.35 1.14 0.15
11 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
12 INT286969 IL2 Regulation of Gene_expression of FOXP3 1 0.04 1.05 0.1
13 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
14 INT296039 Binding of FOXP3 and IL17RB 1 0.01 0.63 0.08
15 INT296034 FOXP3 Negative_regulation of Gene_expression of IL7R 1 0.10 0.63 0.08
16 INT215879 Ddit3 Regulation of Regulation of Atf4 1 0.26 0.29 0.07
17 INT350708 Foxp3 Regulation of Socs1 1 0.08 0.21 0.07
18 INT238207 Binding of Bmx and Sik1 1 0.01 0.43 0.07
19 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
20 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06
21 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
22 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06
23 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06
24 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06
25 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
26 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06
27 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
28 INT238208 Sik1 Positive_regulation of Positive_regulation of Bmx 1 0.01 0 0.05
29 INT238211 Binding of STAT3 and Sik1 1 0.04 0.25 0.04
30 INT215871 Atf4 Regulation of Ddit3 1 0.26 0.43 0.04
31 INT286967 Positive_regulation of STAT3 Regulation of Gene_expression of FOXP3 1 0.35 0.44 0.04
32 INT350704 Foxp3 Negative_regulation of Gene_expression of Mir142 1 0.02 0.13 0.04
33 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03
34 INT350696 Mir31 Regulation of Gene_expression of Foxp3 1 0.04 0 0.03
35 INT355441 VEGFA Positive_regulation of Gene_expression of Ddit3 1 0.05 0.43 0.03
36 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
37 INT316774 Hsp90b1 Positive_regulation of Localization of Ddit3 1 0.12 0.17 0
38 INT355437 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of Ddit3 1 0.04 0.47 0
39 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
40 INT316770 Hsp90b1 Positive_regulation of Ddit3 1 0.12 0.17 0
41 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
42 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 0.03 0 0
43 INT355436 Pdia3 Regulation of Transcription of Ddit3 1 0.04 0.59 0
44 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
45 INT256385 Foxp3 Positive_regulation of Cd4 1 0.32 0.15 0
46 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
47 INT174720 Ddit3 Regulation of Gtf3a 1 0.01 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of CREB transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of CREB transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
2 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
3 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01
4 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32
5 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
6 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98
7 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92
8 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
9 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72
10 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46
11 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
12 INT116144 Positive_regulation of Positive_regulation of Ddit3 2 0.41 2.95 1.2
13 INT229562 Negative_regulation of Foxp3 6 0.36 3.7 1.14
14 INT116140 Localization of Ddit3 2 0.57 1.94 0.96
15 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83
16 INT157492 Transcription of Foxp3 4 0.61 1.69 0.81
17 INT150251 Transcription of FOXP3 7 0.61 0.43 0.76
18 INT318666 Negative_regulation of Ddit3 1 0.56 6.86 0.7
19 INT221428 Negative_regulation of Negative_regulation of FOXP3 1 0.35 1.97 0.7
20 INT118564 Regulation of Gene_expression of Ddit3 1 0.55 0.89 0.68
21 INT318667 Negative_regulation of Gene_expression of Ddit3 6 0.56 3.16 0.65
22 INT297286 Positive_regulation of Foxp3 7 0.58 3.05 0.63
23 INT157490 Regulation of Gene_expression of Foxp3 5 0.37 2.4 0.47
24 INT188345 Regulation of Foxp3 3 0.18 1.59 0.42
25 INT173418 Transcription of Ddit3 6 0.65 7.91 0.41
26 INT260115 Regulation of FOXP3 3 0.29 0.75 0.34
27 INT202373 Transcription of Ddit3 6 0.62 5.52 0.29
28 INT260120 Regulation of Gene_expression of FOXP3 4 0.31 2.74 0.29
29 INT154749 Negative_regulation of Gene_expression of Ddit3 2 0.41 1.15 0.27
30 INT215850 Regulation of Ddit3 5 0.50 6.15 0.25
31 INT252833 Positive_regulation of Gene_expression of Ddit3 4 0.67 7.58 0.25
32 INT188346 Binding of Foxp3 1 0.27 0.4 0.18
33 INT276372 Negative_regulation of Gene_expression of FOXP3 2 0.38 1.49 0.16
34 INT150253 Positive_regulation of Transcription of FOXP3 2 0.39 0 0.15
35 INT335788 Localization of FOXP3 1 0.34 0.42 0.15
36 INT335812 Regulation of Transcription of FOXP3 1 0.21 0.34 0.14
37 INT286970 Binding of FOXP3 1 0.24 1.04 0.13
38 INT276923 Localization of Foxp3 1 0.38 0.52 0.12
39 INT143825 Regulation of Ddit3 3 0.58 2.03 0.11
40 INT286971 Positive_regulation of Positive_regulation of FOXP3 1 0.32 0.57 0.09
41 INT173416 Localization of Ddit3 2 0.71 0.98 0.08
42 INT173421 Positive_regulation of Transcription of Ddit3 2 0.47 0.7 0.08
43 INT327269 Regulation of Transcription of Ddit3 1 0.06 1.24 0.08
44 INT174717 Negative_regulation of Transcription of Ddit3 1 0.32 0.5 0.08
45 INT174709 Positive_regulation of Positive_regulation of Ddit3 1 0.38 0.85 0.08
46 INT263568 Negative_regulation of Positive_regulation of Ddit3 1 0.47 0.98 0.08
47 INT173420 Regulation of Gene_expression of Ddit3 2 0.37 0.84 0.07
48 INT238167 Localization of Sik1 1 0.06 0.16 0.07
49 INT238165 Gene_expression of Sik1 1 0.05 0.2 0.07
50 INT279378 Negative_regulation of Ddit3 2 0.30 1.35 0.06
51 INT296074 Regulation of Positive_regulation of FOXP3 1 0.18 0.28 0.06
52 INT316762 Binding of Ddit3 1 0.11 0.14 0.04
53 INT260113 Positive_regulation of Regulation of FOXP3 1 0.32 0.15 0.04
54 INT215856 Positive_regulation of Transcription of Ddit3 2 0.60 2.12 0.03
55 INT238158 Phosphorylation of Sik1 1 0.06 0.69 0.03
56 INT238181 Binding of Sik1 1 0.04 0.18 0.03
57 INT238182 Positive_regulation of Localization of Sik1 1 0.04 0 0.03
58 INT238161 Positive_regulation of Phosphorylation of Sik1 1 0.04 0 0.03
59 INT333755 Negative_regulation of Positive_regulation of Foxp3 1 0.49 0.18 0.03
60 INT206911 Gene_expression of Msx2 4 0.71 1.26 0
61 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0
62 INT157493 Positive_regulation of Transcription of Foxp3 1 0.59 0.06 0
63 INT206916 Positive_regulation of Gene_expression of Msx2 1 0.40 0.36 0
64 INT220772 Transcription of Msx2 1 0.46 0.08 0
65 INT238166 Positive_regulation of Sik1 1 0.03 0.13 0
66 INT238157 Positive_regulation of Gene_expression of Sik1 1 0.03 0 0
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