GO:0032795

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Name heterotrimeric G-protein binding
Categary Function
Go Slim No
Go Link GO:0032795
Unique Molecular Interactions 95
Total Molecular Interactions 132
Total Single Events 1221
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heterotrimeric G-protein binding. They are ordered first by their pain relevance and then by number of times they were reported for heterotrimeric G-protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
4 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
5 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
6 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
7 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
8 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
9 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
10 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
11 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
12 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
13 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
14 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
15 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
16 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
17 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
18 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
19 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
20 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
21 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
22 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
23 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
24 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
25 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
26 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
27 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
28 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
29 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
30 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
31 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
32 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
33 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
34 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
35 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
36 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
37 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
38 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
39 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
40 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
41 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
42 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
43 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
44 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
45 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
46 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
47 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
48 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
49 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
50 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
51 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
52 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
53 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41
54 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
55 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
56 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
57 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
58 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
59 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
60 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
61 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
62 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
63 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
64 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
65 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
66 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
67 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
68 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
69 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
70 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
71 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
72 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
73 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
74 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
75 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
76 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18
77 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
78 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
79 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
80 INT207117 Binding of VEGFA and F2r 1 0.02 0.56 0.15
81 INT338040 Ctsg Positive_regulation of F2r 1 0.29 0 0.15
82 INT338052 F2r Positive_regulation of F2rl3 1 0.12 0 0.15
83 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
84 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
85 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
86 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
87 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
88 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
89 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
90 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
91 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
92 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
93 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
94 INT338047 Binding of F2r and Pard3 1 0.11 0 0
95 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heterotrimeric G-protein binding. They are ordered first by their pain relevance and then by number of times they were reported in heterotrimeric G-protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
4 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
5 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
6 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
7 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
8 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
9 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
10 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
11 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
12 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
13 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
14 INT19155 Binding of Adora1 25 0.47 6.41 10.72
15 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
16 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
17 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
18 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
19 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
20 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
21 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
22 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
23 INT9167 Binding of Adora1 6 0.40 0.53 6.9
24 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
25 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
26 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
27 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
28 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
29 INT215604 Localization of Adora1 10 0.78 1.47 3.49
30 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
31 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
32 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
33 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
34 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
35 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
36 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
37 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
38 INT82653 Regulation of F2r 8 0.36 3.78 2.62
39 INT111017 Regulation of F2rl1 3 0.22 0 2.61
40 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
41 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
42 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
43 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
44 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
45 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
46 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
47 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
48 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
49 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
50 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
51 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
52 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
53 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
54 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
55 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
56 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
57 INT156231 Binding of F2r 9 0.23 3.78 1.57
58 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
59 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
60 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
61 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
62 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
63 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
64 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
65 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
66 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
67 INT117498 Regulation of Positive_regulation of F2r 1 0.18 0.91 1.24
68 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
69 INT338033 Localization of F2r 1 0.41 0.62 1.2
70 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
71 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
72 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
73 INT195105 Negative_regulation of Gene_expression of F2r 3 0.37 1.41 0.91
74 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
75 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
76 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
77 INT195099 Positive_regulation of Gene_expression of F2r 7 0.57 5.31 0.78
78 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
79 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
80 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
81 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
82 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
83 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
84 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
85 INT207089 Regulation of Negative_regulation of F2r 1 0.17 1.49 0.62
86 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
87 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
88 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
89 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
90 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
91 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
92 INT338026 Regulation of Localization of F2r 1 0.25 0.05 0.52
93 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
94 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
95 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
96 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
97 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
98 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
99 INT29102 Transcription of ADRA2A 2 0.27 0.83 0.46
100 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
101 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
102 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
103 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
104 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
105 INT29100 Negative_regulation of Binding of ADRA2A 1 0.19 0.84 0.37
106 INT29101 Positive_regulation of Transcription of ADRA2A 1 0.19 0.76 0.32
107 INT92881 Transcription of ADORA1 1 0.69 0 0.31
108 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
109 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
110 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25
111 INT195091 Negative_regulation of Positive_regulation of F2r 1 0.48 1.69 0.25
112 INT25928 Positive_regulation of Negative_regulation of ADRA2A 1 0.05 0 0.23
113 INT186700 Localization of Adora1 1 0.23 0 0.23
114 INT195112 Positive_regulation of Positive_regulation of F2r 1 0.41 0.97 0.18
115 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
116 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
117 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
118 INT207087 Negative_regulation of Binding of F2r 1 0.27 0.06 0.14
119 INT134177 Positive_regulation of Gene_expression of ADRA2A 1 0.10 0.26 0.12
120 INT134178 Positive_regulation of Regulation of ADRA2A 1 0.10 0.24 0.12
121 INT145503 Protein_catabolism of F2r 1 0.66 0.46 0.07
122 INT195082 Regulation of Gene_expression of F2r 1 0.37 0.67 0.07
123 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
124 INT210662 Transcription of Adra2a 1 0.01 0.09 0
125 INT338031 Transcription of F2r 1 0.39 0 0
126 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
127 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
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