GO:0032813

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Name tumor necrosis factor receptor superfamily binding
Categary Function
Go Slim No
Go Link GO:0032813
Unique Molecular Interactions 153
Total Molecular Interactions 271
Total Single Events 1368
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tumor necrosis factor receptor superfamily binding. They are ordered first by their pain relevance and then by number of times they were reported for tumor necrosis factor receptor superfamily binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
2 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
3 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
4 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
5 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
6 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
7 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
8 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
9 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
10 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
11 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
12 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
13 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
14 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
15 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57
16 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
17 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
18 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
19 INT162991 Binding of Fadd and Ppm1e 1 0.03 0.09 0.52
20 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
21 INT187227 Vip Negative_regulation of Gene_expression of Tnfsf11 1 0.35 1.23 0.51
22 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
23 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
24 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
25 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
26 INT162993 Binding of Trib3 and Fadd 1 0.05 0.1 0.46
27 INT315333 Binding of Cflar and Fadd 1 0.01 0.49 0.42
28 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41
29 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33
30 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
31 INT165765 Tnfsf11 Positive_regulation of Nfkb1 1 0.01 1.07 0.33
32 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
33 INT187223 Il1 Positive_regulation of Gene_expression of Tnfsf11 1 0.09 0.64 0.32
34 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31
35 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
36 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3
37 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3
38 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28
39 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22
40 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21
41 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21
42 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21
43 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21
44 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21
45 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2
46 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
47 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
48 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
49 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19
50 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19
51 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17
52 INT259017 Binding of TNFSF18 and Tnfrsf18 1 0.08 1.27 0.16
53 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
54 INT81992 IL1A Positive_regulation of Positive_regulation of Tnfsf11 1 0.05 0.27 0.13
55 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12
56 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11
57 INT93535 PTH Negative_regulation of Gene_expression of Tnfsf11 1 0.19 0.22 0.11
58 INT107909 Binding of Tnfsf11 and Tnfrsf22 1 0.01 2.12 0.11
59 INT254284 Binding of TNF and Tnfsf11 1 0.04 0.44 0.1
60 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09
61 INT210595 Binding of TNF and TNFSF11 1 0.10 5.13 0.09
62 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08
63 INT210600 IL1B Regulation of TNFSF11 1 0.04 1.45 0.08
64 INT338999 Binding of BTF3P11 and Tnfsf11 1 0.01 0.35 0.08
65 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08
66 INT321867 TNFRSF11B Negative_regulation of TNFSF11 1 0.00 0.85 0.08
67 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08
68 INT334061 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.01 0.52 0.08
69 INT321868 Binding of TNFRSF11B and Negative_regulation of TNFSF11 1 0.00 0.91 0.08
70 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08
71 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08
72 INT127722 CSF1 Positive_regulation of TNFSF11 1 0.08 0.26 0.06
73 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05
74 INT224421 TNFRSF11B Regulation of TNFSF11 1 0.27 0 0.05
75 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04
76 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04
77 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04
78 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
79 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
80 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04
81 INT251565 Binding of Casp8 and Fadd 1 0.04 1.18 0.04
82 INT340276 Tnfsf11 Positive_regulation of Localization of RELA 1 0.02 0.58 0.03
83 INT165988 PTGER1 Positive_regulation of TNFSF11 1 0.05 0.13 0
84 INT340270 Negative_regulation of Tnfsf11 Positive_regulation of TRAP 1 0.03 0.37 0
85 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0
86 INT323703 FADD Positive_regulation of FAS 1 0.26 0.75 0
87 INT259014 Tnfrsf18 Positive_regulation of TNFSF18 1 0.08 0.39 0
88 INT298585 TNFSF11 Positive_regulation of ACP5 1 0.16 0.09 0
89 INT165986 PTGER1 Regulation of Positive_regulation of TNFSF11 1 0.04 0.12 0
90 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0
91 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0
92 INT298586 PTGER2 Regulation of Gene_expression of TNFSF11 1 0.06 0 0
93 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0
94 INT259016 Positive_regulation of Binding of TNFSF18 and Relt 1 0.06 0.67 0
95 INT298587 TNFSF11 Regulation of IL1B 1 0.18 0 0
96 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0
97 INT292559 Binding of TNFRSF1A and FADD 1 0.05 0.09 0
98 INT267256 Binding of FAS and Fadd 1 0.11 1.14 0
99 INT210580 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.07 0.19 0
100 INT135179 DCSTAMP Positive_regulation of Gene_expression of TNFSF11 1 0.06 0 0
101 INT340277 Tnfsf11 Positive_regulation of TRAP 1 0.03 0.76 0
102 INT340272 Tnfsf11 Positive_regulation of Gene_expression of NFATC1 1 0.09 0.56 0
103 INT165987 PTGER1 Regulation of Gene_expression of TNFSF11 1 0.06 0.16 0
104 INT298582 IL1B Regulation of Gene_expression of TNFSF11 1 0.46 0 0
105 INT340238 Tnfsf11 Positive_regulation of Gene_expression of Fig4 1 0.02 0.4 0
106 INT259018 Positive_regulation of Binding of TNFSF18 and Tnfrsf18 1 0.11 0.67 0
107 INT259015 Binding of TNFSF18 and Relt 1 0.04 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tumor necrosis factor receptor superfamily binding. They are ordered first by their pain relevance and then by number of times they were reported in tumor necrosis factor receptor superfamily binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
2 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
3 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
4 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
5 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
6 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
7 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
8 INT133602 Positive_regulation of Fadd 2 0.54 0.38 4.02
9 INT133604 Negative_regulation of Fadd 4 0.57 0.81 3.5
10 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
11 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
12 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
13 INT158827 Positive_regulation of FADD 7 0.43 2.6 2.54
14 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
15 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
16 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
17 INT133607 Regulation of Fadd 1 0.60 0.41 2.04
18 INT133605 Positive_regulation of Negative_regulation of Fadd 1 0.46 0.28 1.96
19 INT139174 Positive_regulation of Fadd 1 0.59 0.83 1.94
20 INT139185 Phosphorylation of Fadd 1 0.69 0.59 1.92
21 INT133609 Negative_regulation of Positive_regulation of Fadd 2 0.46 0.24 1.9
22 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82
23 INT139177 Regulation of Fadd 1 0.60 0.78 1.69
24 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61
25 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54
26 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46
27 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38
28 INT134147 Positive_regulation of Gene_expression of FADD 2 0.59 1.59 1.31
29 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27
30 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25
31 INT133610 Negative_regulation of Negative_regulation of Fadd 1 0.50 0.19 1.19
32 INT105552 Positive_regulation of Transcription of Tnfsf11 3 0.31 2.94 1.17
33 INT224429 Regulation of TNFSF11 8 0.61 4.35 1.13
34 INT210586 Negative_regulation of Positive_regulation of Tnfsf11 3 0.41 1.4 1.02
35 INT132847 Negative_regulation of Localization of Tnfsf11 1 0.32 0.16 1.01
36 INT153628 Phosphorylation of Fadd 2 0.74 0.45 1
37 INT171963 Positive_regulation of Positive_regulation of Tnfsf11 3 0.42 2.44 0.93
38 INT139176 Gene_expression of Fadd 5 0.51 5.26 0.92
39 INT158825 Phosphorylation of FADD 1 0.81 1.63 0.89
40 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79
41 INT133612 Gene_expression of Fadd 1 0.76 0.27 0.76
42 INT139173 Positive_regulation of Phosphorylation of Fadd 1 0.42 0.28 0.76
43 INT133613 Regulation of Gene_expression of Fadd 1 0.44 0.27 0.76
44 INT298598 Positive_regulation of Positive_regulation of TNFSF11 2 0.38 1.26 0.72
45 INT139182 Binding of Fadd 3 0.36 2.74 0.71
46 INT155089 Negative_regulation of FADD 2 0.42 1.31 0.71
47 INT165760 Positive_regulation of Binding of Tnfsf11 2 0.36 1.83 0.71
48 INT162988 Positive_regulation of Positive_regulation of Fadd 1 0.36 0.07 0.7
49 INT185729 Negative_regulation of Gene_expression of Tnfsf11 3 0.52 2.07 0.69
50 INT205171 Localization of TNFSF11 4 0.74 3.94 0.66
51 INT139179 Negative_regulation of Fadd 1 0.36 0.35 0.64
52 INT139175 Regulation of Binding of Fadd 1 0.44 0.34 0.63
53 INT264991 Positive_regulation of Localization of Tnfsf11 5 0.24 3.22 0.59
54 INT174797 Regulation of Tnfsf4 1 0.03 4.05 0.54
55 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5
56 INT259010 Gene_expression of TNFSF18 1 0.31 4.54 0.49
57 INT158823 Positive_regulation of Binding of FADD 1 0.43 0.23 0.47
58 INT158826 Binding of FADD 1 0.41 0.23 0.47
59 INT172800 Binding of Tnfsf4 2 0.04 4.58 0.45
60 INT172801 Positive_regulation of Tnfsf4 4 0.08 7.95 0.44
61 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44
62 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44
63 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42
64 INT165761 Phosphorylation of Tnfsf11 3 0.75 2.76 0.4
65 INT187214 Negative_regulation of Binding of Tnfsf11 1 0.25 1.01 0.38
66 INT135188 Transcription of TNFSF11 4 0.59 0.72 0.36
67 INT162980 Binding of Fadd 1 0.33 0.1 0.36
68 INT158821 Positive_regulation of Phosphorylation of FADD 1 0.49 0.58 0.33
69 INT295000 Binding of Tnfsf11 5 0.32 2.27 0.32
70 INT174805 Gene_expression of Tnfsf4 1 0.04 3.49 0.28
71 INT158822 Regulation of Phosphorylation of FADD 1 0.39 0.55 0.25
72 INT137847 Negative_regulation of Tnfsf11 4 0.42 1.31 0.24
73 INT210588 Protein_catabolism of Tnfsf11 1 0.72 1.43 0.23
74 INT259013 Positive_regulation of TNFSF18 1 0.24 3.64 0.16
75 INT172790 Negative_regulation of Tnfsf4 1 0.05 2.43 0.14
76 INT294997 Regulation of Gene_expression of Tnfsf11 1 0.35 0.81 0.13
77 INT172785 Positive_regulation of Binding of Tnfsf4 1 0.05 2.89 0.12
78 INT323740 Regulation of FADD 1 0.13 1.08 0.11
79 INT210605 Negative_regulation of Negative_regulation of TNFSF11 2 0.42 1.65 0.1
80 INT251553 Positive_regulation of Binding of Fadd 1 0.19 1.19 0.07
81 INT224430 Positive_regulation of Transcription of TNFSF11 1 0.43 0.06 0.07
82 INT144491 Negative_regulation of Transcription of Tnfsf11 1 0.42 0.82 0.07
83 INT259012 Positive_regulation of Gene_expression of TNFSF18 1 0.27 2.82 0.06
84 INT174802 Positive_regulation of Regulation of Tnfsf4 1 0.03 0.92 0.06
85 INT210608 Negative_regulation of Binding of TNFSF11 2 0.25 2.31 0.04
86 INT302962 Positive_regulation of Gene_expression of Fadd 2 0.27 1.45 0.04
87 INT232197 Positive_regulation of Phosphorylation of Tnfsf11 1 0.46 0.6 0.04
88 INT174799 Regulation of Binding of Tnfsf4 1 0.03 0.92 0.04
89 INT232196 Negative_regulation of Negative_regulation of Tnfsf11 1 0.39 1.5 0.04
90 INT210609 Positive_regulation of Localization of TNFSF11 1 0.41 1.12 0.04
91 INT210591 Positive_regulation of Negative_regulation of Tnfsf11 1 0.47 1.46 0.03
92 INT259011 Transcription of TNFSF18 1 0.25 0.25 0
93 INT292588 Positive_regulation of Positive_regulation of FADD 1 0.11 0.2 0
94 INT221486 Positive_regulation of Binding of TNFSF11 1 0.15 0.98 0
95 INT274022 Regulation of Positive_regulation of TNFSF11 1 0.05 0.29 0
96 INT205176 Protein_catabolism of TNFSF11 1 0.29 0.25 0
97 INT185731 Negative_regulation of Regulation of Tnfsf11 1 0.34 0.89 0
98 INT329484 Regulation of Regulation of TNFSF11 1 0.23 0.71 0
99 INT185728 Positive_regulation of Positive_regulation of Tnfsf11 1 0.36 0.25 0
100 INT340267 Negative_regulation of Localization of Tnfsf11 1 0.19 0.45 0
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