GO:0032862

From wiki-pain
Jump to: navigation, search
Name activation of Rho GTPase activity
Categary Process
Go Slim No
Go Link GO:0032862
Unique Molecular Interactions 70
Total Molecular Interactions 90
Total Single Events 708
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of Rho GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of Rho GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75
2 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97
3 INT181437 Binding of Ccr7 and Ccl21b 1 0.01 2.23 0.87
4 INT181452 Binding of Ccl19 and Ccl21b 1 0.02 2.22 0.86
5 INT276865 Regulation of Trpv1 Regulation of Gene_expression of Gpr65 1 0.25 0.62 0.76
6 INT249536 Binding of EPHA1 and Efnb2 1 0.02 0.28 0.52
7 INT208571 CCL21 Positive_regulation of Gene_expression of CCL16 1 0.51 0.63 0.38
8 INT7893 Binding of Oprm1 and Ccl21b 1 0.00 0.08 0.35
9 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
10 INT225021 PDGFB Positive_regulation of Ccl21 1 0.10 0.07 0.3
11 INT225026 PDGFB Positive_regulation of Gene_expression of Ccl21 1 0.10 0.07 0.3
12 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18
13 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
14 INT181842 PHB2 Regulation of CCR7 1 0.00 0.7 0.14
15 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13
16 INT265388 CCL21 Positive_regulation of Gene_expression of CXCL9 1 0.13 0.88 0.1
17 INT265389 CCL21 Positive_regulation of Gene_expression of CXCL10 1 0.16 0.88 0.1
18 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
19 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09
20 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09
21 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08
22 INT194740 EPHA1 Positive_regulation of MAPK1 1 0.01 0.28 0.08
23 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
24 INT225023 PDGFB Regulation of Transcription of Ccl21 1 0.11 0 0.06
25 INT225022 PDGFB Regulation of Ccl21 1 0.11 0 0.06
26 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
27 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
28 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03
29 INT337174 Binding of TLR3 and Positive_regulation of CCR7 1 0.15 0.31 0.03
30 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
31 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
32 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
33 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
34 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
35 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0
36 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
37 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0
38 INT212409 Binding of Efna1 and Epha1 1 0.02 0.39 0
39 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
40 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0
41 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0
42 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0
43 INT352082 Binding of CCR7 and ADAM11 1 0.15 0.76 0
44 INT259093 Binding of TSC1 and LMO4 1 0.02 0.74 0
45 INT217786 TSC1 Regulation of MITF 1 0.00 1.27 0
46 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 1 0.27 0 0
47 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 0.01 1.43 0
48 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0
49 INT259092 TSC1 Positive_regulation of Gene_expression of TCEAL1 1 0.01 4.58 0
50 INT268596 Mir10a Regulation of TSC1 1 0.01 0.44 0
51 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0
52 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
53 INT300337 Gene_expression of MITF Negative_regulation of Gene_expression of TSC1 1 0.00 0.65 0
54 INT217784 Binding of MITF and TSC1 1 0.00 1.21 0
55 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0
56 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0
57 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0
58 INT217791 TP53 Positive_regulation of TSC1 1 0.04 0.61 0
59 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0
60 INT269939 Foxa1 Regulation of Gene_expression of Foxj1 1 0.26 0 0
61 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
62 INT268509 MIR146B Regulation of TSC1 1 0.03 0.44 0
63 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0
64 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of Rho GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of Rho GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT233457 Gene_expression of Gpr65 56 0.68 26.57 27.94
2 INT276855 Positive_regulation of Gene_expression of Gpr65 1 0.61 17.04 16.96
3 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42
4 INT146053 Positive_regulation of Gpr65 2 0.61 12.11 13.38
5 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76
6 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
7 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48
8 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
9 INT276843 Positive_regulation of Positive_regulation of Gpr65 1 0.44 1.85 3.29
10 INT126514 Positive_regulation of CCR7 16 0.43 16.21 2.79
11 INT182224 Binding of CCL21 6 0.34 5.91 2.54
12 INT108483 Positive_regulation of Gene_expression of CCL21 7 0.69 5.76 2.45
13 INT183159 Gene_expression of Epha1 3 0.25 3.15 2.17
14 INT181368 Gene_expression of Ccl21b 1 0.03 3.48 2.01
15 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87
16 INT177509 Regulation of CCL21 6 0.45 5.43 1.66
17 INT276837 Positive_regulation of Transcription of Gpr65 1 0.61 1.76 1.62
18 INT276848 Transcription of Gpr65 1 0.63 1.75 1.61
19 INT221059 Negative_regulation of CCL21 5 0.28 2.48 1.58
20 INT145921 Localization of CCL21 4 0.73 2.41 1.58
21 INT33299 Binding of CCR7 3 0.31 2.88 1.45
22 INT214073 Binding of TSC1 9 0.37 22 1.34
23 INT276836 Localization of Gpr65 1 0.70 1.19 1.03
24 INT181367 Negative_regulation of Ccl21b 1 0.01 1.72 0.98
25 INT73465 Transcription of TSC1 4 0.07 3.47 0.96
26 INT276852 Negative_regulation of Gene_expression of Gpr65 1 0.38 1.15 0.96
27 INT276827 Regulation of Gpr65 1 0.24 0.65 0.95
28 INT182239 Negative_regulation of Gene_expression of CCR7 1 0.36 1.16 0.91
29 INT276838 Binding of Gpr65 1 0.33 0.38 0.81
30 INT74019 Regulation of TSC1 27 0.35 23.61 0.79
31 INT136600 Binding of EPHA1 1 0.47 0.28 0.73
32 INT145922 Positive_regulation of Positive_regulation of CCL21 1 0.39 0.82 0.69
33 INT181366 Regulation of Ccl21b 1 0.01 0.52 0.69
34 INT116716 Positive_regulation of Gene_expression of CCR7 5 0.68 6.92 0.67
35 INT208591 Negative_regulation of Gene_expression of CCL21 2 0.40 0.92 0.6
36 INT276847 Regulation of Positive_regulation of Gpr65 1 0.39 0.07 0.54
37 INT276846 Negative_regulation of Gpr65 1 0.17 0.13 0.52
38 INT221052 Positive_regulation of Negative_regulation of CCL21 1 0.22 0.85 0.48
39 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47
40 INT182236 Transcription of CCR7 2 0.58 1.07 0.47
41 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45
42 INT136601 Regulation of EPHA1 1 0.12 0.17 0.43
43 INT177505 Regulation of CCR7 3 0.38 2.19 0.42
44 INT225008 Gene_expression of Ccl21 1 0.27 0.07 0.36
45 INT225010 Positive_regulation of Ccl21 1 0.20 0.12 0.33
46 INT184803 Localization of TSC1 5 0.37 6.13 0.32
47 INT276835 Positive_regulation of Localization of Gpr65 1 0.44 0.36 0.31
48 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3
49 INT208587 Transcription of CCL21 2 0.49 0.84 0.3
50 INT177508 Regulation of Gene_expression of CCL21 1 0.27 1.23 0.3
51 INT322756 Negative_regulation of Tsc1 1 0.07 1.4 0.26
52 INT265418 Negative_regulation of Negative_regulation of CCL21 1 0.20 0.32 0.22
53 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21
54 INT227245 Localization of CCR7 4 0.47 0.74 0.18
55 INT183168 Regulation of Gene_expression of Epha1 2 0.03 0.08 0.16
56 INT183171 Positive_regulation of Gene_expression of Epha1 1 0.04 0.08 0.16
57 INT173222 Negative_regulation of Negative_regulation of TSC1 1 0.01 0.92 0.09
58 INT265420 Negative_regulation of Transcription of CCL21 1 0.23 0.52 0.08
59 INT190703 Regulation of Negative_regulation of TSC1 3 0.06 3.08 0.07
60 INT271938 Binding of Tsc1 1 0.43 3.18 0.07
61 INT188349 Localization of Epha1 1 0.52 0.19 0.07
62 INT119223 Gene_expression of EPHA1 3 0.55 2.59 0.06
63 INT225009 Transcription of Ccl21 1 0.24 0 0.06
64 INT225005 Positive_regulation of Transcription of Ccl21 1 0.18 0 0.06
65 INT333292 Negative_regulation of EPHA1 1 0.41 0.07 0.05
66 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04
67 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04
68 INT246758 Gene_expression of Tsc1 1 0.11 0.55 0.04
69 INT190057 Positive_regulation of Negative_regulation of TSC1 2 0.01 1.08 0.03
70 INT216078 Negative_regulation of CCR7 2 0.27 0.36 0.03
71 INT271960 Positive_regulation of Binding of TSC1 1 0.25 0.88 0.03
72 INT190054 Negative_regulation of Positive_regulation of TSC1 1 0.01 0.83 0.03
73 INT337244 Positive_regulation of Binding of CCR7 1 0.31 0.6 0.03
74 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0
75 INT175424 Regulation of Transcription of TSC1 2 0.05 1.39 0
76 INT271963 Phosphorylation of TSC1 2 0.31 2.02 0
77 INT352097 Positive_regulation of Positive_regulation of CCR7 1 0.25 1.06 0
78 INT271965 Negative_regulation of Binding of TSC1 1 0.33 0.44 0
79 INT246748 Regulation of Tsc1 1 0.04 0.05 0
80 INT269905 Positive_regulation of Foxj1 1 0.32 0.08 0
81 INT212392 Binding of Epha1 1 0.03 0.2 0
82 INT246773 Phosphorylation of Tsc1 1 0.13 0.05 0
83 INT271913 Protein_catabolism of Tsc1 1 0.51 0.45 0
84 INT271906 Negative_regulation of Binding of Tsc1 1 0.38 0.06 0
85 INT271927 Positive_regulation of Tsc1 1 0.44 0.4 0
86 INT271931 Negative_regulation of Gene_expression of Tsc1 1 0.38 0.44 0
87 INT322758 Positive_regulation of Localization of TSC1 1 0.06 1.4 0
88 INT237846 Positive_regulation of Localization of CCL21 1 0.23 0.94 0
89 INT331195 Positive_regulation of Negative_regulation of Tsc1 1 0.18 0.15 0
90 INT269900 Gene_expression of Foxj1 1 0.49 0.25 0
91 INT246757 Binding of Tsc1 1 0.06 0.19 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox