GO:0032863

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Name activation of Rac GTPase activity
Categary Process
Go Slim No
Go Link GO:0032863
Unique Molecular Interactions 32
Total Molecular Interactions 37
Total Single Events 282
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of Rac GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of Rac GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22
2 INT319311 Binding of Glud1 and Ptk2b 1 0.36 0 0.19
3 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18
4 INT319314 Binding of Ptk2b and Rbm39 1 0.01 0.08 0.14
5 INT319316 Binding of GRIN1 and Ptk2b 1 0.52 0.08 0.14
6 INT337676 Binding of TIMP1 and Scrib 1 0.01 1.24 0.13
7 INT253328 Binding of IL8 and Scrib 1 0.04 0.79 0.12
8 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1
9 INT355604 VEGFA Regulation of Positive_regulation of Ptk2b 1 0.22 1.47 0.08
10 INT319309 Egr2 Regulation of Ptk2b 1 0.29 0.37 0.07
11 INT333256 Gene_expression of Cxcl12 Negative_regulation of Ptk2b 1 0.10 0.99 0.07
12 INT263743 Rasgrf1 Positive_regulation of Positive_regulation of Mapk1 1 0.11 0 0.06
13 INT263770 Rasgrf1 Positive_regulation of Positive_regulation of Grin1 1 0.24 0 0.06
14 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05
15 INT263727 Binding of Grin2b and Rasgrf1 1 0.18 0 0.05
16 INT263730 Binding of Grin2a and Rasgrf1 1 0.23 0 0.05
17 INT89385 INS Positive_regulation of Phosphorylation of PTK2B 1 0.15 0.59 0.04
18 INT337677 Scrib Positive_regulation of Gene_expression of MMP9 1 0.03 1.12 0
19 INT307804 Ace Positive_regulation of Gene_expression of Scrib 1 0.21 2.43 0
20 INT302909 Nav2 Positive_regulation of Arhgef16 1 0.02 0.52 0
21 INT326162 Binding of ABHD2 and Scrib 1 0.00 1.07 0
22 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
23 INT235648 Binding of EFNA1 and EPHA2 1 0.23 1.3 0
24 INT235647 TP63 Regulation of EPHA2 1 0.15 0.97 0
25 INT337680 Binding of TP53 and Scrib 1 0.03 1.6 0
26 INT337678 Scrib Positive_regulation of MMP7 1 0.03 1.11 0
27 INT235651 TP73 Regulation of EPHA2 1 0.15 0.98 0
28 INT337681 Scrib Positive_regulation of MMP9 1 0.01 1.12 0
29 INT351675 Efna1 Positive_regulation of Epha2 1 0.05 0.68 0
30 INT326165 Binding of ABHD12 and Scrib 1 0.00 1.01 0
31 INT326164 Binding of S100A2 and Scrib 1 0.01 1.16 0
32 INT337679 Binding of MSI1 and Scrib 1 0.00 1.61 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of Rac GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of Rac GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81
2 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66
3 INT108325 Gene_expression of Scrib 26 0.39 48.33 1.39
4 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
5 INT319293 Phosphorylation of Ptk2b 9 0.80 3.14 1.24
6 INT190031 Binding of Scrib 19 0.36 21.9 1.01
7 INT290411 Gene_expression of Ptk2b 10 0.65 3.72 1.01
8 INT236927 Positive_regulation of Ptk2b 9 0.67 3.41 0.94
9 INT319254 Localization of Ptk2b 1 0.78 0.26 0.46
10 INT214067 Regulation of Scrib 11 0.20 12.48 0.45
11 INT30080 Binding of Arhgef16 1 0.11 0.54 0.45
12 INT319284 Binding of Ptk2b 1 0.36 0.9 0.45
13 INT34037 Regulation of Arhgef16 1 0.15 0.6 0.45
14 INT109920 Positive_regulation of PTK2B 5 0.43 2.21 0.43
15 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
16 INT319286 Transcription of Ptk2b 1 0.52 1.17 0.4
17 INT109922 Negative_regulation of PTK2B 3 0.26 1.63 0.39
18 INT190017 Localization of Scrib 6 0.10 7 0.38
19 INT108326 Positive_regulation of Gene_expression of Scrib 5 0.26 9.02 0.36
20 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
21 INT109919 Positive_regulation of Positive_regulation of PTK2B 1 0.31 0.09 0.35
22 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
23 INT319276 Positive_regulation of Phosphorylation of Ptk2b 1 0.49 0.62 0.32
24 INT267831 Negative_regulation of Positive_regulation of Scrib 1 0.04 1.56 0.31
25 INT352913 Regulation of EPHA2 1 0.05 0.74 0.2
26 INT89400 Phosphorylation of PTK2B 4 0.38 1.16 0.19
27 INT267829 Regulation of Gene_expression of Scrib 2 0.20 5.89 0.19
28 INT267830 Regulation of Negative_regulation of Scrib 1 0.04 0.95 0.19
29 INT319247 Regulation of Ptk2b 1 0.60 0 0.18
30 INT253320 Positive_regulation of Positive_regulation of Scrib 1 0.05 0.4 0.14
31 INT89409 Negative_regulation of Phosphorylation of PTK2B 2 0.13 0.89 0.12
32 INT135555 Localization of PTK2B 1 0.57 0.32 0.1
33 INT253323 Negative_regulation of Binding of Scrib 1 0.05 0.82 0.09
34 INT302629 Positive_regulation of Rhog 1 0.33 0.07 0.07
35 INT296753 Protein_catabolism of Scrib 1 0.05 0.73 0.07
36 INT302628 Gene_expression of Rhog 1 0.45 0.2 0.05
37 INT336399 Transcription of EPHA2 1 0.24 2.21 0.03
38 INT235654 Binding of EPHA2 5 0.36 4.26 0
39 INT200683 Gene_expression of PTK2B 2 0.67 1.02 0
40 INT243389 Transcription of PTK2B 1 0.64 0.52 0
41 INT190036 Positive_regulation of Localization of Scrib 1 0.04 0.83 0
42 INT200665 Negative_regulation of Gene_expression of PTK2B 1 0.04 0.69 0
43 INT273545 Negative_regulation of Epha2 1 0.28 0.08 0
44 INT307791 Negative_regulation of Gene_expression of Scrib 1 0.19 2.55 0
45 INT156922 Positive_regulation of Phosphorylation of PTK2B 1 0.23 0 0
46 INT290418 Regulation of Gene_expression of Ptk2b 1 0.17 0.1 0
47 INT235652 Localization of EPHA2 1 0.72 0.89 0
48 INT300629 Transcription of Epha2 1 0.22 1.11 0
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