GO:0032873

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Name negative regulation of stress-activated MAPK cascade
Categary Process
Go Slim No
Go Link GO:0032873
Unique Molecular Interactions 85
Total Molecular Interactions 102
Total Single Events 734
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of stress-activated MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of stress-activated MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
2 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
3 INT149390 Foxm1 Positive_regulation of Trpa1 1 0.28 0.31 0.94
4 INT314560 RYBP Positive_regulation of Gene_expression of MYC 1 0.02 0.06 0.67
5 INT120348 Negative_regulation of Binding of DES and MYC 1 0.06 0.18 0.58
6 INT120350 Binding of DES and MYC 1 0.05 0.17 0.58
7 INT120347 Binding of KNG1 and MYC 1 0.21 0.17 0.58
8 INT138353 Foxm1 Positive_regulation of Phosphorylation of Trpv1 1 0.10 0.31 0.51
9 INT138352 Foxm1 Positive_regulation of Trpa1 1 0.05 0.33 0.51
10 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5
11 INT86088 Foxm1 Positive_regulation of Binding of Crygs 1 0.04 0 0.49
12 INT86089 Foxm1 Regulation of Binding of Crygs 1 0.02 0 0.49
13 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
14 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
15 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
16 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
17 INT239540 Binding of CXCR2 and MYC 1 0.15 0.09 0.33
18 INT239537 CXCR2 Regulation of MYC 1 0.15 0.05 0.29
19 INT225118 Foxm1 Positive_regulation of Gene_expression of MMP2 1 0.01 0.34 0.23
20 INT225117 Foxm1 Regulation of Gene_expression of FN1 1 0.01 0.4 0.22
21 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
22 INT306261 AKT2 Negative_regulation of Phosphorylation of FOXO1 1 0.25 0.41 0.17
23 INT240899 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Foxo1 1 0.14 0.41 0.15
24 INT286769 Tusc2 Regulation of Foxm1 1 0.02 1.55 0.15
25 INT239557 Binding of MYC and Hopx 1 0.14 0 0.14
26 INT69909 Binding of MYC and PURA 1 0.24 0 0.1
27 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
28 INT240897 Akt1 Negative_regulation of Positive_regulation of Foxo1 1 0.21 0.22 0.08
29 INT278164 GSTM1 Positive_regulation of Transcription of GSTP1 1 0.57 0.94 0.07
30 INT265883 IGF1 Positive_regulation of Transcription of FOXO1 1 0.17 1.14 0.07
31 INT265893 BAD Regulation of FOXO1 1 0.03 1.08 0.06
32 INT262190 Foxo1 Positive_regulation of Pck1 1 0.04 0.15 0.06
33 INT338902 Binding of MAX and MYC 1 0.02 0.23 0.06
34 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
35 INT316499 Stat3 Positive_regulation of Transcription of MYC 1 0.55 1.27 0.04
36 INT352385 MIR27A Regulation of Foxo1 1 0.45 0.48 0.04
37 INT213803 Binding of Foxm1 and Tfe3 1 0.00 1.09 0.03
38 INT240881 Gene_expression of Sod1 Positive_regulation of Phosphorylation of Foxo1 1 0.38 0.07 0.03
39 INT213810 Binding of Foxm1 and Tfeb 1 0.00 1.09 0.03
40 INT262198 Foxo1 Positive_regulation of Igfbp1 1 0.11 0.08 0.03
41 INT265879 IGF1 Regulation of FOXO1 1 0.11 1.37 0.03
42 INT338900 MYC Positive_regulation of Gene_expression of TP73 1 0.05 0.27 0.03
43 INT240883 Foxo1 Positive_regulation of Ppargc1a 1 0.43 0.06 0.03
44 INT268514 MYC Regulation of MIR17HG 1 0.05 0.8 0
45 INT268517 MYC Regulation of CTGF 1 0.03 0.92 0
46 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
47 INT206178 Foxm1 Positive_regulation of Protein_catabolism of Olr1 1 0.00 0.47 0
48 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
49 INT232045 Binding of FOXM1 and RNPC3 1 0.00 0.31 0
50 INT232051 Binding of FOXM1 and KRAS 1 0.00 0.63 0
51 INT206180 Foxm1 Positive_regulation of Transcription of Olr1 1 0.00 0.48 0
52 INT339118 Binding of MYC and PVT1 1 0.21 0.76 0
53 INT145339 Binding of PYGO1 and Positive_regulation of Transcription of MYC 1 0.05 0 0
54 INT354309 Binding of MYC and PITX2 1 0.01 0.51 0
55 INT293981 MYC Negative_regulation of DKK1 1 0.07 0.62 0
56 INT251069 Binding of Cldn5 and Positive_regulation of Foxo1 1 0.09 0.15 0
57 INT345483 Binding of MYC and PMAIP1 1 0.16 0.63 0
58 INT232044 Binding of FOXM1 and LMBRD1 1 0.00 0.32 0
59 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
60 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
61 INT262191 Binding of Nr1i2 and Foxo1 1 0.22 0.09 0
62 INT300900 Binding of MYC and IGF2BP1 1 0.06 0.71 0
63 INT249828 Foxm1 Positive_regulation of Transcription of BIRC5 1 0.56 0.12 0
64 INT262174 Binding of Casr and Foxo1 1 0.05 0.09 0
65 INT289521 Binding of Foxo1 and Positive_regulation of Acsm3 1 0.01 0.12 0
66 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
67 INT249824 Ppp4c Positive_regulation of Foxm1 1 0.24 0 0
68 INT232046 Binding of DDR1 and FOXM1 1 0.00 0.63 0
69 INT145331 Binding of BCL9 and Positive_regulation of Transcription of MYC 1 0.29 0 0
70 INT339114 Binding of ERBB2 and MYC 1 0.22 0.81 0
71 INT249827 Foxm1 Positive_regulation of Transcription of Cenpb 1 0.56 0.12 0
72 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
73 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0
74 INT240944 Akt1 Positive_regulation of Phosphorylation of Foxo1 1 0.22 0.06 0
75 INT281607 Foxo1 Positive_regulation of Transcription of Trim63 1 0.27 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of stress-activated MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of stress-activated MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
2 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48
3 INT55513 Binding of Foxm1 19 0.37 2.37 5.54
4 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17
5 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07
6 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29
7 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95
8 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81
9 INT113203 Regulation of Foxm1 8 0.34 7.5 2.36
10 INT82798 Regulation of MYC 19 0.60 12.06 2.31
11 INT107685 Phosphorylation of MYC 3 0.80 2.52 2.28
12 INT73476 Transcription of MYC 18 0.69 12.14 2.13
13 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9
14 INT155110 Negative_regulation of Phosphorylation of MYC 1 0.57 1.61 1.83
15 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
16 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66
17 INT20418 Regulation of Gene_expression of MYC 6 0.60 4.4 1.29
18 INT84130 Gene_expression of Foxo1 1 0.26 0.97 1.22
19 INT138349 Phosphorylation of Foxm1 1 0.10 0.9 1.05
20 INT82795 Binding of MYC 16 0.47 6.1 0.9
21 INT72710 Negative_regulation of Negative_regulation of Foxm1 3 0.10 0.55 0.84
22 INT226179 Phosphorylation of Foxo1 15 0.68 3.14 0.7
23 INT268557 Regulation of Regulation of MYC 1 0.44 0.86 0.69
24 INT129006 Negative_regulation of Gstp1 1 0.34 1.85 0.65
25 INT203749 Binding of FOXM1 10 0.31 6.1 0.64
26 INT107686 Positive_regulation of Negative_regulation of MYC 2 0.49 1.59 0.6
27 INT249764 Regulation of Binding of Foxm1 1 0.39 0.19 0.58
28 INT206006 Negative_regulation of Gene_expression of Foxm1 4 0.43 2.63 0.56
29 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
30 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
31 INT86087 Negative_regulation of Binding of Foxm1 1 0.28 0 0.52
32 INT206009 Transcription of Foxm1 2 0.68 1.49 0.51
33 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48
34 INT122525 Regulation of FOXO1 3 0.58 1.76 0.44
35 INT265898 Transcription of FOXO1 2 0.50 2.29 0.41
36 INT50336 Negative_regulation of Positive_regulation of Foxm1 1 0.30 0 0.38
37 INT325423 Localization of Gstp1 1 0.06 0.85 0.37
38 INT325425 Positive_regulation of Localization of Gstp1 1 0.04 0.9 0.37
39 INT249785 Positive_regulation of Gene_expression of Foxm1 13 0.69 4.71 0.36
40 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35
41 INT144474 Protein_catabolism of Gstp1 1 0.06 0.57 0.33
42 INT199762 Positive_regulation of Gstp1 2 0.55 2.02 0.32
43 INT278169 Regulation of Regulation of GSTP1 1 0.45 1.1 0.25
44 INT265902 Phosphorylation of FOXO1 2 0.59 1.47 0.24
45 INT276188 Negative_regulation of Foxo1 5 0.40 1.75 0.23
46 INT265903 Gene_expression of FOXO1 3 0.48 2.66 0.2
47 INT63067 Localization of MYC 13 0.78 6.93 0.19
48 INT201239 Gene_expression of FOXM1 9 0.51 4.07 0.19
49 INT203750 Positive_regulation of FOXM1 8 0.39 2.72 0.19
50 INT120761 Positive_regulation of GSTP1 3 0.50 3.4 0.19
51 INT226163 Negative_regulation of Phosphorylation of Foxo1 2 0.36 0.83 0.19
52 INT289565 Binding of Foxo1 5 0.45 2.47 0.17
53 INT306278 Negative_regulation of Phosphorylation of FOXO1 1 0.31 0.41 0.17
54 INT276173 Phosphorylation of Foxo1 7 0.56 1.79 0.15
55 INT265904 Localization of FOXO1 3 0.25 2.28 0.15
56 INT276178 Negative_regulation of Phosphorylation of Foxo1 3 0.30 1.03 0.15
57 INT240848 Positive_regulation of Phosphorylation of Foxo1 4 0.58 0.28 0.14
58 INT240838 Negative_regulation of Foxo1 5 0.43 2.04 0.13
59 INT226162 Binding of Foxo1 3 0.28 0.77 0.13
60 INT156350 Positive_regulation of FOXO1 2 0.49 1.53 0.13
61 INT278171 Positive_regulation of Transcription of GSTP1 1 0.50 1.86 0.13
62 INT240827 Positive_regulation of Foxo1 3 0.58 1.01 0.11
63 INT314712 Negative_regulation of Localization of MYC 2 0.22 1.43 0.11
64 INT203751 Negative_regulation of FOXM1 2 0.20 0.94 0.11
65 INT226187 Transcription of Foxo1 1 0.06 0.6 0.11
66 INT223834 Localization of GSTP1 2 0.70 1.28 0.1
67 INT240861 Regulation of Phosphorylation of Foxo1 1 0.51 0.23 0.1
68 INT120767 Negative_regulation of Gene_expression of GSTP1 3 0.42 1.15 0.09
69 INT239552 Regulation of Positive_regulation of MYC 1 0.44 0.09 0.09
70 INT240847 Negative_regulation of Positive_regulation of Foxo1 1 0.36 0.22 0.08
71 INT120771 Negative_regulation of Positive_regulation of GSTP1 1 0.30 0.39 0.08
72 INT120766 Regulation of Positive_regulation of GSTP1 1 0.32 0.39 0.08
73 INT278173 Transcription of GSTP1 1 0.68 0.93 0.07
74 INT234424 Negative_regulation of Transcription of MYC 2 0.57 1.38 0.06
75 INT265900 Positive_regulation of Gene_expression of FOXO1 1 0.19 1.1 0.06
76 INT106252 Regulation of Transcription of MYC 1 0.44 0.41 0.06
77 INT289592 Positive_regulation of Foxo1 2 0.41 1.44 0.04
78 INT249792 Regulation of Gene_expression of Foxm1 1 0.45 0.45 0.04
79 INT301583 Positive_regulation of Negative_regulation of Foxo1 1 0.21 0.84 0.04
80 INT301520 Negative_regulation of Negative_regulation of Foxo1 1 0.27 0.84 0.04
81 INT289571 Positive_regulation of Binding of Foxo1 2 0.48 1.94 0.03
82 INT289566 Transcription of Foxo1 1 0.47 0.36 0.03
83 INT289573 Gene_expression of Foxo1 7 0.73 1.92 0
84 INT249769 Localization of Foxm1 6 0.74 1.13 0
85 INT203874 Positive_regulation of Gene_expression of GSTP1 3 0.49 1.91 0
86 INT281596 Regulation of Foxo1 2 0.19 0.18 0
87 INT240915 Regulation of Foxo1 2 0.39 1.31 0
88 INT217822 Positive_regulation of Regulation of MYC 2 0.49 0.85 0
89 INT323478 Localization of Foxo1 1 0.43 0.08 0
90 INT240836 Positive_regulation of Positive_regulation of Foxo1 1 0.36 0.55 0
91 INT289582 Negative_regulation of Binding of Foxo1 1 0.29 0.13 0
92 INT213579 Binding of FOXO1 1 0.46 1.48 0
93 INT305470 Regulation of Gene_expression of GSTP1 1 0.06 0.59 0
94 INT262081 Negative_regulation of Binding of Foxo1 1 0.18 0.08 0
95 INT203877 Phosphorylation of GSTP1 1 0.79 0.22 0
96 INT260282 Positive_regulation of Positive_regulation of MYC 1 0.49 0.19 0
97 INT225856 Protein_catabolism of MYC 1 0.64 0.06 0
98 INT207724 Transcription of FOXM1 1 0.58 0.85 0
99 INT289544 Positive_regulation of Phosphorylation of Foxo1 1 0.34 0.24 0
100 INT199764 Positive_regulation of Gene_expression of Gstp1 1 0.55 2.21 0
101 INT249793 Regulation of Transcription of Foxm1 1 0.45 0 0
102 INT281591 Localization of Foxo1 1 0.48 0 0
103 INT249780 Positive_regulation of Binding of Foxm1 1 0.50 0.5 0
104 INT289577 Regulation of Gene_expression of Foxo1 1 0.31 0.24 0
105 INT249768 Regulation of Localization of Foxm1 1 0.39 0 0
106 INT203870 Negative_regulation of Binding of GSTP1 1 0.42 0.22 0
107 INT289557 Negative_regulation of Negative_regulation of Foxo1 1 0.30 0.18 0
108 INT323467 Positive_regulation of Localization of Foxo1 1 0.29 0.08 0
109 INT249776 Negative_regulation of Localization of Foxm1 1 0.37 0.46 0
110 INT289559 Positive_regulation of Gene_expression of Foxo1 1 0.34 0.5 0
111 INT289560 Negative_regulation of Gene_expression of Foxo1 1 0.29 0.48 0
112 INT203752 Regulation of FOXM1 1 0.02 0 0
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