GO:0032874

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Name positive regulation of stress-activated MAPK cascade
Categary Process
Go Slim No
Go Link GO:0032874
Unique Molecular Interactions 780
Total Molecular Interactions 1121
Total Single Events 6037
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of stress-activated MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of stress-activated MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
4 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
5 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
6 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
7 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
8 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
9 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
10 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
11 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
12 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
13 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
14 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
15 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
16 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
17 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
18 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
19 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
20 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
21 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
22 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
23 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
24 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
25 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
26 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
27 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
28 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
29 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
30 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
31 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
32 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
33 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
34 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
35 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
36 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
37 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
38 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
39 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
40 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
41 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
42 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
43 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
44 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
45 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
46 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
47 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
48 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
49 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
50 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
51 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
52 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
53 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
54 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
55 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
56 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
57 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
58 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
59 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
60 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
61 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
62 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
63 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
64 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
65 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
66 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
67 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
68 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
69 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
70 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
71 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
72 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
73 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
74 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
75 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
76 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
77 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
78 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
79 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
80 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
81 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
82 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
83 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
84 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
85 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
86 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
87 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
88 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
89 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
90 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
91 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
92 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
93 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
94 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
95 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
96 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
97 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
98 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
99 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
100 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
101 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
102 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
103 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
104 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
105 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
106 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
107 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
108 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
109 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
110 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
111 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
112 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
113 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
114 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
115 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
116 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
117 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
118 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
119 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
120 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
121 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
122 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
123 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
124 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
125 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
126 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
127 INT96240 Il13 Negative_regulation of Il1b 1 0.17 0.6 0.59
128 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
129 INT96242 Il13 Negative_regulation of Gene_expression of Il1b 1 0.15 0.67 0.59
130 INT128603 Il1b Positive_regulation of Gene_expression of Fos 1 0.50 0.59 0.58
131 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
132 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
133 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
134 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
135 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
136 INT60665 Il1b Regulation of Oprd1 1 0.05 0 0.57
137 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
138 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
139 INT58805 Il1b Negative_regulation of LH 1 0.24 0 0.56
140 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
141 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
142 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
143 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
144 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
145 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
146 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
147 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
148 INT80752 Binding of Il1b and El4 1 0.49 0.08 0.54
149 INT134488 Il1b Regulation of Oxt 1 0.30 0.08 0.54
150 INT80751 Negative_regulation of Binding of Il1b and El4 1 0.60 0.08 0.54
151 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
152 INT59601 Il1b Regulation of Localization of LH 1 0.18 0 0.54
153 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
154 INT8396 Il1a Regulation of Nts 1 0.00 0.38 0.53
155 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
156 INT8399 Il1a Regulation of Vip 1 0.00 0.38 0.53
157 INT66769 Negative_regulation of Il1b Positive_regulation of Pla2g10 1 0.04 0.25 0.53
158 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
159 INT105849 Il1b Positive_regulation of Positive_regulation of Ptgs1 1 0.07 0.38 0.51
160 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
161 INT58804 Il1b Negative_regulation of Negative_regulation of LH 1 0.24 0 0.51
162 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
163 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
164 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
165 INT143939 Il1b Regulation of Gene_expression of Fos 1 0.10 0.44 0.49
166 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
167 INT10277 Il1b Positive_regulation of Transcription of Penk 1 0.46 0.26 0.49
168 INT155621 Tnf Regulation of Transcription of Il1b 1 0.51 0.77 0.49
169 INT114593 Il1b Positive_regulation of Gene_expression of Ppt1 1 0.05 0.06 0.48
170 INT85736 Positive_regulation of Il1b Positive_regulation of Tpgs2 1 0.02 0.2 0.48
171 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
172 INT114595 Il1b Positive_regulation of Gene_expression of Rent1 1 0.00 0.06 0.48
173 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
174 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
175 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
176 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
177 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
178 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
179 INT85735 Il1b Positive_regulation of Tpgs2 1 0.02 0.2 0.47
180 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
181 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
182 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
183 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
184 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
185 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
186 INT57983 Il1b Regulation of Crh 1 0.37 0.09 0.44
187 INT57981 Regulation of Il1b Positive_regulation of Crh 1 0.22 0.1 0.44
188 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
189 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
190 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
191 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
192 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
193 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
194 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
195 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
196 INT308696 Binding of Tlr4 and Tlr4 1 0.00 0.34 0.42
197 INT290269 KNG1 Positive_regulation of Binding of MID1 1 0.02 1.06 0.41
198 INT114601 Il1b Positive_regulation of Transcription of Ppt1 1 0.35 0.1 0.41
199 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41
200 INT83913 Il1b Positive_regulation of Gene_expression of IL6 1 0.01 0.5 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of stress-activated MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of stress-activated MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
3 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
4 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
5 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
6 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
7 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
8 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
9 INT9347 Localization of Il1b 58 0.81 26.13 31.53
10 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
11 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
12 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
13 INT5966 Localization of Il1a 50 0.78 22.91 26.54
14 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
15 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
16 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
17 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
18 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
19 INT48081 Localization of Il1b 46 0.80 21.59 22.4
20 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
21 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
22 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
23 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
24 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
25 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
26 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
27 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
28 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
29 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
30 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
31 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
32 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
33 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
34 INT15768 Gene_expression of Il1a 20 0.71 9.31 8.78
35 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
36 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
37 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
38 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
39 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
40 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
41 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4
42 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
43 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
44 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
45 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
46 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
47 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
48 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
49 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
50 INT23034 Positive_regulation of Il1a 15 0.70 8.75 6.29
51 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
52 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
53 INT80750 Binding of Il1b 11 0.47 7.97 5.95
54 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
55 INT10705 Binding of Il1b 9 0.36 2.8 5.53
56 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
57 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
58 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
59 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
60 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
61 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67
62 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
63 INT20459 Regulation of Ripk2 5 0.44 0 4.53
64 INT50309 Binding of Il1a 22 0.40 5.4 4.49
65 INT23035 Regulation of Il1a 6 0.60 5.69 4.25
66 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
67 INT15462 Negative_regulation of Il1a 4 0.59 4.68 4.17
68 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1
69 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54
70 INT174807 Gene_expression of IL26 7 0.37 8.06 3.26
71 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
72 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
73 INT165057 Binding of MID1 7 0.32 4.13 3.12
74 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
75 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
76 INT103910 Binding of NOD2 19 0.47 12.24 2.93
77 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
78 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
79 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
80 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
81 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
82 INT49984 Localization of Il1a 5 0.77 3.61 2.42
83 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42
84 INT165059 Gene_expression of MID1 11 0.58 3.68 2.31
85 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
86 INT150884 Transcription of Il1a 6 0.47 3.12 2.19
87 INT49988 Positive_regulation of Gene_expression of Il1a 2 0.47 1.49 2.11
88 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
89 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
90 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
91 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
92 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
93 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
94 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
95 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
96 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
97 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
98 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
99 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
100 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
101 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
102 INT234116 Positive_regulation of MID1 9 0.03 3.78 1.61
103 INT219183 Localization of IL26 3 0.39 3.61 1.49
104 INT49987 Transcription of Il1a 1 0.68 0.66 1.4
105 INT113777 Binding of Hmgcr 3 0.09 2.29 1.35
106 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
107 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
108 INT129253 Positive_regulation of Positive_regulation of Il1a 5 0.49 2.97 1.31
109 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3
110 INT204766 Gene_expression of Nod2 4 0.75 4.14 1.3
111 INT278567 Gene_expression of Kiss1 2 0.78 36 1.3
112 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
113 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
114 INT162757 Regulation of Localization of Il1a 3 0.37 1.22 1.25
115 INT28888 Positive_regulation of Crhr2 6 0.68 3.8 1.23
116 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
117 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
118 INT236163 Localization of Hmgcr 6 0.64 0.66 1.12
119 INT165056 Regulation of Gene_expression of MID1 2 0.39 0.93 1.1
120 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06
121 INT9348 Regulation of Localization of Il1b 2 0.27 0.14 1.04
122 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02
123 INT353959 Positive_regulation of IL26 1 0.22 2.99 1.01
124 INT118738 Transcription of Tlr4 4 0.70 1.39 1
125 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
126 INT53571 Negative_regulation of Localization of Il1a 2 0.50 1.59 0.99
127 INT190077 Regulation of Transcription of Il1a 2 0.02 0.87 0.99
128 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
129 INT226450 Binding of IL26 4 0.18 1.81 0.93
130 INT168280 Positive_regulation of Phosphorylation of Il1b 1 0.49 1.1 0.93
131 INT344365 Phosphorylation of Il1a 1 0.61 1.01 0.92
132 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
133 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
134 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
135 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
136 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
137 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
138 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81
139 INT23033 Negative_regulation of Positive_regulation of Il1a 2 0.42 0.76 0.78
140 INT93737 Gene_expression of Tgfb2 2 0.03 1.16 0.77
141 INT93736 Positive_regulation of Gene_expression of Tgfb2 2 0.02 1.16 0.77
142 INT101952 Negative_regulation of Crhr2 1 0.17 0.97 0.77
143 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
144 INT151128 Positive_regulation of Negative_regulation of Tlr4 2 0.46 1 0.75
145 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
146 INT53576 Regulation of Gene_expression of Il1a 2 0.41 0.6 0.73
147 INT127822 Negative_regulation of Transcription of Il1b 2 0.42 1.2 0.72
148 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
149 INT155081 Gene_expression of Kiss1 5 0.78 1.32 0.69
150 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69
151 INT28889 Transcription of Crhr2 2 0.64 1.13 0.66
152 INT292526 Negative_regulation of Negative_regulation of Il1a 1 0.05 0.87 0.66
153 INT89812 Negative_regulation of Gene_expression of Il1a 1 0.24 0.58 0.66
154 INT115297 Positive_regulation of TGFB2 4 0.29 1.91 0.65
155 INT311777 Regulation of MID1 3 0.16 4.43 0.6
156 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58
157 INT83618 Regulation of Positive_regulation of Il1b 2 0.44 1.04 0.58
158 INT204864 Negative_regulation of Negative_regulation of Tlr4 3 0.30 2.05 0.56
159 INT101949 Negative_regulation of Binding of Crhr2 1 0.24 0.6 0.55
160 INT89813 Positive_regulation of Localization of Il1a 1 0.28 0.47 0.55
161 INT130047 Localization of TGFB2 3 0.16 3.65 0.53
162 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52
163 INT246926 Negative_regulation of Transcription of Tlr4 3 0.41 1.78 0.49
164 INT250838 Protein_catabolism of Il1a 1 0.13 1.16 0.49
165 INT324555 Positive_regulation of Gene_expression of Kiss1 1 0.69 12.97 0.48
166 INT155079 Positive_regulation of Kiss1 1 0.70 0.46 0.48
167 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46
168 INT152229 Positive_regulation of Regulation of Tlr4 2 0.40 0.29 0.46
169 INT324550 Positive_regulation of Kiss1 1 0.69 7.03 0.45
170 INT302554 Localization of MID1 3 0.19 0.67 0.44
171 INT353961 Positive_regulation of Negative_regulation of IL26 1 0.24 0.9 0.44
172 INT353960 Negative_regulation of Gene_expression of IL26 1 0.20 0.9 0.44
173 INT353957 Negative_regulation of IL26 1 0.20 0.89 0.44
174 INT222266 Transcription of NOD2 5 0.68 0.76 0.43
175 INT250843 Negative_regulation of Protein_catabolism of Il1a 1 0.06 0.9 0.43
176 INT148784 Negative_regulation of Crhr2 2 0.40 0.76 0.42
177 INT248931 Positive_regulation of Tgfb2 1 0.03 0 0.4
178 INT185313 Regulation of Transcription of Tlr4 3 0.20 0.49 0.39
179 INT292528 Regulation of Positive_regulation of Il1a 1 0.06 0.52 0.39
180 INT178182 Negative_regulation of Binding of Tlr4 3 0.33 2.13 0.38
181 INT171764 Localization of NOD2 2 0.74 0.86 0.37
182 INT144599 Gene_expression of Crhr2 3 0.49 2.16 0.36
183 INT153878 Negative_regulation of Negative_regulation of Il1b 1 0.42 0.78 0.36
184 INT118736 Positive_regulation of Transcription of Tlr4 1 0.49 0.42 0.35
185 INT183240 Negative_regulation of NOD2 6 0.43 1.52 0.33
186 INT232236 Negative_regulation of Gene_expression of Hmgcr 3 0.35 1.36 0.31
187 INT230494 Regulation of Binding of Tlr4 3 0.45 2.97 0.31
188 INT244148 Positive_regulation of Positive_regulation of NOD2 1 0.47 0.68 0.31
189 INT311448 Gene_expression of TAOK1 1 0.21 2.47 0.31
190 INT316692 Regulation of Localization of TGFB2 1 0.03 1.13 0.3
191 INT86771 Positive_regulation of TAOK1 2 0.38 4.55 0.29
192 INT155083 Regulation of Gene_expression of Kiss1 1 0.62 0.32 0.29
193 INT226456 Regulation of Localization of IL26 1 0.10 0.59 0.29
194 INT322907 Positive_regulation of Gene_expression of Hmgcr 4 0.03 1.45 0.28
195 INT222270 Regulation of Localization of NOD2 1 0.45 0.63 0.28
196 INT346895 Positive_regulation of Gene_expression of Nod2 1 0.33 0.74 0.28
197 INT346896 Binding of Nod2 1 0.21 0.72 0.26
198 INT204866 Regulation of Localization of Tlr4 3 0.37 0.66 0.25
199 INT250545 Regulation of Hmgcr 5 0.11 4.94 0.23
200 INT215080 Positive_regulation of Negative_regulation of Tlr4 1 0.31 0.05 0.23
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