GO:0032880

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Name regulation of protein localization
Categary Process
Go Slim No
Go Link GO:0032880
Unique Molecular Interactions 1479
Total Molecular Interactions 2017
Total Single Events 17937
Pain Genes Associated 36

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of protein localization. They are ordered first by their pain relevance and then by number of times they were reported for regulation of protein localization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
5 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
6 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
7 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
8 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
9 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
10 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
11 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
12 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
13 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
14 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
15 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
16 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
17 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
18 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
19 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
20 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
21 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
22 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
23 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
24 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
25 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
26 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
27 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
28 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
29 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
30 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
31 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
32 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
33 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
34 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
35 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
36 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
37 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
38 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
39 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
40 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
41 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
42 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
43 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
44 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
45 INT318462 Nnat Positive_regulation of Nfkb1 1 0.46 0.9 0.88
46 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
47 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
48 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
49 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
50 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
51 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
52 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
53 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
54 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
55 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
56 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
57 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
58 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
59 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
60 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
61 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
62 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
63 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
64 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
65 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
66 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
67 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
68 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
69 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
70 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
71 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
72 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
73 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
74 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
75 INT12238 CCK Positive_regulation of CDH2 1 0.02 0 0.7
76 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
77 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
78 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
79 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
80 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
81 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
82 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
83 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
84 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
85 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
86 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
87 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
88 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
89 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
90 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
91 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
92 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
93 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
94 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
95 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
96 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
97 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
98 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
99 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
100 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
101 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
102 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
103 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
104 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
105 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
106 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
107 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
108 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
109 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
110 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
111 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
112 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
113 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
114 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
115 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
116 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
117 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
118 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
119 INT7120 Nppb Positive_regulation of Localization of Rab8a 1 0.08 0 0.51
120 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
121 INT122107 Plbd2 Negative_regulation of Cdh2 1 0.03 0.42 0.5
122 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
123 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
124 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
125 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
126 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
127 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
128 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
129 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
130 INT191686 Igh-Dex Positive_regulation of Sgk1 1 0.04 1.79 0.46
131 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
132 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
133 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
134 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
135 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
136 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
137 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
138 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
139 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 0.01 1.92 0.43
140 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
141 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
142 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
143 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
144 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
145 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
146 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
147 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
148 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
149 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
150 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
151 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
152 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
153 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
154 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
155 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
156 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
157 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
158 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
159 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
160 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
161 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
162 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
163 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
164 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
165 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
166 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
167 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
168 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
169 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
170 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
171 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
172 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
173 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
174 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
175 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
176 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
177 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
178 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
179 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
180 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
181 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
182 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35
183 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
184 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
185 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
186 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
187 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
188 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
189 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
190 INT134080 OPA1 Negative_regulation of Phosphorylation of Gnb2l1 1 0.03 0.22 0.34
191 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
192 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
193 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34
194 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
195 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
196 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
197 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
198 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
199 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
200 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of protein localization. They are ordered first by their pain relevance and then by number of times they were reported in regulation of protein localization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
4 INT251 Regulation of INS 398 0.62 232.47 55.04
5 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
6 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
7 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
8 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
9 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
10 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
11 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
12 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
13 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
14 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
15 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
16 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
17 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
18 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
19 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
20 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
21 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
22 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
23 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
24 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
25 INT168482 Gene_expression of Nnat 45 0.77 24.01 21.53
26 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
27 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
28 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
29 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
30 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
31 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
32 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
33 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
34 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
35 INT14572 Binding of INS 205 0.48 175.43 13.38
36 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
37 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
38 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
39 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
40 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
41 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
42 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
43 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
44 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
45 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
46 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
47 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
48 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
49 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
50 INT318459 Positive_regulation of Gene_expression of Nnat 1 0.60 9.92 8.49
51 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
52 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
53 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
54 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
55 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
56 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
57 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
58 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
59 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
60 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
61 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
62 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
63 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
64 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
65 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
66 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
67 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
68 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
69 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56
70 INT168483 Regulation of Gene_expression of Nnat 3 0.61 5.93 5.5
71 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
72 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
73 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
74 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
75 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
76 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
77 INT134657 Localization of Akt1 37 0.68 11.58 4.62
78 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
79 INT168151 Gene_expression of Sgk1 10 0.76 5.58 4.35
80 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
81 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
82 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
83 INT75136 Binding of Akt1 27 0.27 8.81 4.15
84 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
85 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
86 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
87 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
88 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
89 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
90 INT136692 Localization of Akt1 12 0.78 2.14 3.65
91 INT191667 Positive_regulation of Sgk1 6 0.68 4.59 3.45
92 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
93 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
94 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
95 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
96 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
97 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
98 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
99 INT105884 Binding of Bcl2 19 0.35 15.67 3
100 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
101 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
102 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
103 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
104 INT215185 Localization of Nnat 7 0.69 3.62 2.75
105 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
106 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
107 INT214355 Binding of Akt1 13 0.36 3.72 2.59
108 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
109 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
110 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
111 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
112 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
113 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
114 INT169705 Negative_regulation of Gene_expression of Cdh1 10 0.57 8.8 2.1
115 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
116 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
117 INT233660 Transcription of Sgk1 3 0.70 0.51 2.03
118 INT318456 Regulation of Nnat 1 0.39 2.32 2.03
119 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
120 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
121 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
122 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
123 INT7116 Localization of Rab8a 10 0.70 1.2 1.95
124 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
125 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
126 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
127 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
128 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
129 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
130 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
131 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
132 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
133 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
134 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
135 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
136 INT18503 Binding of SUMO1 7 0.27 6.21 1.48
137 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
138 INT180712 Gene_expression of Sgk1 2 0.47 1.52 1.41
139 INT116262 Gene_expression of Mycbp2 6 0.76 1.72 1.32
140 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
141 INT233665 Positive_regulation of Transcription of Sgk1 2 0.49 0.3 1.29
142 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
143 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
144 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
145 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
146 INT122103 Negative_regulation of Cdh1 5 0.49 2.05 1.18
147 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
148 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
149 INT139236 Regulation of Sgk1 2 0.37 0.84 1.14
150 INT183046 Transcription of INS 25 0.70 11.14 1.13
151 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
152 INT172855 Binding of Bcl2 37 0.32 23.41 1.09
153 INT70021 Localization of BCL2 23 0.74 21.6 1.09
154 INT169704 Regulation of Gene_expression of Cdh1 4 0.35 1.75 1.09
155 INT233633 Negative_regulation of Positive_regulation of Sgk1 1 0.37 0.11 1.08
156 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
157 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
158 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
159 INT233644 Negative_regulation of Sgk1 1 0.38 0.11 1.02
160 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
161 INT122106 Localization of Cdh2 3 0.69 0.95 1
162 INT170106 Binding of Nnat 3 0.31 1.65 0.98
163 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
164 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
165 INT53710 Regulation of Negative_regulation of Arhgdia 1 0.18 0 0.92
166 INT53711 Negative_regulation of Arhgdia 1 0.28 0 0.91
167 INT144543 Localization of Sgk1 1 0.71 0.96 0.91
168 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88
169 INT117444 Regulation of Sgk1 4 0.60 1.35 0.87
170 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
171 INT276620 Negative_regulation of Cdh1 7 0.57 6.48 0.86
172 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
173 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
174 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
175 INT70019 Binding of BCL2 25 0.47 17.55 0.79
176 INT233632 Regulation of Transcription of Sgk1 1 0.39 0.22 0.78
177 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
178 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
179 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
180 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76
181 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
182 INT124844 Regulation of Positive_regulation of Bcl2 3 0.43 2.55 0.75
183 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
184 INT155392 Negative_regulation of Negative_regulation of Bcl2 3 0.21 1.64 0.74
185 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
186 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
187 INT47481 Localization of SUMO1 1 0.01 0 0.73
188 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
189 INT134444 Positive_regulation of Binding of Bcl2 3 0.47 2.67 0.72
190 INT247255 Positive_regulation of Gene_expression of Sgk1 1 0.30 0.84 0.72
191 INT235069 Localization of Cdh1 9 0.74 3.81 0.71
192 INT116267 Binding of Mycbp2 1 0.35 0.37 0.71
193 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
194 INT189877 Gene_expression of Cdh1 55 0.58 9.36 0.66
195 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
196 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
197 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64
198 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63
199 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
200 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62
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