GO:0032909

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Name regulation of transforming growth factor beta2 production
Categary Process
Go Slim No
Go Link GO:0032909
Unique Molecular Interactions 108
Total Molecular Interactions 143
Total Single Events 1023
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of transforming growth factor beta2 production. They are ordered first by their pain relevance and then by number of times they were reported for regulation of transforming growth factor beta2 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
2 INT161949 TGFB2 Positive_regulation of Gene_expression of Ngf 1 0.21 0.97 0.74
3 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
4 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
5 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
6 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
7 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
8 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
9 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
10 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
11 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
12 INT209851 TGFB2 Negative_regulation of Gene_expression of CD36 1 0.16 0.16 0.21
13 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
14 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
15 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
16 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17
17 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
18 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
19 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
20 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
21 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
22 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
23 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
24 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
25 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
26 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
27 INT323431 Binding of Hif1a and Vhl 1 0.07 0.68 0.12
28 INT249923 Binding of Pah and Hif1a 1 0.31 1.16 0.12
29 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
30 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11
31 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1
32 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
33 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1
34 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
35 INT149178 IL4 Negative_regulation of Positive_regulation of TGFB2 1 0.15 0.29 0.1
36 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1
37 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
38 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09
39 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09
40 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08
41 INT249920 Negative_regulation of Binding of Pah and Hif1a 1 0.37 0.76 0.08
42 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
43 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08
44 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
45 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07
46 INT247578 Hif1a Regulation of VEGFA 1 0.02 1.59 0.07
47 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
48 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
49 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05
50 INT304322 Hif1a Positive_regulation of Positive_regulation of VEGFA 1 0.11 0.39 0.05
51 INT249921 Binding of Hif1a and Asph 1 0.05 0.41 0.04
52 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
53 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04
54 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
55 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
56 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
57 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03
58 INT297159 Gsta3 Negative_regulation of Hif1a 1 0.00 0.54 0.03
59 INT322471 Hif1a Positive_regulation of VEGFA 1 0.05 0.26 0.03
60 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
61 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
62 INT277927 WIF1 Negative_regulation of SMAD4 1 0.23 0.37 0
63 INT247576 Binding of Hif1a and Vbp1 1 0.01 0.6 0
64 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
65 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
66 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
67 INT135174 Myst2 Positive_regulation of Binding of Hif1a 1 0.41 0 0
68 INT143438 HIF1A Regulation of Gene_expression of VEGFA 1 0.69 0.13 0
69 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0
70 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
71 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
72 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0
73 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
74 INT314862 Binding of Ltbp3 and Tgfb2 1 0.24 0.52 0
75 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
76 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
77 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
78 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0
79 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
80 INT135175 Myst2 Positive_regulation of Hif1a 1 0.41 0 0
81 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
82 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
83 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0
84 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
85 INT249924 Cpox Positive_regulation of Hif1a 1 0.01 0.68 0
86 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
87 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0
88 INT119045 HIF1A Regulation of Regulation of TP53 1 0.09 1.06 0
89 INT262710 Binding of Crem and Hif1a 1 0.00 1.85 0
90 INT119046 HIF1A Regulation of TP53 1 0.05 1.06 0
91 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
92 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
93 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
94 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
95 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
96 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
97 INT143439 Positive_regulation of HIF1A Regulation of Gene_expression of VEGFA 1 0.30 0.13 0
98 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0
99 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
100 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
101 INT172981 PAN3 Negative_regulation of SMAD4 1 0.01 0.98 0
102 INT119044 HIF1A Regulation of TCEAL1 1 0.02 1.06 0
103 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0
104 INT119047 HIF1A Regulation of Regulation of TCEAL1 1 0.08 1.06 0
105 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of transforming growth factor beta2 production. They are ordered first by their pain relevance and then by number of times they were reported in regulation of transforming growth factor beta2 production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
2 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
3 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
4 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
5 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
6 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
7 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
8 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
9 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
10 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
11 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
12 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
13 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
14 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
15 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
16 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
17 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
18 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
19 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
20 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
21 INT81878 Gene_expression of TGFB2 3 0.42 2.02 0.97
22 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
23 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
24 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
25 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
26 INT93737 Gene_expression of Tgfb2 2 0.03 1.16 0.77
27 INT93736 Positive_regulation of Gene_expression of Tgfb2 2 0.02 1.16 0.77
28 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
29 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
30 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
31 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
32 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
33 INT115297 Positive_regulation of TGFB2 4 0.29 1.91 0.65
34 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
35 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
36 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
37 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
38 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
39 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
40 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58
41 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
42 INT130047 Localization of TGFB2 3 0.16 3.65 0.53
43 INT135173 Regulation of Gene_expression of Hif1a 3 0.44 2.49 0.53
44 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53
45 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51
46 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47
47 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
48 INT248931 Positive_regulation of Tgfb2 1 0.03 0 0.4
49 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
50 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
51 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36
52 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
53 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34
54 INT247563 Negative_regulation of Positive_regulation of Hif1a 1 0.16 9.12 0.32
55 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
56 INT92100 Binding of Smad4 5 0.31 2.23 0.3
57 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
58 INT316692 Regulation of Localization of TGFB2 1 0.03 1.13 0.3
59 INT173105 Transcription of HIF1A 6 0.67 4.47 0.28
60 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27
61 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
62 INT173103 Positive_regulation of Transcription of HIF1A 3 0.49 2.11 0.21
63 INT247564 Positive_regulation of Transcription of Hif1a 1 0.19 2.05 0.2
64 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
65 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
66 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
67 INT249919 Regulation of Regulation of Hif1a 2 0.29 1.81 0.14
68 INT249908 Binding of Hif1a 2 0.31 1.48 0.14
69 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
70 INT249913 Regulation of Gene_expression of Hif1a 2 0.32 1.82 0.13
71 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
72 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1
73 INT153064 Positive_regulation of Regulation of Hif1a 1 0.45 1.52 0.1
74 INT260478 Negative_regulation of Positive_regulation of Hif1a 2 0.30 1.23 0.09
75 INT260462 Negative_regulation of Binding of Hif1a 1 0.30 1.13 0.09
76 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
77 INT260451 Positive_regulation of Positive_regulation of Hif1a 1 0.36 1.01 0.08
78 INT343551 Positive_regulation of Localization of TGFB2 1 0.10 1.48 0.08
79 INT297157 Negative_regulation of Negative_regulation of Hif1a 1 0.03 0.54 0.07
80 INT247560 Negative_regulation of Negative_regulation of Hif1a 1 0.16 2.06 0.07
81 INT251229 Negative_regulation of Tgfb2 1 0.34 0.06 0.07
82 INT143444 Positive_regulation of Localization of HIF1A 3 0.45 1.26 0.06
83 INT254790 Localization of Smad4 2 0.37 0.54 0.06
84 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
85 INT247553 Regulation of Negative_regulation of Hif1a 1 0.17 1.36 0.06
86 INT297158 Regulation of Localization of Hif1a 1 0.03 0.32 0.06
87 INT247559 Regulation of Positive_regulation of Hif1a 2 0.23 1.64 0.05
88 INT247555 Positive_regulation of Binding of Hif1a 2 0.31 1.15 0.05
89 INT297156 Localization of Hif1a 1 0.06 0.32 0.05
90 INT322464 Regulation of Localization of Hif1a 1 0.28 0.59 0.05
91 INT262799 Localization of Smad3 6 0.56 2.09 0.04
92 INT155174 Regulation of Regulation of HIF1A 3 0.24 1.57 0.04
93 INT173079 Positive_regulation of Regulation of HIF1A 1 0.26 0.64 0.04
94 INT249918 Regulation of Protein_catabolism of Hif1a 1 0.29 0.4 0.04
95 INT249916 Protein_catabolism of Hif1a 1 0.64 0.39 0.04
96 INT258058 Phosphorylation of TGFB2 1 0.08 0.89 0.04
97 INT334291 Positive_regulation of Gene_expression of SMAD4 1 0.18 0 0.04
98 INT105389 Negative_regulation of Binding of HIF1A 4 0.42 3.2 0.03
99 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03
100 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
101 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
102 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
103 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
104 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0
105 INT334327 Regulation of SMAD4 2 0.35 1.73 0
106 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0
107 INT265337 Binding of Smad3 2 0.35 1 0
108 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
109 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
110 INT268368 Transcription of SMAD4 1 0.54 1.7 0
111 INT314821 Binding of Tgfb2 1 0.36 0.51 0
112 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
113 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
114 INT189594 Negative_regulation of Transcription of HIF1A 1 0.05 0.94 0
115 INT249915 Regulation of Positive_regulation of Hif1a 1 0.29 0.85 0
116 INT159211 Positive_regulation of Gene_expression of TGFB2 1 0.06 0 0
117 INT173000 Negative_regulation of Localization of SMAD4 1 0.22 0.98 0
118 INT173008 Localization of SMAD4 1 0.38 0.97 0
119 INT112706 Negative_regulation of Gene_expression of Hif1a 1 0.08 0 0
120 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
121 INT322450 Negative_regulation of Binding of Hif1a 1 0.26 0.32 0
122 INT351109 Transcription of TGFB2 1 0.24 0.94 0
123 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
124 INT334289 Regulation of Binding of SMAD4 1 0.16 0 0
125 INT334288 Regulation of Negative_regulation of SMAD4 1 0.16 0 0
126 INT189606 Regulation of Transcription of HIF1A 1 0.06 0.46 0
127 INT228250 Positive_regulation of Smad4 1 0.45 1.93 0
128 INT249917 Regulation of Negative_regulation of Hif1a 1 0.29 0.29 0
129 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
130 INT228247 Regulation of Positive_regulation of Smad4 1 0.26 0.97 0
131 INT247562 Negative_regulation of Transcription of Hif1a 1 0.16 2.39 0
132 INT268363 Binding of SMAD3 1 0.20 0.56 0
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