GO:0032947

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Name protein complex scaffold
Categary Function
Go Slim No
Go Link GO:0032947
Unique Molecular Interactions 100
Total Molecular Interactions 153
Total Single Events 1176
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein complex scaffold. They are ordered first by their pain relevance and then by number of times they were reported for protein complex scaffold. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT305406 Binding of CAV3 and ST8SIA2 1 0.16 0 0.86
2 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
3 INT152946 Homer1 Regulation of Cap1 1 0.32 0.18 0.76
4 INT152948 Homer1 Regulation of Gpr88 1 0.36 0.18 0.75
5 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68
6 INT205733 Gphn Regulation of Gene_expression of Gabrd 1 0.03 0.18 0.51
7 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
8 INT81064 Negative_regulation of Nts Negative_regulation of Gene_expression of Homer1 1 0.01 0 0.48
9 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
10 INT309370 Positive_regulation of Glyr1 Positive_regulation of Positive_regulation of Gphn 1 0.01 0 0.47
11 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
12 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
13 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
14 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
15 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
16 INT346221 Positive_regulation of Braf Positive_regulation of Positive_regulation of Map2k2 1 0.11 0.67 0.39
17 INT346219 Positive_regulation of Braf Positive_regulation of Map2k2 1 0.11 0.67 0.39
18 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
19 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
20 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
21 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
22 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
23 INT150582 Creb1 Positive_regulation of Gene_expression of Homer1 1 0.00 0 0.22
24 INT174679 Homer1 Regulation of Luc7l3 1 0.02 0.67 0.21
25 INT110384 Binding of Prkaca and Akap11 1 0.08 0.31 0.2
26 INT254691 Gopc Positive_regulation of Positive_regulation of Map2k2 1 0.07 0.07 0.18
27 INT254685 Map2k2 Positive_regulation of Mmp3 1 0.04 0.08 0.18
28 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17
29 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
30 INT58179 Gtf3a Positive_regulation of Gene_expression of Homer1 1 0.07 0.1 0.16
31 INT244045 Binding of Arhgef9 and Gphn 1 0.02 0.2 0.15
32 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
33 INT303128 Tnrc6a Regulation of Gene_expression of Nos2 1 0.00 0.57 0.14
34 INT244059 Binding of Gabarap and Gphn 1 0.05 0.05 0.13
35 INT179424 Map2k2 Regulation of Mapk3 1 0.00 0.17 0.12
36 INT265982 Homer1 Regulation of Grm5 1 0.04 0.38 0.12
37 INT244013 Gphn Positive_regulation of Gabrg1 1 0.07 0 0.11
38 INT244039 Binding of Gabrg1 and Gphn 1 0.09 0.16 0.1
39 INT101880 Oxt Positive_regulation of Gene_expression of Homer1 1 0.23 0.14 0.1
40 INT265981 Homer1 Regulation of Localization of Grm5 1 0.04 0.06 0.09
41 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
42 INT346752 Binding of Dlg1 and Gria1 1 0.02 0 0.06
43 INT183853 Gene_expression of CAV1 Negative_regulation of Positive_regulation of MAPK1 1 0.28 0.25 0.05
44 INT282503 Binding of ocd and Dlgap3 1 0.28 1.58 0.03
45 INT183896 Gene_expression of CAV1 Negative_regulation of Positive_regulation of Racgap1 1 0.01 0.64 0.03
46 INT351167 CAV1 Negative_regulation of Ppp2r1a 1 0.08 1.5 0
47 INT329996 Binding of SGCD and AKAP6 1 0.37 0.46 0
48 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
49 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0
50 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
51 INT288594 Regulation of Binding of CAV1 and Kcnma1 1 0.01 0 0
52 INT183895 CAV1 Regulation of Positive_regulation of Racgap1 1 0.01 0.37 0
53 INT280960 Binding of Cav3 and Fig4 1 0.08 0 0
54 INT256988 Binding of Dlg1 and Rpe 1 0.06 0 0
55 INT351166 Gtf3a Positive_regulation of Gene_expression of CAV1 1 0.01 0.79 0
56 INT254695 Positive_regulation of Map2k2 Regulation of Mcl1 1 0.03 0.84 0
57 INT263737 Binding of Dlg1 and Neto1 1 0.07 0 0
58 INT351156 VEGFA Positive_regulation of Gene_expression of CAV1 1 0.07 0.79 0
59 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
60 INT280969 Binding of Cav3 and Mgst1 1 0.01 0 0
61 INT287077 Chrm2 Positive_regulation of Homer1 1 0.05 0.08 0
62 INT288597 Binding of CAV1 and Kcnma1 1 0.01 0.17 0
63 INT329995 Binding of KCNMA1 and AKAP6 1 0.40 0.48 0
64 INT288596 Positive_regulation of Binding of CAV1 and Kcnma1 1 0.01 0.1 0
65 INT183857 CAV1 Positive_regulation of RHOC 1 0.46 0.21 0
66 INT183861 Binding of CAV1 and CDC42EP5 1 0.03 3.21 0
67 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
68 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0
69 INT183864 Gene_expression of CAV1 Negative_regulation of Positive_regulation of RHOC 1 0.39 0.95 0
70 INT351165 Binding of CAV1 and Nos3 1 0.09 1.46 0
71 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 0.01 1.43 0
72 INT183860 Binding of RHOC and CAV1 1 0.34 0.4 0
73 INT183856 Negative_regulation of RHOC Positive_regulation of Gene_expression of CAV1 1 0.42 0.09 0
74 INT183868 CAV1 Positive_regulation of PAF1 1 0.54 0.41 0
75 INT254696 Map2k2 Regulation of Map2k1 1 0.18 0.78 0
76 INT351164 CAV1 Negative_regulation of Ppp1cc 1 0.11 1.5 0
77 INT254708 Map2k2 Positive_regulation of Phosphorylation of MAPK1 1 0.11 0.86 0
78 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
79 INT254699 Positive_regulation of Map2k2 Regulation of Bcl2l1 1 0.04 0.89 0
80 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
81 INT329992 Binding of SNRNP70 and AKAP6 1 0.03 0.95 0
82 INT254688 Gene_expression of Map2k2 Regulation of Gene_expression of Mdk 1 0.09 0.42 0
83 INT183866 CAV1 Regulation of RHOC 1 0.25 0.2 0
84 INT183867 Binding of CAV1 and Positive_regulation of Positive_regulation of RHOC 1 0.46 0.1 0
85 INT254684 Map2k2 Positive_regulation of Map2k1 1 0.45 0.4 0
86 INT183852 CAV1 Regulation of Positive_regulation of RHOC 1 0.41 0.63 0
87 INT288558 Binding of CAV1 and KCNMA1 1 0.00 0 0
88 INT356253 Binding of CLTC and Gphn 1 0.00 0 0
89 INT254705 Map2k2 Positive_regulation of Phosphorylation of MAPK3 1 0.08 0.86 0
90 INT351159 CAV1 Positive_regulation of AKT1 1 0.11 0.87 0
91 INT183854 Regulation of CAV1 Positive_regulation of RHOC 1 0.41 0.26 0
92 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0
93 INT254694 Positive_regulation of Map2k2 Regulation of Bcl2 1 0.02 0.89 0
94 INT272197 Binding of CAPN3 and DYSF 1 0.42 0.38 0
95 INT280959 Binding of Cav3 and IgG-2a 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein complex scaffold. They are ordered first by their pain relevance and then by number of times they were reported in protein complex scaffold. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67
2 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98
3 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05
4 INT60995 Negative_regulation of Positive_regulation of Homer1 9 0.38 1.63 9.63
5 INT15242 Regulation of Gene_expression of Homer1 14 0.62 4.33 9.28
6 INT168096 Transcription of Cav3 1 0.72 7.23 8.58
7 INT63852 Gene_expression of Gphn 21 0.63 5.64 8.2
8 INT117212 Gene_expression of Hcn2 13 0.78 5.83 8.19
9 INT53974 Regulation of Homer1 14 0.39 4.71 4.9
10 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
11 INT179391 Phosphorylation of Map2k2 1 0.02 7.01 3.89
12 INT9798 Negative_regulation of Gene_expression of Homer1 10 0.41 2.04 3.77
13 INT60714 Regulation of Positive_regulation of Homer1 3 0.04 0.64 3.46
14 INT94688 Negative_regulation of Gphn 4 0.21 2.35 2.95
15 INT159770 Positive_regulation of Gene_expression of Hcn2 2 0.67 2.65 2.82
16 INT58173 Negative_regulation of Homer1 5 0.43 1 2.79
17 INT82278 Positive_regulation of Positive_regulation of Homer1 5 0.13 2.32 2.73
18 INT89830 Positive_regulation of Gphn 4 0.45 0.81 2.61
19 INT179396 Positive_regulation of Map2k2 7 0.30 2.84 2.56
20 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47
21 INT168959 Gene_expression of CAV3 5 0.65 0.7 2.2
22 INT117210 Binding of Hcn2 3 0.48 0.82 1.91
23 INT61845 Transcription of Homer1 9 0.72 2.28 1.85
24 INT139402 Negative_regulation of Tnrc6a 1 0.00 2.22 1.8
25 INT168964 Negative_regulation of Gene_expression of CAV3 1 0.47 0 1.68
26 INT63520 Localization of Homer1 4 0.75 0.38 1.63
27 INT179420 Positive_regulation of Phosphorylation of Map2k2 1 0.01 2.17 1.58
28 INT82279 Regulation of Negative_regulation of Homer1 1 0.02 0 1.36
29 INT254666 Positive_regulation of Map2k2 37 0.56 23.85 1.35
30 INT63845 Regulation of Gene_expression of Gphn 5 0.36 0.23 1.23
31 INT168095 Positive_regulation of Transcription of Cav3 1 0.47 0.91 1.2
32 INT149261 Negative_regulation of Hcn2 1 0.11 0.45 1.17
33 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
34 INT243982 Gene_expression of Gphn 13 0.63 1.39 1.09
35 INT168957 Positive_regulation of CAV3 1 0.40 0 1.06
36 INT138640 Transcription of Hcn2 2 0.66 0.51 1.05
37 INT168960 Binding of CAV3 1 0.30 0 1.05
38 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
39 INT126102 Binding of Tnrc6a 1 0.00 1.03 0.96
40 INT72990 Binding of Gphn 4 0.25 0.34 0.94
41 INT149903 Localization of Cav3 3 0.80 1.1 0.93
42 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
43 INT117215 Positive_regulation of Hcn2 1 0.50 0.15 0.92
44 INT9797 Binding of Homer1 2 0.48 1.14 0.9
45 INT243977 Positive_regulation of Gene_expression of Gphn 3 0.41 0.11 0.83
46 INT149905 Negative_regulation of Cav3 2 0.43 0.98 0.82
47 INT72992 Transcription of Gphn 3 0.50 0.19 0.8
48 INT144789 Negative_regulation of Hcn2 2 0.53 0.24 0.8
49 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
50 INT211908 Regulation of Positive_regulation of Map2k2 1 0.27 0.48 0.76
51 INT159772 Regulation of Hcn2 1 0.26 0.53 0.71
52 INT272206 Gene_expression of CAPN3 4 0.77 3.83 0.7
53 INT117216 Localization of Hcn2 1 0.75 0.16 0.69
54 INT153667 Localization of CAV1 15 0.76 11.92 0.68
55 INT165963 Gene_expression of Map2k2 37 0.75 20.68 0.66
56 INT99750 Localization of Gphn 2 0.73 1.28 0.63
57 INT211910 Negative_regulation of Map2k2 2 0.26 0.59 0.63
58 INT168963 Negative_regulation of Binding of CAV3 1 0.30 0 0.62
59 INT168962 Positive_regulation of Localization of CAV3 1 0.40 0 0.62
60 INT168953 Localization of CAV3 1 0.60 0 0.62
61 INT131001 Regulation of CAV1 6 0.44 3.77 0.59
62 INT76505 Positive_regulation of Transcription of Homer1 3 0.21 0.48 0.59
63 INT168955 Phosphorylation of CAV3 1 0.56 0 0.58
64 INT84854 Regulation of Transcription of Homer1 1 0.00 0.15 0.57
65 INT179409 Regulation of Phosphorylation of Map2k2 1 0.01 0.74 0.56
66 INT132967 Gene_expression of Hcn2 2 0.71 0.09 0.54
67 INT243949 Positive_regulation of Gphn 3 0.41 0.29 0.52
68 INT92523 Phosphorylation of Homer1 3 0.63 0.15 0.52
69 INT89829 Positive_regulation of Positive_regulation of Gphn 1 0.00 0.29 0.47
70 INT153672 Negative_regulation of Negative_regulation of CAV1 1 0.25 0.2 0.46
71 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
72 INT130270 Gene_expression of Map2k2 2 0.24 0.25 0.45
73 INT230265 Binding of Cav3 2 0.42 0.74 0.44
74 INT309338 Positive_regulation of Positive_regulation of Gphn 1 0.09 0 0.44
75 INT144790 Negative_regulation of Negative_regulation of Hcn2 1 0.53 0.06 0.4
76 INT168952 Positive_regulation of Gene_expression of CAV3 1 0.49 0 0.4
77 INT72991 Regulation of Gphn 4 0.22 0.34 0.38
78 INT163277 Negative_regulation of Gene_expression of CAV1 17 0.56 10.77 0.35
79 INT243956 Negative_regulation of Gphn 3 0.35 0.94 0.35
80 INT149904 Regulation of Gene_expression of Cav3 1 0.27 0.35 0.35
81 INT342958 Positive_regulation of Gene_expression of CAPN3 1 0.69 0.66 0.35
82 INT149906 Regulation of Localization of Cav3 1 0.61 0.41 0.35
83 INT319280 Positive_regulation of Dlg1 1 0.45 0.42 0.28
84 INT215979 Binding of Gphn 4 0.34 0.77 0.26
85 INT209224 Binding of Dlg1 3 0.13 0.22 0.23
86 INT72994 Localization of Gphn 2 0.51 0 0.23
87 INT320581 Positive_regulation of Gene_expression of Gphn 1 0.34 0 0.23
88 INT282473 Gene_expression of Dlgap3 1 0.71 3.11 0.23
89 INT272202 Negative_regulation of CAPN3 4 0.59 0.99 0.2
90 INT254675 Regulation of Positive_regulation of Map2k2 1 0.36 0.85 0.2
91 INT342960 Regulation of CAPN3 1 0.45 0.39 0.18
92 INT131000 Positive_regulation of Positive_regulation of CAV1 1 0.49 0 0.17
93 INT210123 Localization of Axin1 1 0.04 0.84 0.17
94 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
95 INT342959 Protein_catabolism of CAPN3 1 0.87 0.41 0.16
96 INT163278 Regulation of Gene_expression of CAV1 5 0.45 4.36 0.14
97 INT303120 Regulation of Tnrc6a 1 0.00 0.28 0.14
98 INT271765 Regulation of Cav3 1 0.05 0 0.14
99 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
100 INT243962 Negative_regulation of Gene_expression of Gphn 1 0.13 0.13 0.12
101 INT179397 Positive_regulation of Positive_regulation of Map2k2 1 0.01 0.17 0.11
102 INT72993 Regulation of Localization of Gphn 1 0.09 0 0.11
103 INT311132 Regulation of Regulation of Gphn 1 0.22 0.34 0.11
104 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
105 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
106 INT174848 Gene_expression of ISCU 2 0.59 2.79 0.08
107 INT303119 Positive_regulation of Tnrc6a 1 0.01 0.74 0.08
108 INT283601 Negative_regulation of Localization of Gphn 1 0.30 0.33 0.08
109 INT254667 Positive_regulation of Gene_expression of Map2k2 5 0.56 2.98 0.07
110 INT282484 Localization of Dlgap3 1 0.74 0.66 0.07
111 INT329999 Binding of AKAP6 1 0.36 0.91 0.07
112 INT256975 Binding of Dlg1 7 0.36 0 0.06
113 INT342956 Positive_regulation of Negative_regulation of CAPN3 1 0.46 0.16 0.06
114 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
115 INT314252 Transcription of CAV1 1 0.50 0.07 0.04
116 INT283603 Regulation of Gene_expression of Gphn 1 0.37 0.17 0.04
117 INT228192 Negative_regulation of Map2k2 2 0.35 0.96 0.03
118 INT183878 Negative_regulation of Positive_regulation of CAV1 1 0.41 0.16 0.03
119 INT315624 Positive_regulation of Gene_expression of ISCU 1 0.38 0.23 0.03
120 INT282478 Positive_regulation of Dlgap3 1 0.46 0.82 0.03
121 INT183883 Binding of CAV1 8 0.46 3.89 0
122 INT230264 Positive_regulation of Cav3 4 0.41 0 0
123 INT174850 Binding of ISCU 2 0.33 0.51 0
124 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
125 INT315561 Regulation of ISCU 2 0.35 1.1 0
126 INT280966 Negative_regulation of Localization of Cav3 1 0.37 0 0
127 INT254677 Positive_regulation of Positive_regulation of Map2k2 1 0.40 0.94 0
128 INT256961 Regulation of Gene_expression of Dlg1 1 0.33 0 0
129 INT282475 Negative_regulation of Dlgap3 1 0.39 0.7 0
130 INT315581 Positive_regulation of Phosphorylation of ISCU 1 0.44 0.33 0
131 INT254676 Regulation of Gene_expression of Map2k2 1 0.32 0.17 0
132 INT283605 Positive_regulation of Binding of Gphn 1 0.36 0.17 0
133 INT272203 Binding of CAPN3 1 0.37 0.23 0
134 INT256978 Positive_regulation of Dlg1 1 0.34 0 0
135 INT329998 Localization of AKAP6 1 0.72 0.26 0
136 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
137 INT342957 Positive_regulation of CAPN3 1 0.43 0.18 0
138 INT330002 Gene_expression of AKAP6 1 0.75 0.11 0
139 INT315634 Negative_regulation of Binding of ISCU 1 0.33 0.28 0
140 INT315597 Negative_regulation of ISCU 1 0.51 0.22 0
141 INT183890 Regulation of Negative_regulation of CAV1 1 0.43 0.38 0
142 INT254674 Negative_regulation of Positive_regulation of Map2k2 1 0.34 0.51 0
143 INT256952 Localization of Dlg1 1 0.55 0 0
144 INT288581 Negative_regulation of Binding of CAV1 1 0.03 0 0
145 INT174845 Protein_catabolism of ISCU 1 0.04 0.25 0
146 INT254672 Negative_regulation of Gene_expression of Map2k2 1 0.35 0.78 0
147 INT254678 Phosphorylation of Map2k2 1 0.66 2.21 0
148 INT342954 Positive_regulation of Positive_regulation of CAPN3 1 0.43 0.1 0
149 INT342961 Negative_regulation of Gene_expression of CAPN3 1 0.43 0.1 0
150 INT280968 Negative_regulation of Gene_expression of Cav3 1 0.51 0 0
151 INT315615 Positive_regulation of ISCU 1 0.44 0.11 0
152 INT315639 Localization of ISCU 1 0.66 0 0
153 INT315629 Phosphorylation of ISCU 1 0.71 0.33 0
154 INT288580 Regulation of Binding of CAV1 1 0.03 0 0
155 INT283606 Regulation of Gphn 1 0.44 0.13 0
156 INT283599 Positive_regulation of Localization of Gphn 1 0.41 0.05 0
157 INT254682 Regulation of Map2k2 1 0.36 0.99 0
158 INT256974 Gene_expression of Dlg1 1 0.50 0.08 0
159 INT263679 Transcription of Dlg1 1 0.12 0.07 0
160 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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