GO:0032959

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Name inositol trisphosphate biosynthetic process
Categary Process
Go Slim No
Go Link GO:0032959
Unique Molecular Interactions 83
Total Molecular Interactions 115
Total Single Events 629
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inositol trisphosphate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for inositol trisphosphate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
2 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
3 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
4 INT96260 Pik3cd Regulation of Plcg2 1 0.02 0 0.92
5 INT272144 PTAFR Positive_regulation of HRASLS 1 0.08 1.08 0.89
6 INT121467 Binding of Avp and Ptafr 1 0.11 0.98 0.88
7 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
8 INT16014 Ptafr Regulation of Ns5atp9 1 0.32 1.17 0.78
9 INT342992 Negative_regulation of PTAFR Negative_regulation of Gene_expression of HIST2H2AA3 1 0.01 0.4 0.78
10 INT308483 Paf Positive_regulation of Gene_expression of Ptafr 1 0.12 1.14 0.78
11 INT308485 Paf Positive_regulation of Ptafr 1 0.12 1.13 0.77
12 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71
13 INT342981 PTAFR Regulation of SFTPA1 1 0.03 0.38 0.6
14 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59
15 INT342983 HCL1 Positive_regulation of PTAFR 1 0.03 0.07 0.47
16 INT342987 TRPV1 Positive_regulation of Localization of PTAFR 1 0.33 0.84 0.43
17 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38
18 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
19 INT75947 Positive_regulation of Binding of Frk and Ptafr 1 0.11 1.26 0.34
20 INT75954 Negative_regulation of Binding of Frk and Ptafr 1 0.09 1.28 0.34
21 INT75949 Negative_regulation of Binding of Cpe and Ptafr 1 0.03 1.27 0.33
22 INT75953 Binding of Cpe and Ptafr 1 0.03 1.27 0.33
23 INT75945 Binding of Frk and Ptafr 1 0.08 1.25 0.33
24 INT75948 Positive_regulation of Binding of Ptafr and Sst 1 0.23 1.26 0.33
25 INT75951 Binding of Ptafr and Sst 1 0.17 1.26 0.33
26 INT75940 Positive_regulation of Binding of Cpe and Ptafr 1 0.04 1.27 0.33
27 INT75952 Negative_regulation of Binding of Ptafr and Sst 1 0.19 1.27 0.33
28 INT123398 TPSAB1 Positive_regulation of Gene_expression of PTAFR 1 0.14 0.51 0.32
29 INT123397 F2 Positive_regulation of Gene_expression of PTAFR 1 0.05 0.51 0.32
30 INT39317 Binding of ADRA1D and PTAFR 1 0.54 0.54 0.3
31 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28
32 INT10177 Binding of Ptafr and Gtf3a 1 0.02 1.34 0.28
33 INT269313 Binding of Ptafr and Gp6 1 0.00 0.48 0.26
34 INT55901 Negative_regulation of Alox5 Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
35 INT55902 Negative_regulation of Pla2g1b Negative_regulation of Localization of Ptafr 1 0.11 0.35 0.24
36 INT102620 PTAFR Regulation of Gene_expression of IL6 1 0.24 0.29 0.24
37 INT102622 PTAFR Regulation of IL6 1 0.24 0.29 0.24
38 INT342997 PTAFR Positive_regulation of Gene_expression of HIST2H2AA3 1 0.01 0.61 0.24
39 INT55903 Negative_regulation of Mthfs Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
40 INT102617 PTAFR Regulation of Gene_expression of PTGS2 1 0.12 0.29 0.24
41 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23
42 INT342994 IL1B Positive_regulation of Gene_expression of PTAFR 1 0.09 0.39 0.22
43 INT337295 PTAFR Positive_regulation of Localization of STAT3 1 0.43 0.85 0.22
44 INT272150 Positive_regulation of PTAFR Positive_regulation of HRASLS 1 0.06 0.16 0.21
45 INT39318 Binding of MPG and PTAFR 1 0.54 0.36 0.2
46 INT267629 PTAFR Positive_regulation of Localization of Il1 1 0.00 1.32 0.18
47 INT337310 PTAFR Regulation of Gene_expression of TLR4 1 0.24 0.8 0.18
48 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18
49 INT26190 PTAFR Regulation of AVP 1 0.16 0 0.14
50 INT272145 Binding of PTAFR and HRASLS 1 0.04 0.06 0.13
51 INT272149 PTAFR Positive_regulation of Localization of IL6 1 0.24 0 0.12
52 INT345011 Binding of GSN and PTAFR 1 0.09 0.83 0.12
53 INT337308 PTAFR Regulation of TLR4 1 0.24 0.1 0.1
54 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09
55 INT110220 Pla2g2a Positive_regulation of Gene_expression of Ptafr 1 0.11 0.5 0.09
56 INT110219 Pla2g1b Positive_regulation of Gene_expression of Ptafr 1 0.17 0.5 0.09
57 INT337290 PTAFR Positive_regulation of Phosphorylation of STAT3 1 0.43 0.07 0.07
58 INT337302 PLA2G6 Regulation of Gene_expression of PTAFR 1 0.09 1.18 0.07
59 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06
60 INT337303 Positive_regulation of PTAFR Positive_regulation of EDNRA 1 0.04 1.21 0.06
61 INT73194 GRB2 Positive_regulation of Positive_regulation of PLCG2 1 0.19 0.81 0.05
62 INT347463 Binding of PTAFR and ST7L 1 0.00 0 0.04
63 INT142141 Oxt Regulation of Plcg1 1 0.03 0.08 0
64 INT337305 PTAFR Regulation of Localization of IL8 1 0.06 0.47 0
65 INT102626 PTAFR Positive_regulation of Gene_expression of CPOX 1 0.11 0.1 0
66 INT337309 PTAFR Regulation of Localization of IRF6 1 0.06 0.89 0
67 INT337292 STAT3 Negative_regulation of Gene_expression of PTAFR 1 0.27 0.3 0
68 INT102618 PTAFR Regulation of Gene_expression of CPOX 1 0.08 0.38 0
69 INT102624 IL6 Positive_regulation of PTAFR 1 0.21 0.05 0
70 INT165438 PTAFR Positive_regulation of Gene_expression of ITGAM 1 0.45 0 0
71 INT337299 PTAFR Regulation of STAT3 1 0.28 0 0
72 INT142143 F2r Regulation of Plcg1 1 0.02 0.07 0
73 INT337307 Positive_regulation of PTAFR Positive_regulation of Localization of STAT3 1 0.25 0 0
74 INT142142 F2r Positive_regulation of Phosphorylation of Plcg1 1 0.03 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inositol trisphosphate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in inositol trisphosphate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
2 INT5160 Localization of PTAFR 61 0.80 42.6 19.16
3 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56
4 INT96259 Positive_regulation of Plcg1 11 0.49 3.01 11.15
5 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19
6 INT308473 Positive_regulation of Ptafr 1 0.58 13.26 7.92
7 INT110004 Gene_expression of Plcg1 7 0.41 2.61 7.87
8 INT32454 Gene_expression of Ptafr 3 0.65 15.19 7.87
9 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83
10 INT10507 Positive_regulation of Gene_expression of PTAFR 15 0.61 10.24 6.61
11 INT48234 Negative_regulation of Gene_expression of PTAFR 11 0.57 3.97 6.25
12 INT308479 Transcription of Ptafr 1 0.60 10.05 4.76
13 INT97847 Regulation of Ptafr 3 0.43 5.41 4.64
14 INT10896 Regulation of PTAFR 16 0.61 4.22 4.5
15 INT54701 Localization of Ptafr 19 0.49 18.68 3.82
16 INT13302 Binding of PTAFR 20 0.48 7.03 3.7
17 INT308474 Positive_regulation of Transcription of Ptafr 1 0.58 7.33 3.66
18 INT32453 Positive_regulation of Gene_expression of Ptafr 2 0.58 7.01 3.47
19 INT79360 Negative_regulation of Ptafr 6 0.36 4.15 2.77
20 INT51683 Regulation of Gene_expression of PTAFR 11 0.60 5.06 2.59
21 INT51680 Protein_catabolism of PTAFR 7 0.64 3.69 2.59
22 INT337317 Positive_regulation of Localization of PTAFR 2 0.51 3.88 2.5
23 INT205683 Localization of Ptafr 4 0.12 4.63 2.31
24 INT308477 Positive_regulation of Positive_regulation of Ptafr 1 0.51 4.3 2.29
25 INT55469 Positive_regulation of Positive_regulation of PTAFR 9 0.47 3 2.17
26 INT91519 Negative_regulation of Positive_regulation of PTAFR 4 0.41 1.52 2.15
27 INT7745 Regulation of Ptafr 7 0.40 1.99 2.12
28 INT55070 Binding of Ptafr 5 0.41 3.5 2.07
29 INT110003 Phosphorylation of Plcg1 2 0.37 0.91 1.96
30 INT55899 Positive_regulation of Ptafr 6 0.63 4.7 1.34
31 INT27911 Negative_regulation of Gene_expression of Ptafr 3 0.37 0.58 1.32
32 INT145550 Phosphorylation of Ptafr 1 0.52 1.03 1.28
33 INT73720 Positive_regulation of Gene_expression of Ptafr 4 0.42 4.15 1.25
34 INT110001 Binding of Plcg1 2 0.36 0.44 1.21
35 INT110000 Positive_regulation of Phosphorylation of Plcg1 1 0.23 0.49 1.02
36 INT77639 Phosphorylation of Plcg1 5 0.68 0.47 0.97
37 INT19584 Negative_regulation of Ptafr 3 0.56 1.82 0.61
38 INT110002 Regulation of Positive_regulation of Plcg1 1 0.11 0.4 0.59
39 INT32452 Binding of Ptafr 5 0.42 2.6 0.58
40 INT64980 Positive_regulation of Localization of Ptafr 2 0.05 2.36 0.54
41 INT308481 Negative_regulation of Transcription of Ptafr 1 0.36 1.37 0.53
42 INT54700 Negative_regulation of Localization of Ptafr 2 0.26 0.98 0.41
43 INT238901 Phosphorylation of PTAFR 2 0.58 1.54 0.3
44 INT77634 Binding of Plcg1 1 0.07 0 0.27
45 INT337320 Negative_regulation of Protein_catabolism of PTAFR 1 0.40 1.66 0.22
46 INT55071 Regulation of Binding of Ptafr 1 0.43 0.65 0.21
47 INT272151 Transcription of PTAFR 1 0.51 1.43 0.21
48 INT142137 Regulation of Phosphorylation of Plcg1 1 0.37 0.1 0.19
49 INT13304 Negative_regulation of Binding of PTAFR 1 0.43 0 0.19
50 INT272153 Negative_regulation of Localization of PTAFR 1 0.42 0.08 0.18
51 INT142138 Positive_regulation of Plcg1 1 0.41 0 0.18
52 INT142140 Gene_expression of Plcg1 1 0.64 0 0.17
53 INT77418 Negative_regulation of Binding of Ptafr 1 0.51 0.45 0.16
54 INT69523 Regulation of Localization of PTAFR 2 0.45 0.32 0.12
55 INT39320 Regulation of Regulation of PTAFR 1 0.27 0.25 0.11
56 INT51641 Regulation of Positive_regulation of PTAFR 1 0.45 0 0.07
57 INT337318 Positive_regulation of Regulation of PTAFR 1 0.47 0.06 0.06
58 INT73201 Positive_regulation of PLCG2 1 0.17 0.8 0.05
59 INT336019 Positive_regulation of Positive_regulation of Ptafr 1 0.12 0.79 0
60 INT337313 Positive_regulation of Phosphorylation of PTAFR 1 0.43 0.32 0
61 INT142139 Negative_regulation of Phosphorylation of Plcg1 1 0.48 0.07 0
62 INT142135 Positive_regulation of Phosphorylation of Plcg1 1 0.41 0.08 0
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