GO:0032964

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Name collagen biosynthetic process
Categary Process
Go Slim No
Go Link GO:0032964
Unique Molecular Interactions 86
Total Molecular Interactions 95
Total Single Events 1196
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for collagen biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for collagen biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
2 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
3 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
4 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
5 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
6 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
7 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
8 INT331927 Ptger2 Positive_regulation of Arg1 1 0.06 1.8 0.42
9 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
10 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
11 INT179838 Col3a1 Regulation of Negative_regulation of Il11 1 0.21 0 0.29
12 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
13 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
14 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
15 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
16 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
17 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
18 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
19 INT115875 Col5a1 Positive_regulation of Localization of Gcg 1 0.08 0 0.23
20 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22
21 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
22 INT225099 ZNF630 Positive_regulation of Gene_expression of COL1A1 1 0.00 0.17 0.2
23 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
24 INT326737 IL8 Positive_regulation of Gene_expression of ARG1 1 0.38 2.41 0.19
25 INT331768 Binding of Arg1 and NOSTRIN 1 0.01 0.6 0.17
26 INT331766 Binding of Arg1 and Nos2 1 0.17 0.6 0.17
27 INT326735 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG1 1 0.32 0.33 0.14
28 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
29 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
30 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1
31 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
32 INT294608 Binding of Serpinh1 and Col5a1 1 0.03 0.45 0.09
33 INT58630 Calca Negative_regulation of Positive_regulation of COL1A1 1 0.02 0.23 0.08
34 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08
35 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
36 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
37 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05
38 INT331924 Binding of Arg1 and Actvty1 1 0.03 1.11 0.05
39 INT179840 Binding of Col3a1 and Sparc 1 0.25 0 0.04
40 INT222980 TNF Positive_regulation of Localization of COL1A1 1 0.01 0.56 0.04
41 INT199526 Ceacam1 Negative_regulation of Col1a1 1 0.01 0.06 0.03
42 INT222977 Positive_regulation of COL1A1 Positive_regulation of MMP1 1 0.01 0.61 0.03
43 INT222987 Positive_regulation of COL1A1 Positive_regulation of Protein_catabolism of MMP1 1 0.01 0.61 0.03
44 INT326742 AR Regulation of Gene_expression of ARG1 1 0.24 0.43 0.03
45 INT170329 Binding of Col4a1 and Col1a1 1 0.03 0.14 0.03
46 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
47 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
48 INT170331 Binding of Col7a1 and Col1a1 1 0.00 0.14 0.03
49 INT252820 ELANE Positive_regulation of Gene_expression of COL1A1 1 0.01 0.58 0
50 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
51 INT197677 Binding of ESR1 and Arg1 1 0.04 0 0
52 INT326744 ARG1 Regulation of ARG2 1 0.50 1.04 0
53 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0
54 INT252796 ELANE Regulation of COL1A1 1 0.01 0.57 0
55 INT180847 Binding of COL1A1 and NID2 1 0.05 0.91 0
56 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0
57 INT249960 Arg1 Negative_regulation of NOS1 1 0.01 0.1 0
58 INT316811 Negative_regulation of Col1a2 Negative_regulation of Col3a1 1 0.33 0.07 0
59 INT252773 ROS1 Positive_regulation of COL1A1 1 0.05 0.57 0
60 INT252800 ROS1 Regulation of COL1A1 1 0.05 0.57 0
61 INT252813 ELANE Positive_regulation of COL1A1 1 0.01 0.57 0
62 INT118660 Binding of COL1A1 and GAPDH 1 0.16 0.09 0
63 INT197675 Regulation of Binding of ESR1 and Arg1 1 0.05 0 0
64 INT96782 FAM176C Regulation of Gene_expression of COL1A1 1 0.32 0.05 0
65 INT180859 Binding of COL1A1 and NID1 1 0.01 0.9 0
66 INT326743 Gene_expression of AR Negative_regulation of Gene_expression of ARG1 1 0.32 0.8 0
67 INT326738 Gene_expression of IL8 Positive_regulation of Gene_expression of ARG1 1 0.26 0.41 0
68 INT252802 ROS1 Regulation of Gene_expression of COL1A1 1 0.05 0.58 0
69 INT252776 ELANE Regulation of Gene_expression of COL1A1 1 0.01 0.58 0
70 INT206621 Col1a1 Positive_regulation of Col3a1 1 0.00 0.28 0
71 INT316821 Col1a2 Negative_regulation of Col3a1 1 0.33 0.07 0
72 INT326748 IL8 Positive_regulation of ARG1 1 0.26 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for collagen biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in collagen biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
2 INT94051 Positive_regulation of Arg1 41 0.60 36.22 13.72
3 INT94055 Gene_expression of Arg1 22 0.68 20.81 6.13
4 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
5 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
6 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
7 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
8 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
9 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18
10 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
11 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
12 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
13 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47
14 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
15 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32
16 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
17 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
18 INT94050 Negative_regulation of Arg1 6 0.39 6.07 2.06
19 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
20 INT94056 Positive_regulation of Gene_expression of Arg1 8 0.60 6.57 1.95
21 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
22 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91
23 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9
24 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
25 INT94054 Regulation of Arg1 5 0.47 5.37 1.57
26 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
27 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
28 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39
29 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36
30 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
31 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
32 INT124861 Positive_regulation of Col5a1 2 0.09 0.75 1.27
33 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
34 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
35 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
36 INT331764 Regulation of Gene_expression of Arg1 7 0.36 4.65 1.1
37 INT94053 Transcription of Arg1 5 0.46 3.11 1.02
38 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
39 INT156727 Gene_expression of Arg1 4 0.44 2.1 0.97
40 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
41 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95
42 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
43 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
44 INT73977 Gene_expression of Serpinh1 14 0.54 8.14 0.69
45 INT104305 Binding of COL3A1 2 0.35 3.45 0.68
46 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66
47 INT125709 Positive_regulation of Gene_expression of Col3a1 7 0.27 5.17 0.65
48 INT22556 Positive_regulation of Gene_expression of COL3A1 5 0.37 4.25 0.64
49 INT11890 Protein_catabolism of COL3A1 2 0.77 2.41 0.64
50 INT124858 Negative_regulation of Positive_regulation of Col5a1 1 0.01 0.75 0.64
51 INT138429 Negative_regulation of Gene_expression of Col3a1 3 0.17 2.51 0.54
52 INT68092 Negative_regulation of Localization of COL1A1 1 0.48 0 0.53
53 INT94047 Negative_regulation of Gene_expression of Arg1 1 0.37 1.37 0.5
54 INT8886 Regulation of Transcription of Col1a1 1 0.04 0 0.5
55 INT110165 Negative_regulation of Arg1 8 0.38 3.21 0.48
56 INT92684 Positive_regulation of Col3a1 5 0.56 1.79 0.45
57 INT197674 Positive_regulation of Gene_expression of Arg1 2 0.33 0.63 0.44
58 INT326766 Positive_regulation of Gene_expression of ARG1 12 0.67 8.32 0.42
59 INT125708 Negative_regulation of Col3a1 2 0.16 1.37 0.42
60 INT236948 Positive_regulation of Gene_expression of Col5a1 1 0.10 1.15 0.41
61 INT320812 Positive_regulation of Localization of COL1A1 1 0.05 1.04 0.4
62 INT296112 Positive_regulation of Positive_regulation of Arg1 1 0.05 0.55 0.4
63 INT136851 Regulation of Arg1 7 0.38 3.05 0.37
64 INT294604 Binding of Serpinh1 5 0.16 4.02 0.36
65 INT163709 Regulation of Negative_regulation of COL1A1 1 0.29 0.93 0.34
66 INT94048 Positive_regulation of Positive_regulation of Arg1 2 0.44 1.91 0.32
67 INT131134 Regulation of Col5a1 1 0.06 0 0.32
68 INT27399 Protein_catabolism of Arg1 1 0.64 0 0.31
69 INT254811 Localization of Col1a1 3 0.29 1.39 0.3
70 INT291615 Negative_regulation of Localization of Col1a1 1 0.06 1.28 0.3
71 INT157605 Localization of COL3A1 3 0.80 0.55 0.29
72 INT179809 Regulation of Col3a1 2 0.25 0.1 0.29
73 INT330614 Positive_regulation of Transcription of Arg1 1 0.15 0.92 0.29
74 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27
75 INT176464 Protein_catabolism of Col1a1 1 0.19 0.83 0.26
76 INT179798 Regulation of Gene_expression of Col3a1 2 0.22 0.57 0.25
77 INT94052 Negative_regulation of Protein_catabolism of Arg1 1 0.37 0.69 0.25
78 INT94049 Protein_catabolism of Arg1 1 0.77 0.6 0.25
79 INT292362 Negative_regulation of Gene_expression of Col3a1 1 0.10 1.01 0.25
80 INT271432 Positive_regulation of Regulation of Col1a1 1 0.10 0.61 0.24
81 INT314003 Negative_regulation of Positive_regulation of Arg1 1 0.13 0.63 0.23
82 INT225109 Regulation of Localization of COL1A1 1 0.05 0.41 0.23
83 INT115873 Negative_regulation of Col5a1 1 0.06 0 0.22
84 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21
85 INT218694 Binding of Col1a1 2 0.21 1.52 0.21
86 INT211657 Localization of Arg1 4 0.53 3.48 0.2
87 INT22560 Positive_regulation of COL3A1 3 0.23 1.16 0.2
88 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19
89 INT120859 Positive_regulation of Localization of Col1a1 1 0.16 0.05 0.18
90 INT187816 Positive_regulation of Transcription of Col1a1 1 0.06 0.82 0.17
91 INT22559 Regulation of Gene_expression of COL3A1 1 0.13 0.99 0.17
92 INT326763 Negative_regulation of ARG1 1 0.57 1.49 0.16
93 INT280717 Positive_regulation of Regulation of Arg1 1 0.12 0 0.16
94 INT130000 Positive_regulation of Protein_catabolism of Col1a1 1 0.49 1.15 0.15
95 INT187815 Transcription of Col1a1 1 0.09 0.76 0.15
96 INT73297 Positive_regulation of Transcription of Col1a1 2 0.32 3.12 0.14
97 INT241037 Regulation of Col3a1 2 0.05 1.94 0.14
98 INT142657 Regulation of Gene_expression of Col3a1 2 0.15 1.6 0.14
99 INT239485 Regulation of Gene_expression of Serpinh1 1 0.02 0.35 0.14
100 INT142656 Transcription of Col3a1 3 0.37 0.82 0.13
101 INT257290 Negative_regulation of Transcription of COL1A1 3 0.27 1.64 0.13
102 INT313999 Regulation of Positive_regulation of Arg1 1 0.08 0.22 0.13
103 INT326764 Negative_regulation of Gene_expression of ARG1 1 0.57 3.52 0.13
104 INT73984 Positive_regulation of Serpinh1 2 0.35 5.92 0.1
105 INT294606 Negative_regulation of Positive_regulation of Serpinh1 1 0.09 2.69 0.09
106 INT294605 Negative_regulation of Gene_expression of Serpinh1 1 0.13 2.68 0.09
107 INT280705 Localization of Arg1 2 0.22 0.26 0.08
108 INT197395 Positive_regulation of Gene_expression of Serpinh1 2 0.19 2.81 0.07
109 INT331917 Negative_regulation of Positive_regulation of Arg1 1 0.48 1.22 0.07
110 INT197397 Localization of Serpinh1 2 0.20 0.56 0.05
111 INT179886 Negative_regulation of Negative_regulation of COL1A1 1 0.05 0.5 0.05
112 INT244700 Regulation of Gene_expression of ARG1 2 0.60 3.09 0.04
113 INT296111 Negative_regulation of Binding of Arg1 1 0.04 0.12 0.04
114 INT296110 Binding of Arg1 1 0.03 0.07 0.04
115 INT179793 Binding of Col3a1 1 0.29 0 0.04
116 INT180589 Phosphorylation of COL1A1 3 0.34 0.37 0.03
117 INT255522 Transcription of COL3A1 1 0.07 0.09 0.03
118 INT222999 Positive_regulation of Positive_regulation of COL1A1 1 0.04 0.61 0.03
119 INT326776 Localization of ARG1 1 0.73 0 0.03
120 INT331922 Binding of Arg1 1 0.30 0.74 0.03
121 INT180582 Negative_regulation of Phosphorylation of COL1A1 1 0.07 0 0.03
122 INT180579 Negative_regulation of Protein_catabolism of COL1A1 1 0.07 0 0.03
123 INT255537 Positive_regulation of Positive_regulation of COL3A1 1 0.05 0.09 0.03
124 INT179799 Negative_regulation of Col3a1 1 0.47 0 0.03
125 INT206617 Regulation of Gene_expression of Col1a1 2 0.06 0.49 0
126 INT230374 Regulation of ARG1 2 0.60 1.94 0
127 INT257285 Positive_regulation of Transcription of COL1A1 2 0.29 1.23 0
128 INT329612 Positive_regulation of Gene_expression of Col3a1 1 0.17 0.32 0
129 INT326779 Binding of ARG1 1 0.36 0.56 0
130 INT245725 Positive_regulation of Negative_regulation of Col1a1 1 0.21 0.7 0
131 INT326765 Positive_regulation of Transcription of ARG1 1 0.67 0.6 0
132 INT329344 Positive_regulation of Positive_regulation of ARG1 1 0.01 0.73 0
133 INT326774 Regulation of Transcription of ARG1 1 0.44 0.11 0
134 INT179819 Localization of Col3a1 1 0.64 0 0
135 INT252761 Positive_regulation of Regulation of COL1A1 1 0.08 0.17 0
136 INT342934 Negative_regulation of Transcription of Col3a1 1 0.10 0.06 0
137 INT349649 Negative_regulation of Localization of Col1a1 1 0.04 0 0
138 INT197673 Regulation of Gene_expression of Arg1 1 0.29 0 0
139 INT326780 Transcription of ARG1 1 0.69 0.71 0
140 INT264310 Regulation of Col1a1 1 0.19 0 0
141 INT277704 Regulation of Regulation of COL1A1 1 0.08 0.61 0
142 INT179811 Transcription of Col3a1 1 0.55 0.18 0
143 INT209434 Negative_regulation of Protein_catabolism of Col1a1 1 0.10 0 0
144 INT73985 Transcription of Serpinh1 1 0.37 0.08 0
145 INT179789 Negative_regulation of Transcription of Col3a1 1 0.34 0.18 0
146 INT179834 Regulation of Transcription of Col3a1 1 0.36 0 0
147 INT326782 Regulation of Regulation of ARG1 1 0.26 0.81 0
148 INT211649 Regulation of Negative_regulation of Arg1 1 0.26 0.41 0
149 INT254803 Positive_regulation of Localization of Col1a1 1 0.10 0.11 0
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