GO:0032966

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Name negative regulation of collagen biosynthetic process
Categary Process
Go Slim No
Go Link GO:0032966
Unique Molecular Interactions 932
Total Molecular Interactions 1404
Total Single Events 12772
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of collagen biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of collagen biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
2 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
3 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
4 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
5 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
6 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
7 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
8 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
9 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
10 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
11 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
12 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
13 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
14 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
15 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
16 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
17 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
18 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
19 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
20 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
21 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
22 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
23 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
24 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
25 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
26 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
27 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
28 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
29 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
30 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
31 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
32 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
33 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
34 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
35 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
36 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
37 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
38 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
39 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
40 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
41 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
42 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
43 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
44 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
45 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
46 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
47 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
48 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
49 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
50 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
51 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
52 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
53 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
54 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
55 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
56 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
57 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
58 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
59 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
60 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
61 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
62 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
63 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
64 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
65 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
66 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
67 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
68 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
69 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
70 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
71 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
72 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
73 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
74 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
75 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
76 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
77 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
78 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
79 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
80 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
81 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
82 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
83 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
84 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
85 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
86 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
87 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
88 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
89 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
90 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
91 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
92 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
93 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
94 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
95 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
96 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
97 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
98 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
99 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
100 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
101 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
102 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
103 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
104 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
105 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
106 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
107 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81
108 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
109 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 0.02 0.26 0.8
110 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
111 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 0.02 0.23 0.78
112 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
113 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
114 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
115 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
116 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
117 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
118 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
119 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
120 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
121 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
122 INT237325 Il6 Positive_regulation of Gene_expression of Ik 2 0.00 2.09 0.72
123 INT209057 Il6 Positive_regulation of Csf2 1 0.03 0.38 0.72
124 INT209039 Il6 Positive_regulation of Il17a 1 0.05 0.38 0.72
125 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
126 INT209059 Il6 Positive_regulation of Cxcl1 1 0.06 0.38 0.72
127 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
128 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
129 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
130 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
131 INT260551 Igh-Dex Negative_regulation of Il6 1 0.09 0.37 0.72
132 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
133 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
134 INT91700 Il6 Negative_regulation of Oprd1 1 0.23 0 0.7
135 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
136 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
137 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
138 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
139 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
140 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
141 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
142 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
143 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67
144 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
145 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 0.27 0.79 0.67
146 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
147 INT82384 Penk Positive_regulation of Gene_expression of Il6 1 0.15 0 0.66
148 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
149 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
150 INT209054 Il17a Positive_regulation of Gene_expression of Il6 1 0.10 0.45 0.65
151 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
152 INT209055 S100a8 Positive_regulation of Gene_expression of Il6 1 0.01 0.45 0.64
153 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
154 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63
155 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
156 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
157 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
158 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
159 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62
160 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62
161 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
162 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
163 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
164 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
165 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
166 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6
167 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6
168 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6
169 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
170 INT140890 Il10 Regulation of Il6 1 0.35 0.73 0.58
171 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
172 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
173 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
174 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
175 INT151461 Olr1745 Negative_regulation of Gene_expression of Il6 1 0.03 0.81 0.57
176 INT142312 Lalba Negative_regulation of Localization of Il6 1 0.23 0.73 0.57
177 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57
178 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
179 INT307016 IGKV1-17 Positive_regulation of Gene_expression of IL6 1 0.00 1.01 0.56
180 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
181 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
182 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
183 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
184 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54
185 INT137016 Il6 Positive_regulation of Gene_expression of Acta2 1 0.01 0.75 0.54
186 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53
187 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53
188 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53
189 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53
190 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
191 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52
192 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
193 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51
194 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
195 INT269057 Il6 Positive_regulation of Crp 1 0.37 1.83 0.51
196 INT348322 Il6 Positive_regulation of Localization of Crp 1 0.06 3.51 0.51
197 INT62446 Il6 Positive_regulation of Crh 1 0.22 0.05 0.5
198 INT64720 Regulation of IL1B Positive_regulation of IL6 1 0.36 0.65 0.5
199 INT97801 Gm5564 Regulation of Gene_expression of IL6 1 0.00 0.07 0.5
200 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of collagen biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of collagen biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
7 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
8 INT12082 Localization of IL6 365 0.81 241.78 105.78
9 INT19511 Localization of Il6 212 0.81 118.17 67.67
10 INT11937 Localization of Il6 228 0.81 139.83 64.39
11 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
12 INT10706 Regulation of Il6 150 0.62 93.23 62.34
13 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
14 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
15 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
16 INT9210 Regulation of IL6 166 0.62 125.61 49.95
17 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
18 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
19 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
20 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
21 INT9655 Regulation of Il6 98 0.62 70.92 31.95
22 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
23 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
24 INT86437 Binding of IL6 154 0.48 121.22 29.3
25 INT51474 Binding of Il6 55 0.48 44.99 20.52
26 INT49985 Transcription of Il6 62 0.72 40.13 20.29
27 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
28 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
29 INT61626 Transcription of IL6 73 0.72 42.04 17.86
30 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
31 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
32 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
33 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
34 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
35 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
36 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
37 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
38 INT54763 Binding of Il6 82 0.48 63.27 12.89
39 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
40 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
41 INT50933 Transcription of Il6 38 0.72 24.31 11.58
42 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
43 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
44 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
45 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
46 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
47 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62
48 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
49 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
50 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
51 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
52 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
53 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
54 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
55 INT174816 Binding of IL6R 14 0.09 11.26 3.63
56 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
57 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
58 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
59 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
60 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
61 INT102034 Positive_regulation of Ppard 10 0.69 3.97 3.17
62 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
63 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
64 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
65 INT112758 Binding of Ppard 7 0.37 3.6 2.87
66 INT64714 Positive_regulation of Phosphorylation of Il6 4 0.50 3.22 2.67
67 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61
68 INT102033 Negative_regulation of Ppard 5 0.37 4.14 2.48
69 INT10558 Regulation of Regulation of IL6 6 0.45 4.94 2.33
70 INT333961 Binding of Il6r 1 0.07 3.67 2.29
71 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14
72 INT224047 Regulation of Adora2b 7 0.27 3.23 2.12
73 INT52197 Negative_regulation of Transcription of Il6 8 0.43 3.8 2.05
74 INT216839 Positive_regulation of Positive_regulation of Adora2b 5 0.45 2.27 2
75 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
76 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86
77 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
78 INT155455 Negative_regulation of Phosphorylation of Il6 1 0.31 2.5 1.76
79 INT160814 Gene_expression of Il6ra 15 0.07 9.61 1.73
80 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
81 INT224049 Transcription of Adora2b 6 0.69 5.12 1.67
82 INT135275 Regulation of Negative_regulation of Il6 4 0.45 0.89 1.67
83 INT95056 Positive_regulation of Gene_expression of Ppard 5 0.52 3.84 1.6
84 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55
85 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
86 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46
87 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45
88 INT98449 Positive_regulation of Binding of Il6 3 0.44 2.96 1.44
89 INT87062 Positive_regulation of Binding of IL6 10 0.49 11.8 1.42
90 INT132495 Negative_regulation of Gene_expression of Ppard 4 0.44 2.64 1.28
91 INT190075 Regulation of Transcription of Il6 2 0.45 2.17 1.18
92 INT241724 Localization of Adora2b 2 0.75 1.21 1.14
93 INT10559 Negative_regulation of Regulation of IL6 4 0.37 1.76 1.1
94 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
95 INT224042 Phosphorylation of Adora2b 1 0.29 0.25 1.08
96 INT112759 Negative_regulation of Binding of Ppard 2 0.39 2.08 0.99
97 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99
98 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98
99 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92
100 INT217050 Positive_regulation of Gene_expression of Adora2b 3 0.50 1.19 0.92
101 INT163603 Transcription of CIITA 2 0.56 0.16 0.87
102 INT115192 Phosphorylation of IL6 7 0.70 1.55 0.84
103 INT261600 Positive_regulation of Gene_expression of Il6ra 7 0.05 6.22 0.84
104 INT333963 Localization of Il6r 1 0.10 0.75 0.83
105 INT192851 Phosphorylation of Il6 7 0.68 3.12 0.82
106 INT300843 Regulation of Transcription of Il6 3 0.37 3.4 0.76
107 INT194851 Protein_catabolism of Adora2b 1 0.17 0.6 0.75
108 INT289232 Localization of Il6ra 1 0.06 2.12 0.75
109 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
110 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74
111 INT241715 Negative_regulation of Gene_expression of Adora2b 2 0.43 0.48 0.73
112 INT158354 Negative_regulation of Binding of Il6 2 0.20 2.21 0.71
113 INT252430 Negative_regulation of Binding of Adora2b 1 0.26 0.27 0.65
114 INT216750 Positive_regulation of Gene_expression of ADORA2B 1 0.34 0 0.64
115 INT216761 Positive_regulation of Binding of ADORA2B 1 0.34 0 0.63
116 INT261602 Positive_regulation of Binding of Il6 2 0.50 1.75 0.62
117 INT138730 Negative_regulation of Negative_regulation of Il6 3 0.09 1.04 0.61
118 INT264490 Regulation of Negative_regulation of Il6 2 0.23 1.18 0.6
119 INT169725 Binding of Il6ra 4 0.07 3.99 0.59
120 INT224056 Regulation of Gene_expression of Adora2b 2 0.27 0.12 0.59
121 INT289237 Positive_regulation of Il6ra 1 0.05 3.84 0.59
122 INT188433 Negative_regulation of Binding of IL6 6 0.42 2.03 0.56
123 INT61025 Negative_regulation of Negative_regulation of Il6 3 0.43 1.15 0.56
124 INT169726 Negative_regulation of Il6ra 3 0.05 3.14 0.53
125 INT216757 Protein_catabolism of ADORA2B 1 0.67 0 0.5
126 INT220268 Regulation of Regulation of Il6 2 0.12 0.89 0.49
127 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
128 INT216753 Regulation of Binding of ADORA2B 1 0.18 0 0.48
129 INT115189 Regulation of Phosphorylation of IL6 1 0.04 0 0.48
130 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46
131 INT98447 Positive_regulation of Negative_regulation of Il6 1 0.44 0.75 0.45
132 INT132946 Negative_regulation of Positive_regulation of Ppard 1 0.42 0.09 0.44
133 INT216855 Negative_regulation of ADORA2B 1 0.32 0.05 0.43
134 INT285471 Negative_regulation of Binding of Il6 2 0.21 1.33 0.41
135 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
136 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
137 INT252432 Positive_regulation of Localization of Adora2b 1 0.30 0.06 0.37
138 INT82552 Negative_regulation of Regulation of Il6 2 0.38 1.43 0.36
139 INT252431 Negative_regulation of Positive_regulation of Adora2b 1 0.26 0.76 0.35
140 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
141 INT143536 Protein_catabolism of Il6 2 0.69 1.89 0.31
142 INT144419 Regulation of Ppard 1 0.24 0.91 0.3
143 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
144 INT61115 Localization of Ppard 2 0.66 1.99 0.28
145 INT159198 Positive_regulation of Binding of Ppard 1 0.34 0.68 0.28
146 INT194162 Protein_catabolism of Il6 2 0.12 0.79 0.27
147 INT211287 Regulation of Binding of Il6 1 0.06 0.1 0.27
148 INT201071 Positive_regulation of Regulation of Il6 2 0.39 0.45 0.25
149 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
150 INT298665 Positive_regulation of Protein_catabolism of IL6 1 0.09 2.03 0.25
151 INT294140 Positive_regulation of CIITA 2 0.38 2.24 0.24
152 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
153 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
154 INT224051 Regulation of Phosphorylation of Adora2b 1 0.09 0.09 0.18
155 INT191161 Gene_expression of CIITA 4 0.55 4.35 0.17
156 INT294145 Negative_regulation of Transcription of CIITA 1 0.35 0.08 0.17
157 INT224055 Negative_regulation of Phosphorylation of Adora2b 1 0.15 0 0.16
158 INT224054 Positive_regulation of Phosphorylation of Adora2b 1 0.17 0 0.16
159 INT289225 Positive_regulation of Positive_regulation of Il6ra 1 0.04 0.77 0.14
160 INT188222 Positive_regulation of Regulation of IL6 2 0.29 0.51 0.13
161 INT298669 Negative_regulation of Protein_catabolism of IL6 1 0.08 1.02 0.13
162 INT333743 Regulation of Gene_expression of Il6ra 1 0.05 0.45 0.12
163 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
164 INT252433 Regulation of Positive_regulation of Adora2b 1 0.44 0 0.09
165 INT294136 Negative_regulation of CIITA 1 0.35 0 0.08
166 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
167 INT241716 Positive_regulation of Transcription of Adora2b 1 0.50 0.28 0.06
168 INT253097 Negative_regulation of Phosphorylation of Il6 1 0.35 0.23 0.06
169 INT280648 Negative_regulation of Transcription of Il6r 1 0.38 0 0.05
170 INT280667 Transcription of Il6r 1 0.62 0 0.05
171 INT295175 Regulation of CIITA 1 0.11 1.18 0
172 INT295177 Binding of CIITA 1 0.15 1.99 0
173 INT327819 Localization of ADORA2B 1 0.22 0.3 0
174 INT295176 Regulation of Binding of CIITA 1 0.18 0.58 0
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