GO:0033076

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Name isoquinoline alkaloid metabolic process
Categary Process
Go Slim No
Go Link GO:0033076
Unique Molecular Interactions 97
Total Molecular Interactions 122
Total Single Events 2490
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for isoquinoline alkaloid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for isoquinoline alkaloid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
3 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
4 INT40887 Penk Regulation of Th 1 0.04 0 1.53
5 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
6 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
7 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
8 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
9 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
10 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
11 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
12 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
13 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
14 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
15 INT31547 Binding of Th and Vip 1 0.31 0 1.08
16 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
17 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
18 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
19 INT60827 Ddc Positive_regulation of Localization of Abat 1 0.12 0.34 0.94
20 INT60828 Ddc Positive_regulation of Abat 1 0.13 0.34 0.93
21 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
22 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
23 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
24 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
25 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
26 INT99937 Ddc Regulation of Transcription of Qrfp 1 0.02 0 0.69
27 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66
28 INT50634 Ddc Regulation of Gene_expression of Glul 1 0.02 0 0.65
29 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
30 INT127057 Ddc Positive_regulation of Gene_expression of Slc1a2 1 0.01 0.06 0.63
31 INT113146 Ddc Positive_regulation of Gene_expression of Nr4a1 1 0.06 0.1 0.63
32 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
33 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
34 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
35 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
36 INT56733 Ddc Positive_regulation of Localization of GLUL 1 0.00 0 0.54
37 INT93740 Ddc Positive_regulation of Tnf 1 0.00 1.45 0.5
38 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
39 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
40 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
41 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
42 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
43 INT64639 Slc1a1 Positive_regulation of Ddc 1 0.30 0.3 0.38
44 INT50635 Ddc Regulation of Gene_expression of Penk 1 0.03 0 0.38
45 INT281155 Binding of ITIH4 and Ddc 1 0.09 1.27 0.37
46 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
47 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
48 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
49 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33
50 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
51 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
52 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
53 INT1757 DDC Regulation of Localization of GH1 1 0.01 0 0.31
54 INT55404 Binding of ENG and Th 1 0.02 0 0.3
55 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
56 INT78484 Binding of DBH and TH 1 0.09 0 0.28
57 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
58 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
59 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
60 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
61 INT325767 Negative_regulation of Omd Positive_regulation of Ddc 1 0.01 0.38 0.25
62 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
63 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
64 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23
65 INT164 Ddc Negative_regulation of Prl 1 0.06 0 0.23
66 INT61987 Th Regulation of Penk 1 0.46 0 0.2
67 INT342744 Ddc Regulation of Trh 1 0.02 0.37 0.18
68 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
69 INT88450 Uncx Regulation of Gene_expression of Th 1 0.06 0 0.17
70 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
71 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
72 INT157097 Ddc Positive_regulation of Drd3 1 0.30 0.88 0.16
73 INT99084 Ddc Positive_regulation of Pdyn 2 0.15 0.87 0.14
74 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
75 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
76 INT99085 Ddc Positive_regulation of Transcription of Pdyn 1 0.15 0.31 0.11
77 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
78 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
79 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
80 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
81 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
82 INT325766 Binding of Ddc and Omd 1 0.01 0.59 0.04
83 INT105726 Ddc Positive_regulation of Gene_expression of Pdyn 1 0.04 0.62 0.04
84 INT281125 Binding of Ddc and Cd4 1 0.09 0.37 0.03
85 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0
86 INT292970 Fto Regulation of Th 1 0.18 0.48 0
87 INT127058 Vta1 Negative_regulation of Positive_regulation of Th 1 0.33 0 0
88 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
89 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
90 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
91 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
92 INT163744 Binding of Th and Gfra4 1 0.09 0 0
93 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
94 INT145555 Ddc Positive_regulation of Phosphorylation of Mapk1 1 0.03 0 0
95 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
96 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for isoquinoline alkaloid metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in isoquinoline alkaloid metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT7327 Regulation of Th 164 0.62 29.67 110.14
4 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
5 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
6 INT350 Localization of Th 79 0.80 10.26 41.17
7 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
8 INT7326 Transcription of Th 83 0.72 13.5 35.33
9 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
10 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
11 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
12 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
13 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
14 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
15 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
16 INT6230 Localization of Ddc 40 0.79 13.11 20.88
17 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
18 INT13716 Positive_regulation of TH 33 0.68 19.11 16
19 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
20 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
21 INT141 Binding of Th 21 0.48 3.53 11.04
22 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
23 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19
24 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
25 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63
26 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
27 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6
28 INT4284 Regulation of Ddc 17 0.43 8.17 7.31
29 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
30 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
31 INT3506 Localization of TH 12 0.81 0.78 6.66
32 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
33 INT30317 Regulation of TH 14 0.43 7.27 5.38
34 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
35 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
36 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
37 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
38 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
39 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
40 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
41 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
42 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
43 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
44 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
45 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
46 INT47812 Negative_regulation of Localization of Ddc 5 0.51 1.99 2.8
47 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
48 INT16406 Positive_regulation of Negative_regulation of Ddc 6 0.67 0.53 2.6
49 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
50 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
51 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
52 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
53 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
54 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
55 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
56 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
57 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02
58 INT157095 Binding of Ddc 5 0.27 4.6 2
59 INT243846 Localization of DDC 3 0.63 0.66 1.99
60 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
61 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
62 INT3505 Binding of TH 5 0.39 2.6 1.8
63 INT145545 Transcription of TH 3 0.67 1.48 1.64
64 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
65 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
66 INT82676 Negative_regulation of Gene_expression of Ddc 4 0.55 0.55 1.43
67 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
68 INT333291 Positive_regulation of Gene_expression of DDC 1 0.49 0.13 1.35
69 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32
70 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
71 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
72 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
73 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
74 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
75 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
76 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
77 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
78 INT86036 Negative_regulation of Positive_regulation of Ddc 2 0.35 0.42 0.8
79 INT87728 Regulation of Gene_expression of Ddc 4 0.25 1.1 0.71
80 INT258710 Regulation of Negative_regulation of Ddc 2 0.25 1.28 0.66
81 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63
82 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
83 INT13929 Protein_catabolism of Th 3 1.00 0 0.58
84 INT232442 Negative_regulation of Gene_expression of DDC 1 0.05 1.44 0.58
85 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56
86 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54
87 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
88 INT144737 Regulation of Gene_expression of DDC 1 0.06 0 0.49
89 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
90 INT111304 Regulation of Gene_expression of TH 2 0.17 0.57 0.44
91 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
92 INT258772 Regulation of DDC 1 0.36 0.05 0.4
93 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38
94 INT325303 Binding of DDC 3 0.30 1.04 0.28
95 INT40588 Regulation of Negative_regulation of Th 1 0.16 0.26 0.26
96 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
97 INT343976 Negative_regulation of Negative_regulation of TH 1 0.23 0.19 0.23
98 INT237448 Negative_regulation of Binding of TH 1 0.30 0.29 0.22
99 INT342740 Positive_regulation of Binding of Ddc 1 0.03 0.1 0.22
100 INT140716 Negative_regulation of Protein_catabolism of Th 1 0.59 0 0.19
101 INT140717 Positive_regulation of Protein_catabolism of Th 1 0.47 0 0.19
102 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
103 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
104 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
105 INT258692 Transcription of Ddc 1 0.67 0.29 0.14
106 INT14359 Regulation of Positive_regulation of DDC 1 0.45 0.92 0.12
107 INT325760 Phosphorylation of Ddc 1 0.27 0.06 0.12
108 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
109 INT258696 Negative_regulation of Transcription of Ddc 1 0.55 0.11 0.09
110 INT314508 Regulation of Positive_regulation of TH 1 0.04 0.92 0.08
111 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
112 INT258699 Regulation of Transcription of Ddc 1 0.57 0 0.03
113 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
114 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
115 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
116 INT258702 Positive_regulation of Transcription of Ddc 1 0.43 0.05 0
117 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0
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