GO:0033143

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Name regulation of intracellular steroid hormone receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0033143
Unique Molecular Interactions 189
Total Molecular Interactions 325
Total Single Events 4924
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of intracellular steroid hormone receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of intracellular steroid hormone receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
2 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
5 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
6 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
7 INT52568 HTR1D Regulation of Localization of Gh 2 0.20 0.16 1.34
8 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
9 INT70570 su Positive_regulation of Gh 1 0.01 0.15 1.24
10 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
11 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
12 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 0.06 0 0.94
13 INT54800 Grin1 Regulation of Gene_expression of Gh 1 0.01 0 0.79
14 INT92793 Gh Positive_regulation of CTS 1 0.04 1.39 0.78
15 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
16 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
17 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75
18 INT54802 SST Negative_regulation of Localization of Gh 1 0.01 0 0.75
19 INT54801 SST Negative_regulation of Positive_regulation of Gh 1 0.01 0 0.75
20 INT17528 Prl Regulation of Gh 2 0.28 1.28 0.73
21 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
22 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
23 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
24 INT30502 Negative_regulation of OPRM1 Negative_regulation of Gh 1 0.00 0 0.63
25 INT15731 SST Regulation of Gh 1 0.04 0 0.62
26 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
27 INT56520 DDX21 Positive_regulation of Localization of Gh 1 0.11 0.16 0.6
28 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
29 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
30 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
31 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
32 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
33 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
34 INT24869 GAL Regulation of Localization of Gh 1 0.19 0.4 0.51
35 INT47222 Binding of Gh and Prl 1 0.22 0.18 0.46
36 INT47221 Prl Regulation of Localization of Gh 1 0.28 0.27 0.46
37 INT8181 Grm5 Positive_regulation of Gh 1 0.00 0 0.44
38 INT86972 PDE1B Positive_regulation of Localization of Gh 1 0.00 0 0.42
39 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41
40 INT62107 Ghrh Negative_regulation of Regulation of Gh 1 0.06 0 0.39
41 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 0.04 0.55 0.39
42 INT62110 SLC25A4 Negative_regulation of Regulation of Gh 1 0.06 0 0.39
43 INT30501 Sst Negative_regulation of Localization of Gh 1 0.01 0 0.38
44 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
45 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
46 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
47 INT84030 Regulation of Ghrh Positive_regulation of Gh 1 0.18 0 0.35
48 INT25526 Dst Regulation of Gh 1 0.00 0.26 0.34
49 INT134324 Gh Regulation of Gene_expression of F8a 1 0.07 0 0.33
50 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
51 INT68482 Cga Regulation of Gh 1 0.00 1.89 0.31
52 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
53 INT25169 GHRH Positive_regulation of Localization of Gh 1 0.12 0 0.29
54 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29
55 INT25375 Trh Regulation of Gh 1 0.04 1.01 0.28
56 INT68613 GNRH1 Positive_regulation of Gh 1 0.01 0 0.28
57 INT68614 Positive_regulation of GNRH1 Positive_regulation of Gh 1 0.01 0 0.28
58 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27
59 INT20029 Ghrh Positive_regulation of Negative_regulation of Gh 1 0.05 0.14 0.26
60 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26
61 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26
62 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
63 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
64 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
65 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
66 INT20031 Negative_regulation of SST Positive_regulation of Gh 1 0.00 0.16 0.23
67 INT20186 TRH Regulation of Gene_expression of Gh 1 0.22 0.54 0.22
68 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
69 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
70 INT73168 Lhb Positive_regulation of Gh 2 0.00 0.95 0.2
71 INT73165 Gh Positive_regulation of Prl 2 0.00 0.95 0.2
72 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
73 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
74 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
75 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19
76 INT246468 GHS Regulation of Gh 1 0.05 1.12 0.19
77 INT75355 Negative_regulation of GCG Regulation of Gh 1 0.01 1.26 0.18
78 INT75356 GCG Regulation of Gh 1 0.01 1.25 0.18
79 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
80 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
81 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
82 INT250533 Ghrh Regulation of Localization of Gh 1 0.13 0 0.15
83 INT250535 Ghrh Regulation of Gene_expression of Gh 1 0.31 0 0.15
84 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15
85 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
86 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
87 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
88 INT17523 Ghsr Positive_regulation of Localization of Gh 2 0.02 0.24 0.13
89 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
90 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
91 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
92 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
93 INT184091 Socs2 Negative_regulation of Gh 1 0.11 0.05 0.13
94 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
95 INT295540 Binding of Gh and Ghrl 2 0.10 0.13 0.12
96 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
97 INT221620 Fes Regulation of Gh 1 0.01 0.39 0.12
98 INT162763 Binding of Gh and Son 1 0.39 0.09 0.12
99 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
100 INT221628 Sema3a Regulation of Gh 1 0.01 0.39 0.12
101 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
102 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
103 INT295538 Ghrh Positive_regulation of Gh 1 0.21 0 0.11
104 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
105 INT295545 Ghrl Positive_regulation of Gh 1 0.15 0 0.11
106 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1
107 INT295551 Ghrl Positive_regulation of Localization of Gh 1 0.15 0 0.1
108 INT73167 Regulation of Lhb Positive_regulation of Gh 1 0.00 0.48 0.1
109 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
110 INT27844 Binding of INS and Gh 1 0.03 0.1 0.1
111 INT246467 GHS Regulation of Localization of Gh 1 0.03 0.52 0.09
112 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
113 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
114 INT124732 Gh Regulation of Positive_regulation of IGFBP3 1 0.00 0.24 0.08
115 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
116 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
117 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
118 INT49372 Gh Positive_regulation of Gene_expression of IGFBP3 1 0.00 0.51 0.08
119 INT184126 Gh Positive_regulation of Gene_expression of Socs2 1 0.14 1.25 0.08
120 INT88054 ABL2 Regulation of Gh 1 0.02 0.57 0.08
121 INT70762 IGF1 Regulation of Gh 1 0.00 0.17 0.07
122 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
123 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
124 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
125 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
126 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
127 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
128 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
129 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
130 INT295529 Ghrl Regulation of Localization of Gh 1 0.20 0 0.06
131 INT17524 Negative_regulation of Ghsr Regulation of Gh 1 0.01 0 0.06
132 INT17526 Ghsr Regulation of Gh 1 0.01 0 0.06
133 INT215036 Gh Positive_regulation of Gene_expression of Trh 1 0.08 1.4 0.06
134 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
135 INT295537 Ghsr Positive_regulation of Localization of Gh 1 0.24 0 0.06
136 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
137 INT184133 Binding of Gh and Socs2 1 0.10 0.66 0.05
138 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05
139 INT315986 Igf1 Positive_regulation of Pik3c3 1 0.00 0.48 0.05
140 INT184083 Positive_regulation of Gh Positive_regulation of Igf1 1 0.09 0.7 0.04
141 INT184115 Igf1 Positive_regulation of Gene_expression of Socs2 1 0.16 0.62 0.04
142 INT239605 Ghrh Negative_regulation of Gh 1 0.01 0.53 0.04
143 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04
144 INT97896 Ghrl Positive_regulation of Localization of Gh 1 0.48 0.37 0.03
145 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0
146 INT295573 Igf1 Positive_regulation of Gene_expression of Mstn 1 0.19 0 0
147 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
148 INT315984 Rhd Positive_regulation of Localization of Igf1 1 0.07 0.25 0
149 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0
150 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0
151 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0
152 INT295574 Binding of Igf1 and Mstn 1 0.16 0.08 0
153 INT72269 Positive_regulation of GHRH Positive_regulation of Gh 1 0.02 0.06 0
154 INT284370 Igf1 Regulation of Gene_expression of VEGFA 1 0.37 0.05 0
155 INT11606 Regulation of Ghrh Regulation of Gh 1 0.06 0.05 0
156 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0
157 INT75319 IGF1 Positive_regulation of Gh 1 0.00 0.26 0
158 INT253007 Igf1 Regulation of Gene_expression of PTTG1 1 0.03 0.46 0
159 INT215206 Gh Positive_regulation of Transcription of Igf1 1 0.03 0 0
160 INT17529 Igf1 Regulation of Gh 1 0.01 0.07 0
161 INT215209 Binding of Igf1 and Igfbp3 1 0.11 0 0
162 INT239182 Gene_expression of Gh Negative_regulation of Cat 1 0.17 0.33 0
163 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0
164 INT333845 Igf1 Positive_regulation of Gene_expression of Creb1 1 0.21 0.13 0
165 INT199369 DST Regulation of Igf1 1 0.02 0.8 0
166 INT162437 Binding of Igf1 and Igfals 1 0.10 1.45 0
167 INT246469 Binding of IGF1 and Gh 1 0.03 0.2 0
168 INT17531 Lhb Regulation of Gh 1 0.00 0 0
169 INT215035 Trh Positive_regulation of Gh 1 0.07 0.89 0
170 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0
171 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0
172 INT315985 Rhd Positive_regulation of Igf1 1 0.07 0.25 0
173 INT295127 Proc Regulation of Igf1 1 0.00 0.48 0
174 INT285387 Binding of Gh and Nr4a1 1 0.01 0 0
175 INT331405 Binding of Gh and Ghsr 1 0.08 0.13 0
176 INT75318 Gh Regulation of Gene_expression of IGF1 1 0.00 0.26 0
177 INT284369 Igf1 Regulation of VEGFA 1 0.27 0.05 0
178 INT72268 GHRH Positive_regulation of Gh 1 0.02 0.06 0
179 INT269769 Gh Regulation of Gene_expression of Igf1 1 0.04 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of intracellular steroid hormone receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of intracellular steroid hormone receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1893 Localization of Gh 1041 0.79 340.23 256.58
2 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18
3 INT1530 Regulation of Gh 382 0.61 115.96 112.47
4 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5
5 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16
6 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
7 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45
8 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
9 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
10 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
11 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49
12 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96
13 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
14 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16
15 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86
16 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
17 INT28861 Binding of Gh 61 0.46 25.61 6.38
18 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
19 INT10843 Regulation of Regulation of Gh 14 0.22 5.56 5.93
20 INT151032 Localization of Igf1 49 0.76 26.32 5.71
21 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
22 INT16220 Negative_regulation of Regulation of Gh 13 0.42 3.59 4.33
23 INT10842 Transcription of Gh 18 0.64 2.94 4.13
24 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88
25 INT11605 Regulation of Positive_regulation of Gh 10 0.45 2.08 3.85
26 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
27 INT20179 Positive_regulation of Regulation of Gh 12 0.54 3.99 3.42
28 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73
29 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
30 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
31 INT45719 Positive_regulation of Transcription of Gh 5 0.47 0.68 1.66
32 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
33 INT65892 Negative_regulation of Binding of Gh 8 0.32 3.61 1.38
34 INT90491 Binding of Igf1 25 0.44 9.75 1.36
35 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
36 INT47495 Protein_catabolism of Gh 2 0.98 0.68 1.08
37 INT142205 Negative_regulation of Transcription of Gh 1 0.16 0 1.08
38 INT55982 Negative_regulation of Negative_regulation of Gh 4 0.55 1.02 0.88
39 INT7867 Regulation of Negative_regulation of Gh 5 0.33 1.92 0.87
40 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
41 INT61506 Localization of Ghrhr 1 0.51 0 0.61
42 INT87505 Positive_regulation of Binding of Gh 2 0.49 0 0.42
43 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
44 INT215028 Phosphorylation of Gh 3 0.56 2.11 0.28
45 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
46 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
47 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
48 INT90672 Regulation of Binding of Gh 3 0.56 1.07 0.13
49 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
50 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
51 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
52 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
53 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
54 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
55 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
56 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
57 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
58 INT262891 Positive_regulation of Ghrhr 1 0.15 0.33 0
59 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
60 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
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