GO:0033144

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Name negative regulation of intracellular steroid hormone receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0033144
Unique Molecular Interactions 97
Total Molecular Interactions 147
Total Single Events 808
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of intracellular steroid hormone receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of intracellular steroid hormone receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
2 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
3 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
4 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
5 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
6 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
7 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
8 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
9 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
10 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
11 INT193029 CHRM2 Positive_regulation of RHOA 1 0.01 0.12 0.24
12 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
13 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
14 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
15 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
16 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
17 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
18 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
19 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
20 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
21 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
22 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
23 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
24 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
25 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
26 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
27 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
28 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
29 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
30 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
31 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
32 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
33 INT326384 Slc9a3r2 Positive_regulation of Positive_regulation of Rhoa 1 0.03 0.16 0.05
34 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
35 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
36 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
37 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
38 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03
39 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
40 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
41 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0
42 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
43 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
44 INT269586 Negative_regulation of TMPO Positive_regulation of RHOA 1 0.14 0 0
45 INT295704 Positive_regulation of Binding of RHOA and Racgap1 1 0.15 0.16 0
46 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0
47 INT334472 Gopc Regulation of Positive_regulation of Rhoa 1 0.02 0.3 0
48 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
49 INT269547 PTGIR Regulation of Phosphorylation of RHOA 1 0.02 0 0
50 INT335705 Binding of ITGA4 and Calr 1 0.01 0.43 0
51 INT295706 PTGER2 Regulation of Regulation of RHOA 1 0.01 0.61 0
52 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
53 INT254851 C3 Negative_regulation of Rhoa 1 0.06 0 0
54 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
55 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0
56 INT342432 Binding of Rhoa and Positive_regulation of Atp9a 1 0.20 0 0
57 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
58 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
59 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
60 INT334469 Gopc Regulation of Localization of Rhoa 1 0.02 0.3 0
61 INT269549 Regulation of GOPC Positive_regulation of RHOA 1 0.09 0 0
62 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
63 INT254854 Positive_regulation of C3 Negative_regulation of Rhoa 1 0.05 0 0
64 INT269581 PTGIR Regulation of RHOA 1 0.02 0 0
65 INT295714 PTGER2 Positive_regulation of RHOA 1 0.01 0.34 0
66 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
67 INT334473 PGGT1B Regulation of Localization of Rhoa 1 0.04 0.47 0
68 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
69 INT269571 Positive_regulation of GOPC Positive_regulation of RHOA 1 0.10 0 0
70 INT254865 Rhoa Positive_regulation of Fbrs 1 0.08 0.81 0
71 INT269555 GOPC Positive_regulation of RHOA 1 0.10 0 0
72 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
73 INT254864 Rhoa Positive_regulation of Egfl7 1 0.02 0.82 0
74 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
75 INT322843 Positive_regulation of PIK3CD Positive_regulation of Positive_regulation of RHOA 1 0.03 0 0
76 INT269564 MAPKAP1 Regulation of Positive_regulation of RHOA 1 0.03 0 0
77 INT269590 Positive_regulation of TMPO Positive_regulation of RHOA 1 0.16 0 0
78 INT269583 TMPO Positive_regulation of Gene_expression of RHOA 1 0.16 0.14 0
79 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
80 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
81 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
82 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0
83 INT307309 Binding of CALR and EREG 1 0.00 0.83 0
84 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
85 INT269574 Regulation of TMPO Positive_regulation of RHOA 1 0.20 0 0
86 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
87 INT295703 Binding of RHOA and Racgap1 1 0.11 0.16 0
88 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
89 INT269576 Negative_regulation of GOPC Positive_regulation of RHOA 1 0.08 0 0
90 INT180125 Rhoa Positive_regulation of Rock1 1 0.14 0 0
91 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0
92 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
93 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
94 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
95 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0
96 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
97 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of intracellular steroid hormone receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of intracellular steroid hormone receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
2 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
3 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
4 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
5 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
6 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
7 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
8 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
9 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
10 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
11 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
12 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
13 INT70526 Binding of CALR 11 0.35 7.09 1.97
14 INT21941 Regulation of CALR 7 0.53 3.88 1.96
15 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
16 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
17 INT85348 Localization of RHOA 12 0.59 4.81 1.83
18 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59
19 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
20 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
21 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
22 INT66118 Binding of Calr 4 0.46 1.46 1.26
23 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
24 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
25 INT136817 Negative_regulation of Positive_regulation of RHOA 8 0.57 0 1.04
26 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
27 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
28 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
29 INT131824 Negative_regulation of RHOA 10 0.57 2.9 0.92
30 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
31 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
32 INT173338 Positive_regulation of Localization of RHOA 2 0.14 1.52 0.76
33 INT85347 Negative_regulation of Localization of RHOA 1 0.31 0 0.74
34 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
35 INT177557 Positive_regulation of Calr 12 0.48 5.47 0.61
36 INT162801 Localization of CALR 7 0.73 8.69 0.6
37 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
38 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
39 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
40 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55
41 INT180422 Regulation of Gene_expression of Rhoa 2 0.39 0.6 0.55
42 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
43 INT183879 Binding of RHOA 6 0.34 2.1 0.31
44 INT131822 Positive_regulation of Positive_regulation of RHOA 2 0.45 0.33 0.29
45 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
46 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
47 INT140371 Positive_regulation of Negative_regulation of Rhoa 1 0.46 0 0.26
48 INT109859 Localization of Rhoa 3 0.54 1.09 0.24
49 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
50 INT289343 Regulation of Gene_expression of Rhoa 1 0.13 0.28 0.23
51 INT140365 Negative_regulation of Protein_catabolism of Rhoa 1 0.43 0 0.23
52 INT140358 Negative_regulation of Positive_regulation of Rhoa 1 0.43 0 0.23
53 INT289342 Negative_regulation of Gene_expression of Rhoa 1 0.20 0.28 0.23
54 INT289353 Positive_regulation of Gene_expression of Rhoa 1 0.23 0.28 0.23
55 INT180415 Regulation of Rhoa 7 0.53 3.92 0.22
56 INT222087 Regulation of Calr 3 0.42 0.56 0.22
57 INT140359 Positive_regulation of Protein_catabolism of Rhoa 1 0.69 0 0.22
58 INT140369 Protein_catabolism of Rhoa 1 0.99 0 0.22
59 INT180418 Binding of Rhoa 16 0.32 7.05 0.2
60 INT335675 Localization of Calr 1 0.63 1.23 0.2
61 INT140361 Regulation of Positive_regulation of Rhoa 1 0.45 0 0.17
62 INT177555 Regulation of Gene_expression of Calr 3 0.28 0.82 0.16
63 INT177554 Positive_regulation of Gene_expression of Calr 3 0.37 1.08 0.14
64 INT335686 Regulation of Localization of Calr 1 0.48 0.12 0.12
65 INT269666 Regulation of Gene_expression of RHOA 1 0.32 0.38 0.1
66 INT282407 Transcription of Rhoa 1 0.15 0.52 0.1
67 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
68 INT192855 Transcription of Calr 1 0.11 0.99 0.08
69 INT109862 Negative_regulation of Localization of Rhoa 1 0.33 0.37 0.08
70 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07
71 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
72 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
73 INT126629 Negative_regulation of Transcription of Rhoa 1 0.33 0 0.05
74 INT180419 Regulation of Positive_regulation of Rhoa 2 0.39 0.9 0.04
75 INT269659 Negative_regulation of Gene_expression of RHOA 1 0.42 0.26 0.04
76 INT126630 Transcription of Rhoa 1 0.54 0 0.04
77 INT316766 Negative_regulation of Calr 2 0.40 0.71 0.03
78 INT242969 Protein_catabolism of Calr 2 0.68 0.94 0.03
79 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03
80 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
81 INT307326 Negative_regulation of Gene_expression of CALR 3 0.25 1.78 0
82 INT295675 Protein_catabolism of RHOA 2 0.24 0.21 0
83 INT273277 Phosphorylation of Calr 2 0.56 0.82 0
84 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
85 INT196923 Binding of Hmga2 1 0.47 2.5 0
86 INT322860 Regulation of Protein_catabolism of RHOA 1 0.08 0 0
87 INT269608 Regulation of Positive_regulation of RHOA 1 0.32 0.06 0
88 INT335676 Positive_regulation of Localization of Calr 1 0.48 0 0
89 INT335682 Negative_regulation of Positive_regulation of Calr 1 0.29 0 0
90 INT212954 Positive_regulation of Negative_regulation of Rhoa 1 0.19 1.18 0
91 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
92 INT307324 Positive_regulation of Positive_regulation of CALR 1 0.25 0.36 0
93 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
94 INT191647 Regulation of Regulation of Rhoa 1 0.13 0.32 0
95 INT335679 Negative_regulation of Gene_expression of Calr 1 0.29 0 0
96 INT335685 Negative_regulation of Localization of Calr 1 0.29 0 0
97 INT269627 Regulation of Phosphorylation of RHOA 1 0.32 0 0
98 INT269597 Negative_regulation of Phosphorylation of RHOA 1 0.31 0 0
99 INT307331 Negative_regulation of Positive_regulation of CALR 1 0.29 0.36 0
100 INT269624 Positive_regulation of Phosphorylation of RHOA 1 0.36 0 0
101 INT334441 Regulation of Localization of Rhoa 1 0.33 0.88 0
102 INT196921 Localization of Hmga2 1 0.74 0.44 0
103 INT335678 Regulation of Binding of Calr 1 0.35 0 0
104 INT307332 Negative_regulation of Localization of CALR 1 0.29 0.72 0
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