GO:0033146

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Name regulation of intracellular estrogen receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0033146
Unique Molecular Interactions 124
Total Molecular Interactions 137
Total Single Events 571
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of intracellular estrogen receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of intracellular estrogen receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
2 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
3 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
4 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
5 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
6 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
7 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
8 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
9 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
10 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
11 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
12 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
13 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
14 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
15 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
16 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
17 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
18 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
19 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
20 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
21 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
22 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
23 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
24 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
25 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
26 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
27 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
28 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
29 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
30 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
31 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
32 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
33 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
34 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
35 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
36 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
37 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
38 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
39 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
40 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
41 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
42 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
43 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
44 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
45 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
46 INT171389 Src Positive_regulation of Positive_regulation of Mapk1 1 0.16 0 0.11
47 INT171388 Src Positive_regulation of Phosphorylation of Gpbar1 1 0.05 0 0.11
48 INT276064 Src Regulation of Positive_regulation of Rpa1 1 0.02 0.18 0.11
49 INT171387 Ppp1cc Positive_regulation of Phosphorylation of Src 1 0.07 0 0.11
50 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
51 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
52 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
53 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
54 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05
55 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05
56 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04
57 INT178435 Mapk1 Regulation of Phosphorylation of Src 1 0.03 0.49 0.04
58 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04
59 INT231839 Pcdh8 Positive_regulation of Src 1 0.00 0 0.04
60 INT263377 Abl1 Regulation of Src 1 0.15 0 0.04
61 INT178439 Binding of Ar and Src 1 0.01 0.44 0.04
62 INT263381 Trib3 Regulation of Src 1 0.01 0 0.04
63 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
64 INT229006 MIA3 Positive_regulation of Phosphorylation of Src 1 0.02 0.44 0.03
65 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
66 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03
67 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03
68 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
69 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
70 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0
71 INT285579 Binding of S100A8 and SRC 1 0.05 0.2 0
72 INT225550 Binding of Mybbp1a and Carm1 1 0.06 0 0
73 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0
74 INT243106 Binding of Crebbp and Src 1 0.05 0.52 0
75 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
76 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
77 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
78 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
79 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0
80 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0
81 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
82 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0
83 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
84 INT299308 SRC Regulation of PI3 1 0.20 0 0
85 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0
86 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0
87 INT309906 Binding of EGF and SRC 1 0.11 0.64 0
88 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
89 INT340928 Negative_regulation of SRC Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
90 INT299294 SRC Regulation of VEGFA 1 0.20 0 0
91 INT238120 SRC Positive_regulation of Positive_regulation of STAT3 1 0.71 0 0
92 INT238114 Binding of CSK and SRC 1 0.07 0 0
93 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
94 INT338196 Binding of SRC and CDCP1 1 0.00 0.31 0
95 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0
96 INT198019 NPY6R Negative_regulation of Gene_expression of SRC 1 0.06 1.75 0
97 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0
98 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 0.01 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of intracellular estrogen receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of intracellular estrogen receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
2 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
3 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
4 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
5 INT100222 Binding of Src 9 0.26 5.41 5.37
6 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
7 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
8 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
9 INT122327 Regulation of Src 6 0.59 0.59 3.6
10 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
11 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
12 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
13 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
14 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
15 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
16 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
17 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
18 INT98455 Regulation of Src 4 0.20 1.76 1.48
19 INT114715 Binding of SRC 8 0.36 4.26 1.32
20 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
21 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
22 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
23 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
24 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
25 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
26 INT143912 Localization of Src 4 0.48 2.51 0.78
27 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77
28 INT235996 Negative_regulation of Gene_expression of Src 3 0.09 1.29 0.58
29 INT143910 Negative_regulation of Positive_regulation of Src 1 0.27 0.14 0.56
30 INT117998 Positive_regulation of Gene_expression of Src 4 0.36 1.45 0.51
31 INT82608 Positive_regulation of Phosphorylation of SRC 3 0.49 1.28 0.48
32 INT249504 Localization of Src 1 0.36 0.32 0.46
33 INT98456 Negative_regulation of Src 17 0.42 8.3 0.42
34 INT138051 Negative_regulation of Positive_regulation of SRC 3 0.57 0.84 0.33
35 INT249533 Regulation of Localization of Src 1 0.22 0.22 0.32
36 INT171374 Binding of Src 2 0.13 0.44 0.24
37 INT164162 Negative_regulation of Phosphorylation of SRC 3 0.29 2.12 0.21
38 INT235725 Regulation of SRC 7 0.44 4.71 0.19
39 INT249526 Positive_regulation of Localization of Src 1 0.24 0.1 0.16
40 INT299357 Localization of SRC 1 0.51 0 0.09
41 INT338740 Transcription of Src 1 0.43 1.24 0.07
42 INT238187 Regulation of Positive_regulation of SRC 2 0.26 1.37 0.05
43 INT238193 Regulation of Gene_expression of SRC 1 0.44 0 0.03
44 INT225256 Positive_regulation of Gene_expression of Src 3 0.20 0.75 0
45 INT338741 Negative_regulation of Binding of Src 1 0.30 0.75 0
46 INT225249 Negative_regulation of Phosphorylation of Src 1 0.16 1.51 0
47 INT301444 Positive_regulation of Carm1 1 0.04 0 0
48 INT301437 Regulation of Carm1 1 0.02 0.06 0
49 INT200801 Positive_regulation of Localization of Src 1 0.28 1.92 0
50 INT225388 Binding of Carm1 1 0.17 0 0
51 INT238185 Regulation of Binding of SRC 1 0.44 0.06 0
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