GO:0033148

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Name positive regulation of intracellular estrogen receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0033148
Unique Molecular Interactions 146
Total Molecular Interactions 189
Total Single Events 1283
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of intracellular estrogen receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of intracellular estrogen receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT137699 AR Regulation of PDYN 1 0.46 0.93 0.75
2 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
3 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
4 INT252425 Positive_regulation of AR Positive_regulation of Gene_expression of CXCL10 1 0.00 0.9 0.44
5 INT139047 Negative_regulation of AR Negative_regulation of Positive_regulation of CPOX 1 0.07 0.76 0.4
6 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
7 INT75641 AR Positive_regulation of Positive_regulation of EIF2B3 1 0.02 0 0.33
8 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32
9 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32
10 INT223042 AR Positive_regulation of ADCY1 1 0.01 0.41 0.25
11 INT257776 Phosphorylation of AR Positive_regulation of Localization of TAB2 1 0.26 0.38 0.24
12 INT252427 IGKV2D-29 Regulation of Gene_expression of AR 1 0.02 0 0.24
13 INT139046 Negative_regulation of AR Negative_regulation of Phosphorylation of DYT10 1 0.33 0.34 0.23
14 INT139050 Negative_regulation of AR Negative_regulation of Phosphorylation of PRKCB 1 0.02 0.34 0.23
15 INT139045 Negative_regulation of AR Negative_regulation of CPOX 1 0.07 0.34 0.23
16 INT139048 Negative_regulation of AR Negative_regulation of Positive_regulation of TRAF3IP2 1 0.02 0.34 0.23
17 INT139049 Negative_regulation of AR Negative_regulation of Positive_regulation of DYT10 1 0.33 0.34 0.23
18 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17
19 INT122361 Binding of AR and OPRM1 1 0.26 0.14 0.16
20 INT122362 AR Positive_regulation of Positive_regulation of OPRM1 1 0.32 0.19 0.14
21 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
22 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
23 INT169128 Trove2 Negative_regulation of Gene_expression of AR 1 0.05 0.94 0.13
24 INT223040 AR Positive_regulation of Negative_regulation of TFPI 1 0.03 0 0.13
25 INT354620 AR Positive_regulation of Hspg2 1 0.00 0 0.12
26 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
27 INT185918 AR Positive_regulation of Gene_expression of NOS2 1 0.12 0.21 0.11
28 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
29 INT20959 Binding of PTPRC and Pak1 1 0.01 0.76 0.09
30 INT20957 Binding of Pak1 and Pak2 1 0.27 0.65 0.08
31 INT178434 Il6 Positive_regulation of Ar 1 0.01 0.93 0.08
32 INT257777 INCENP Positive_regulation of AR 1 0.04 0.49 0.08
33 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
34 INT224293 AR Positive_regulation of Protein_catabolism of ESR1 1 0.24 0.4 0.07
35 INT328380 AR Negative_regulation of Gene_expression of Ghrl 1 0.01 0.55 0.07
36 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
37 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
38 INT201866 Binding of AR and PGR 1 0.07 0.34 0.06
39 INT338019 Egf Positive_regulation of AR 1 0.07 1.02 0.05
40 INT349665 Positive_regulation of Binding of AR and TFPI 1 0.02 0 0.05
41 INT194688 PAK1 Positive_regulation of GADD45A 1 0.11 0 0.05
42 INT349667 Binding of AR and TFPI 1 0.02 0 0.05
43 INT209644 Binding of AR and C4B 1 0.00 0.32 0.04
44 INT178441 Binding of Ar and Sra1 1 0.00 0.45 0.04
45 INT213383 Srd5a3 Negative_regulation of Gene_expression of AR 1 0.01 0.7 0.04
46 INT319384 Binding of AR and SCGB2A2 1 0.01 1.36 0.04
47 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
48 INT178439 Binding of Ar and Src 1 0.01 0.44 0.04
49 INT178428 Regulation of Il6 Positive_regulation of Ar 1 0.01 0.47 0.04
50 INT279632 Positive_regulation of Binding of Ar and Nr4a1 1 0.01 0.86 0.03
51 INT326736 AR Regulation of Gene_expression of ARG2 1 0.34 0.43 0.03
52 INT185651 GOPC Positive_regulation of AR 1 0.03 0.06 0.03
53 INT194707 RAC1 Positive_regulation of PAK1 1 0.01 0 0.03
54 INT349661 PYCARD Positive_regulation of AR 1 0.08 0 0.03
55 INT194738 Binding of PAK1 and RAC1 1 0.01 0 0.03
56 INT198143 Binding of AR and ANTXR2 1 0.01 0.19 0.03
57 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
58 INT326742 AR Regulation of Gene_expression of ARG1 1 0.24 0.43 0.03
59 INT279634 Binding of Ar and Nr4a1 1 0.01 0.85 0.03
60 INT218964 Dlst Regulation of AR 1 0.01 0 0.03
61 INT265730 Binding of AR and VEGFA 1 0.09 0 0
62 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
63 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 0.01 0.08 0
64 INT338180 Binding of AR and STAT3 1 0.18 0.3 0
65 INT304020 AR Regulation of TP53 1 0.24 1.11 0
66 INT339404 Binding of Ar and Tymp 1 0.10 0.06 0
67 INT218963 Dlst Negative_regulation of AR 1 0.00 0.1 0
68 INT209636 TRPV1 Regulation of Gene_expression of AR 1 0.17 0.38 0
69 INT339403 Negative_regulation of Binding of Ar and Tymp 1 0.12 0 0
70 INT293809 MAPK1 Positive_regulation of AR 1 0.03 0.12 0
71 INT209633 AR Regulation of Gene_expression of PCa 1 0.06 1.19 0
72 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0
73 INT213365 AR Regulation of Gene_expression of VEGFA 1 0.09 1.52 0
74 INT338018 Binding of AR and Flna 1 0.11 0.33 0
75 INT209634 Binding of AR and PCa 1 0.04 1.03 0
76 INT293818 AKT1 Positive_regulation of Gene_expression of AR 1 0.05 0.31 0
77 INT339107 Binding of BCS1L and PAK1 1 0.01 0.08 0
78 INT349666 Binding of AR and PYCARD 1 0.06 0 0
79 INT326740 Gene_expression of AR Negative_regulation of Gene_expression of ARG2 1 0.24 0.8 0
80 INT177267 Binding of CXADR and NCOA3 1 0.17 0 0
81 INT209630 ALG12 Regulation of Gene_expression of AR 1 0.13 0.38 0
82 INT209635 AR Positive_regulation of ALG12 1 0.14 0.32 0
83 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0
84 INT293803 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of AR 1 0.10 0 0
85 INT293819 EPHB2 Positive_regulation of AR 1 0.23 0.12 0
86 INT219425 CCNA2 Regulation of SKP2 1 0.11 0.11 0
87 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0
88 INT354619 AR Positive_regulation of Gene_expression of Nppa 1 0.00 0.38 0
89 INT338022 Cuedc2 Positive_regulation of Protein_catabolism of AR 1 0.23 0.29 0
90 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0
91 INT219411 CCNF Regulation of SKP2 1 0.22 0.11 0
92 INT218960 Binding of AR and Esyt1 1 0.00 0 0
93 INT209637 AR Positive_regulation of TRPV1 1 0.18 0.32 0
94 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0
95 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0
96 INT293806 AR Positive_regulation of PIK3CG 1 0.06 0.12 0
97 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0
98 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
99 INT209629 AR Negative_regulation of Gene_expression of MRFAP1 1 0.26 0.16 0
100 INT185652 Binding of AR and GOPC 1 0.03 0 0
101 INT338182 CDCP1 Positive_regulation of Phosphorylation of AR 1 0.01 0.29 0
102 INT339407 Negative_regulation of Binding of AR and Tymp 1 0.04 0 0
103 INT269941 Sox17 Regulation of Gene_expression of Foxa1 1 0.56 0 0
104 INT219354 FGFR1 Positive_regulation of Gene_expression of PAK1 1 0.10 0.55 0
105 INT102124 Binding of AR and ESRRB 1 0.03 0.13 0
106 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
107 INT269917 Foxa1 Regulation of Gene_expression of Scgb1a1 1 0.24 0 0
108 INT218965 Esyt1 Negative_regulation of AR 1 0.00 0 0
109 INT209641 AR Positive_regulation of PCa 1 0.06 1.17 0
110 INT338021 Binding of Flna and Regulation of Transcription of AR 1 0.14 0.33 0
111 INT265737 Binding of AR and NRP1 1 0.10 0 0
112 INT326743 Gene_expression of AR Negative_regulation of Gene_expression of ARG1 1 0.32 0.8 0
113 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0
114 INT209638 AR Regulation of MRFAP1 1 0.12 0.41 0
115 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
116 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0
117 INT339406 Binding of AR and Tymp 1 0.03 0.06 0
118 INT338023 Psma7 Positive_regulation of AR 1 0.17 0.38 0
119 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
120 INT279635 Ar Regulation of Abpe 1 0.01 1.55 0
121 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0
122 INT265756 Positive_regulation of Binding of AR and NRP1 1 0.10 0 0
123 INT293816 Binding of AR and PIK3CG 1 0.03 0.27 0
124 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0
125 INT225537 Binding of Paxip1 and Mll2 1 0.12 0 0
126 INT198110 Ar Positive_regulation of Gene_expression of Aqp9 1 0.13 0 0
127 INT218962 Dlst Regulation of Gene_expression of AR 1 0.01 0 0
128 INT185654 DBT Negative_regulation of AR 1 0.02 0.09 0
129 INT269939 Foxa1 Regulation of Gene_expression of Foxj1 1 0.26 0 0
130 INT338020 Binding of AR and Ddr1 1 0.03 0.45 0
131 INT279633 Binding of Ar and Abpe 1 0.01 0.99 0
132 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0
133 INT293810 Binding of AR and RORC 1 0.01 0.13 0
134 INT338185 VAV3 Regulation of Positive_regulation of AR 1 0.19 0.49 0
135 INT225888 AKT1 Positive_regulation of PAK1 1 0.01 0.08 0
136 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0
137 INT338193 VAV3 Regulation of AR 1 0.31 0.49 0
138 INT209643 AR Positive_regulation of PYCR1 1 0.31 1.17 0
139 INT194925 Binding of CD22 and MLL2 1 0.08 0.18 0
140 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0
141 INT213364 AR Regulation of VEGFA 1 0.09 0.68 0
142 INT117173 OCM Regulation of Transcription of AR 1 0.18 0.06 0
143 INT219415 CCNE2 Regulation of SKP2 1 0.11 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of intracellular estrogen receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of intracellular estrogen receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
2 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
3 INT35366 Binding of AR 87 0.47 30.52 8.9
4 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61
5 INT99091 Regulation of AR 70 0.45 31.68 5.05
6 INT5205 Localization of AR 43 0.80 12.87 4.63
7 INT84727 Negative_regulation of Gene_expression of AR 38 0.58 12.46 4.63
8 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53
9 INT185927 Positive_regulation of Positive_regulation of AR 12 0.34 6.35 2.5
10 INT84722 Regulation of Gene_expression of AR 20 0.61 7.73 1.69
11 INT10598 Gene_expression of Ar 10 0.64 3.44 1.61
12 INT15969 Negative_regulation of Ar 11 0.43 2.77 1.59
13 INT82932 Transcription of AR 14 0.67 5.75 1.34
14 INT68500 Regulation of Ar 6 0.27 4.16 1.32
15 INT213379 Phosphorylation of AR 6 0.63 2.03 1.21
16 INT209679 Positive_regulation of Regulation of AR 3 0.37 1.88 0.96
17 INT167424 Positive_regulation of Pak1 1 0.14 1.43 0.83
18 INT156529 Positive_regulation of Gene_expression of Ar 1 0.05 0.09 0.8
19 INT185669 Positive_regulation of Localization of AR 7 0.33 1.83 0.73
20 INT156060 Regulation of Binding of AR 2 0.09 0.42 0.69
21 INT106608 Regulation of Gene_expression of SKP2 1 0.50 0.26 0.63
22 INT106603 Gene_expression of SKP2 5 0.63 6.99 0.62
23 INT17493 Binding of Ar 14 0.48 3.62 0.6
24 INT49343 Positive_regulation of Ar 8 0.42 4.38 0.58
25 INT306885 Positive_regulation of SKP2 1 0.21 0.6 0.45
26 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
27 INT203568 Regulation of SKP2 3 0.26 1.61 0.38
28 INT104312 Positive_regulation of Transcription of AR 2 0.37 0.96 0.38
29 INT17492 Negative_regulation of Binding of Ar 3 0.59 0.76 0.28
30 INT293387 Regulation of Localization of AR 1 0.05 0 0.28
31 INT266974 Protein_catabolism of AR 2 0.34 1.91 0.27
32 INT123520 Gene_expression of Ar 12 0.32 6.98 0.25
33 INT279628 Negative_regulation of Ar 5 0.04 6.1 0.25
34 INT185930 Regulation of Positive_regulation of AR 3 0.20 1.01 0.25
35 INT152667 Negative_regulation of Transcription of AR 3 0.42 0.72 0.24
36 INT112378 Negative_regulation of Regulation of Ar 1 0.43 0.19 0.23
37 INT257784 Positive_regulation of Phosphorylation of AR 2 0.45 0.96 0.21
38 INT219361 Gene_expression of PAK1 1 0.75 2.91 0.21
39 INT213914 Positive_regulation of NCOA3 1 0.44 1.34 0.2
40 INT213912 Positive_regulation of Gene_expression of NCOA3 1 0.44 1.06 0.15
41 INT49346 Transcription of Ar 3 0.63 0.8 0.14
42 INT123527 Negative_regulation of Gene_expression of Ar 2 0.10 0 0.14
43 INT233867 Negative_regulation of SKP2 3 0.24 2.25 0.13
44 INT152669 Negative_regulation of Localization of AR 2 0.25 0.75 0.13
45 INT219368 Negative_regulation of PAK1 1 0.42 1.11 0.13
46 INT185673 Negative_regulation of Negative_regulation of AR 3 0.28 1.12 0.12
47 INT243079 Regulation of Ar 3 0.08 1.22 0.12
48 INT162432 Positive_regulation of Ar 3 0.23 2.34 0.11
49 INT219376 Positive_regulation of PAK1 1 0.67 4.84 0.11
50 INT213913 Gene_expression of NCOA3 3 0.50 1.11 0.1
51 INT213911 Positive_regulation of Positive_regulation of NCOA3 1 0.32 0.67 0.1
52 INT20955 Binding of Pak1 1 0.30 0.76 0.09
53 INT233872 Negative_regulation of Negative_regulation of SKP2 2 0.24 0.94 0.08
54 INT162428 Localization of Ar 4 0.37 2.4 0.07
55 INT20954 Gene_expression of Pak1 3 0.58 1.47 0.07
56 INT162430 Negative_regulation of Positive_regulation of Ar 1 0.21 1.52 0.07
57 INT243082 Binding of Ar 2 0.11 1.81 0.06
58 INT185666 Positive_regulation of Binding of AR 2 0.33 0.19 0.04
59 INT213380 Regulation of Negative_regulation of AR 1 0.35 0.72 0.04
60 INT172624 Binding of NCOA3 4 0.22 1.05 0.03
61 INT249790 Protein_catabolism of Skp2 2 0.58 1.02 0.03
62 INT213363 Regulation of Gene_expression of Ar 2 0.11 1.63 0.03
63 INT219373 Positive_regulation of Phosphorylation of PAK1 1 0.48 0.69 0.03
64 INT249798 Positive_regulation of Localization of Skp2 1 0.41 0.56 0.03
65 INT219367 Phosphorylation of PAK1 1 0.79 0.69 0.03
66 INT249791 Localization of Skp2 1 0.62 0.55 0.03
67 INT219356 Regulation of Phosphorylation of PAK1 1 0.44 0.7 0.03
68 INT219363 Localization of PAK1 3 0.72 1.14 0
69 INT307189 Localization of Med1 3 0.53 0.32 0
70 INT123526 Positive_regulation of Gene_expression of Ar 2 0.11 1.29 0
71 INT209673 Negative_regulation of Binding of AR 2 0.27 0.5 0
72 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
73 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
74 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
75 INT182748 Positive_regulation of Transcription of Ar 1 0.46 0.43 0
76 INT307188 Transcription of Med1 1 0.48 0.7 0
77 INT287660 Negative_regulation of Negative_regulation of Ar 1 0.03 0.07 0
78 INT276328 Negative_regulation of Skp2 1 0.04 0.56 0
79 INT185672 Positive_regulation of Negative_regulation of AR 1 0.27 0 0
80 INT335677 Regulation of Localization of Ar 1 0.00 0 0
81 INT219371 Positive_regulation of Gene_expression of PAK1 1 0.67 0.62 0
82 INT194935 Binding of MLL2 1 0.10 0.17 0
83 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
84 INT269871 Gene_expression of Foxa1 1 0.61 0 0
85 INT146803 Negative_regulation of Gene_expression of Ar 1 0.16 0.08 0
86 INT225457 Binding of Med1 1 0.35 0.28 0
87 INT219362 Transcription of PAK1 1 0.51 0.61 0
88 INT293401 Regulation of Gene_expression of Ar 1 0.06 0.07 0
89 INT219380 Regulation of Transcription of PAK1 1 0.26 0.61 0
90 INT152665 Negative_regulation of Regulation of AR 1 0.25 0.38 0
91 INT235469 Positive_regulation of Gene_expression of SKP2 1 0.26 1.24 0
92 INT225430 Gene_expression of Mll2 1 0.33 0 0
93 INT219369 Positive_regulation of Localization of PAK1 1 0.48 0.61 0
94 INT271903 Positive_regulation of Protein_catabolism of Skp2 1 0.14 0.47 0
95 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
96 INT271920 Negative_regulation of Protein_catabolism of Skp2 1 0.12 0.37 0
97 INT249786 Gene_expression of Skp2 1 0.59 0.13 0
98 INT152664 Regulation of Transcription of AR 1 0.16 0.25 0
99 INT219364 Regulation of PAK1 1 0.60 0.61 0
100 INT293772 Negative_regulation of Positive_regulation of AR 1 0.19 0 0
101 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
102 INT123516 Phosphorylation of Ar 1 0.19 0.07 0
103 INT219379 Regulation of Gene_expression of PAK1 1 0.44 0.71 0
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