GO:0033194

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Name response to hydroperoxide
Categary Process
Go Slim No
Go Link GO:0033194
Unique Molecular Interactions 60
Total Molecular Interactions 69
Total Single Events 625
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to hydroperoxide. They are ordered first by their pain relevance and then by number of times they were reported for response to hydroperoxide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
2 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
3 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
4 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
5 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
6 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
7 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
8 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
9 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
10 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
11 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
12 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
13 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
14 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
15 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
16 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
17 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
18 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
19 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
20 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
21 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
22 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
23 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
24 INT327383 Il13 Positive_regulation of Gene_expression of Cd38 1 0.19 0 0.25
25 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
26 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
27 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
28 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
29 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
30 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
31 INT249198 CD38 Positive_regulation of CA2 1 0.16 0.16 0.08
32 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
33 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
34 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
35 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
36 INT249158 CD38 Regulation of CA2 1 0.13 0.07 0.04
37 INT347414 Tlr4 Negative_regulation of Gpx1 1 0.01 0.36 0.04
38 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
39 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04
40 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
41 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
42 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
43 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
44 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
45 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
46 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
47 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
48 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
49 INT286268 Binding of GSR and Gpx1 2 0.02 0 0
50 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
51 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
52 INT253850 Binding of TRPM2 and Ssr1 1 0.02 0 0
53 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
54 INT155123 Binding of Gpx1 and Cat 1 0.04 0.05 0
55 INT240722 Cd38 Positive_regulation of Localization of Ca2 1 0.04 0.79 0
56 INT264864 Cd38 Positive_regulation of Localization of INS 1 0.06 0.51 0
57 INT155124 Positive_regulation of Binding of Gpx1 and Cat 1 0.05 0.05 0
58 INT351596 Regulation of Binding of GSR and Gpx1 1 0.02 0 0
59 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
60 INT206963 Lipg Regulation of Gpx1 1 0.00 0.5 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to hydroperoxide. They are ordered first by their pain relevance and then by number of times they were reported in response to hydroperoxide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
2 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
3 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
4 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27
5 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
6 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
7 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
8 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
9 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
10 INT137616 Gene_expression of Cd38 19 0.67 9.37 2.54
11 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
12 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
13 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95
14 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
15 INT168860 Positive_regulation of Cd38 5 0.70 4.07 1.57
16 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
17 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
18 INT168861 Positive_regulation of Gene_expression of Cd38 2 0.50 2.01 1.47
19 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
20 INT168859 Regulation of Cd38 1 0.27 0.11 1.33
21 INT142274 Gene_expression of TRPM2 7 0.78 2.29 1.31
22 INT117933 Positive_regulation of Gene_expression of Cd38 3 0.38 1.62 1.23
23 INT168864 Positive_regulation of Positive_regulation of Cd38 1 0.47 0.05 1.18
24 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
25 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
26 INT193069 Positive_regulation of Gene_expression of CD38 4 0.15 4.06 1.01
27 INT169336 Binding of Jak2 2 0.42 1.31 0.93
28 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
29 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
30 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
31 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
32 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
33 INT142276 Positive_regulation of Gene_expression of TRPM2 1 0.70 1.26 0.74
34 INT142277 Positive_regulation of TRPM2 7 0.70 1 0.69
35 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
36 INT184062 Binding of Jak2 5 0.37 3.13 0.47
37 INT117932 Positive_regulation of Cd38 2 0.35 1.17 0.43
38 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
39 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
40 INT134731 Localization of Cd38 4 0.70 0.87 0.41
41 INT107462 Localization of Jak2 2 0.60 0.78 0.4
42 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
43 INT22236 Negative_regulation of CD38 2 0.41 0.1 0.36
44 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
45 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
46 INT164126 Negative_regulation of TRPM2 2 0.42 0 0.32
47 INT264860 Binding of Cd38 1 0.39 2.36 0.31
48 INT214579 Positive_regulation of CD38 4 0.24 1.22 0.3
49 INT137586 Binding of Gpx1 8 0.23 2.76 0.29
50 INT116703 Negative_regulation of Negative_regulation of Gpx1 3 0.18 0.81 0.28
51 INT142275 Negative_regulation of Gene_expression of TRPM2 1 0.43 0.43 0.27
52 INT117931 Positive_regulation of Positive_regulation of Cd38 1 0.35 0.3 0.26
53 INT325293 Negative_regulation of Gene_expression of CD38 1 0.14 0.55 0.22
54 INT164125 Binding of TRPM2 4 0.36 0.15 0.2
55 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2
56 INT130457 Binding of CD38 2 0.16 0.75 0.17
57 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
58 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
59 INT177568 Localization of Gpx1 5 0.49 1.82 0.16
60 INT154771 Positive_regulation of Localization of Cd38 1 0.08 0.87 0.16
61 INT143657 Phosphorylation of Gpx1 1 0.82 0.97 0.14
62 INT143658 Regulation of Phosphorylation of Gpx1 1 0.45 0.97 0.14
63 INT264858 Negative_regulation of Binding of Cd38 1 0.34 0.79 0.14
64 INT143659 Positive_regulation of Phosphorylation of Gpx1 1 0.50 0.98 0.14
65 INT264863 Negative_regulation of Cd38 1 0.34 0.79 0.14
66 INT314341 Positive_regulation of Localization of Gpx1 1 0.08 0.82 0.13
67 INT264857 Negative_regulation of Gene_expression of Cd38 1 0.34 1.57 0.12
68 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
69 INT309757 Negative_regulation of Positive_regulation of TRPM2 1 0.16 0 0.1
70 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
71 INT252568 Negative_regulation of Regulation of Gpx1 1 0.08 1.11 0.09
72 INT133351 Regulation of Cd38 1 0.15 1.6 0.09
73 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
74 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
75 INT106237 Protein_catabolism of CD38 1 0.62 0.06 0.06
76 INT214575 Localization of CD38 3 0.34 2.31 0.04
77 INT249254 Regulation of TRPM2 1 0.33 0.16 0.04
78 INT214568 Positive_regulation of Localization of CD38 1 0.21 1.09 0
79 INT239147 Regulation of Binding of Gpx1 1 0.28 0.53 0
80 INT268724 Positive_regulation of Negative_regulation of Gpx1 1 0.04 0.13 0
81 INT264862 Regulation of Gene_expression of Cd38 1 0.36 0.84 0
82 INT202420 Transcription of Jak2 1 0.56 0.91 0
83 INT335757 Positive_regulation of Positive_regulation of Gpx1 1 0.07 0.66 0
84 INT347402 Negative_regulation of Binding of Gpx1 1 0.05 0 0
85 INT351593 Positive_regulation of Binding of Gpx1 1 0.08 0 0
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