GO:0033209

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Name tumor necrosis factor-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0033209
Unique Molecular Interactions 1802
Total Molecular Interactions 2624
Total Single Events 23705
Pain Genes Associated 39

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tumor necrosis factor-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for tumor necrosis factor-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
3 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
4 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
5 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
6 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
7 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
8 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
9 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
10 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
11 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
12 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
13 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
14 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
15 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
16 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
17 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
18 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
19 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
20 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
21 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
22 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
23 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
24 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
25 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
26 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
27 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
28 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
29 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
30 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
31 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
32 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
33 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
34 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
35 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
36 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
37 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
38 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
39 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
40 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
41 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
42 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
43 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
44 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
45 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
46 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
47 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
48 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
49 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
50 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
51 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
52 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
53 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
54 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
55 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
56 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
57 INT139191 Binding of Fas and RFFL 1 0.00 0.61 1.22
58 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
59 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
60 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
61 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
62 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
63 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
64 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
65 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
66 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
67 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
68 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14
69 INT289659 Tnfrsf1b Negative_regulation of Mcpt3 1 0.02 0.82 1.13
70 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
71 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
72 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
73 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
74 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
75 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1
76 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
77 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
78 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
79 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
80 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
81 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
82 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
83 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
84 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
85 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
86 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
87 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
88 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
89 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
90 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
91 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
92 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
93 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
94 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
95 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
96 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98
97 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
98 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
99 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
100 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
101 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
102 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
103 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
104 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
105 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
106 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
107 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
108 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
109 INT139330 Binding of SGCG and Stat1 1 0.37 0.75 0.94
110 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
111 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
112 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
113 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
114 INT36999 Binding of HLA-DRB2 and TNFRSF25 1 0.05 3.46 0.91
115 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
116 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
117 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
118 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
119 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
120 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
121 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
122 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
123 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
124 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88
125 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
126 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
127 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
128 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
129 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
130 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
131 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
132 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
133 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
134 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
135 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
136 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
137 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
138 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
139 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
140 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
141 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
142 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
143 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
144 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
145 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
146 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79
147 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
148 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
149 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
150 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
151 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
152 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
153 INT130138 TNF Negative_regulation of Gene_expression of S100A10 1 0.06 1.32 0.78
154 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
155 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
156 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
157 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
158 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
159 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77
160 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
161 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
162 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
163 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76
164 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
165 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76
166 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
167 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
168 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
169 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
170 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
171 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
172 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
173 INT301141 Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
174 INT301142 Negative_regulation of Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
175 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
176 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
177 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
178 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
179 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74
180 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73
181 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
182 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
183 INT51006 PDYN Positive_regulation of TNF 1 0.11 0.84 0.72
184 INT187171 Binding of Tnfrsf1b and Gtf3a 1 0.03 2.15 0.72
185 INT275285 Ros1 Positive_regulation of Tnfrsf1a 1 0.27 1.06 0.72
186 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
187 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
188 INT113499 TNF Positive_regulation of Gene_expression of BHLHE23 1 0.25 0.1 0.71
189 INT278812 PYCARD Positive_regulation of VTA1 1 0.09 0.11 0.71
190 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
191 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71
192 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
193 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
194 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7
195 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
196 INT117533 TNF Positive_regulation of Positive_regulation of SETBP1 1 0.34 0.29 0.7
197 INT83628 TNF Positive_regulation of Gene_expression of Cd59 1 0.06 1.09 0.7
198 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
199 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69
200 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69

Single Events

The table below shows the top 100 pain related interactions that have been reported for tumor necrosis factor-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in tumor necrosis factor-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
8 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
9 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
10 INT9660 Regulation of TNF 363 0.62 312.94 139.99
11 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
12 INT10166 Localization of Tnf 237 0.81 153.95 88.64
13 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
14 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
15 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
16 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
17 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
18 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
19 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
20 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
21 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
22 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
23 INT13354 Transcription of TNF 108 0.72 85.81 42.32
24 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
25 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
26 INT35406 Localization of Tnf 94 0.81 64.63 31.65
27 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
28 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
29 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
30 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
31 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
32 INT100026 Gene_expression of Tnfrsf1b 73 0.72 43.26 23.23
33 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
34 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
35 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
36 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
37 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
38 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
39 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
40 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
41 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
42 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61
43 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
44 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
45 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36
46 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
47 INT10173 Binding of Tnf 45 0.48 35.6 14.32
48 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
49 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
50 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94
51 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
52 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
53 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
54 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
55 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
56 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97
57 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
58 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22
59 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
60 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
61 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
62 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
63 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
64 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
65 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
66 INT68299 Binding of Tnf 17 0.39 12.55 7.49
67 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47
68 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
69 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
70 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31
71 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
72 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2
73 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
74 INT77789 Positive_regulation of Tnfrsf1b 12 0.65 13.77 6.58
75 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
76 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
77 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
78 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17
79 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11
80 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
81 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 8 0.48 6.44 5.97
82 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93
83 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
84 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85
85 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81
86 INT166765 Localization of PYCARD 21 0.70 3.89 5.66
87 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
88 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61
89 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
90 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
91 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41
92 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32
93 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25
94 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15
95 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
96 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87
97 INT113373 Positive_regulation of Gene_expression of Tnfrsf1b 15 0.65 8.64 4.79
98 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
99 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
100 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
101 INT113517 Binding of Fas 16 0.37 15.86 4.62
102 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44
103 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44
104 INT118230 Binding of Tnfrsf1a 15 0.42 7.63 4.39
105 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33
106 INT89963 Regulation of Fas 15 0.59 8.25 4.32
107 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23
108 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
109 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
110 INT115889 Binding of Fas 27 0.36 28.87 4.08
111 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
112 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
113 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
114 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
115 INT77786 Negative_regulation of Tnfrsf1a 5 0.56 5.03 3.58
116 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53
117 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5
118 INT96700 Positive_regulation of Positive_regulation of Tnfrsf1a 6 0.69 3.93 3.42
119 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34
120 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
121 INT140107 Negative_regulation of Tnfrsf1b 6 0.36 6.11 3.2
122 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19
123 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
124 INT124974 Regulation of Tnfrsf1b 4 0.59 4.59 3.01
125 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
126 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
127 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
128 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
129 INT94327 Phosphorylation of Stat1 9 0.80 2.06 2.8
130 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
131 INT184255 Binding of Tnfrsf1b 4 0.43 4.45 2.78
132 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
133 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
134 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
135 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
136 INT122651 Transcription of Tnfrsf1b 6 0.67 3.63 2.49
137 INT94119 Localization of Tnfrsf1b 8 0.75 5.66 2.42
138 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
139 INT113339 Binding of JAK2 6 0.40 5.31 2.4
140 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
141 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
142 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
143 INT88017 Regulation of Fas 12 0.62 8.27 2.29
144 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
145 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
146 INT77784 Regulation of Tnfrsf1b 7 0.57 4.61 2.17
147 INT275279 Positive_regulation of Localization of Tnfrsf1a 3 0.48 1.13 2.17
148 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
149 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08
150 INT77621 Regulation of Gene_expression of Fas 10 0.56 7.62 2.08
151 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
152 INT100021 Localization of Tnfrsf1b 7 0.80 3.4 1.96
153 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
154 INT142461 Positive_regulation of Positive_regulation of Stat1 7 0.54 5.06 1.94
155 INT113515 Positive_regulation of Positive_regulation of Fas 4 0.69 0.95 1.92
156 INT97019 Negative_regulation of Binding of TNFRSF11A 4 0.17 1.8 1.89
157 INT121784 Regulation of Gene_expression of Fas 7 0.38 5.68 1.86
158 INT134890 Localization of TNFRSF11A 1 0.79 3.75 1.86
159 INT183381 Transcription of Tnfrsf1a 3 0.46 2.08 1.83
160 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82
161 INT148705 Binding of TNFRSF1A 8 0.38 5.19 1.81
162 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
163 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76
164 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
165 INT171964 Positive_regulation of Gene_expression of Tnfrsf11a 5 0.37 4.11 1.73
166 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71
167 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
168 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61
169 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
170 INT139334 Regulation of Gene_expression of Tnfrsf1b 2 0.55 3.89 1.6
171 INT186309 Binding of Stat1 18 0.48 5.31 1.58
172 INT140089 Positive_regulation of Stat1 5 0.68 3.42 1.58
173 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56
174 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
175 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
176 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
177 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46
178 INT60528 Negative_regulation of TNFRSF1A 6 0.42 4.86 1.45
179 INT89965 Transcription of Fas 5 0.71 5.28 1.45
180 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
181 INT220077 Negative_regulation of Binding of TNFRSF1B 1 0.26 1.1 1.42
182 INT139326 Gene_expression of Stat1 6 0.76 2.49 1.41
183 INT121820 Binding of STAT1 9 0.46 2.54 1.4
184 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38
185 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
186 INT107924 Localization of Tnfrsf1a 5 0.70 3.86 1.37
187 INT188404 Positive_regulation of Binding of Fas 3 0.15 5.22 1.37
188 INT77785 Negative_regulation of Gene_expression of Tnfrsf1a 4 0.56 3.1 1.35
189 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34
190 INT251554 Negative_regulation of Gene_expression of Tnfrsf1a 2 0.41 1.8 1.32
191 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
192 INT190067 Binding of Traf2 5 0.20 3.28 1.27
193 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27
194 INT151820 Positive_regulation of Binding of Tnfrsf1b 4 0.48 2.49 1.27
195 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25
196 INT135144 Negative_regulation of Gene_expression of Tnfrsf1b 7 0.40 3.84 1.25
197 INT319293 Phosphorylation of Ptk2b 9 0.80 3.14 1.24
198 INT228328 Positive_regulation of Gene_expression of PYCARD 7 0.34 0.27 1.23
199 INT139183 Regulation of Binding of Fas 3 0.43 2.5 1.23
200 INT271886 Transcription of TNFRSF1B 1 0.51 1.76 1.23
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