GO:0033210

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Name leptin-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0033210
Unique Molecular Interactions 218
Total Molecular Interactions 307
Total Single Events 2068
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leptin-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for leptin-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
3 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
4 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
5 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
6 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
7 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
8 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
9 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
10 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
11 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
12 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
13 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
14 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
15 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
16 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
17 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
18 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
19 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
20 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
21 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
22 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
23 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
24 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
25 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
26 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
27 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
28 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
29 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
30 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
31 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
32 INT28237 BBS2 Positive_regulation of Localization of Cck 1 0.04 0.33 0.39
33 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
34 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
35 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
36 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
37 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
38 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
39 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
40 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
41 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
42 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
43 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
44 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
45 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
46 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
47 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
48 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
49 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
50 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
51 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
52 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
53 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
54 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
55 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
56 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
57 INT240807 Arc Regulation of Gene_expression of Lepr 1 0.05 0.72 0.28
58 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
59 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
60 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
61 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
62 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
63 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
64 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
65 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
66 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
67 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
68 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
69 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
70 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
71 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
72 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
73 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
74 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
75 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
76 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
77 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
78 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
79 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
80 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
81 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
82 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
83 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
84 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
85 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
86 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
87 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
88 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
89 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
90 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
91 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
92 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
93 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
94 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
95 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
96 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
97 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
98 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
99 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
100 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
101 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11
102 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
103 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1
104 INT303990 Binding of Lep and Positive_regulation of Gene_expression of LPL 1 0.03 0.35 0.1
105 INT323879 LEP Regulation of SOAT1 1 0.15 1.15 0.1
106 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1
107 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
108 INT123864 Lep Positive_regulation of Positive_regulation of Cck 1 0.45 0.1 0.09
109 INT242324 Lep Regulation of Gene_expression of Ucp1 1 0.58 1.47 0.09
110 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
111 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09
112 INT213482 Lep Positive_regulation of Mapk1 1 0.06 0.08 0.09
113 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09
114 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
115 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08
116 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08
117 INT123866 Lep Negative_regulation of Olfr544 1 0.00 0.09 0.08
118 INT303999 Lep Positive_regulation of Gene_expression of ITGA2 1 0.06 0.29 0.08
119 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
120 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
121 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
122 INT268325 Lep Positive_regulation of Ptgs2 1 0.09 0.39 0.08
123 INT157268 Adipor1 Positive_regulation of Adipor2 1 0.01 0.89 0.08
124 INT303970 Lep Positive_regulation of Gene_expression of Itga2 1 0.09 0.29 0.08
125 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07
126 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07
127 INT157272 Adipor1 Positive_regulation of APRT 1 0.12 0.88 0.07
128 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
129 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
130 INT214153 Lep Regulation of Transcription of Nucb2 1 0.35 0.15 0.06
131 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
132 INT323878 Binding of LEP and MMP13 1 0.17 0.77 0.05
133 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
134 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
135 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05
136 INT314135 Negative_regulation of Nos2 Positive_regulation of Lep 1 0.52 0.44 0.05
137 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
138 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
139 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05
140 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
141 INT303986 Lep Positive_regulation of Gene_expression of TNF 1 0.49 0.29 0.04
142 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
143 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
144 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04
145 INT222534 Gnrh1 Positive_regulation of Localization of Lep 1 0.07 0 0.04
146 INT303996 Lep Positive_regulation of Gene_expression of IL12A 1 0.08 0.29 0.04
147 INT303965 Lep Positive_regulation of Gene_expression of Il6 1 0.07 0.29 0.04
148 INT214149 Binding of Lepr and Pomc 1 0.33 0.21 0.03
149 INT249046 Binding of LEP and ARID1B 1 0.01 1.3 0.03
150 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
151 INT253374 Lep Positive_regulation of Phosphorylation of Eif4ebp1 1 0.04 0.16 0.03
152 INT253375 Lep Positive_regulation of Phosphorylation of Rps6kb1 1 0.41 0.16 0.03
153 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03
154 INT299368 Mkks Positive_regulation of Mapk8 1 0.41 0.17 0.03
155 INT253414 Lep Negative_regulation of BCL2A1 1 0.16 0 0.03
156 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03
157 INT333885 Lep Positive_regulation of Il1 1 0.17 0.05 0.03
158 INT214148 Binding of Lepr and Cartpt 1 0.09 0.21 0.03
159 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
160 INT213160 AGT Positive_regulation of Gene_expression of LEP 1 0.08 1.29 0.03
161 INT174290 Lep Positive_regulation of Pomc 2 0.50 0.47 0
162 INT138526 Lep Positive_regulation of Localization of Gnrh1 1 0.39 0 0
163 INT305279 Lep Regulation of Gene_expression of Akt1 1 0.18 0.83 0
164 INT200058 Binding of Ndn and Bbs4 1 0.30 0.29 0
165 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
166 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0
167 INT305273 Binding of Lep and Leprot 1 0.06 0.92 0
168 INT214139 Lep Regulation of Localization of Pomc 1 0.20 0.4 0
169 INT214155 Lep Regulation of Gene_expression of Pomc 1 0.20 0.4 0
170 INT314133 Lep Positive_regulation of Gene_expression of Ppargc1a 1 0.51 0.79 0
171 INT176535 Ass1 Positive_regulation of Lepr 1 0.00 0 0
172 INT249045 CENPJ Regulation of Regulation of LEP 1 0.14 0.81 0
173 INT305278 Lep Negative_regulation of Obsty1 1 0.07 0.94 0
174 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0
175 INT303963 Lep Positive_regulation of Gene_expression of Il7 1 0.02 0.41 0
176 INT174287 Agrp Positive_regulation of Lep 1 0.19 0.49 0
177 INT163585 Lep Positive_regulation of Gene_expression of Epm2a 1 0.03 0.14 0
178 INT309834 Binding of Lepr and Zfp366 1 0.00 0.28 0
179 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
180 INT225085 Binding of ADM and Negative_regulation of LEP 1 0.16 1.04 0
181 INT305272 Gene_expression of Lep Positive_regulation of Positive_regulation of Stat3 1 0.40 0.46 0
182 INT305264 Positive_regulation of Binding of Lep and Leprot 1 0.08 0.93 0
183 INT305280 Lep Positive_regulation of Gene_expression of Leprot 1 0.07 1.03 0
184 INT305258 Lep Regulation of Gene_expression of Stat3 1 0.24 0.92 0
185 INT289532 Lep Regulation of Arc 1 0.04 0.19 0
186 INT305277 Positive_regulation of Binding of Lep and Obsty1 1 0.08 0.93 0
187 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0
188 INT288214 Lep Negative_regulation of Gene_expression of Ins1 1 0.35 0.05 0
189 INT186401 Binding of MKKS and MKS1 1 0.09 0.07 0
190 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0
191 INT204085 Binding of LEP and TNF 1 0.37 0.39 0
192 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0
193 INT174288 Lep Positive_regulation of Npy 1 0.36 0.45 0
194 INT305267 Lep Regulation of Obsty1 1 0.04 0.97 0
195 INT174283 Lep Negative_regulation of Agrp 1 0.32 0.48 0
196 INT253364 Lep Positive_regulation of Rps6kb1 1 0.30 0.08 0
197 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
198 INT305261 Gene_expression of Lep Positive_regulation of Gene_expression of Stat3 1 0.40 0.46 0
199 INT253360 Lep Positive_regulation of Eif4ebp1 1 0.01 0.08 0
200 INT289520 Lep Regulation of Prkag1 1 0.00 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leptin-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in leptin-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
2 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
3 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
4 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
5 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
6 INT75908 Regulation of LEP 77 0.60 60.16 15.19
7 INT73641 Regulation of Lep 45 0.62 26.2 12.59
8 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
9 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
10 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
11 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
12 INT82082 Localization of Lep 63 0.81 26.41 8.56
13 INT75907 Binding of LEP 53 0.46 46.65 8.44
14 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
15 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
16 INT65356 Localization of LEP 46 0.79 41.17 5.43
17 INT91338 Binding of Lep 31 0.48 26.86 5.39
18 INT102935 Regulation of Lep 31 0.60 18.47 5.24
19 INT97391 Binding of Lep 18 0.48 8.97 4.47
20 INT9349 Gene_expression of BBS2 15 0.49 12.77 4.22
21 INT163581 Localization of Lep 27 0.79 18.99 4.08
22 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
23 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
24 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
25 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78
26 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
27 INT199798 Positive_regulation of BBS2 2 0.50 5.85 2.55
28 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
29 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
30 INT83392 Transcription of Lep 6 0.54 5.07 2.04
31 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
32 INT89008 Gene_expression of Lepr 2 0.65 5.39 1.66
33 INT93350 Binding of Lepr 17 0.05 27.21 1.5
34 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
35 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
36 INT213465 Transcription of Lep 4 0.68 2.11 1.15
37 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
38 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
39 INT54794 Binding of Lepr 1 0.01 0 1.07
40 INT177481 Negative_regulation of BBS2 6 0.31 5.34 1.06
41 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
42 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
43 INT28236 Localization of BBS2 2 0.54 1.9 0.83
44 INT274178 Binding of BBS2 1 0.27 2.12 0.82
45 INT191926 Negative_regulation of Lepr 13 0.48 17.68 0.8
46 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
47 INT156533 Transcription of LEP 9 0.69 4.35 0.74
48 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
49 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
50 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
51 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
52 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
53 INT274177 Positive_regulation of Gene_expression of BBS2 2 0.36 1.55 0.49
54 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
55 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
56 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
57 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
58 INT346261 Gene_expression of MKKS 1 0.40 0.66 0.34
59 INT14382 Regulation of BBS2 3 0.43 2.07 0.33
60 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
61 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
62 INT346249 Phosphorylation of MKKS 1 0.43 0.61 0.31
63 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
64 INT274176 Negative_regulation of Gene_expression of BBS2 1 0.31 0.94 0.29
65 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
66 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
67 INT214119 Regulation of Lepr 2 0.23 3.17 0.23
68 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
69 INT214103 Transcription of Lepr 1 0.57 0.36 0.22
70 INT284157 Regulation of Negative_regulation of BBS2 1 0.08 1.08 0.21
71 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
72 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
73 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
74 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
75 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
76 INT272845 Transcription of BBS2 1 0.04 0.42 0.16
77 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
78 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
79 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
80 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
81 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
82 INT163225 Gene_expression of Bbs4 1 0.60 0.09 0.13
83 INT163230 Gene_expression of Mkks 1 0.48 0.09 0.13
84 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
85 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
86 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
87 INT187729 Positive_regulation of Binding of LEP 1 0.18 0.3 0.08
88 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07
89 INT213466 Negative_regulation of Regulation of Lep 1 0.41 0 0.06
90 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05
91 INT176521 Positive_regulation of Lepr 8 0.07 6.6 0.03
92 INT335848 Positive_regulation of Gene_expression of Lepr 1 0.05 1.25 0.03
93 INT253406 Negative_regulation of Positive_regulation of Lep 2 0.41 0.74 0
94 INT259197 Negative_regulation of Lepr 2 0.11 0.33 0
95 INT309830 Positive_regulation of Positive_regulation of Lepr 1 0.07 0.6 0
96 INT150408 Regulation of Regulation of Lep 1 0.27 0 0
97 INT305226 Negative_regulation of Phosphorylation of Lep 1 0.42 1.89 0
98 INT305239 Positive_regulation of Phosphorylation of Lep 1 0.43 1.09 0
99 INT332953 Regulation of Gene_expression of Lepr 1 0.52 2.43 0
100 INT290862 Regulation of Regulation of Lepr 1 0.00 1 0
101 INT332954 Regulation of Transcription of Lep 1 0.11 1.4 0
102 INT157243 Negative_regulation of Transcription of LEP 1 0.02 0.09 0
103 INT177482 Negative_regulation of Negative_regulation of BBS2 1 0.03 0.73 0
104 INT174279 Positive_regulation of Negative_regulation of Lep 1 0.46 0.16 0
105 INT309421 Positive_regulation of Regulation of Lep 1 0.41 0.61 0
106 INT288213 Positive_regulation of Negative_regulation of Lep 1 0.47 0.06 0
107 INT259196 Localization of Lepr 1 0.04 0 0
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