GO:0033327

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Name Leydig cell differentiation
Categary Process
Go Slim No
Go Link GO:0033327
Unique Molecular Interactions 67
Total Molecular Interactions 87
Total Single Events 790
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Leydig cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for Leydig cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
2 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63
3 INT13077 Tac2 Positive_regulation of NKX2-1 1 0.00 0 0.39
4 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
5 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34
6 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26
7 INT111313 IL36RN Positive_regulation of Gene_expression of MGST1 1 0.07 0.66 0.22
8 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
9 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16
10 INT327325 Binding of Hnrnpd and Ccnd1 1 0.03 0.38 0.16
11 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15
12 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
13 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
14 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
15 INT127156 HSD17B10 Regulation of Acaa2 1 0.02 0 0.12
16 INT184522 Positive_regulation of Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.95 0.11
17 INT184521 Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.94 0.11
18 INT184520 Ptger2 Regulation of Ccnd1 1 0.00 0.94 0.11
19 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
20 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08
21 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
22 INT340567 Jun Positive_regulation of Gene_expression of Ccnd1 1 0.05 0.27 0.07
23 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07
24 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04
25 INT207702 CCND1 Regulation of MSMB 1 0.22 0.69 0.04
26 INT263431 Trib3 Regulation of Pdgfra 1 0.00 0 0.04
27 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
28 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03
29 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
30 INT223067 IFI27 Negative_regulation of CCND1 1 0.05 0.65 0.03
31 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
32 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0
33 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0
34 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
35 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
36 INT259451 Binding of DHCR7 and Cyp11a1 1 0.01 0.3 0
37 INT272518 Positive_regulation of Binding of Ccnd1 and Celf1 1 0.01 0 0
38 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
39 INT269920 Positive_regulation of Binding of Ccnd1 and Qsox1 1 0.10 0 0
40 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
41 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0
42 INT250658 FOS Positive_regulation of CCND1 1 0.03 0.6 0
43 INT145338 Binding of PYGO1 and Positive_regulation of Transcription of CCND1 1 0.07 0 0
44 INT269925 Binding of Ccnd1 and Qsox1 1 0.07 0 0
45 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0
46 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
47 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0
48 INT315486 Slfn1 Negative_regulation of Ccnd1 1 0.07 0.28 0
49 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0
50 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0
51 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
52 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0
53 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0
54 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
55 INT186051 IFI27 Regulation of Gene_expression of CCND1 1 0.30 0.66 0
56 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
57 INT159977 Binding of Mgst1 and Gnat3 1 0.03 0 0
58 INT259452 Binding of STAR and Cyp11a1 1 0.25 0.06 0
59 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
60 INT201756 CDKN1B Positive_regulation of Localization of Ccnd1 1 0.04 0 0
61 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
62 INT229007 MIA3 Positive_regulation of Gene_expression of Ccnd1 1 0.01 0.55 0
63 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0
64 INT224290 ESR1 Positive_regulation of CCND1 1 0.17 0.07 0
65 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0
66 INT145334 Binding of BCL9 and Positive_regulation of Transcription of CCND1 1 0.41 0 0
67 INT287071 Tlr4 Positive_regulation of Ccnd1 1 0.02 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Leydig cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in Leydig cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
2 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93
3 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7
4 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65
5 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61
6 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24
7 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01
8 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66
9 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26
10 INT93398 Negative_regulation of Gene_expression of Ccnd1 5 0.44 2.61 2.12
11 INT104402 Positive_regulation of CCND1 15 0.70 11.77 2.08
12 INT13075 Binding of NKX2-1 6 0.05 0.12 2.08
13 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99
14 INT122346 Gene_expression of Hsd3b1 1 0.75 0 1.78
15 INT112867 Positive_regulation of Gene_expression of Ccnd1 15 0.56 13.22 1.77
16 INT112339 Localization of Cyp11a1 2 0.71 0.94 1.68
17 INT10570 Positive_regulation of Cyp11a1 9 0.47 2.67 1.4
18 INT122345 Positive_regulation of Gene_expression of Hsd3b1 1 0.49 0 1.34
19 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31
20 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15
21 INT78266 Localization of NKX2-1 2 0.73 0.16 1.12
22 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07
23 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02
24 INT122347 Transcription of Hsd3b1 1 0.52 0 0.99
25 INT59575 Gene_expression of MGST1 2 0.52 3.47 0.98
26 INT106746 Gene_expression of Mtap7 1 0.39 2.09 0.95
27 INT10578 Transcription of Cyp11a1 3 0.53 0.84 0.93
28 INT59198 Regulation of Ccnd1 11 0.47 6.54 0.9
29 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87
30 INT13074 Positive_regulation of NKX2-1 4 0.19 0.86 0.87
31 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86
32 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
33 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81
34 INT15039 Negative_regulation of NKX2-1 3 0.21 0 0.72
35 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63
36 INT128498 Regulation of CCND1 17 0.39 12.51 0.58
37 INT59576 Positive_regulation of Gene_expression of MGST1 2 0.34 2.07 0.54
38 INT146802 Positive_regulation of Ccnd1 4 0.38 1.37 0.53
39 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51
40 INT258835 Localization of Ccnd1 3 0.53 2.7 0.5
41 INT146522 Negative_regulation of Positive_regulation of CCND1 3 0.30 2.04 0.48
42 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47
43 INT93400 Negative_regulation of Ccnd1 4 0.33 0.77 0.47
44 INT122348 Regulation of Hsd3b1 1 0.60 0 0.46
45 INT158643 Negative_regulation of Negative_regulation of CCND1 2 0.31 2.43 0.45
46 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44
47 INT121113 Protein_catabolism of Cyp11a1 2 0.65 0.37 0.44
48 INT20056 Positive_regulation of MGST1 2 0.47 0.7 0.42
49 INT98419 Positive_regulation of Mtap7 3 0.38 2.66 0.41
50 INT111315 Regulation of Gene_expression of MGST1 1 0.42 1.04 0.34
51 INT156411 Gene_expression of Pdgfra 8 0.75 5.5 0.3
52 INT186057 Binding of CCND1 8 0.31 5.92 0.26
53 INT156410 Positive_regulation of Pdgfra 3 0.08 1.51 0.25
54 INT117760 Regulation of Gene_expression of Cyp11a1 2 0.42 0.36 0.25
55 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24
56 INT146801 Regulation of Ccnd1 5 0.34 2.4 0.19
57 INT159231 Positive_regulation of PDGFRA 3 0.47 2.39 0.18
58 INT187614 Phosphorylation of Cyp17a1 1 0.25 0.06 0.17
59 INT187609 Negative_regulation of Phosphorylation of Cyp17a1 1 0.13 0.06 0.17
60 INT10575 Positive_regulation of Transcription of Cyp11a1 1 0.05 0 0.17
61 INT187610 Positive_regulation of Cyp17a1 1 0.14 0.06 0.17
62 INT151741 Regulation of PDGFRA 2 0.44 0.78 0.16
63 INT10572 Positive_regulation of Positive_regulation of Cyp11a1 1 0.05 0 0.16
64 INT159975 Positive_regulation of Gene_expression of Mgst1 1 0.45 0.14 0.14
65 INT159974 Gene_expression of Mgst1 1 0.50 0.14 0.14
66 INT145248 Negative_regulation of Negative_regulation of Ccnd1 1 0.23 0.47 0.13
67 INT24324 Regulation of NKX2-1 1 0.03 0.1 0.13
68 INT196428 Negative_regulation of Binding of Ccnd1 1 0.14 1.17 0.13
69 INT196427 Negative_regulation of Transcription of Ccnd1 1 0.14 1.17 0.12
70 INT169908 Localization of Ccnd1 7 0.57 2.68 0.11
71 INT184473 Regulation of Gene_expression of Ccnd1 5 0.40 2.73 0.1
72 INT59572 Localization of MGST1 1 0.19 0.16 0.1
73 INT127149 Gene_expression of HSD17B10 3 0.58 2.06 0.09
74 INT215750 Transcription of Ccnd1 2 0.14 2.23 0.09
75 INT136182 Negative_regulation of PDGFRA 3 0.43 2.43 0.08
76 INT232713 Binding of PDGFRA 1 0.35 1.43 0.08
77 INT145375 Transcription of CCND1 7 0.52 3.86 0.07
78 INT215731 Positive_regulation of Transcription of Ccnd1 1 0.13 0.1 0.06
79 INT176590 Positive_regulation of Transcription of CCND1 1 0.17 0.27 0.05
80 INT159973 Positive_regulation of Positive_regulation of Mgst1 1 0.33 0.05 0.05
81 INT159976 Positive_regulation of Mgst1 1 0.33 0.05 0.05
82 INT140315 Regulation of Positive_regulation of Cyp11a1 1 0.19 0.07 0.05
83 INT176561 Gene_expression of Cyp17a1 3 0.25 1.38 0.04
84 INT127148 Negative_regulation of HSD17B10 1 0.04 0.19 0.04
85 INT221830 Negative_regulation of Transcription of CCND1 3 0.18 2.15 0.03
86 INT196407 Binding of HSD17B10 2 0.21 0.58 0.03
87 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03
88 INT258832 Regulation of Transcription of Ccnd1 1 0.16 1.57 0.03
89 INT215727 Regulation of Gene_expression of Ccnd1 2 0.12 0.49 0
90 INT225215 Negative_regulation of Positive_regulation of Ccnd1 2 0.13 1.33 0
91 INT236700 Phosphorylation of Ccnd1 2 0.18 1.89 0
92 INT225220 Positive_regulation of Positive_regulation of Ccnd1 1 0.14 1.2 0
93 INT94755 Binding of Mtap7 1 0.31 0 0
94 INT305634 Localization of CCND1 1 0.07 2.69 0
95 INT276362 Protein_catabolism of CCND1 1 0.10 0.66 0
96 INT242099 Binding of Nkx2-1 1 0.02 1.15 0
97 INT352608 Binding of Pdgfra 1 0.27 0.7 0
98 INT297265 Positive_regulation of Positive_regulation of CCND1 1 0.07 0.94 0
99 INT295427 Localization of PDGFRA 1 0.40 1.04 0
100 INT330350 Positive_regulation of Negative_regulation of CCND1 1 0.08 1.3 0
101 INT235459 Positive_regulation of Protein_catabolism of Ccnd1 1 0.13 0.49 0
102 INT276346 Regulation of Protein_catabolism of CCND1 1 0.04 0.66 0
103 INT352609 Positive_regulation of Gene_expression of Pdgfra 1 0.58 1.18 0
104 INT269909 Positive_regulation of Localization of Ccnd1 1 0.38 0 0
105 INT228997 Phosphorylation of Ccnd1 1 0.10 0.52 0
106 INT259446 Positive_regulation of Gene_expression of Cyp11a1 1 0.28 0 0
107 INT200836 Transcription of Pdgfra 1 0.30 0.26 0
108 INT92060 Localization of Mtap7 1 0.22 0.07 0
109 INT302232 Negative_regulation of Binding of CCND1 1 0.11 0.84 0
110 INT92061 Phosphorylation of Mtap7 1 0.20 0.07 0
111 INT176563 Binding of Cyp17a1 1 0.13 0.32 0
112 INT235458 Protein_catabolism of Ccnd1 1 0.19 0.24 0
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