GO:0033552

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Name response to vitamin B3
Categary Process
Go Slim No
Go Link GO:0033552
Unique Molecular Interactions 131
Total Molecular Interactions 185
Total Single Events 2066
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to vitamin B3. They are ordered first by their pain relevance and then by number of times they were reported for response to vitamin B3. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
2 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
3 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
4 INT128997 Cxcl1 Positive_regulation of Localization of Ccl2 1 0.72 1.54 2.16
5 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
6 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
7 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
8 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
9 INT135585 CSF2 Regulation of CCL2 1 0.13 2.51 0.95
10 INT129003 Ccl2 Positive_regulation of ANTXRL 1 0.00 0.68 0.92
11 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
12 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83
13 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
14 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
15 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 0.43 0.14 0.81
16 INT239671 Binding of Ccl2 and Gtf3a 1 0.02 1.34 0.79
17 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77
18 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
19 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
20 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
21 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
22 INT120035 CCL2 Positive_regulation of Prap1 1 0.00 0.99 0.7
23 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68
24 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
25 INT153750 Binding of CCL2 and Crp 1 0.02 1.8 0.65
26 INT153751 Regulation of Binding of CCL2 and Crp 1 0.03 1.8 0.65
27 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
28 INT264329 Binding of IL-17 and Positive_regulation of Localization of Ccl2 1 0.13 1.65 0.64
29 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
30 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
31 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
32 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
33 INT252826 ROS1 Regulation of Gene_expression of CCL2 1 0.20 2.17 0.62
34 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58
35 INT147201 Binding of CCL2 and Hsp70-2os 1 0.00 0.76 0.57
36 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
37 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
38 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
39 INT112800 CASP1 Positive_regulation of Gene_expression of CCL2 1 0.04 0.48 0.43
40 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
41 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
42 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
43 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
44 INT163906 CCL2 Positive_regulation of CCR2 1 0.18 0.2 0.35
45 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
46 INT134888 Negative_regulation of TNFRSF11A Negative_regulation of Gene_expression of CCL2 1 0.24 0.38 0.33
47 INT313740 Negative_regulation of NOS1 Positive_regulation of Gene_expression of Ccl2 1 0.02 0.38 0.3
48 INT171257 TNFSF12 Positive_regulation of CCL2 1 0.01 0.3 0.29
49 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
50 INT294709 IRF6 Positive_regulation of Gene_expression of CCL2 1 0.08 0.14 0.28
51 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
52 INT252806 F2 Positive_regulation of Gene_expression of CCL2 1 0.01 0.8 0.27
53 INT306941 Tnfsf12 Positive_regulation of Gene_expression of CCL2 1 0.03 1.65 0.27
54 INT132363 Lgals1 Positive_regulation of Gene_expression of Ccl2 1 0.26 0.14 0.27
55 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27
56 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
57 INT120896 Binding of CCL2 and Il6 1 0.08 1.2 0.26
58 INT312768 Pon1 Negative_regulation of Gene_expression of Ccl2 1 0.06 1.42 0.26
59 INT252822 CCL2 Positive_regulation of Positive_regulation of FOS 1 0.04 0.75 0.25
60 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
61 INT252786 CCL2 Regulation of Positive_regulation of FOS 1 0.05 0.75 0.25
62 INT281133 Binding of Ccl2 and Cxcr4 1 0.06 0.63 0.24
63 INT252777 ROS1 Positive_regulation of Gene_expression of CCL2 1 0.31 0.77 0.23
64 INT112796 IL4I1 Positive_regulation of Gene_expression of CCL2 1 0.07 0 0.23
65 INT112801 IL4I1 Positive_regulation of CCL2 1 0.03 0 0.23
66 INT303029 Binding of TEK and Angpt1 1 0.26 1.82 0.22
67 INT112798 CASP1 Positive_regulation of CCL2 1 0.02 0.19 0.21
68 INT252814 ELANE Positive_regulation of Positive_regulation of CCL2 1 0.05 0.8 0.2
69 INT306108 CCL2 Positive_regulation of Positive_regulation of Mapk3 1 0.03 0.15 0.2
70 INT252782 ROS1 Positive_regulation of Positive_regulation of CCL2 1 0.22 0.8 0.2
71 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18
72 INT116440 LY9 Negative_regulation of Gene_expression of CCL2 1 0.14 0.09 0.16
73 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
74 INT352417 Ccl2 Positive_regulation of Ccr5 1 0.06 0.26 0.14
75 INT352416 Ccl2 Positive_regulation of Ccr2 1 0.23 0.26 0.14
76 INT220318 Binding of CPB1 and CCL2 1 0.01 0.46 0.13
77 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
78 INT221989 Cpn1 Positive_regulation of Localization of Ccl2 1 0.07 1.6 0.12
79 INT355590 VEGFA Positive_regulation of Gene_expression of CCL2 1 0.07 1.35 0.1
80 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1
81 INT294453 KLK4 Negative_regulation of CCL2 1 0.00 0 0.1
82 INT213416 Binding of CCL2 and SET 1 0.11 0.17 0.1
83 INT355585 VEGFA Positive_regulation of Positive_regulation of CCL2 1 0.07 1.35 0.1
84 INT184537 Ccl2 Positive_regulation of Spp1 1 0.34 1.37 0.09
85 INT132804 Positive_regulation of IL4 Positive_regulation of CCL2 1 0.22 0.6 0.09
86 INT184542 Positive_regulation of Ccl2 Positive_regulation of Gpbar1 1 0.10 1.39 0.09
87 INT132794 Positive_regulation of IL13 Positive_regulation of CCL2 1 0.21 0.6 0.09
88 INT294711 CRP Regulation of CCL2 1 0.12 0 0.09
89 INT184538 Positive_regulation of Ccl2 Positive_regulation of Spp1 1 0.34 1.38 0.09
90 INT184541 Ccl2 Positive_regulation of Gpbar1 1 0.10 1.37 0.09
91 INT132815 Positive_regulation of TNF Positive_regulation of CCL2 1 0.21 0.6 0.09
92 INT132793 IL4 Positive_regulation of CCL2 1 0.22 0.73 0.08
93 INT132816 IL13 Positive_regulation of CCL2 1 0.21 0.73 0.08
94 INT340425 Hmmr Regulation of Ccl2 1 0.01 1.12 0.08
95 INT116439 CD8B Negative_regulation of Gene_expression of CCL2 1 0.02 0 0.08
96 INT286899 Binding of IL6 and CCL2 1 0.03 0.92 0.08
97 INT132811 IL1B Positive_regulation of CCL2 1 0.15 0.6 0.08
98 INT132814 TNF Positive_regulation of CCL2 1 0.21 0.6 0.08
99 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07
100 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
101 INT332305 Binding of CRP and Ccl2 1 0.15 0.86 0.06
102 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
103 INT288027 VEGFA Regulation of CCL2 1 0.44 0.26 0.03
104 INT291199 Binding of VEGFA and Angpt1 1 0.08 0.69 0
105 INT132799 IL4 Positive_regulation of Localization of CCL2 1 0.22 0.13 0
106 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
107 INT127457 Ccl2 Positive_regulation of Gene_expression of Slc6a4 1 0.13 0 0
108 INT340423 Il1rn Regulation of Binding of Ccl2 1 0.21 0.99 0
109 INT315397 Binding of IFNA1 and Tp53 1 0.00 0.43 0
110 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
111 INT164895 IL33 Positive_regulation of Gene_expression of CCL2 1 0.16 0.05 0
112 INT337708 Naf1 Regulation of Gene_expression of Tp53 1 0.09 0.22 0
113 INT103680 Serpinf1 Negative_regulation of Positive_regulation of CCL2 1 0.00 0.15 0
114 INT206082 IL6 Positive_regulation of Gene_expression of CCL2 1 0.07 0.3 0
115 INT132790 IL13 Positive_regulation of Localization of CCL2 1 0.21 0.13 0
116 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
117 INT83446 CD40LG Positive_regulation of Localization of CCL2 1 0.00 0.17 0
118 INT355638 OLR1 Positive_regulation of Localization of CCL2 1 0.02 1.42 0
119 INT351977 Binding of Tp53 and Trib3 1 0.01 0.79 0
120 INT132797 IL1B Positive_regulation of Localization of CCL2 1 0.48 0.12 0
121 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
122 INT351976 Binding of Tp53 and Stk11 1 0.13 2.3 0
123 INT286029 Binding of Tp53 and Atf2 1 0.03 0.33 0
124 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
125 INT132798 TNF Positive_regulation of Localization of CCL2 1 0.29 0.12 0
126 INT355642 OLR1 Positive_regulation of Gene_expression of CCL2 1 0.03 2.85 0
127 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
128 INT232514 RS1 Regulation of Gene_expression of CCL2 1 0.00 0.26 0
129 INT103678 Serpinf1 Negative_regulation of CCL2 1 0.00 0.28 0
130 INT265547 Positive_regulation of Tp53 Positive_regulation of Gene_expression of Kras 1 0.01 0.93 0
131 INT103679 Serpinf1 Negative_regulation of Gene_expression of CCL2 1 0.00 0.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to vitamin B3. They are ordered first by their pain relevance and then by number of times they were reported in response to vitamin B3. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
2 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35
3 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
4 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
5 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27
6 INT65698 Localization of CCL2 118 0.81 77.54 32.69
7 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43
8 INT82882 Localization of Ccl2 61 0.80 41.96 28
9 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
10 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28
11 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
12 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
13 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
14 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
15 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
16 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
17 INT106200 Binding of Ccl2 22 0.42 16.7 9.75
18 INT82881 Regulation of Ccl2 19 0.57 15.29 7.19
19 INT81493 Transcription of CCL2 20 0.65 13.63 6.78
20 INT120895 Binding of CCL2 22 0.37 15.86 6.55
21 INT92504 Negative_regulation of Ccl2 17 0.43 8.98 6.29
22 INT83290 Regulation of Gene_expression of Ccl2 8 0.59 9.06 5.56
23 INT103073 Positive_regulation of Positive_regulation of Ccl2 10 0.50 6.74 4.7
24 INT96851 Negative_regulation of Localization of CCL2 14 0.53 5.98 4.57
25 INT117518 Transcription of Ccl2 12 0.68 11.12 3.61
26 INT117519 Positive_regulation of Transcription of Ccl2 5 0.49 6.01 2.54
27 INT82880 Positive_regulation of Localization of Ccl2 4 0.49 2.65 2.31
28 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17
29 INT128993 Negative_regulation of Localization of Ccl2 1 0.42 1.5 2.1
30 INT113907 Regulation of Localization of CCL2 5 0.62 2.46 2.05
31 INT100490 Negative_regulation of Positive_regulation of CCL2 6 0.23 1.48 1.96
32 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
33 INT67980 Positive_regulation of Positive_regulation of CCL2 7 0.49 5.89 1.85
34 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
35 INT123926 Gene_expression of Angpt1 28 0.54 21.74 1.47
36 INT322712 Negative_regulation of Binding of Ccl2 4 0.32 1.29 1.44
37 INT145221 Binding of Tp53 10 0.37 8.59 1.37
38 INT81497 Positive_regulation of Transcription of CCL2 4 0.63 2 1.25
39 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
40 INT294735 Positive_regulation of Binding of Ccl2 2 0.34 0.69 1.11
41 INT117552 Regulation of Regulation of CCL2 1 0.13 0.57 0.8
42 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
43 INT120010 Negative_regulation of Transcription of CCL2 1 0.02 0.99 0.72
44 INT123927 Positive_regulation of Gene_expression of Angpt1 12 0.48 10.18 0.71
45 INT352413 Phosphorylation of Ccl2 1 0.42 0 0.69
46 INT136363 Negative_regulation of Positive_regulation of Ccl2 3 0.32 1.46 0.64
47 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
48 INT222998 Positive_regulation of Negative_regulation of CCL2 1 0.12 1.11 0.59
49 INT102776 Phosphorylation of CCL2 1 0.65 1.55 0.56
50 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
51 INT302877 Regulation of Localization of Ccl2 2 0.19 1.08 0.49
52 INT281138 Regulation of Binding of Ccl2 1 0.07 0.92 0.47
53 INT290397 Positive_regulation of Binding of CCL2 1 0.22 0.99 0.46
54 INT119574 Regulation of Regulation of Ccl2 1 0.04 0.35 0.43
55 INT134259 Negative_regulation of Transcription of Ccl2 2 0.11 0.93 0.42
56 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
57 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
58 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
59 INT290923 Positive_regulation of Angpt1 3 0.48 3.62 0.14
60 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
61 INT306938 Regulation of Transcription of CCL2 1 0.05 0.81 0.13
62 INT239550 Negative_regulation of Binding of CCL2 1 0.18 0 0.13
63 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
64 INT111139 Localization of Tp53 4 0.45 2.4 0.09
65 INT184550 Positive_regulation of Regulation of Ccl2 1 0.46 1.11 0.09
66 INT291188 Regulation of Gene_expression of Angpt1 1 0.31 1.78 0.08
67 INT291183 Negative_regulation of Angpt1 1 0.30 0.89 0.08
68 INT291195 Negative_regulation of Gene_expression of Angpt1 1 0.41 2.29 0.07
69 INT290930 Localization of Angpt1 1 0.21 0 0.06
70 INT290916 Regulation of Angpt1 2 0.31 1.01 0.04
71 INT291193 Binding of Angpt1 1 0.26 1.87 0.04
72 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
73 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
74 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
75 INT152022 Regulation of Negative_regulation of CCL2 1 0.14 0 0
76 INT179957 Positive_regulation of Binding of Tp53 1 0.08 0.48 0
77 INT223765 Negative_regulation of Positive_regulation of Tp53 1 0.07 1.69 0
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