GO:0033596

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Name TSC1-TSC2 complex
Categary Component
Go Slim No
Go Link GO:0033596
Unique Molecular Interactions 120
Total Molecular Interactions 173
Total Single Events 886
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for TSC1-TSC2 complex. They are ordered first by their pain relevance and then by number of times they were reported for TSC1-TSC2 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152857 PRS Regulation of Nefl 1 0.00 0.19 0.77
2 INT152833 Nefl Regulation of Prkcg 1 0.12 0.19 0.77
3 INT152834 Nefl Regulation of Nefh 1 0.10 0.19 0.77
4 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
5 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
6 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13
7 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
8 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09
9 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09
10 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09
11 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08
12 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
13 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
14 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
15 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
16 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03
17 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
18 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
19 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
20 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
21 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
22 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
23 INT225969 Binding of Aqp4 and Nefl 1 0.07 0.3 0
24 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
25 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
26 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0
27 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
28 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0
29 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
30 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
31 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
32 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0
33 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0
34 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
35 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0
36 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
37 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
38 INT259093 Binding of TSC1 and LMO4 1 0.02 0.74 0
39 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0
40 INT217786 TSC1 Regulation of MITF 1 0.00 1.27 0
41 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0
42 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
43 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
44 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 0.01 1.43 0
45 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0
46 INT259092 TSC1 Positive_regulation of Gene_expression of TCEAL1 1 0.01 4.58 0
47 INT268596 Mir10a Regulation of TSC1 1 0.01 0.44 0
48 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0
49 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0
50 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
51 INT300337 Gene_expression of MITF Negative_regulation of Gene_expression of TSC1 1 0.00 0.65 0
52 INT216350 Binding of NEFM and NEFL 1 0.05 0.18 0
53 INT217784 Binding of MITF and TSC1 1 0.00 1.21 0
54 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0
55 INT246797 Tgfb1i1 Positive_regulation of Phosphorylation of Tsc2 1 0.01 0.66 0
56 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0
57 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
58 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0
59 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0
60 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0
61 INT246806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.32 0
62 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0
63 INT246803 Binding of Akt1 and Tsc2 1 0.14 0.85 0
64 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0
65 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0
66 INT217791 TP53 Positive_regulation of TSC1 1 0.04 0.61 0
67 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0
68 INT246790 Gene_expression of Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.02 0 0
69 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0
70 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
71 INT268509 MIR146B Regulation of TSC1 1 0.03 0.44 0
72 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0
73 INT246800 Binding of Tsc2 and Ogg1 1 0.16 0.38 0
74 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0
75 INT216349 Binding of NEFH and NEFL 1 0.05 0.18 0
76 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for TSC1-TSC2 complex. They are ordered first by their pain relevance and then by number of times they were reported in TSC1-TSC2 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94
2 INT61118 Gene_expression of Nefl 11 0.75 4.02 4.02
3 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53
4 INT69990 Negative_regulation of Nefl 11 0.59 2.82 3.38
5 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67
6 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87
7 INT70210 Negative_regulation of NEFL 3 0.30 1.11 1.8
8 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37
9 INT214073 Binding of TSC1 9 0.37 22 1.34
10 INT73465 Transcription of TSC1 4 0.07 3.47 0.96
11 INT89547 Negative_regulation of Gene_expression of NEFL 2 0.36 0.57 0.95
12 INT152841 Positive_regulation of Nefl 2 0.28 0.38 0.92
13 INT89544 Phosphorylation of NEFL 2 0.79 1.05 0.86
14 INT74019 Regulation of TSC1 27 0.35 23.61 0.79
15 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
16 INT69989 Negative_regulation of Gene_expression of Nefl 2 0.43 0.44 0.67
17 INT22714 Binding of Nefl 1 0.32 0 0.64
18 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47
19 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45
20 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
21 INT184803 Localization of TSC1 5 0.37 6.13 0.32
22 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3
23 INT95476 Localization of NEFL 2 0.33 0.42 0.28
24 INT140122 Transcription of Nefl 3 0.62 0.16 0.27
25 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
26 INT322756 Negative_regulation of Tsc1 1 0.07 1.4 0.26
27 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
28 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
29 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21
30 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13
31 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13
32 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
33 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
34 INT271941 Binding of Tsc2 12 0.24 2.96 0.11
35 INT173222 Negative_regulation of Negative_regulation of TSC1 1 0.01 0.92 0.09
36 INT246772 Regulation of Phosphorylation of Tsc2 1 0.26 1.37 0.09
37 INT140120 Positive_regulation of Transcription of Nefl 1 0.43 0.09 0.08
38 INT190703 Regulation of Negative_regulation of TSC1 3 0.06 3.08 0.07
39 INT144613 Regulation of NEFL 2 0.31 1.55 0.07
40 INT271938 Binding of Tsc1 1 0.43 3.18 0.07
41 INT246770 Positive_regulation of Negative_regulation of Tsc2 1 0.20 1.91 0.05
42 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04
43 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04
44 INT261207 Binding of NEFL 2 0.06 1.09 0.04
45 INT242338 Binding of TSC2 2 0.22 1.56 0.04
46 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04
47 INT246758 Gene_expression of Tsc1 1 0.11 0.55 0.04
48 INT271937 Positive_regulation of Binding of Tsc2 1 0.25 0 0.04
49 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03
50 INT190057 Positive_regulation of Negative_regulation of TSC1 2 0.01 1.08 0.03
51 INT271960 Positive_regulation of Binding of TSC1 1 0.25 0.88 0.03
52 INT190054 Negative_regulation of Positive_regulation of TSC1 1 0.01 0.83 0.03
53 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0
54 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0
55 INT228895 Binding of Tsc2 5 0.30 2.41 0
56 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0
57 INT246755 Regulation of Tsc2 4 0.50 1.01 0
58 INT216011 Regulation of TSC2 2 0.26 3.31 0
59 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0
60 INT175424 Regulation of Transcription of TSC1 2 0.05 1.39 0
61 INT271944 Negative_regulation of Phosphorylation of Tsc2 2 0.30 0.42 0
62 INT246761 Positive_regulation of Gene_expression of Tsc2 2 0.41 1.17 0
63 INT271963 Phosphorylation of TSC1 2 0.31 2.02 0
64 INT246777 Regulation of Gene_expression of Tsc2 1 0.19 0 0
65 INT246754 Negative_regulation of Binding of Tsc2 1 0.18 0.12 0
66 INT271905 Positive_regulation of Protein_catabolism of Tsc2 1 0.35 1.46 0
67 INT271965 Negative_regulation of Binding of TSC1 1 0.33 0.44 0
68 INT246748 Regulation of Tsc1 1 0.04 0.05 0
69 INT246747 Negative_regulation of Negative_regulation of Tsc2 1 0.18 0.56 0
70 INT271904 Localization of Tsc2 1 0.41 1.31 0
71 INT246773 Phosphorylation of Tsc1 1 0.13 0.05 0
72 INT246780 Protein_catabolism of Tsc2 1 0.28 0.15 0
73 INT286549 Regulation of Tsc2 1 0.11 0.42 0
74 INT246752 Negative_regulation of Gene_expression of Tsc2 1 0.25 0.52 0
75 INT271913 Protein_catabolism of Tsc1 1 0.51 0.45 0
76 INT182680 Positive_regulation of Gene_expression of NEFL 1 0.22 0.16 0
77 INT271940 Protein_catabolism of Tsc2 1 0.50 0.7 0
78 INT271906 Negative_regulation of Binding of Tsc1 1 0.38 0.06 0
79 INT246759 Positive_regulation of Phosphorylation of Tsc2 1 0.29 9.31 0
80 INT271927 Positive_regulation of Tsc1 1 0.44 0.4 0
81 INT271931 Negative_regulation of Gene_expression of Tsc1 1 0.38 0.44 0
82 INT322758 Positive_regulation of Localization of TSC1 1 0.06 1.4 0
83 INT276884 Regulation of Phosphorylation of TSC2 1 0.25 0.21 0
84 INT246751 Positive_regulation of Binding of Tsc2 1 0.21 0.15 0
85 INT331195 Positive_regulation of Negative_regulation of Tsc1 1 0.18 0.15 0
86 INT246757 Binding of Tsc1 1 0.06 0.19 0
87 INT271909 Positive_regulation of Tsc2 1 0.25 0.06 0
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