GO:0033625

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Name positive regulation of integrin activation
Categary Process
Go Slim No
Go Link GO:0033625
Unique Molecular Interactions 93
Total Molecular Interactions 110
Total Single Events 819
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of integrin activation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of integrin activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
2 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
3 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
4 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95
5 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95
6 INT182189 Binding of CXCL1 and CXCL13 1 0.14 1.24 0.93
7 INT182209 Binding of CXCL12 and CXCL13 1 0.30 1.24 0.93
8 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93
9 INT182204 Binding of CXCL5 and CXCL13 1 0.30 1.24 0.93
10 INT325807 CXCL13 Positive_regulation of CISH 1 0.16 3.65 0.89
11 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
12 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
13 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
14 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
15 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
16 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
17 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
18 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
19 INT236832 CSF2 Regulation of CXCL13 1 0.09 0.34 0.45
20 INT324802 Binding of Cd24a and Siglecg 1 0.03 1.34 0.4
21 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
22 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
23 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
24 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
25 INT236955 Binding of Cxcr5 and Cxcl13 1 0.28 2.26 0.34
26 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
27 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
28 INT237082 Binding of Cxcl9 and Cxcl13 1 0.22 1.51 0.26
29 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
30 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
31 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
32 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
33 INT324824 Positive_regulation of Binding of Cd24a and Siglecg 1 0.03 0.68 0.2
34 INT64964 Binding of Alb and Cd24 1 0.02 0.2 0.2
35 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
36 INT324822 Binding of Cd24a and Hsp90aa1 1 0.10 0.71 0.19
37 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
38 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18
39 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
40 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
41 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
42 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
43 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
44 INT64966 Binding of AGFG1 and Cd24 1 0.00 0.1 0.1
45 INT61385 FANCB Negative_regulation of PLEK 1 0.42 0.13 0.07
46 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
47 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05
48 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05
49 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05
50 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04
51 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
52 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03
53 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
54 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
55 INT308131 PLEK Positive_regulation of F2 1 0.12 0.08 0
56 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0
57 INT285579 Binding of S100A8 and SRC 1 0.05 0.2 0
58 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0
59 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
60 INT289301 Binding of CD59 and Cd24a 1 0.02 1.06 0
61 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0
62 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
63 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0
64 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
65 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
66 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0
67 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0
68 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
69 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0
70 INT286682 Maob Positive_regulation of Positive_regulation of PLEK 1 0.51 0.89 0
71 INT354487 Binding of F9 and PLEK 1 0.52 0.14 0
72 INT299308 SRC Regulation of PI3 1 0.20 0 0
73 INT275985 Binding of PLEK and Gp6 1 0.29 0 0
74 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0
75 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0
76 INT270084 Binding of PLEK and PSMG1 1 0.09 0.26 0
77 INT309906 Binding of EGF and SRC 1 0.11 0.64 0
78 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
79 INT340928 Negative_regulation of SRC Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
80 INT299294 SRC Regulation of VEGFA 1 0.20 0 0
81 INT238120 SRC Positive_regulation of Positive_regulation of STAT3 1 0.71 0 0
82 INT238114 Binding of CSK and SRC 1 0.07 0 0
83 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
84 INT338196 Binding of SRC and CDCP1 1 0.00 0.31 0
85 INT198019 NPY6R Negative_regulation of Gene_expression of SRC 1 0.06 1.75 0
86 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 0.01 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of integrin activation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of integrin activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
2 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
3 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96
4 INT18412 Binding of PLEK 49 0.47 17.82 10.72
5 INT3366 Localization of PLEK 44 0.78 15.83 9.55
6 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
7 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
8 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
9 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81
10 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
11 INT181347 Gene_expression of Cxcl13 9 0.63 9.08 3.75
12 INT111482 Gene_expression of Cd24a 23 0.72 13.74 3.37
13 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
14 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55
15 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
16 INT182238 Binding of CXCL13 5 0.33 5.32 2.37
17 INT220178 Positive_regulation of Cxcl13 5 0.42 5.98 2.21
18 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
19 INT264881 Localization of CXCL13 4 0.42 9.52 1.85
20 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
21 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
22 INT114715 Binding of SRC 8 0.36 4.26 1.32
23 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
24 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
25 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
26 INT236945 Positive_regulation of Gene_expression of Cxcl13 3 0.38 3.98 1.11
27 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
28 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
29 INT236947 Transcription of Cxcl13 2 0.43 1.74 0.84
30 INT236841 Negative_regulation of Gene_expression of CXCL13 3 0.27 2.17 0.83
31 INT182227 Transcription of CXCL13 2 0.60 2.07 0.81
32 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
33 INT340843 Binding of Cd24a 1 0.02 0.24 0.8
34 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
35 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
36 INT181338 Regulation of Cxcl13 1 0.10 0.52 0.69
37 INT325809 Positive_regulation of Positive_regulation of CXCL13 1 0.28 1.19 0.64
38 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
39 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
40 INT340842 Regulation of Gene_expression of Cd24a 1 0.42 0.08 0.53
41 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
42 INT64961 Binding of Cd24 4 0.15 0.64 0.5
43 INT236944 Positive_regulation of Transcription of Cxcl13 1 0.38 1.13 0.49
44 INT82608 Positive_regulation of Phosphorylation of SRC 3 0.49 1.28 0.48
45 INT326696 Regulation of Cd24a 2 0.44 0 0.48
46 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
47 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
48 INT319417 Positive_regulation of Localization of CXCL13 1 0.23 3.84 0.36
49 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
50 INT138051 Negative_regulation of Positive_regulation of SRC 3 0.57 0.84 0.33
51 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
52 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
53 INT236843 Negative_regulation of CXCL13 1 0.27 0.24 0.29
54 INT319429 Positive_regulation of Transcription of CXCL13 1 0.23 1.19 0.26
55 INT164162 Negative_regulation of Phosphorylation of SRC 3 0.29 2.12 0.21
56 INT42592 Negative_regulation of Transcription of PLEK 1 0.41 0 0.21
57 INT325808 Regulation of Gene_expression of CXCL13 1 0.25 0.95 0.21
58 INT42593 Transcription of PLEK 1 0.67 0 0.2
59 INT235725 Regulation of SRC 7 0.44 4.71 0.19
60 INT236954 Binding of Cxcl13 1 0.29 1.13 0.17
61 INT108192 Regulation of Binding of PLEK 1 0.60 0.17 0.17
62 INT16719 Positive_regulation of Positive_regulation of PLEK 1 0.45 0.13 0.14
63 INT299357 Localization of SRC 1 0.51 0 0.09
64 INT254742 Gene_expression of Cd24 1 0.11 0.46 0.09
65 INT254732 Localization of Cd24 1 0.12 0.46 0.09
66 INT355318 Positive_regulation of Gene_expression of Cd24a 1 0.47 1.17 0.09
67 INT254740 Negative_regulation of Cd24 1 0.07 0.08 0.07
68 INT238187 Regulation of Positive_regulation of SRC 2 0.26 1.37 0.05
69 INT238193 Regulation of Gene_expression of SRC 1 0.44 0 0.03
70 INT326709 Negative_regulation of Gene_expression of Cd24a 3 0.40 0.86 0
71 INT200854 Transcription of Cd24a 2 0.66 0.4 0
72 INT355323 Negative_regulation of Cd24a 1 0.40 0.08 0
73 INT180099 Binding of Plek 1 0.02 0 0
74 INT238185 Regulation of Binding of SRC 1 0.44 0.06 0
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