GO:0033673

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Name negative regulation of kinase activity
Categary Process
Go Slim No
Go Link GO:0033673
Unique Molecular Interactions 78
Total Molecular Interactions 88
Total Single Events 552
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
2 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
3 INT118001 Csk Regulation of Trpv1 1 0.08 0.09 0.58
4 INT120870 Binding of Wnk1 and Sptlc1 1 0.14 1.24 0.56
5 INT118002 Binding of Trpv1 and Csk 1 0.06 0.08 0.38
6 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34
7 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
8 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
9 INT220521 Ugt1a6b Positive_regulation of Cdkn1b 1 0.01 2.38 0.31
10 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
11 INT210785 Cdkn1c Positive_regulation of Itgbl1 1 0.38 0 0.23
12 INT322543 Binding of FOXO3 and Cdkn1b 1 0.08 0.84 0.19
13 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
14 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
15 INT148800 VEGFA Positive_regulation of Positive_regulation of Csk 1 0.06 0 0.14
16 INT148802 Negative_regulation of VEGFA Positive_regulation of Csk 1 0.05 0 0.14
17 INT148801 VEGFA Positive_regulation of Csk 1 0.06 0 0.14
18 INT340421 Il1a Positive_regulation of Csk 1 0.00 0.98 0.12
19 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
20 INT301641 Irs2 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
21 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
22 INT301628 Irs2 Negative_regulation of Transcription of G6pc 1 0.04 0.65 0.08
23 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
24 INT301646 Srebf1 Negative_regulation of Gene_expression of Irs2 1 0.08 0.62 0.08
25 INT220514 Ppara Positive_regulation of Gene_expression of Cdkn1b 1 0.08 1 0.08
26 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
27 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
28 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
29 INT257879 Negative_regulation of Eif4e Positive_regulation of Cdkn1b 1 0.28 0.54 0.06
30 INT204079 HP Positive_regulation of Gene_expression of Cdkn1b 1 0.00 0.6 0.05
31 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
32 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
33 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
34 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
35 INT270659 Wnk1 Regulation of Napg 1 0.04 1.12 0.04
36 INT270661 Regulation of Wnk1 Regulation of Napg 1 0.04 1.13 0.04
37 INT184101 Binding of Irs2 and Sh2 1 0.05 0.15 0.03
38 INT184136 Binding of Socs7 and Irs2 1 0.13 0.15 0.03
39 INT220512 Cav1 Regulation of Positive_regulation of Cdkn1b 1 0.06 0.85 0.03
40 INT184131 Binding of Socs6 and Irs2 1 0.11 0.2 0.03
41 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
42 INT295045 Akt1 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.09 2.06 0
43 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
44 INT215686 Cdkn2b Negative_regulation of Cdkn1c 1 0.01 0 0
45 INT322546 Negative_regulation of PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
46 INT246217 Cdkn1b Positive_regulation of VEGFA 1 0.03 1.13 0
47 INT323120 Negative_regulation of Irs2 Positive_regulation of Positive_regulation of Akt1 1 0.37 0 0
48 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
49 INT321720 Binding of Ppp1r13b and Irs2 1 0.11 0.13 0
50 INT322536 Negative_regulation of Ctsb Positive_regulation of Gene_expression of Cdkn1b 1 0.02 0.3 0
51 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
52 INT322547 FOXO3 Regulation of Transcription of Cdkn1b 1 0.12 0.32 0
53 INT215697 Lamtor1 Negative_regulation of Cdkn1b 1 0.02 0 0
54 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0
55 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0
56 INT322548 FOXO3 Regulation of Cdkn1b 1 0.09 0.23 0
57 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
58 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
59 INT322545 PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
60 INT322540 Positive_regulation of Plaur Regulation of Gene_expression of Cdkn1b 1 0.06 0 0
61 INT240892 Negative_regulation of Ros1 Negative_regulation of Phosphorylation of Irs2 1 0.11 0.17 0
62 INT322537 Ctsb Regulation of Gene_expression of Cdkn1b 1 0.01 0.1 0
63 INT354115 MIR222 Regulation of Gene_expression of CDKN1B 1 0.07 0.98 0
64 INT240884 Negative_regulation of Ros1 Negative_regulation of Gene_expression of Irs2 1 0.15 0.12 0
65 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0
66 INT322538 Plaur Regulation of Cdkn1b 1 0.14 0.19 0
67 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0
68 INT215695 Lamtor1 Negative_regulation of Cdkn1c 1 0.02 0 0
69 INT215704 Stmn1 Negative_regulation of Cdkn1c 1 0.00 0 0
70 INT215692 Stmn1 Negative_regulation of Cdkn1b 1 0.00 0 0
71 INT201756 CDKN1B Positive_regulation of Localization of Ccnd1 1 0.04 0 0
72 INT215694 Cdkn2b Negative_regulation of Cdkn1b 1 0.01 0 0
73 INT220519 Ugt1a6b Positive_regulation of Negative_regulation of Cdkn1b 1 0.01 0.24 0
74 INT322539 Ctsb Regulation of Cdkn1b 1 0.03 0.19 0
75 INT220523 Ugt1a6b Positive_regulation of Gene_expression of Cdkn1b 1 0.01 0.24 0
76 INT149996 Npy6r Negative_regulation of Csk 1 0.01 0 0
77 INT323121 Negative_regulation of Irs2 Negative_regulation of Positive_regulation of Akt1 1 0.34 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
2 INT140378 Negative_regulation of Irs2 4 0.57 1.77 2.86
3 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
4 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22
5 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
6 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9
7 INT148788 Binding of Csk 2 0.12 2.14 1.89
8 INT132837 Positive_regulation of Csk 5 0.45 1.75 1.79
9 INT148937 Positive_regulation of Csk 2 0.13 2.25 1.63
10 INT137505 Positive_regulation of Cdkn1b 18 0.67 10.55 1.54
11 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
12 INT114220 Negative_regulation of Gene_expression of Cdkn1b 4 0.33 4.11 1.23
13 INT93625 Gene_expression of Cdkn1c 2 0.75 0.42 1.2
14 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
15 INT111036 Positive_regulation of Cdkn1b 16 0.45 9 1.06
16 INT111037 Positive_regulation of Gene_expression of Cdkn1b 5 0.39 11.17 1.06
17 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
18 INT132835 Phosphorylation of Csk 2 0.36 0 0.83
19 INT220498 Negative_regulation of Gene_expression of Cdkn1b 9 0.21 7.48 0.8
20 INT93621 Positive_regulation of Gene_expression of Cdkn1c 1 0.67 0.42 0.77
21 INT115252 Phosphorylation of Irs2 5 0.65 3.1 0.7
22 INT62688 Binding of Wnk1 2 0.17 2.83 0.63
23 INT148786 Negative_regulation of Csk 4 0.09 0.97 0.62
24 INT241621 Regulation of Cdkn1b 2 0.06 0.36 0.62
25 INT113850 Negative_regulation of Cdkn1b 4 0.42 3.45 0.6
26 INT132836 Regulation of Csk 1 0.30 0.42 0.59
27 INT98786 Positive_regulation of Gene_expression of Cdkn1b 21 0.67 8.7 0.56
28 INT115254 Negative_regulation of Phosphorylation of Irs2 2 0.46 2.61 0.56
29 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
30 INT130791 Regulation of Csk 1 0.07 0.86 0.54
31 INT322158 Phosphorylation of Csk 2 0.10 1.49 0.52
32 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48
33 INT137504 Positive_regulation of Positive_regulation of Cdkn1b 2 0.45 1.71 0.45
34 INT163829 Positive_regulation of Localization of Cdkn1b 2 0.17 0.96 0.45
35 INT15332 Regulation of Irs2 2 0.04 0.56 0.43
36 INT158518 Regulation of Regulation of Irs2 1 0.03 0.61 0.34
37 INT285500 Binding of Cdkn1c 1 0.18 0.76 0.34
38 INT204065 Regulation of Gene_expression of Cdkn1b 1 0.06 3.49 0.34
39 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
40 INT15331 Localization of Irs2 1 0.06 0 0.33
41 INT158519 Negative_regulation of Gene_expression of Irs2 1 0.02 0.56 0.33
42 INT240825 Gene_expression of Irs2 14 0.78 3.88 0.32
43 INT158520 Gene_expression of Irs2 1 0.03 0.55 0.32
44 INT126864 Negative_regulation of Csk 1 0.12 0.58 0.3
45 INT90168 Regulation of Wnk1 2 0.04 0.63 0.29
46 INT228468 Localization of Csk 1 0.12 0.79 0.29
47 INT228467 Positive_regulation of Gene_expression of Csk 1 0.08 0.79 0.29
48 INT228473 Positive_regulation of Localization of Csk 1 0.08 0.79 0.29
49 INT228471 Gene_expression of Csk 1 0.11 0.79 0.29
50 INT203616 Positive_regulation of CDKN1C 2 0.60 12.62 0.27
51 INT164728 Positive_regulation of Cdkn1c 1 0.36 0.3 0.26
52 INT240819 Phosphorylation of Irs2 10 0.71 4.75 0.25
53 INT248401 Gene_expression of CDKN1C 21 0.67 14.52 0.23
54 INT250513 Negative_regulation of Irs2 8 0.56 4.04 0.23
55 INT179043 Negative_regulation of Cdkn1b 7 0.36 5.99 0.22
56 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
57 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
58 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
59 INT179044 Regulation of Cdkn1b 4 0.22 2.64 0.18
60 INT248400 Regulation of CDKN1C 1 0.45 2.92 0.17
61 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
62 INT257863 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.45 0.43 0.14
63 INT148793 Negative_regulation of Positive_regulation of Csk 1 0.06 0 0.14
64 INT248403 Positive_regulation of Gene_expression of CDKN1C 1 0.40 7.77 0.14
65 INT257865 Negative_regulation of Protein_catabolism of Cdkn1b 1 0.42 0.43 0.14
66 INT257858 Protein_catabolism of Cdkn1b 1 0.64 0.43 0.14
67 INT148789 Negative_regulation of Binding of Csk 1 0.06 0 0.13
68 INT179034 Binding of Cdkn1b 7 0.31 5.12 0.12
69 INT15329 Regulation of Localization of Irs2 1 0.02 0 0.1
70 INT220494 Negative_regulation of Positive_regulation of Cdkn1b 1 0.14 0.35 0.1
71 INT233868 Localization of CDKN1B 2 0.73 0.37 0.09
72 INT301519 Positive_regulation of Negative_regulation of Irs2 2 0.50 0.93 0.09
73 INT349622 Negative_regulation of Negative_regulation of Irs2 1 0.41 1.98 0.09
74 INT210778 Negative_regulation of Cdkn1c 1 0.36 0 0.08
75 INT115257 Positive_regulation of Phosphorylation of Irs2 1 0.34 0.26 0.08
76 INT15333 Positive_regulation of Localization of Irs2 1 0.04 0 0.08
77 INT301523 Positive_regulation of Gene_expression of Irs2 1 0.09 0.68 0.08
78 INT233871 Negative_regulation of Protein_catabolism of CDKN1B 1 0.57 0.27 0.08
79 INT240855 Negative_regulation of Phosphorylation of Irs2 4 0.34 2.18 0.07
80 INT301577 Binding of Irs2 2 0.26 0.62 0.07
81 INT131835 Positive_regulation of Wnk1 1 0.07 1.28 0.07
82 INT15330 Binding of Irs2 1 0.03 0 0.07
83 INT179033 Negative_regulation of Regulation of Cdkn1b 1 0.36 1.34 0.05
84 INT303073 Positive_regulation of Gene_expression of Csk 1 0.13 0.25 0.04
85 INT220489 Regulation of Gene_expression of Cdkn1b 1 0.20 1.57 0.04
86 INT184067 Protein_catabolism of Irs2 1 0.26 0.4 0.04
87 INT246285 Gene_expression of Cdkn1c 1 0.03 0.43 0.04
88 INT303070 Gene_expression of Csk 1 0.14 0.25 0.04
89 INT240853 Regulation of Irs2 2 0.45 1.1 0.03
90 INT203619 Positive_regulation of Positive_regulation of CDKN1C 1 0.13 0.34 0.03
91 INT123524 Phosphorylation of Cdkn1b 4 0.29 2.29 0
92 INT248399 Negative_regulation of CDKN1C 2 0.37 2.71 0
93 INT276307 Protein_catabolism of Cdkn1b 2 0.45 2.57 0
94 INT295040 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.21 1 0
95 INT144997 Negative_regulation of Wnk1 1 0.08 0 0
96 INT325178 Regulation of Positive_regulation of CDKN1B 1 0.44 0.05 0
97 INT325180 Negative_regulation of Gene_expression of CDKN1B 1 0.57 0.25 0
98 INT322505 Transcription of Cdkn1b 1 0.26 1.02 0
99 INT323104 Positive_regulation of Irs2 1 0.50 1.37 0
100 INT322508 Regulation of Localization of Cdkn1b 1 0.10 0.4 0
101 INT204070 Negative_regulation of Positive_regulation of Cdkn1b 1 0.05 0.47 0
102 INT323106 Negative_regulation of Gene_expression of Irs2 1 0.37 0 0
103 INT246216 Localization of Cdkn1b 1 0.42 0.22 0
104 INT323101 Transcription of Irs2 1 0.60 0.52 0
105 INT322519 Negative_regulation of Transcription of Cdkn1b 1 0.16 0.07 0
106 INT322517 Positive_regulation of Transcription of Cdkn1b 1 0.17 0.64 0
107 INT240829 Localization of Irs2 1 0.51 0.05 0
108 INT246212 Positive_regulation of Positive_regulation of Cdkn1b 1 0.39 1.12 0
109 INT248402 Negative_regulation of Positive_regulation of CDKN1C 1 0.37 1.04 0
110 INT240851 Regulation of Gene_expression of Irs2 1 0.35 0.12 0
111 INT276316 Positive_regulation of Negative_regulation of Cdkn1b 1 0.07 0.56 0
112 INT246215 Positive_regulation of Localization of Cdkn1b 1 0.28 0.22 0
113 INT323098 Positive_regulation of Transcription of Irs2 1 0.44 0 0
114 INT322506 Negative_regulation of Phosphorylation of Cdkn1b 1 0.16 0.07 0
115 INT321699 Negative_regulation of Binding of Irs2 1 0.30 0 0
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