GO:0033686

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Name positive regulation of luteinizing hormone secretion
Categary Process
Go Slim No
Go Link GO:0033686
Unique Molecular Interactions 139
Total Molecular Interactions 208
Total Single Events 1682
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of luteinizing hormone secretion. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of luteinizing hormone secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
3 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
4 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
5 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
6 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
7 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
8 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
9 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
10 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
11 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
12 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
13 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
14 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
15 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
16 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
17 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
18 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
19 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
20 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
21 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
22 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
23 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
24 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
25 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
26 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
27 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
28 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
29 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
30 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
31 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
32 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
33 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
34 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
35 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
36 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
37 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
38 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
39 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
40 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
41 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
42 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
43 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
44 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
45 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
46 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
47 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
48 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
49 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
50 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
51 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
52 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
53 INT155084 Kiss1 Positive_regulation of Kiss1r 1 0.66 0.13 0.15
54 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
55 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
56 INT324560 Binding of Kiss1r and Kiss1 1 0.35 0 0.14
57 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
58 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
59 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
60 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
61 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
62 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
63 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
64 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
65 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
66 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
67 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
68 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
69 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11
70 INT323879 LEP Regulation of SOAT1 1 0.15 1.15 0.1
71 INT204086 TNF Positive_regulation of Gene_expression of LEP 1 0.48 0.74 0.1
72 INT123864 Lep Positive_regulation of Positive_regulation of Cck 1 0.45 0.1 0.09
73 INT242324 Lep Regulation of Gene_expression of Ucp1 1 0.58 1.47 0.09
74 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
75 INT306794 Binding of LEP and COPD 1 0.15 3.94 0.09
76 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09
77 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
78 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08
79 INT123866 Lep Negative_regulation of Olfr544 1 0.00 0.09 0.08
80 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
81 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
82 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
83 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07
84 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07
85 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
86 INT324559 Atp6v1e1 Positive_regulation of Localization of Kiss1 1 0.16 0.52 0.06
87 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
88 INT323878 Binding of LEP and MMP13 1 0.17 0.77 0.05
89 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
90 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
91 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
92 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
93 INT267153 Binding of LEP and SUGT1 1 0.02 0.69 0.05
94 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
95 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
96 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
97 INT222534 Gnrh1 Positive_regulation of Localization of Lep 1 0.07 0 0.04
98 INT249046 Binding of LEP and ARID1B 1 0.01 1.3 0.03
99 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
100 INT253374 Lep Positive_regulation of Phosphorylation of Eif4ebp1 1 0.04 0.16 0.03
101 INT253375 Lep Positive_regulation of Phosphorylation of Rps6kb1 1 0.41 0.16 0.03
102 INT253414 Lep Negative_regulation of BCL2A1 1 0.16 0 0.03
103 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03
104 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
105 INT213160 AGT Positive_regulation of Gene_expression of LEP 1 0.08 1.29 0.03
106 INT138526 Lep Positive_regulation of Localization of Gnrh1 1 0.39 0 0
107 INT324564 Atp6v1e1 Positive_regulation of Kiss1 1 0.15 0.21 0
108 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
109 INT187675 DBT Positive_regulation of Gene_expression of LEP 1 0.04 0.27 0
110 INT324567 S100a10 Positive_regulation of Gene_expression of Kiss1 1 0.28 0 0
111 INT249045 CENPJ Regulation of Regulation of LEP 1 0.14 0.81 0
112 INT324565 Tpt1 Positive_regulation of Kiss1 1 0.13 0.77 0
113 INT324570 Binding of ANTXR2 and Kiss1 1 0.42 0.06 0
114 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
115 INT225085 Binding of ADM and Negative_regulation of LEP 1 0.16 1.04 0
116 INT289532 Lep Regulation of Arc 1 0.04 0.19 0
117 INT187667 DBT Positive_regulation of Localization of LEP 1 0.05 0.55 0
118 INT288214 Lep Negative_regulation of Gene_expression of Ins1 1 0.35 0.05 0
119 INT165146 Kiss1 Regulation of Nppa 1 0.42 0 0
120 INT204085 Binding of LEP and TNF 1 0.37 0.39 0
121 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0
122 INT253364 Lep Positive_regulation of Rps6kb1 1 0.30 0.08 0
123 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
124 INT253360 Lep Positive_regulation of Eif4ebp1 1 0.01 0.08 0
125 INT289520 Lep Regulation of Prkag1 1 0.00 0.08 0
126 INT218731 Lep Positive_regulation of Gene_expression of Trh 1 0.19 0.07 0
127 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0
128 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0
129 INT249047 CENPJ Negative_regulation of LEP 1 0.22 0.8 0
130 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 0.20 5.03 0
131 INT253367 Il6 Regulation of Gene_expression of Lep 1 0.31 1.66 0
132 INT332904 Binding of LEP and SNRNP70 1 0.00 1.34 0
133 INT324562 Binding of Arc and Kiss1 1 0.24 0.51 0
134 INT138525 Lep Positive_regulation of Localization of LH 1 0.18 0 0
135 INT289527 Lep Regulation of Rps6kb1 1 0.10 0.07 0
136 INT324557 Binding of Gnrh1 and Kiss1 1 0.48 0.51 0
137 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of luteinizing hormone secretion. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of luteinizing hormone secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
2 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
3 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
4 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
5 INT75908 Regulation of LEP 77 0.60 60.16 15.19
6 INT73641 Regulation of Lep 45 0.62 26.2 12.59
7 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
8 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
9 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
10 INT82082 Localization of Lep 63 0.81 26.41 8.56
11 INT75907 Binding of LEP 53 0.46 46.65 8.44
12 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
13 INT65356 Localization of LEP 46 0.79 41.17 5.43
14 INT97391 Binding of Lep 18 0.48 8.97 4.47
15 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
16 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
17 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
18 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
19 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
20 INT83392 Transcription of Lep 6 0.54 5.07 2.04
21 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
22 INT278567 Gene_expression of Kiss1 2 0.78 36 1.3
23 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
24 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
25 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
26 INT156533 Transcription of LEP 9 0.69 4.35 0.74
27 INT155081 Gene_expression of Kiss1 5 0.78 1.32 0.69
28 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
29 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
30 INT324555 Positive_regulation of Gene_expression of Kiss1 1 0.69 12.97 0.48
31 INT155079 Positive_regulation of Kiss1 1 0.70 0.46 0.48
32 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
33 INT324550 Positive_regulation of Kiss1 1 0.69 7.03 0.45
34 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
35 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
36 INT155083 Regulation of Gene_expression of Kiss1 1 0.62 0.32 0.29
37 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
38 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
39 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
40 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
41 INT155076 Positive_regulation of Positive_regulation of Kiss1 1 0.47 0.16 0.17
42 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
43 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
44 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
45 INT155078 Positive_regulation of Gene_expression of Kiss1 1 0.70 0.14 0.15
46 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
47 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
48 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
49 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
50 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
51 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
52 INT324556 Regulation of Kiss1 1 0.27 3.35 0.12
53 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
54 INT324554 Negative_regulation of Gene_expression of Kiss1 1 0.43 1.17 0.1
55 INT187729 Positive_regulation of Binding of LEP 1 0.18 0.3 0.08
56 INT324553 Localization of Kiss1 1 0.75 1.72 0.06
57 INT324548 Regulation of Gene_expression of Kiss1 1 0.62 4.65 0.06
58 INT324545 Negative_regulation of Kiss1 1 0.43 0.54 0.05
59 INT324542 Negative_regulation of Positive_regulation of Kiss1 1 0.43 0.81 0.03
60 INT253406 Negative_regulation of Positive_regulation of Lep 2 0.41 0.74 0
61 INT165145 Protein_catabolism of Kiss1 1 0.84 0 0
62 INT324549 Transcription of Kiss1 1 0.53 0 0
63 INT157243 Negative_regulation of Transcription of LEP 1 0.02 0.09 0
64 INT324543 Positive_regulation of Regulation of Kiss1 1 0.41 0 0
65 INT324544 Positive_regulation of Positive_regulation of Kiss1 1 0.44 0.05 0
66 INT309421 Positive_regulation of Regulation of Lep 1 0.41 0.61 0
67 INT288213 Positive_regulation of Negative_regulation of Lep 1 0.47 0.06 0
68 INT165144 Negative_regulation of Protein_catabolism of Kiss1 1 0.40 0 0
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