GO:0033690

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Name positive regulation of osteoblast proliferation
Categary Process
Go Slim No
Go Link GO:0033690
Unique Molecular Interactions 87
Total Molecular Interactions 124
Total Single Events 1105
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of osteoblast proliferation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of osteoblast proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
2 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
3 INT70947 Penk Regulation of Hpse 1 0.20 0 0.96
4 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
5 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
6 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
7 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
8 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
9 INT352387 Binding of CFP and HPSE 1 0.01 1.25 0.46
10 INT177440 Binding of HPSE and Gnrh1 1 0.00 1.82 0.45
11 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
12 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
13 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
14 INT245640 Nr3c2 Regulation of Positive_regulation of Hpse 1 0.08 0.66 0.26
15 INT118418 Gata1 Positive_regulation of Transcription of Tac2 1 0.61 0.77 0.25
16 INT118419 Binding of Gata1 and Tac2 1 0.31 0.7 0.24
17 INT319555 gr Positive_regulation of Positive_regulation of Hpse 1 0.09 0.11 0.22
18 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
19 INT222499 Il10 Regulation of Positive_regulation of Hpse 1 0.00 0.8 0.19
20 INT222531 Il6 Positive_regulation of Hpse 1 0.00 0.61 0.18
21 INT222414 Tlr4 Positive_regulation of Hpse 1 0.00 0.61 0.18
22 INT245641 Nr3c2 Regulation of Gene_expression of Hpse 1 0.14 2.67 0.17
23 INT222505 Gene_expression of Crh Negative_regulation of Gene_expression of Hpse 1 0.02 0.55 0.17
24 INT222420 Tlr4 Positive_regulation of Positive_regulation of Hpse 1 0.00 0.67 0.15
25 INT222551 Il6 Positive_regulation of Positive_regulation of Hpse 1 0.01 0.5 0.13
26 INT311191 ecs Negative_regulation of HPSE 1 0.00 0.94 0.12
27 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
28 INT341879 Oxt Negative_regulation of Positive_regulation of Hpse 1 0.01 0.83 0.11
29 INT186539 Crh Regulation of Hpse 1 0.09 0.52 0.1
30 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
31 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08
32 INT245642 Nr3c1 Regulation of Gene_expression of Hpse 1 0.05 1.33 0.08
33 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
34 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
35 INT159461 SCN5A Negative_regulation of HPSE 1 0.00 0 0.07
36 INT159463 Ptprn2 Negative_regulation of HPSE 1 0.00 0 0.07
37 INT118417 Gata1 Regulation of Gene_expression of Serpinb9g 1 0.17 0.12 0.06
38 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
39 INT330487 Binding of MME and HPSE 1 0.35 0 0.06
40 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
41 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
42 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
43 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
44 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
45 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
46 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0
47 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
48 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0
49 INT233267 Hoxa10 Regulation of Itgb3 1 0.15 0.14 0
50 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
51 INT185733 Hpse Positive_regulation of Gene_expression of Tnfrsf11b 1 0.20 0.24 0
52 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
53 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
54 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0
55 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
56 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0
57 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
58 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0
59 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
60 INT162510 Binding of ITPR1 and HPSE 1 0.02 0.05 0
61 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
62 INT317597 Binding of Gnrh1 and Hpse 1 0.08 0 0
63 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
64 INT222537 Binding of Nmu and Hpse 1 0.01 0.15 0
65 INT233270 Meis1 Regulation of Gene_expression of Itgb3 1 0.47 0 0
66 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of osteoblast proliferation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of osteoblast proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53
2 INT12575 Regulation of Hpse 33 0.59 17.7 18.45
3 INT49474 Gene_expression of Hpse 24 0.55 20.11 10.03
4 INT65554 Positive_regulation of Hpse 13 0.69 8.16 5.17
5 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09
6 INT68978 Regulation of Positive_regulation of Hpse 6 0.45 1.88 4.02
7 INT61734 Regulation of HPSE 16 0.60 13.05 3.5
8 INT13321 Negative_regulation of Hpse 11 0.56 4.64 3.39
9 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
10 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
11 INT69621 Positive_regulation of Positive_regulation of Hpse 7 0.42 4.1 2.85
12 INT96338 Gene_expression of HPSE 17 0.75 18.71 2.73
13 INT13414 Regulation of Regulation of Hpse 4 0.16 1.71 2.55
14 INT175797 Regulation of Gene_expression of Hpse 6 0.07 6.52 2.49
15 INT74707 Negative_regulation of Hpse 4 0.58 2.29 1.73
16 INT33591 Negative_regulation of Positive_regulation of Hpse 6 0.32 3.42 1.63
17 INT118412 Gene_expression of Gata1 5 0.62 0.83 1.6
18 INT129492 Gene_expression of Hpse 11 0.75 6.56 1.59
19 INT74955 Negative_regulation of HPSE 6 0.57 4.75 1.57
20 INT118413 Positive_regulation of Gene_expression of Gata1 3 0.40 0.68 1.56
21 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
22 INT65553 Regulation of Hpse 6 0.27 3.89 1.37
23 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
24 INT148638 Protein_catabolism of Hpse 1 0.48 1.09 1.28
25 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
26 INT175794 Negative_regulation of Gene_expression of Hpse 2 0.12 1.82 1.08
27 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
28 INT96229 Localization of HPSE 3 0.20 2.76 1.05
29 INT114664 Binding of BMP2 12 0.37 6.54 0.91
30 INT55580 Localization of Hpse 5 0.23 3.51 0.89
31 INT109854 Negative_regulation of Positive_regulation of Hpse 1 0.23 0 0.81
32 INT65552 Binding of Hpse 2 0.30 2.48 0.8
33 INT144995 Positive_regulation of Gata1 1 0.37 0.14 0.71
34 INT96339 Protein_catabolism of HPSE 5 0.96 2.87 0.63
35 INT317596 Positive_regulation of Gene_expression of Hpse 3 0.14 2.24 0.6
36 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
37 INT129493 Protein_catabolism of Hpse 2 0.55 2.81 0.57
38 INT177436 Binding of HPSE 2 0.47 1.81 0.52
39 INT85808 Localization of BMP2 7 0.77 1.94 0.51
40 INT190590 Localization of Hpse 2 0.28 0.49 0.48
41 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
42 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
43 INT177437 Transcription of HPSE 2 0.23 3.44 0.41
44 INT84900 Positive_regulation of Localization of Hpse 1 0.16 0.16 0.41
45 INT319548 Positive_regulation of Localization of Hpse 1 0.17 0.08 0.38
46 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
47 INT129494 Regulation of Gene_expression of Hpse 2 0.23 1.36 0.36
48 INT129495 Negative_regulation of Gene_expression of Hpse 1 0.36 0.52 0.36
49 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
50 INT74954 Positive_regulation of Positive_regulation of HPSE 2 0.40 0.45 0.34
51 INT55582 Positive_regulation of Negative_regulation of Hpse 2 0.13 0.56 0.32
52 INT177439 Negative_regulation of Positive_regulation of HPSE 1 0.21 1.48 0.32
53 INT175796 Binding of Hpse 6 0.35 2.19 0.28
54 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
55 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
56 INT125780 Negative_regulation of Itgb3 2 0.39 0.66 0.25
57 INT96337 Positive_regulation of Gene_expression of HPSE 1 0.67 2.28 0.25
58 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
59 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
60 INT91278 Positive_regulation of Itgb3 4 0.31 1.73 0.19
61 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
62 INT233246 Localization of Itgb3 3 0.54 0.25 0.17
63 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
64 INT239859 Protein_catabolism of Itgb3 1 0.64 0.25 0.17
65 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
66 INT220570 Transcription of Gata1 2 0.05 0.91 0.14
67 INT145276 Transcription of Hpse 1 0.53 0.65 0.14
68 INT145275 Regulation of Transcription of Hpse 1 0.27 0.65 0.14
69 INT233217 Gene_expression of Itgb3 16 0.75 0.98 0.11
70 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
71 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
72 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
73 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
74 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
75 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
76 INT233253 Regulation of Gene_expression of Itgb3 1 0.41 0.34 0.09
77 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
78 INT74953 Positive_regulation of Regulation of HPSE 2 0.49 1.02 0.07
79 INT118191 Regulation of Regulation of HPSE 2 0.26 0.87 0.07
80 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06
81 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
82 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
83 INT347453 Negative_regulation of Regulation of Hpse 1 0.12 0.3 0.04
84 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
85 INT219663 Binding of Itgb3 1 0.08 1.18 0.03
86 INT349102 Positive_regulation of Gene_expression of Hpse 1 0.03 0.21 0.03
87 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03
88 INT233234 Negative_regulation of Gene_expression of Itgb3 3 0.29 0.65 0
89 INT297757 Transcription of Lrp5 2 0.68 0.82 0
90 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
91 INT297820 Regulation of Transcription of Lrp5 2 0.44 0.83 0
92 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
93 INT196031 Binding of Bmp2 1 0.16 0 0
94 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
95 INT233231 Regulation of Transcription of Itgb3 1 0.30 0.12 0
96 INT233238 Negative_regulation of Localization of Itgb3 1 0.29 0 0
97 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
98 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
99 INT342375 Positive_regulation of Binding of Lrp5 1 0.46 0.85 0
100 INT296566 Regulation of Binding of Hpse 1 0.02 0.84 0
101 INT233251 Regulation of Localization of Itgb3 1 0.30 0 0
102 INT335965 Negative_regulation of Localization of HPSE 1 0.11 0.93 0
103 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
104 INT262679 Phosphorylation of Gata1 1 0.18 0.55 0
105 INT233240 Negative_regulation of Transcription of Itgb3 1 0.29 0 0
106 INT233257 Transcription of Itgb3 1 0.48 0.11 0
107 INT233227 Positive_regulation of Transcription of Itgb3 1 0.47 0.12 0
108 INT233228 Regulation of Itgb3 1 0.30 0 0
109 INT262696 Binding of Gata1 1 0.08 0.56 0
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