GO:0033861

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Name negative regulation of NAD(P)H oxidase activity
Categary Process
Go Slim No
Go Link GO:0033861
Unique Molecular Interactions 256
Total Molecular Interactions 342
Total Single Events 5793
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of NAD(P)H oxidase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of NAD(P)H oxidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
2 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
3 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
4 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
5 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
6 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
7 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
8 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
9 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
10 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
11 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
12 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
13 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
14 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
15 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
16 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
17 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
18 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
19 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
20 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
21 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
22 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
23 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
24 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
25 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
26 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
27 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
28 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
29 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
30 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
31 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
32 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
33 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
34 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
35 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
36 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
37 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
38 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
39 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
40 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
41 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
42 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31
43 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
44 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
45 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
46 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
47 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
48 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
49 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
50 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27
51 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27
52 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
53 INT291261 INS Positive_regulation of Phosphorylation of Mdk 1 0.01 0.28 0.25
54 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25
55 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
56 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
57 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
58 INT63196 INS Positive_regulation of IL2 1 0.10 0.3 0.23
59 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
60 INT63195 INS Positive_regulation of CD8A 1 0.19 0.3 0.23
61 INT63199 INS Positive_regulation of PGR 1 0.11 0.3 0.23
62 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23
63 INT108808 Binding of IAPP and INS 1 0.32 1.36 0.23
64 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22
65 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22
66 INT214481 ROS1 Negative_regulation of Gene_expression of INS 1 0.00 0.37 0.22
67 INT39263 POMC Negative_regulation of INS 1 0.23 0.6 0.22
68 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
69 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
70 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
71 INT78622 POMC Positive_regulation of Localization of INS 1 0.07 0 0.2
72 INT3592 INS Positive_regulation of AVP 1 0.05 0.28 0.2
73 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2
74 INT3591 Negative_regulation of INS Positive_regulation of AVP 1 0.04 0.28 0.2
75 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
76 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
77 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
78 INT110717 CGA Positive_regulation of Localization of INS 1 0.03 0.5 0.19
79 INT32395 POMC Positive_regulation of INS 1 0.41 0.52 0.19
80 INT300563 Binding of Drd5 and ADHD1 1 0.01 1.13 0.19
81 INT15523 INS Negative_regulation of FFAR1 1 0.02 0.35 0.16
82 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16
83 INT311227 INS Negative_regulation of HBA1 1 0.01 0.52 0.16
84 INT71548 ADRA2C Negative_regulation of Localization of INS 1 0.04 0.13 0.16
85 INT240620 Binding of INS and SHBG 4 0.12 3.35 0.15
86 INT207253 INS Negative_regulation of TXNIP 1 0.45 1.2 0.15
87 INT194136 Binding of HLA-E and INS 1 0.01 0.95 0.15
88 INT31641 POMC Regulation of Gene_expression of INS 1 0.26 0.25 0.15
89 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
90 INT141001 Negative_regulation of CPOX Regulation of Localization of INS 1 0.17 0.07 0.14
91 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
92 INT294106 Binding of DNASE1L3 and DRD5 1 0.02 0 0.14
93 INT321408 INS Positive_regulation of EGR1 1 0.03 2.36 0.13
94 INT117371 SUCLA2 Positive_regulation of Localization of INS 1 0.03 0 0.13
95 INT117372 SUCLA2 Regulation of Localization of INS 1 0.02 0 0.13
96 INT321414 INS Positive_regulation of Transcription of EGR1 1 0.03 2.36 0.13
97 INT255710 Binding of INS and LOC691138 1 0.00 0.51 0.12
98 INT352501 PRKAB1 Positive_regulation of INS 1 0.04 1.36 0.12
99 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
100 INT164923 INS Positive_regulation of GIP 1 0.43 0.18 0.11
101 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
102 INT26176 POMC Negative_regulation of Localization of INS 1 0.36 0.06 0.1
103 INT352500 Binding of FAT1 and INS 1 0.01 1.38 0.1
104 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
105 INT350820 INS Regulation of SELS 1 0.13 1.11 0.1
106 INT27844 Binding of INS and Gh 1 0.03 0.1 0.1
107 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
108 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
109 INT27841 Binding of INS and GAL 1 0.04 0.1 0.1
110 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09
111 INT164925 GIP Positive_regulation of Localization of INS 2 0.59 0.86 0.09
112 INT341235 Negative_regulation of INS Positive_regulation of Phosphorylation of Eif4ebp1 1 0.01 0.24 0.09
113 INT114414 TF Regulation of INS 1 0.18 0.09 0.09
114 INT109959 INS Positive_regulation of FBF1 1 0.27 0.24 0.09
115 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08
116 INT173130 Binding of INS and PPARA 2 0.04 1.8 0.08
117 INT172836 Binding of INS and T2dm2 1 0.00 1.65 0.08
118 INT291040 Binding of CFH and INS 1 0.25 1.32 0.08
119 INT258756 Binding of Drd5 and Lmo1 1 0.03 0.64 0.08
120 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
121 INT328306 GH1 Positive_regulation of Localization of INS 1 0.01 0.12 0.07
122 INT58648 Binding of HSD11B1 and INS 1 0.04 1.65 0.07
123 INT207824 KCNJ5 Regulation of Localization of INS 1 0.01 0 0.07
124 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07
125 INT207552 Binding of GH1 and INS 1 0.23 0.55 0.07
126 INT311225 GLP1R Positive_regulation of Gene_expression of INS 1 0.49 0.33 0.06
127 INT202244 Igfbp1 Regulation of Localization of INS 1 0.06 0 0.06
128 INT328305 GHS Positive_regulation of Localization of INS 1 0.02 0.07 0.05
129 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05
130 INT298733 INS Regulation of ACSBG1 1 0.00 0.97 0.05
131 INT328387 INS Negative_regulation of Gene_expression of Ghrl 1 0.01 0.6 0.05
132 INT328371 Ghrl Negative_regulation of INS 1 0.03 0.13 0.05
133 INT258084 Binding of IL6 and Regulation of Gene_expression of INS 1 0.11 0.62 0.05
134 INT280057 Zglp1 Positive_regulation of Transcription of INS 1 0.04 0.52 0.05
135 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
136 INT218616 Binding of IGFBP3 and INS 1 0.07 0.68 0.05
137 INT112644 INS Negative_regulation of OVGP1 1 0.43 0 0.05
138 INT89384 Negative_regulation of INS Positive_regulation of AKT1 2 0.36 1.37 0.04
139 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04
140 INT207846 Hypism Regulation of INS 1 0.06 1.14 0.04
141 INT350015 ARID1B Regulation of Localization of INS 1 0.03 2.6 0.04
142 INT341231 INS Positive_regulation of Phosphorylation of Eif4ebp1 1 0.01 0.13 0.04
143 INT314622 Binding of INS and Ex 1 0.08 0.44 0.04
144 INT267155 Binding of INS and SUGT1 1 0.02 0.81 0.04
145 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04
146 INT199212 Binding of IGFBP1 and INS 1 0.05 1.77 0.04
147 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04
148 INT89385 INS Positive_regulation of Phosphorylation of PTK2B 1 0.15 0.59 0.04
149 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03
150 INT352519 INS Positive_regulation of Localization of Slc2a4 1 0.07 0.97 0.03
151 INT207554 GH1 Negative_regulation of Phosphorylation of INS 1 0.26 0.28 0.03
152 INT230854 INS Regulation of Positive_regulation of SNAP47 1 0.09 1.03 0.03
153 INT230851 INS Regulation of VCAM1 1 0.07 1.02 0.03
154 INT230423 INS Negative_regulation of Lipg 1 0.03 0.74 0.03
155 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03
156 INT285726 Binding of ALB and INS 1 0.22 0.61 0.03
157 INT242884 INS Regulation of SPI1 1 0.03 0.3 0.03
158 INT337728 ADAMTS2 Positive_regulation of Gene_expression of INS 1 0.02 0 0.03
159 INT228522 Tmem170b Positive_regulation of Localization of INS 1 0.01 0.66 0.03
160 INT207553 GH1 Negative_regulation of INS 1 0.27 0.28 0.03
161 INT235626 Binding of IARS and INS 1 0.08 0.15 0
162 INT246152 INS Regulation of S1PR2 1 0.02 0 0
163 INT246151 INS Negative_regulation of TXLNB 1 0.01 0 0
164 INT253085 NPPA Positive_regulation of INS 1 0.32 0 0
165 INT235623 Binding of INS and INSR 1 0.14 0.47 0
166 INT306947 NAMPT Regulation of INS 1 0.13 1.41 0
167 INT291106 INS Regulation of Gene_expression of PDK4 1 0.14 0 0
168 INT238871 Binding of INS and ARMC9 1 0.10 0.31 0
169 INT207260 INS Negative_regulation of Gene_expression of TXNIP 1 0.39 1.71 0
170 INT246148 INS Regulation of TXLNB 1 0.00 0 0
171 INT172759 INS Positive_regulation of Localization of REN 1 0.03 0.64 0
172 INT336296 Il1 Positive_regulation of Gene_expression of INS 1 0.05 0.14 0
173 INT202246 Binding of INS and Igfbp1 1 0.05 0.38 0
174 INT342281 Binding of INS and Esr1 1 0.08 0.57 0
175 INT207256 INS Regulation of Regulation of TXNIP 1 0.48 0.25 0
176 INT311229 DPP4 Positive_regulation of Gene_expression of INS 1 0.32 0.57 0
177 INT290029 Binding of INS and NR1H4 1 0.01 0.47 0
178 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0
179 INT125769 GLP1R Regulation of INS 1 0.44 0.7 0
180 INT145815 Gip Regulation of INS 1 0.00 0.08 0
181 INT290031 Binding of INS and PPARG 1 0.11 0.47 0
182 INT238872 Positive_regulation of Binding of INS and ARMC9 1 0.14 0.31 0
183 INT145817 Gip Positive_regulation of INS 1 0.01 0.08 0
184 INT128489 IGF1 Negative_regulation of Positive_regulation of INS 1 0.26 0.38 0
185 INT101004 INS Positive_regulation of Localization of GGH 1 0.26 0 0
186 INT281259 Binding of INS and TIMP1 1 0.04 0.27 0
187 INT238870 INS Positive_regulation of Gene_expression of GCG 1 0.39 1.06 0
188 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0
189 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0
190 INT101005 INS Regulation of GGH 1 0.09 0 0
191 INT290025 Binding of INS and PPARD 1 0.03 0.47 0
192 INT87748 IGF1 Positive_regulation of INS 1 0.41 0.17 0
193 INT310231 INS Negative_regulation of Binding of SUCLA2 1 0.06 0.46 0
194 INT240546 Binding of ADRB1 and INS 1 0.11 0.34 0
195 INT253212 Negative_regulation of Dpp4 Positive_regulation of Localization of INS 1 0.01 0.42 0
196 INT281266 Binding of INS and Cyp4a3 1 0.01 0.42 0
197 INT277369 INS Positive_regulation of Gene_expression of HK2 1 0.37 0.83 0
198 INT246145 INS Negative_regulation of S1PR2 1 0.03 0 0
199 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
200 INT207255 INS Negative_regulation of Gene_expression of NCKIPSD 1 0.02 0.94 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of NAD(P)H oxidase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of NAD(P)H oxidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT251 Regulation of INS 398 0.62 232.47 55.04
4 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
5 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
6 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
7 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
8 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
9 INT14572 Binding of INS 205 0.48 175.43 13.38
10 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
11 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
12 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
13 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
14 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
15 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
16 INT63394 Gene_expression of Drd5 7 0.76 1.85 2.3
17 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
18 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
19 INT63392 Positive_regulation of Drd5 5 0.46 1.73 2.08
20 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
21 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41
22 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
23 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
24 INT103859 Positive_regulation of Drd5 2 0.49 0.81 1.14
25 INT183046 Transcription of INS 25 0.70 11.14 1.13
26 INT103857 Gene_expression of Drd5 2 0.23 0.92 1.08
27 INT63393 Positive_regulation of Gene_expression of Drd5 3 0.49 1.21 1.02
28 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
29 INT85999 Binding of Drd5 2 0.27 0.84 0.94
30 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
31 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76
32 INT300588 Regulation of Drd5 1 0.32 0.67 0.69
33 INT184846 Negative_regulation of Drd5 1 0.19 2.28 0.68
34 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
35 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64
36 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62
37 INT103858 Regulation of Gene_expression of Drd5 1 0.08 0.92 0.58
38 INT14571 Regulation of Binding of INS 2 0.23 2.44 0.53
39 INT157718 Binding of DRD5 1 0.33 0.57 0.52
40 INT312821 Binding of Ins2 2 0.37 2.13 0.46
41 INT213286 Positive_regulation of Binding of INS 6 0.50 4.85 0.45
42 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
43 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44
44 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
45 INT14569 Positive_regulation of Negative_regulation of INS 4 0.36 3.52 0.37
46 INT344086 Binding of Drd5 1 0.36 0.06 0.37
47 INT183066 Positive_regulation of Transcription of INS 8 0.49 5.31 0.34
48 INT300593 Regulation of Gene_expression of Drd5 1 0.33 0.13 0.28
49 INT207293 Negative_regulation of Negative_regulation of INS 12 0.49 6 0.26
50 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
51 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
52 INT312828 Negative_regulation of Gene_expression of Ins2 1 0.37 0.8 0.12
53 INT355099 Localization of Ins2 1 0.44 0.83 0.09
54 INT312832 Negative_regulation of Ins2 1 0.37 0.64 0.09
55 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07
56 INT223763 Negative_regulation of DRD5 1 0.01 0.06 0.06
57 INT297867 Positive_regulation of Gene_expression of Ins2 1 0.48 2.86 0.04
58 INT183060 Regulation of Transcription of INS 2 0.44 0.34 0
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