GO:0034122

From wiki-pain
Jump to: navigation, search
Name negative regulation of toll-like receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0034122
Unique Molecular Interactions 85
Total Molecular Interactions 99
Total Single Events 771
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
2 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
3 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
4 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
5 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
6 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
7 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
8 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
9 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
10 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
11 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
12 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
13 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
14 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
15 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
16 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
17 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
18 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
19 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
20 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
21 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
22 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
23 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
24 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
25 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
26 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
27 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
28 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
29 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
30 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
31 INT5631 Ubqln1 Positive_regulation of Pdpk1 1 0.05 0 0.53
32 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
33 INT259180 Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
34 INT259181 Phosphorylation of Pdpk1 Positive_regulation of Gene_expression of Gria1 1 0.02 0.4 0.49
35 INT95469 P2ry6 Positive_regulation of Positive_regulation of Pdpk1 1 0.15 0 0.46
36 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
37 INT15024 Prkcg Regulation of Pdpk1 1 0.09 0 0.43
38 INT151184 Pdpk1 Positive_regulation of Trpv1 1 0.08 0 0.42
39 INT151183 Pdpk1 Positive_regulation of Phosphorylation of Trpv1 1 0.08 0 0.42
40 INT209231 Tg(Ngf)47Kma Regulation of Tyro3 1 0.03 0 0.41
41 INT339493 Binding of Irak1 and Irak3 1 0.02 0.17 0.41
42 INT236111 Binding of Pdpk1 and Ppara 1 0.26 1.21 0.39
43 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
44 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
45 INT112617 Pdpk1 Regulation of Il1b 1 0.03 1.11 0.36
46 INT112618 Pdpk1 Regulation of Tnf 1 0.03 1.11 0.36
47 INT222721 Binding of HTR1A and Pdpk1 1 0.00 0.35 0.33
48 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33
49 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
50 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
51 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29
52 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29
53 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
54 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27
55 INT18994 Negative_regulation of Pdpk1 Negative_regulation of Regulation of Cck 1 0.10 0 0.26
56 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
57 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21
58 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2
59 INT329068 Tlr9 Positive_regulation of Localization of IFNA1 1 0.03 1.54 0.19
60 INT58006 DYT10 Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.14 0.18
61 INT334261 Binding of Irf4 and Irf5 1 0.22 0.42 0.18
62 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
63 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
64 INT179849 Il11 Regulation of Positive_regulation of Pdpk1 1 0.05 0.07 0.17
65 INT349559 Mtor Regulation of Pdpk1 1 0.03 0.42 0.14
66 INT1233 Gcg Positive_regulation of Pdpk1 1 0.27 0 0.14
67 INT333271 Tlr9 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
68 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11
69 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
70 INT294773 IRF6 Positive_regulation of TLR9 1 0.06 0.17 0.1
71 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08
72 INT352941 Pik3cb Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.21 0.06
73 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05
74 INT290165 Tlr9 Positive_regulation of Gene_expression of IFNA1 1 0.10 1.2 0.04
75 INT290161 Tlr9 Positive_regulation of Gene_expression of Pdc 1 0.21 1.2 0.04
76 INT276211 Pdpk1 Regulation of Akt1 1 0.07 0.72 0.04
77 INT78615 Pdpk1 Regulation of Gene_expression of Penk 1 0.03 0 0
78 INT287072 Chrm2 Positive_regulation of Gene_expression of Irf4 1 0.18 0.06 0
79 INT287060 Proc Regulation of Irf4 1 0.00 0.13 0
80 INT287076 Chrm2 Regulation of Irf4 1 0.10 0.09 0
81 INT287068 Irf4 Regulation of Igj 1 0.25 0.13 0
82 INT353435 Binding of Pdpk1 and Rock1 1 0.09 0.27 0
83 INT287066 Chrm2 Positive_regulation of Irf4 1 0.18 0.29 0
84 INT324814 Binding of Ighm and Tlr9 1 0.06 0.17 0
85 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of toll-like receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of toll-like receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
2 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
3 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
4 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
5 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
6 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
7 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
8 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
9 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
10 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
11 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
12 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
13 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
14 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
15 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78
16 INT68465 Positive_regulation of Gene_expression of Pdpk1 7 0.19 2.35 5.49
17 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
18 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
19 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
20 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
21 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
22 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
23 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
24 INT1231 Negative_regulation of Positive_regulation of Pdpk1 6 0.35 1.88 4.13
25 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
26 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
27 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
28 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
29 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
30 INT204524 Binding of TLR9 17 0.43 11.69 2.76
31 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75
32 INT96763 Positive_regulation of Localization of Pdpk1 1 0.39 2.08 2.65
33 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
34 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
35 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
36 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
37 INT26735 Regulation of Gene_expression of Pdpk1 2 0.24 0.56 1.84
38 INT104014 Negative_regulation of Phosphorylation of Pdpk1 2 0.23 0.59 1.72
39 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
40 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
41 INT67464 Positive_regulation of Negative_regulation of Pdpk1 1 0.19 0.15 1.41
42 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
43 INT118927 Positive_regulation of Phosphorylation of Pdpk1 2 0.04 0.76 1.38
44 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
45 INT221206 Phosphorylation of Pdpk1 3 0.53 0.13 1.25
46 INT104011 Transcription of Pdpk1 1 0.28 0 1.2
47 INT104012 Regulation of Transcription of Pdpk1 1 0.14 0 1.2
48 INT26734 Binding of Pdpk1 4 0.29 1.01 1.19
49 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
50 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
51 INT68467 Regulation of Regulation of Pdpk1 1 0.05 0.09 0.96
52 INT294787 Localization of TLR9 2 0.67 2.35 0.75
53 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
54 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
55 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
56 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
57 INT79249 Regulation of Negative_regulation of Pdpk1 1 0.03 0.09 0.57
58 INT98037 Negative_regulation of Negative_regulation of Pdpk1 1 0.05 0.26 0.52
59 INT288490 Binding of Tlr9 1 0.25 1.88 0.51
60 INT188677 Positive_regulation of Positive_regulation of Tlr9 2 0.29 1.22 0.49
61 INT200258 Binding of Irf4 2 0.21 0.43 0.43
62 INT339480 Negative_regulation of Positive_regulation of Irak3 1 0.05 0.12 0.41
63 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
64 INT204533 Regulation of Gene_expression of TLR9 8 0.55 2.81 0.4
65 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39
66 INT236105 Negative_regulation of Binding of Pdpk1 1 0.30 1.22 0.39
67 INT219171 Negative_regulation of Positive_regulation of TLR9 1 0.18 1.3 0.39
68 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
69 INT276311 Gene_expression of Irf4 6 0.64 4.95 0.37
70 INT182134 Transcription of TLR9 2 0.72 1.21 0.37
71 INT284455 Regulation of Gene_expression of Tlr9 1 0.30 1.19 0.37
72 INT287043 Positive_regulation of Irf4 7 0.57 2.81 0.36
73 INT179816 Positive_regulation of Pdpk1 4 0.31 0.36 0.35
74 INT329061 Positive_regulation of Tlr9 1 0.47 2.05 0.29
75 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28
76 INT204528 Negative_regulation of Gene_expression of TLR9 5 0.52 4.47 0.27
77 INT209222 Gene_expression of Tyro3 3 0.22 0.47 0.27
78 INT236357 Negative_regulation of Positive_regulation of Tlr9 2 0.33 3.1 0.27
79 INT204531 Negative_regulation of TLR9 1 0.43 1.29 0.25
80 INT350779 Positive_regulation of Positive_regulation of TLR9 1 0.08 0.8 0.15
81 INT204527 Regulation of TLR9 7 0.40 2.88 0.12
82 INT236109 Localization of Pdpk1 1 0.49 0.75 0.12
83 INT151569 Transcription of Tlr9 3 0.69 0.75 0.11
84 INT151566 Positive_regulation of Transcription of Tlr9 2 0.47 0.67 0.11
85 INT280015 Positive_regulation of Binding of TLR9 1 0.12 1.11 0.09
86 INT104656 Regulation of Phosphorylation of Pdpk1 1 0.05 1.74 0.07
87 INT120564 Gene_expression of Pdpk1 2 0.62 1.54 0.06
88 INT120565 Positive_regulation of Gene_expression of Pdpk1 1 0.40 1.26 0.06
89 INT236706 Regulation of Pdpk1 1 0.12 0.38 0.04
90 INT204526 Positive_regulation of Transcription of TLR9 1 0.50 0.06 0.03
91 INT294790 Regulation of Localization of TLR9 1 0.40 0 0
92 INT285438 Regulation of Regulation of TLR9 1 0.40 0 0
93 INT331203 Positive_regulation of Binding of Pdpk1 1 0.15 0.17 0
94 INT161736 Negative_regulation of Gene_expression of Arrb2 1 0.50 0 0
95 INT161253 Regulation of Gene_expression of Tlr9 1 0.09 0.18 0
96 INT324755 Positive_regulation of Binding of Tlr9 1 0.26 0.17 0
97 INT161254 Regulation of Tlr9 1 0.09 0.18 0
98 INT329056 Positive_regulation of Gene_expression of Tlr9 1 0.43 0.09 0
99 INT189989 Negative_regulation of Pdpk1 1 0.08 1.48 0
100 INT151568 Negative_regulation of Transcription of Tlr9 1 0.41 0.08 0
101 INT341498 Negative_regulation of Gene_expression of Tlr9 1 0.11 0.38 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox