GO:0034138

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Name toll-like receptor 3 signaling pathway
Categary Process
Go Slim No
Go Link GO:0034138
Unique Molecular Interactions 867
Total Molecular Interactions 1091
Total Single Events 7629
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for toll-like receptor 3 signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for toll-like receptor 3 signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
2 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
3 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
4 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
5 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
6 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
7 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
8 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
9 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
10 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
11 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
12 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
13 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
14 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
15 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
16 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
17 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
18 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
19 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
20 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
21 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
22 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
23 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
24 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
25 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
26 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
27 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
28 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
29 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
30 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
31 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
32 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
33 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
34 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
35 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
36 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
37 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
38 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
39 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
40 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
41 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
42 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
43 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
44 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
45 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
46 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
47 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
48 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
49 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
50 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
51 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
52 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
53 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
54 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
55 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
56 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
57 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
58 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
59 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
60 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
61 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
62 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
63 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
64 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
65 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
66 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
67 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
68 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
69 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
70 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
71 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
72 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
73 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
74 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
75 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
76 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
77 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
78 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
79 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
80 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
81 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
82 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
83 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
84 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
85 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
86 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
87 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
88 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
89 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
90 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
91 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
92 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
93 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
94 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6
95 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
96 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6
97 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
98 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
99 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
100 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
101 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
102 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57
103 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
104 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
105 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
106 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
107 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
108 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
109 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
110 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
111 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
112 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
113 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
114 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
115 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
116 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
117 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
118 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
119 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
120 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
121 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
122 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
123 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
124 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
125 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
126 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
127 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
128 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
129 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
130 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
131 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
132 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
133 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
134 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
135 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
136 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
137 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
138 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
139 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
140 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
141 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
142 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
143 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
144 INT191950 NFKB2 Regulation of Gene_expression of NOS2 1 0.08 1 0.47
145 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
146 INT102556 HGF Positive_regulation of Phosphorylation of ELK1 1 0.10 0.46 0.47
147 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
148 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
149 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
150 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47
151 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
152 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
153 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
154 INT116929 OPRK1 Positive_regulation of JUN 1 0.28 0.15 0.46
155 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
156 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
157 INT304281 IL8 Positive_regulation of TBK1 1 0.01 2.35 0.44
158 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
159 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44
160 INT104016 RPGR Positive_regulation of Gene_expression of FOS 1 0.16 0 0.43
161 INT103132 Positive_regulation of DCSTAMP Positive_regulation of JUN 1 0.03 0.73 0.43
162 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
163 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
164 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
165 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
166 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
167 INT103128 Positive_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.07 0.73 0.43
168 INT103129 DCSTAMP Positive_regulation of JUN 1 0.03 0.72 0.43
169 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
170 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
171 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
172 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
173 INT107704 IL1B Positive_regulation of Localization of RELA 1 0.02 0.13 0.41
174 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
175 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
176 INT107699 IL1B Positive_regulation of Localization of NFKB1 1 0.03 0.13 0.41
177 INT84516 NFKB1 Positive_regulation of Gene_expression of TF 1 0.10 0.09 0.41
178 INT162041 F2 Positive_regulation of Positive_regulation of FOS 1 0.13 1.14 0.41
179 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
180 INT87605 Binding of FOS and Penk 1 0.07 0.78 0.4
181 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
182 INT103131 Positive_regulation of NFKB1 Regulation of Gene_expression of IL8 1 0.27 0.68 0.4
183 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
184 INT87604 FOS Regulation of Penk 1 0.09 0.76 0.39
185 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
186 INT87603 Binding of FOS and Jund 1 0.03 0.77 0.39
187 INT97404 Nfkb1 Positive_regulation of Transcription of JUN 1 0.00 1.03 0.38
188 INT194713 MAPK1 Regulation of Gene_expression of TNF 1 0.10 1.66 0.38
189 INT97403 JUN Positive_regulation of Transcription of Nfkb1 1 0.00 1.03 0.38
190 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37
191 INT103795 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0.47 0.37
192 INT70185 PRCP Positive_regulation of Gene_expression of FOS 1 0.05 0.1 0.37
193 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
194 INT107705 DCSTAMP Positive_regulation of Localization of NFKB1 1 0.07 0.07 0.36
195 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
196 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
197 INT129293 OPRM1 Positive_regulation of Phosphorylation of IKBKE 1 0.05 0.28 0.35
198 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35
199 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35
200 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for toll-like receptor 3 signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in toll-like receptor 3 signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
3 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
4 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
5 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
6 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
7 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
8 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
9 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
10 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
11 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
12 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
13 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
14 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
15 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
16 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
17 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
18 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
19 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
20 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
21 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
22 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
23 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
24 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
25 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
26 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
27 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
28 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
29 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
30 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
31 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
32 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
33 INT15246 Regulation of FOS 32 0.60 15.34 12.94
34 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
35 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
36 INT60198 Binding of JUN 54 0.48 11.56 10.27
37 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
38 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
39 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
40 INT66213 Localization of RELA 63 0.78 14.71 8.77
41 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
42 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
43 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
44 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
45 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
46 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
47 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
48 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
49 INT75497 Regulation of JUN 28 0.61 11.04 7.09
50 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
51 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
52 INT60196 Binding of FOS 33 0.47 13.11 6.95
53 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
54 INT5847 Transcription of FOS 31 0.69 11.11 6.41
55 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
56 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
57 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
58 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
59 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43
60 INT183467 Negative_regulation of TBK1 6 0.12 9.89 5.41
61 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
62 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
63 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
64 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
65 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
66 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
67 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6
68 INT54911 Localization of FOS 20 0.78 3.27 4.56
69 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
70 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46
71 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
72 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33
73 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
74 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
75 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
76 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
77 INT67936 Transcription of JUN 18 0.52 9.52 4.13
78 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
79 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
80 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
81 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
82 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
83 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
84 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
85 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
86 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
87 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
88 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
89 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
90 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
91 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
92 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
93 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
94 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
95 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
96 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
97 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
98 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
99 INT92335 Gene_expression of TBK1 11 0.28 8.98 3
100 INT103910 Binding of NOD2 19 0.47 12.24 2.93
101 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
102 INT102565 Positive_regulation of Phosphorylation of RPS6KA1 1 0.25 2.77 2.85
103 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
104 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
105 INT97132 Negative_regulation of Positive_regulation of TBK1 5 0.08 6.54 2.76
106 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73
107 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
108 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
109 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
110 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
111 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
112 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
113 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
114 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
115 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
116 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
117 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
118 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
119 INT123682 Localization of JUN 8 0.50 4.15 2.38
120 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
121 INT183468 Localization of TBK1 6 0.32 4.35 2.36
122 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
123 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
124 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
125 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32
126 INT150547 Phosphorylation of MAP2K3 2 0.79 4.92 2.3
127 INT132893 Binding of CHUK 1 0.00 0.63 2.25
128 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
129 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
130 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
131 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
132 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
133 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
134 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
135 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
136 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
137 INT243689 Regulation of NFKB2 1 0.35 2.72 1.97
138 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
139 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
140 INT130208 Positive_regulation of Phosphorylation of JUN 4 0.38 3.07 1.92
141 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83
142 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
143 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
144 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
145 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
146 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
147 INT76608 Regulation of Negative_regulation of NFKB1 1 0.33 0.53 1.75
148 INT55169 Binding of RELA 40 0.36 4.91 1.74
149 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72
150 INT221433 Binding of NFKB2 6 0.11 4.74 1.7
151 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69
152 INT165446 Positive_regulation of Phosphorylation of NFKB1 3 0.56 1.88 1.66
153 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
154 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
155 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
156 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
157 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
158 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
159 INT47972 Positive_regulation of Protein_catabolism of NFKBIA 5 0.46 2.09 1.53
160 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
161 INT171029 Positive_regulation of Transcription of JUN 4 0.14 2.87 1.48
162 INT109916 Positive_regulation of Positive_regulation of MAP2K6 2 0.45 2.28 1.45
163 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44
164 INT258048 Regulation of TBK1 4 0.05 3.81 1.44
165 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
166 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
167 INT102561 Positive_regulation of Phosphorylation of ELK1 1 0.12 1.39 1.42
168 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
169 INT90825 Gene_expression of NFKBIB 3 0.17 4.13 1.41
170 INT186810 Positive_regulation of TLR3 13 0.65 6.37 1.37
171 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
172 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
173 INT110252 Positive_regulation of Gene_expression of RELA 29 0.49 6.36 1.31
174 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
175 INT66214 Regulation of Binding of NFKB1 2 0.35 0.55 1.28
176 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
177 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26
178 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
179 INT130207 Phosphorylation of ATF2 5 0.60 1.34 1.25
180 INT120764 Negative_regulation of Binding of JUN 7 0.25 2.65 1.23
181 INT112823 Negative_regulation of Positive_regulation of MAPK14 5 0.36 1.49 1.22
182 INT166013 Positive_regulation of Gene_expression of NFKBIA 2 0.32 1.15 1.2
183 INT183790 Binding of TBK1 2 0.04 2.97 1.16
184 INT157364 Positive_regulation of Phosphorylation of MAPK9 3 0.56 2.33 1.15
185 INT119348 Binding of IKBKG 7 0.15 4.03 1.14
186 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
187 INT17332 Regulation of Positive_regulation of FOS 6 0.44 0.78 1.11
188 INT75503 Regulation of Gene_expression of JUN 6 0.21 2.87 1.11
189 INT69394 Positive_regulation of Binding of FOS 6 0.49 3.54 1.11
190 INT48982 Positive_regulation of Regulation of FOS 2 0.45 0.15 1.11
191 INT142831 Positive_regulation of Gene_expression of CREB1 3 0.69 0.08 1.1
192 INT135615 Positive_regulation of IKBKB 3 0.59 6.16 1.1
193 INT186807 Positive_regulation of Gene_expression of TLR3 8 0.53 7.19 1.08
194 INT107971 Regulation of NFKBIA 3 0.24 2.03 1.04
195 INT142829 Transcription of CREB1 9 0.46 3.37 1.03
196 INT130209 Positive_regulation of Phosphorylation of ATF2 3 0.36 1.15 1.03
197 INT164381 Regulation of Positive_regulation of MAPK3 2 0.60 1.49 1.03
198 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
199 INT117435 Negative_regulation of IKBKB 3 0.37 2.67 0.97
200 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
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