GO:0034142

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Name toll-like receptor 4 signaling pathway
Categary Process
Go Slim No
Go Link GO:0034142
Unique Molecular Interactions 1058
Total Molecular Interactions 1381
Total Single Events 9475
Pain Genes Associated 55

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for toll-like receptor 4 signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for toll-like receptor 4 signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
3 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
4 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
5 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
6 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
7 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
8 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
9 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
10 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
11 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
12 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
13 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
14 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
15 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
16 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
17 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
18 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
19 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
20 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
21 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
22 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
23 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
24 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
25 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
26 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
27 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
28 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
29 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
30 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
31 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
32 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
33 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
34 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
35 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
36 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
37 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
38 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
39 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
40 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
41 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
42 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
43 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
44 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
45 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
46 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
47 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
48 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
49 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
50 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
51 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
52 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
53 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
54 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
55 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
56 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
57 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
58 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
59 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
60 INT129034 Nfkbia Positive_regulation of Nfkb1 1 0.02 0.67 0.89
61 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
62 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
63 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
64 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
65 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
66 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
67 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
68 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
69 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
70 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
71 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
72 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
73 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
74 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
75 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
76 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
77 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
78 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
79 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
80 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
81 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
82 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
83 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
84 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
85 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
86 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
87 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
88 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
89 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
90 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
91 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
92 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
93 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
94 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
95 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
96 INT66581 Binding of JUN and Rare2 1 0.00 0.07 0.69
97 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
98 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
99 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
100 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
101 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
102 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
103 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
104 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 0.26 0.33 0.64
105 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
106 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
107 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
108 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
109 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
110 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
111 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
112 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6
113 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
114 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6
115 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
116 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
117 INT168416 MIR146A Regulation of Irak1 1 0.24 0.99 0.59
118 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
119 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
120 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
121 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
122 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
123 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57
124 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
125 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
126 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
127 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
128 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
129 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
130 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
131 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
132 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
133 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
134 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
135 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
136 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
137 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
138 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
139 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
140 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
141 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
142 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
143 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
144 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
145 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
146 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
147 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
148 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
149 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
150 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
151 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
152 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
153 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
154 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
155 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
156 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
157 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
158 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
159 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
160 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
161 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
162 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
163 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
164 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
165 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
166 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
167 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
168 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
169 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
170 INT191950 NFKB2 Regulation of Gene_expression of NOS2 1 0.08 1 0.47
171 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
172 INT102556 HGF Positive_regulation of Phosphorylation of ELK1 1 0.10 0.46 0.47
173 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
174 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
175 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
176 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47
177 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
178 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
179 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
180 INT116929 OPRK1 Positive_regulation of JUN 1 0.28 0.15 0.46
181 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
182 INT87934 Phosphorylation of Nfkbia Positive_regulation of Nfkb1 1 0.02 0.1 0.45
183 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
184 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44
185 INT87936 Nfkbia Positive_regulation of Nfkb1 1 0.03 0.1 0.44
186 INT304281 IL8 Positive_regulation of TBK1 1 0.01 2.35 0.44
187 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
188 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44
189 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43
190 INT104016 RPGR Positive_regulation of Gene_expression of FOS 1 0.16 0 0.43
191 INT103132 Positive_regulation of DCSTAMP Positive_regulation of JUN 1 0.03 0.73 0.43
192 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
193 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
194 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
195 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
196 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
197 INT103128 Positive_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.07 0.73 0.43
198 INT103129 DCSTAMP Positive_regulation of JUN 1 0.03 0.72 0.43
199 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
200 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42

Single Events

The table below shows the top 100 pain related interactions that have been reported for toll-like receptor 4 signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in toll-like receptor 4 signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
3 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
4 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
5 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
6 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
7 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
8 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
9 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
10 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
11 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
12 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
13 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
14 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
15 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
16 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
17 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
18 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
19 INT134651 Binding of TLR4 89 0.48 66.96 23.19
20 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
21 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
22 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
23 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
24 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
25 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
26 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
27 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
28 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
29 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
30 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
31 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
32 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
33 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
34 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
35 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
36 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
37 INT15246 Regulation of FOS 32 0.60 15.34 12.94
38 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
39 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
40 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
41 INT81538 Phosphorylation of Nfkbia 27 0.62 8.86 10.49
42 INT150540 Binding of TLR2 50 0.45 35.86 10.43
43 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
44 INT60198 Binding of JUN 54 0.48 11.56 10.27
45 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
46 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
47 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
48 INT66213 Localization of RELA 63 0.78 14.71 8.77
49 INT80872 Protein_catabolism of Nfkbia 28 0.92 10.56 8.62
50 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
51 INT95297 Gene_expression of Nfkbia 14 0.68 7.61 8.24
52 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
53 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
54 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
55 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
56 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
57 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
58 INT81532 Negative_regulation of Protein_catabolism of Nfkbia 21 0.54 8.92 7.38
59 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
60 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
61 INT93481 Negative_regulation of Protein_catabolism of Nfkbia 14 0.39 7.24 7.21
62 INT88498 Protein_catabolism of Nfkbia 14 0.82 6.94 7.1
63 INT75497 Regulation of JUN 28 0.61 11.04 7.09
64 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
65 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
66 INT60196 Binding of FOS 33 0.47 13.11 6.95
67 INT81541 Negative_regulation of Nfkbia 12 0.51 5.73 6.79
68 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
69 INT5847 Transcription of FOS 31 0.69 11.11 6.41
70 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
71 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
72 INT97797 Localization of TLR4 18 0.77 13.78 6
73 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
74 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
75 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
76 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
77 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43
78 INT183467 Negative_regulation of TBK1 6 0.12 9.89 5.41
79 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
80 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
81 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
82 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
83 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
84 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
85 INT81535 Negative_regulation of Phosphorylation of Nfkbia 15 0.44 5.74 5.18
86 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02
87 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
88 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
89 INT88496 Positive_regulation of Protein_catabolism of Nfkbia 8 0.53 3.05 4.78
90 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73
91 INT131253 Positive_regulation of Gene_expression of Nfkbia 4 0.41 3.28 4.71
92 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6
93 INT54911 Localization of FOS 20 0.78 3.27 4.56
94 INT20459 Regulation of Ripk2 5 0.44 0 4.53
95 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
96 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46
97 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
98 INT87210 Positive_regulation of Nfkbia 9 0.61 3.89 4.35
99 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
100 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
101 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
102 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
103 INT67936 Transcription of JUN 18 0.52 9.52 4.13
104 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
105 INT81543 Positive_regulation of Phosphorylation of Nfkbia 7 0.37 2.51 4.1
106 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
107 INT108868 Transcription of Nfkbia 2 0.57 2.91 4.03
108 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
109 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
110 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
111 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83
112 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
113 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
114 INT264972 Positive_regulation of MAP2K3 4 0.65 6.92 3.68
115 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
116 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
117 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
118 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
119 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
120 INT264970 Positive_regulation of Localization of TLR2 1 0.11 4.21 3.37
121 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
122 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23
123 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
124 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
125 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
126 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
127 INT186805 Transcription of TLR2 12 0.63 9.66 3.04
128 INT68651 Negative_regulation of Positive_regulation of JUN 11 0.58 4.28 3.04
129 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
130 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
131 INT92335 Gene_expression of TBK1 11 0.28 8.98 3
132 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
133 INT103910 Binding of NOD2 19 0.47 12.24 2.93
134 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
135 INT102565 Positive_regulation of Phosphorylation of RPS6KA1 1 0.25 2.77 2.85
136 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
137 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
138 INT97132 Negative_regulation of Positive_regulation of TBK1 5 0.08 6.54 2.76
139 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73
140 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
141 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
142 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
143 INT233606 Transcription of Nfkbia 1 0.66 1.55 2.71
144 INT93401 Positive_regulation of Protein_catabolism of Nfkbia 11 0.46 3.89 2.7
145 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
146 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
147 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
148 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
149 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
150 INT108869 Localization of Nfkbia 5 0.56 1.04 2.63
151 INT133029 Regulation of TLR2 18 0.56 11.31 2.62
152 INT186799 Localization of TLR2 5 0.68 2.51 2.58
153 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
154 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
155 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
156 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
157 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
158 INT123682 Localization of JUN 8 0.50 4.15 2.38
159 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
160 INT183468 Localization of TBK1 6 0.32 4.35 2.36
161 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
162 INT60199 Positive_regulation of Binding of JUN 5 0.49 1.3 2.34
163 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
164 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32
165 INT150547 Phosphorylation of MAP2K3 2 0.79 4.92 2.3
166 INT132893 Binding of CHUK 1 0.00 0.63 2.25
167 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
168 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
169 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
170 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
171 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
172 INT148456 Gene_expression of LY96 7 0.19 4.35 2.02
173 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
174 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
175 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
176 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
177 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98
178 INT243689 Regulation of NFKB2 1 0.35 2.72 1.97
179 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
180 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
181 INT130208 Positive_regulation of Phosphorylation of JUN 4 0.38 3.07 1.92
182 INT208890 Gene_expression of Irak1 7 0.65 2.42 1.87
183 INT151269 Positive_regulation of Localization of Nfkbia 1 0.37 0 1.86
184 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83
185 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
186 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
187 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
188 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
189 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
190 INT76608 Regulation of Negative_regulation of NFKB1 1 0.33 0.53 1.75
191 INT55169 Binding of RELA 40 0.36 4.91 1.74
192 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
193 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72
194 INT221433 Binding of NFKB2 6 0.11 4.74 1.7
195 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69
196 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
197 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
198 INT165446 Positive_regulation of Phosphorylation of NFKB1 3 0.56 1.88 1.66
199 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
200 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
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