GO:0034145

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Name positive regulation of toll-like receptor 4 signaling pathway
Categary Process
Go Slim No
Go Link GO:0034145
Unique Molecular Interactions 91
Total Molecular Interactions 140
Total Single Events 2437
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of toll-like receptor 4 signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of toll-like receptor 4 signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
2 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
3 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
4 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
5 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
6 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
7 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
8 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
9 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
10 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
11 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
12 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99
13 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
14 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
15 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
16 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
17 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
18 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
19 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
20 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
21 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
22 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
23 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72
24 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
25 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
26 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
27 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
28 INT112312 tryptase Positive_regulation of F2rl1 2 0.08 0.23 0.57
29 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
30 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
31 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
32 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
33 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
34 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
35 INT285715 Binding of Lbp and Set 1 0.06 0.33 0.33
36 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
37 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
38 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28
39 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
40 INT292568 Binding of F2RL1 and MRGPRX1 1 0.07 0.81 0.28
41 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
42 INT292563 F2RL1 Negative_regulation of TNF 1 0.15 0.73 0.25
43 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
44 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23
45 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
46 INT306333 Lbp Positive_regulation of Binding of Ly96 1 0.09 0.24 0.22
47 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
48 INT306328 Binding of Lbp and Tlr4 1 0.31 0.23 0.21
49 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
50 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
51 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
52 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
53 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
54 INT306326 Tlr4 Positive_regulation of Localization of Lbp 1 0.30 0.31 0.16
55 INT306329 Lbp Regulation of Tlr4 1 0.29 0.32 0.16
56 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
57 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
58 INT343836 Binding of IRF6 and LBP 1 0.02 0.8 0.14
59 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11
60 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11
61 INT285423 LBP Positive_regulation of Gene_expression of IRF6 1 0.07 0.19 0.09
62 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
63 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
64 INT343865 IRF6 Positive_regulation of TIRAP 1 0.03 0.28 0.08
65 INT226787 Trglyd Positive_regulation of Lbp 1 0.04 1.67 0.07
66 INT278441 Lbp Positive_regulation of Gene_expression of ITGAX 1 0.44 1.18 0.07
67 INT226786 Scl1 Positive_regulation of Lbp 1 0.04 1.68 0.07
68 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
69 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
70 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
71 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04
72 INT306006 Binding of CD14 and LBP 1 0.06 0.63 0.04
73 INT105260 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0 0.03
74 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
75 INT341537 F2RL1 Positive_regulation of TSC1 1 0.01 0.76 0.03
76 INT344711 Nr1h3 Regulation of Abcg1 1 0.03 1.67 0
77 INT278438 Lbp Positive_regulation of Il2 1 0.12 0.89 0
78 INT344712 Nr1h3 Regulation of Abca1 1 0.03 1.68 0
79 INT285427 LBP Positive_regulation of Localization of IL8 1 0.10 0.19 0
80 INT155552 Binding of FANCB and LBP 1 0.39 0.06 0
81 INT341540 Positive_regulation of F2RL1 Positive_regulation of Gene_expression of AREG 1 0.18 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of toll-like receptor 4 signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of toll-like receptor 4 signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1026 Binding of Lbp 207 0.48 150.96 119.16
2 INT9664 Binding of LBP 127 0.48 94.9 63.42
3 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
4 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
5 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
6 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
7 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
8 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
9 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
10 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
11 INT1030 Localization of Lbp 52 0.74 38.92 24.91
12 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
13 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
14 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
15 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
16 INT57000 Localization of LBP 21 0.78 11.01 10.01
17 INT32624 Regulation of LBP 15 0.60 11.48 8.71
18 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57
19 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
20 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
21 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15
22 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
23 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18
24 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
25 INT11106 Gene_expression of Lbp 10 0.67 10.29 4.52
26 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
27 INT133733 Positive_regulation of Localization of Lbp 6 0.43 9.19 3.61
28 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49
29 INT11107 Binding of Lbp 12 0.42 4.42 3.41
30 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
31 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
32 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
33 INT111017 Regulation of F2rl1 3 0.22 0 2.61
34 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
35 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
36 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
37 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
38 INT228889 Protein_catabolism of LBP 4 0.77 5.14 2.13
39 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
40 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
41 INT166311 Positive_regulation of Gene_expression of LBP 7 0.49 4.15 1.81
42 INT203541 Regulation of Binding of LBP 1 0.39 1.96 1.79
43 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
44 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
45 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
46 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
47 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
48 INT112311 Regulation of F2rl1 2 0.27 0.73 0.97
49 INT158064 Negative_regulation of Gene_expression of LBP 1 0.41 1.54 0.97
50 INT224489 Negative_regulation of Gene_expression of F2RL1 3 0.57 1.51 0.96
51 INT341431 Regulation of Positive_regulation of LBP 1 0.24 1.14 0.96
52 INT163869 Regulation of Binding of Lbp 3 0.45 1.07 0.93
53 INT160599 Regulation of Gene_expression of LBP 2 0.44 1.23 0.92
54 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91
55 INT61775 Negative_regulation of Binding of Lbp 1 0.42 0.88 0.88
56 INT220161 Negative_regulation of Binding of LBP 2 0.43 1.35 0.87
57 INT351306 Positive_regulation of Localization of LBP 1 0.47 1.82 0.82
58 INT154792 Regulation of Regulation of LBP 1 0.26 0.5 0.81
59 INT154793 Regulation of Localization of LBP 1 0.44 0.5 0.81
60 INT101084 Positive_regulation of Negative_regulation of Lbp 1 0.43 0.98 0.77
61 INT176184 Positive_regulation of Gene_expression of Nr1h3 2 0.49 0 0.68
62 INT176218 Gene_expression of Nr1h3 2 0.65 0 0.67
63 INT292595 Negative_regulation of Positive_regulation of F2RL1 3 0.40 1.29 0.63
64 INT151891 Negative_regulation of Localization of Lbp 1 0.42 0.8 0.63
65 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62
66 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
67 INT124290 Negative_regulation of Gene_expression of F2rl1 3 0.42 1.48 0.52
68 INT284454 Binding of Tirap 4 0.26 2.07 0.49
69 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
70 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
71 INT166066 Negative_regulation of Localization of F2rl1 1 0.43 0.47 0.4
72 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
73 INT112310 Negative_regulation of Regulation of F2rl1 1 0.03 0 0.39
74 INT55437 Transcription of Lbp 2 0.60 0.48 0.38
75 INT292591 Negative_regulation of Negative_regulation of F2RL1 1 0.35 0 0.36
76 INT335077 Regulation of Nr1h3 1 0.44 0.1 0.32
77 INT335072 Regulation of Regulation of Nr1h3 1 0.44 0.1 0.32
78 INT135025 Regulation of Gene_expression of Lbp 1 0.44 2.22 0.28
79 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
80 INT224491 Transcription of F2RL1 1 0.68 0.31 0.26
81 INT94657 Transcription of F2rl1 1 0.69 0.5 0.26
82 INT105257 Regulation of Localization of F2rl1 1 0.23 0 0.26
83 INT176207 Positive_regulation of Nr1h3 2 0.45 0 0.2
84 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
85 INT306317 Localization of Lbp 1 0.53 0.31 0.16
86 INT306309 Positive_regulation of Localization of Lbp 1 0.33 0.32 0.16
87 INT292590 Positive_regulation of Negative_regulation of F2RL1 1 0.38 0 0.15
88 INT193474 Positive_regulation of Phosphorylation of Lbp 1 0.19 0.25 0.15
89 INT193473 Phosphorylation of Lbp 1 0.30 0.25 0.15
90 INT341581 Positive_regulation of Transcription of F2RL1 1 0.44 0 0.11
91 INT343883 Gene_expression of TIRAP 2 0.65 0.28 0.09
92 INT343902 Positive_regulation of Gene_expression of TIRAP 1 0.22 0.28 0.09
93 INT195755 Negative_regulation of Negative_regulation of Lbp 1 0.11 0.98 0.09
94 INT220332 Transcription of LBP 2 0.50 2.2 0.08
95 INT135023 Negative_regulation of Positive_regulation of Lbp 1 0.29 0.97 0.08
96 INT220337 Negative_regulation of Negative_regulation of LBP 1 0.35 0.35 0.08
97 INT135021 Regulation of Positive_regulation of Lbp 1 0.31 0.98 0.08
98 INT292586 Phosphorylation of F2RL1 1 0.51 0 0.07
99 INT292582 Negative_regulation of Phosphorylation of F2RL1 1 0.35 0 0.07
100 INT343889 Positive_regulation of TIRAP 1 0.20 0.11 0.06
101 INT135030 Regulation of Lbp 2 0.45 0.63 0.04
102 INT339489 Binding of TIRAP 1 0.36 0.05 0.03
103 INT137124 Negative_regulation of Lbp 2 0.37 0 0
104 INT115667 Regulation of Negative_regulation of Lbp 2 0.45 0 0
105 INT345270 Negative_regulation of Tirap 1 0.02 0.15 0
106 INT125910 Regulation of Localization of Lbp 1 0.21 0 0
107 INT167265 Positive_regulation of Positive_regulation of Lbp 1 0.43 0 0
108 INT134805 Positive_regulation of Positive_regulation of LBP 1 0.45 0.15 0
109 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
110 INT254185 Positive_regulation of Tirap 1 0.32 0 0
111 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
112 INT254183 Regulation of Positive_regulation of Tirap 1 0.29 0 0
113 INT162927 Protein_catabolism of Lbp 1 0.86 0 0
114 INT254176 Positive_regulation of Positive_regulation of Tirap 1 0.32 0 0
115 INT103299 Positive_regulation of Binding of Lbp 1 0.39 0 0
116 INT292596 Positive_regulation of Binding of F2RL1 1 0.41 0 0
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