GO:0034187

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Name apolipoprotein E binding
Categary Function
Go Slim No
Go Link GO:0034187
Unique Molecular Interactions 56
Total Molecular Interactions 87
Total Single Events 422
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apolipoprotein E binding. They are ordered first by their pain relevance and then by number of times they were reported for apolipoprotein E binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
2 INT335054 LPL Positive_regulation of Localization of VLDLR 1 0.04 1.48 0.67
3 INT334013 Ccl25 Positive_regulation of Gene_expression of Lrp1 1 0.07 0.98 0.56
4 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
5 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
6 INT316672 Binding of LRP1 and SFTPD 1 0.35 0.96 0.37
7 INT199285 Tg(Foxn1)E1Hon Regulation of Gene_expression of Mapt 1 0.01 0.52 0.36
8 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25
9 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24
10 INT149281 Binding of MAPT and Dbp 1 0.00 0.4 0.17
11 INT282708 Binding of MAPT and Y301C7L 1 0.00 0.54 0.16
12 INT21620 Binding of Ttpa and Vldlr 1 0.22 0.27 0.12
13 INT149792 Binding of Reln and Vldlr 3 0.51 0.35 0.11
14 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
15 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09
16 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07
17 INT341019 Binding of VLDLR and Reln 1 0.01 0.1 0.05
18 INT340925 VLDLR Positive_regulation of Phosphorylation of DAB1 1 0.01 0.1 0.05
19 INT311730 Binding of Plat and Lrp1 1 0.14 0.65 0.04
20 INT198922 Lrp8 Negative_regulation of Binding of Vldlr 1 0.19 0 0.04
21 INT149794 Binding of LRP8 and Vldlr 1 0.02 0.17 0.04
22 INT321683 Binding of Aicda and Mapt 1 0.36 1.23 0.04
23 INT198930 Binding of Lrp8 and Vldlr 1 0.16 0 0.04
24 INT198919 Binding of Lrp1 and Lrpap1 1 0.07 0 0.04
25 INT149793 Binding of LRP8 and Reln 1 0.03 0.17 0.04
26 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
27 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
28 INT272596 Binding of Dlg4 and Lrp1 1 0.16 0 0.03
29 INT220636 Binding of Lrp1 and Bace1 2 0.32 0.62 0
30 INT209984 Binding of LDLR and LRP1 1 0.08 0 0
31 INT341015 VLDLR Positive_regulation of Lrp8 1 0.02 0.06 0
32 INT325431 Positive_regulation of Binding of Csf2 and Mapt 1 0.18 1.49 0
33 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
34 INT344879 Binding of ENPEP and Mapt 1 0.07 0.08 0
35 INT306677 Binding of Mapt and Atxn3 1 0.07 0.49 0
36 INT344880 Binding of ANPEP and Mapt 1 0.08 0.15 0
37 INT347124 Binding of FZD1 and Lrp1 1 0.11 0.24 0
38 INT325429 Mapt Positive_regulation of Csf2 1 0.13 1.29 0
39 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
40 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
41 INT340929 VLDLR Positive_regulation of PIK3CB 1 0.01 0.06 0
42 INT211576 Vldlr Positive_regulation of Lpl 1 0.38 0.24 0
43 INT209985 Binding of LRP1 and LTF 1 0.01 0 0
44 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
45 INT341017 Binding of VLDLR and Lrp8 1 0.02 0 0
46 INT347123 Binding of Axin2 and Lrp1 1 0.08 0.2 0
47 INT325428 Csf2 Regulation of Mapt 1 0.08 1.47 0
48 INT211577 Vldlr Regulation of Gene_expression of Lpin1 1 0.27 0.12 0
49 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0
50 INT325433 Binding of Csf2 and Mapt 1 0.12 4.41 0
51 INT340923 VLDLR Positive_regulation of DAB1 1 0.01 0.06 0
52 INT344878 ENPEP Regulation of Gene_expression of Mapt 1 0.09 0.33 0
53 INT341024 VLDLR Positive_regulation of Reln 1 0.02 0 0
54 INT344881 ENPEP Regulation of Mapt 1 0.05 0.33 0
55 INT356104 Positive_regulation of Binding of App and Lrp1 1 0.40 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for apolipoprotein E binding. They are ordered first by their pain relevance and then by number of times they were reported in apolipoprotein E binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8595 Localization of Mapt 26 0.73 6.81 6.41
2 INT75627 Gene_expression of Mapt 41 0.75 22.1 4.58
3 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91
4 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61
5 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3
6 INT63923 Binding of Mapt 4 0.47 6.28 1.19
7 INT198879 Localization of Vldlr 6 0.39 0.58 1.1
8 INT198904 Localization of Lrp1 11 0.62 3.25 1.01
9 INT63922 Positive_regulation of Binding of Mapt 1 0.49 0.25 1.01
10 INT8594 Negative_regulation of Mapt 5 0.57 4.47 0.98
11 INT141936 Phosphorylation of Mapt 14 0.80 10.59 0.95
12 INT198872 Binding of Lrp1 9 0.36 2.73 0.89
13 INT95561 Negative_regulation of Vldlr 9 0.53 2.59 0.84
14 INT68297 Binding of MAPT 9 0.47 4.45 0.75
15 INT198899 Regulation of Localization of Vldlr 1 0.24 0.17 0.67
16 INT122061 Negative_regulation of Lrp1 5 0.30 2.47 0.66
17 INT34187 Localization of MAPT 1 0.78 0 0.65
18 INT34186 Positive_regulation of Localization of MAPT 1 0.49 0 0.65
19 INT14318 Negative_regulation of MAPT 3 0.57 2.05 0.59
20 INT14317 Negative_regulation of Negative_regulation of MAPT 1 0.41 0.28 0.56
21 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54
22 INT164196 Binding of LRP1 5 0.47 2.59 0.53
23 INT8638 Regulation of Vldlr 3 0.44 1.57 0.51
24 INT10862 Positive_regulation of Vldlr 4 0.15 2.96 0.49
25 INT198906 Positive_regulation of Localization of Lrp1 4 0.53 0.51 0.45
26 INT198884 Gene_expression of Vldlr 13 0.70 2.41 0.44
27 INT199262 Negative_regulation of Localization of Mapt 3 0.41 1.19 0.4
28 INT323313 Transcription of MAPT 1 0.69 0.45 0.37
29 INT263689 Positive_regulation of Mapt 6 0.49 5.15 0.36
30 INT199261 Negative_regulation of Gene_expression of Mapt 1 0.06 1.25 0.36
31 INT107340 Negative_regulation of Phosphorylation of MAPT 3 0.57 2.64 0.35
32 INT146107 Positive_regulation of Lrp1 4 0.37 1.91 0.34
33 INT199265 Positive_regulation of Gene_expression of Mapt 3 0.67 1.34 0.34
34 INT159311 Gene_expression of Vldlr 2 0.65 0.89 0.34
35 INT335105 Localization of VLDLR 1 0.21 0.71 0.33
36 INT198889 Protein_catabolism of Lrp1 5 0.68 1.6 0.32
37 INT342668 Regulation of LRP1 1 0.01 0.2 0.31
38 INT127984 Positive_regulation of LRP1 5 0.69 0.74 0.3
39 INT199277 Regulation of Gene_expression of Mapt 1 0.08 1.12 0.3
40 INT10861 Negative_regulation of Vldlr 5 0.11 3.22 0.27
41 INT145070 Regulation of MAPT 2 0.44 0.72 0.25
42 INT198873 Regulation of Lrp1 3 0.35 1.45 0.24
43 INT268222 Negative_regulation of Localization of Vldlr 1 0.02 0.26 0.23
44 INT308636 Positive_regulation of Phosphorylation of MAPT 1 0.67 2.31 0.21
45 INT75874 Positive_regulation of Regulation of Vldlr 1 0.11 0.42 0.2
46 INT212383 Gene_expression of VLDLR 4 0.28 1.19 0.18
47 INT198874 Binding of Vldlr 3 0.32 0.73 0.18
48 INT198877 Regulation of Gene_expression of Lrp1 2 0.32 0.62 0.17
49 INT344867 Protein_catabolism of Mapt 1 0.86 0.25 0.17
50 INT149276 Positive_regulation of Binding of MAPT 1 0.49 0.41 0.17
51 INT127985 Localization of LRP1 1 0.80 0.21 0.16
52 INT198868 Regulation of Vldlr 1 0.14 0.73 0.16
53 INT137827 Negative_regulation of Gene_expression of MAPT 2 0.57 1.39 0.13
54 INT335121 Positive_regulation of Gene_expression of VLDLR 1 0.15 0.35 0.13
55 INT198900 Positive_regulation of Vldlr 3 0.26 1.44 0.12
56 INT215137 Regulation of Gene_expression of Vldlr 1 0.04 0.55 0.12
57 INT17084 Binding of Vldlr 1 0.29 0.42 0.11
58 INT255827 Positive_regulation of Gene_expression of MAPT 3 0.49 2.63 0.1
59 INT175218 Positive_regulation of LRP8 1 0.05 1.55 0.1
60 INT115817 Protein_catabolism of MAPT 1 0.64 1.21 0.1
61 INT198876 Protein_catabolism of Vldlr 1 0.34 0 0.09
62 INT57557 Negative_regulation of VLDLR 2 0.19 1.23 0.08
63 INT286025 Positive_regulation of Phosphorylation of Mapt 1 0.45 0.59 0.08
64 INT344866 Positive_regulation of Protein_catabolism of Mapt 1 0.49 0 0.08
65 INT325424 Negative_regulation of Negative_regulation of Mapt 1 0.12 2.99 0.06
66 INT340996 Phosphorylation of VLDLR 1 0.14 0.1 0.05
67 INT308641 Regulation of Phosphorylation of MAPT 1 0.44 0.28 0.05
68 INT211531 Negative_regulation of Gene_expression of Vldlr 1 0.38 0.21 0.04
69 INT246581 Negative_regulation of Gene_expression of VLDLR 1 0.11 0.22 0.04
70 INT198907 Positive_regulation of Gene_expression of Lrp1 7 0.49 3.2 0
71 INT209993 Transcription of LRP1 2 0.33 0.41 0
72 INT255824 Regulation of Gene_expression of MAPT 2 0.44 2.62 0
73 INT268362 Phosphorylation of LRP1 1 0.08 0.35 0
74 INT353783 Positive_regulation of Gene_expression of Vldlr 1 0.28 0.51 0
75 INT198865 Positive_regulation of Negative_regulation of Lrp1 1 0.35 0.28 0
76 INT115666 Gene_expression of LRP1 1 0.19 0.29 0
77 INT326611 Negative_regulation of Transcription of LRP1 1 0.21 0.41 0
78 INT209991 Negative_regulation of Positive_regulation of LRP1 1 0.12 0 0
79 INT209994 Positive_regulation of Transcription of LRP1 1 0.13 0 0
80 INT209995 Negative_regulation of LRP1 1 0.12 0 0
81 INT331143 Regulation of Binding of Mapt 1 0.26 1.14 0
82 INT274378 Binding of LRP8 1 0.04 0.52 0
83 INT340983 Positive_regulation of Positive_regulation of VLDLR 1 0.08 0.14 0
84 INT268391 Positive_regulation of Phosphorylation of LRP1 1 0.06 0.35 0
85 INT340997 Negative_regulation of Binding of VLDLR 1 0.07 0 0
86 INT340994 Binding of VLDLR 1 0.06 0 0
87 INT340987 Negative_regulation of Positive_regulation of VLDLR 1 0.07 0.08 0
88 INT340991 Positive_regulation of VLDLR 1 0.08 0.2 0
89 INT282705 Regulation of Mapt 1 0.25 2.64 0
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