GO:0034199

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Name activation of protein kinase A activity
Categary Process
Go Slim No
Go Link GO:0034199
Unique Molecular Interactions 68
Total Molecular Interactions 82
Total Single Events 569
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase A activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of protein kinase A activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
2 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
3 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
4 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
5 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
6 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
7 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
8 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
9 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
10 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
11 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
12 INT122191 Binding of Crh and Ucn 4 0.36 0.79 0.82
13 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
14 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
15 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
16 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
17 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
18 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
19 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
20 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
21 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
22 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
23 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
24 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
25 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
26 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
27 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
28 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
29 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
30 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 0.01 0 0.4
31 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
32 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
33 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32
34 INT339001 GSX1 Positive_regulation of ADCY1 1 0.01 0 0.29
35 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
36 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
37 INT210828 POMC Positive_regulation of ADCY1 1 0.03 0.34 0.28
38 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27
39 INT93952 CGA Positive_regulation of ADCY1 1 0.03 0 0.27
40 INT93953 Negative_regulation of CGA Positive_regulation of ADCY1 1 0.03 0 0.27
41 INT223042 AR Positive_regulation of ADCY1 1 0.01 0.41 0.25
42 INT223036 SLURP1 Regulation of Positive_regulation of ADCY1 1 0.00 0.42 0.25
43 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
44 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22
45 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
46 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
47 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
48 INT143394 Ucn Regulation of Crh 1 0.44 0.19 0.2
49 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
50 INT216841 TCIRG1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
51 INT216842 ATP6V0A1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
52 INT74600 Negative_regulation of YY1 Negative_regulation of ADCY1 1 0.36 0.25 0.17
53 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15
54 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15
55 INT77122 WDTC1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0.39 0.15
56 INT61998 GNPTAB Positive_regulation of ADCY1 1 0.03 0 0.13
57 INT52711 BSG Regulation of ADCY1 1 0.01 0.1 0.12
58 INT141426 ANTXRL Negative_regulation of ADCY1 1 0.00 0.41 0.11
59 INT57220 Positive_regulation of ATF3 Positive_regulation of PRKACA 1 0.17 0.1 0.09
60 INT57214 ATF3 Positive_regulation of PRKACA 1 0.17 0.1 0.09
61 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
62 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
63 INT205033 Ucn Positive_regulation of Crhr2 1 0.22 0.15 0.08
64 INT222544 Binding of Ucn and Crh 1 0.02 0 0.05
65 INT222417 Ucn Positive_regulation of Localization of Pomc 1 0.01 0 0.04
66 INT222469 Binding of Ucn and Crhr2 1 0.00 0 0.03
67 INT344893 Binding of ADCY1 and Ptger4 1 0.00 0 0
68 INT344892 Binding of ADCY1 and Ptger2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of protein kinase A activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of protein kinase A activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
2 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
3 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
4 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
5 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
6 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
7 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
8 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
9 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
10 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
11 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
12 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
13 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
14 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
15 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
16 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
17 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
18 INT80162 Localization of Ucn 6 0.80 0.6 1.66
19 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
20 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
21 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
22 INT80887 Negative_regulation of Regulation of ADCY1 3 0.35 0.1 1.26
23 INT75891 Regulation of ADCY2 3 0.06 0.06 1.17
24 INT114326 Phosphorylation of ADCY6 2 0.70 0.05 1.11
25 INT124810 Gene_expression of ADCY6 6 0.65 0 1.06
26 INT72868 Transcription of ADCY1 4 0.57 0.69 1.04
27 INT80871 Negative_regulation of Binding of ADCY1 1 0.03 0.1 0.91
28 INT80159 Gene_expression of Ucn 3 0.67 0.47 0.82
29 INT124814 Localization of ADCY6 1 0.65 0 0.78
30 INT124813 Negative_regulation of ADCY6 1 0.37 0 0.73
31 INT124811 Positive_regulation of Negative_regulation of ADCY6 1 0.40 0 0.73
32 INT353152 Localization of PRKACA 1 0.01 1.15 0.66
33 INT127930 Gene_expression of ADCY2 6 0.11 0.1 0.59
34 INT165848 Protein_catabolism of ADCY1 1 0.25 0.28 0.57
35 INT80160 Negative_regulation of Ucn 2 0.58 0.29 0.56
36 INT98814 Negative_regulation of Ucn 2 0.27 0.14 0.55
37 INT165845 Positive_regulation of Transcription of ADCY1 1 0.26 0.36 0.55
38 INT122186 Binding of Ucn 2 0.23 0.37 0.53
39 INT80163 Positive_regulation of Gene_expression of Ucn 1 0.50 0.41 0.52
40 INT110905 Regulation of Negative_regulation of ADCY1 1 0.59 0 0.48
41 INT123831 Regulation of Ucn 2 0.42 0 0.42
42 INT124808 Positive_regulation of Localization of ADCY6 1 0.43 0 0.38
43 INT138362 Regulation of Negative_regulation of ADCY2 1 0.01 0 0.34
44 INT124812 Positive_regulation of ADCY6 1 0.43 0 0.33
45 INT138363 Positive_regulation of Gene_expression of ADCY2 1 0.01 0 0.3
46 INT280795 Positive_regulation of Ucn 1 0.31 0.06 0.27
47 INT122676 Positive_regulation of Ucn 1 0.43 0.92 0.26
48 INT143391 Gene_expression of Ucn 1 0.67 0.2 0.26
49 INT48785 Gene_expression of PRKACA 1 0.35 0 0.23
50 INT127931 Positive_regulation of Gene_expression of ADCY6 2 0.49 0 0.17
51 INT127934 Regulation of ADCY6 1 0.09 0 0.13
52 INT127929 Regulation of Gene_expression of ADCY6 1 0.21 0 0.13
53 INT127928 Regulation of Gene_expression of ADCY2 1 0.08 0 0.13
54 INT252444 Positive_regulation of Binding of ADCY1 1 0.03 0 0.09
55 INT127926 Negative_regulation of Gene_expression of ADCY2 1 0.06 0 0.08
56 INT280766 Localization of Ucn 1 0.46 0 0.07
57 INT127924 Transcription of ADCY6 1 0.18 0 0.07
58 INT127932 Regulation of Transcription of ADCY6 1 0.09 0 0.07
59 INT222594 Binding of Ucn 1 0.06 0 0.03
60 INT84292 Negative_regulation of Positive_regulation of ADCY2 1 0.03 0 0
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