GO:0034237

From wiki-pain
Jump to: navigation, search
Name protein kinase A regulatory subunit binding
Categary Function
Go Slim No
Go Link GO:0034237
Unique Molecular Interactions 81
Total Molecular Interactions 97
Total Single Events 556
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase A regulatory subunit binding. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase A regulatory subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
2 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
3 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
4 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
5 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
6 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
7 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
8 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
9 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
10 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
11 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
12 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
13 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
14 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
15 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
16 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
17 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
18 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
19 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
20 INT252877 Prkaca Positive_regulation of Regulation of Grip2 1 0.01 0.22 0.94
21 INT252878 Prkaca Regulation of Regulation of Grip2 1 0.01 0.22 0.94
22 INT252880 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Tacr1 1 0.02 0.29 0.92
23 INT252876 Positive_regulation of Prkaca Regulation of Gene_expression of Tacr1 1 0.01 0.28 0.89
24 INT78972 Prkaca Regulation of Ina 1 0.11 0.09 0.82
25 INT186439 Prkaca Regulation of Phosphorylation of Creb1 1 0.06 0.08 0.79
26 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
27 INT351350 Prkaca Regulation of Lpar1 1 0.04 0.58 0.72
28 INT161297 Ppp1r1b Negative_regulation of Prkaca 1 0.10 0.16 0.7
29 INT186162 Phosphorylation of Prkaca Positive_regulation of Phosphorylation of Prkcg 1 0.04 0.22 0.7
30 INT112513 Binding of Prkaca and Prkce 1 0.04 0.4 0.64
31 INT261485 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Ephb1 1 0.05 0.12 0.56
32 INT103184 Prkaca Positive_regulation of Phosphorylation of CRTC1 1 0.01 0.57 0.55
33 INT89059 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Trpv1 1 0.07 0.16 0.54
34 INT87559 Vip Positive_regulation of Prkaca 1 0.28 0 0.52
35 INT87557 Crh Positive_regulation of Prkaca 1 0.27 0 0.52
36 INT89058 Prkaca Regulation of Phosphorylation of Trpv1 1 0.04 0.35 0.51
37 INT87558 Calca Positive_regulation of Prkaca 1 0.35 0 0.51
38 INT155958 Binding of Kcnk2 and Akap5 1 0.15 0.64 0.48
39 INT78975 Positive_regulation of Prkaca Regulation of Ina 1 0.09 0 0.43
40 INT78971 Positive_regulation of Prkaca Positive_regulation of Ina 1 0.09 0.09 0.41
41 INT235887 CALM1 Regulation of Akap5 1 0.00 0 0.39
42 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
43 INT356284 Ptger2 Positive_regulation of Prkaca 1 0.00 0.39 0.37
44 INT85778 Rb1 Regulation of Prkaca 1 0.00 0.38 0.36
45 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35
46 INT235862 Binding of Ppp3r2 and Akap5 1 0.01 0 0.35
47 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
48 INT215173 Prkaca Positive_regulation of Positive_regulation of Ptger2 1 0.06 0 0.33
49 INT126852 Prkaca Positive_regulation of Creb1 1 0.27 0.09 0.32
50 INT156632 Prkaca Regulation of Scn10a 1 0.13 0.67 0.3
51 INT168513 Prkaca Positive_regulation of Phosphorylation of Trpv1 1 0.22 0.11 0.29
52 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
53 INT122312 Prkaca Regulation of Kcnk3 1 0.13 0.28 0.28
54 INT241969 Grm8 Positive_regulation of Prkaca 1 0.05 0.35 0.27
55 INT241965 Prkaca Negative_regulation of Grm8 1 0.03 0.36 0.26
56 INT149356 Prkaca Negative_regulation of Raf1 1 0.10 0.08 0.25
57 INT241970 Acpt Positive_regulation of Positive_regulation of Prkaca 1 0.05 0.36 0.24
58 INT71254 MMD Negative_regulation of Prkaca 1 0.00 0 0.24
59 INT231036 Negative_regulation of Prkaca Negative_regulation of Positive_regulation of Sec22b 1 0.01 0 0.22
60 INT110384 Binding of Prkaca and Akap11 1 0.08 0.31 0.2
61 INT215167 Phosphorylation of Prkaca Positive_regulation of P2rx2 1 0.06 0.13 0.18
62 INT106334 Olr1254 Positive_regulation of Prkaca 1 0.01 0 0.18
63 INT110385 Binding of Prkaca and Trpv1 1 0.14 0.28 0.17
64 INT241963 Prkaca Positive_regulation of Positive_regulation of Grm8 1 0.03 0 0.13
65 INT330542 Prkaca Regulation of Regulation of Trpm8 1 0.03 0.1 0.05
66 INT92567 Creb1 Positive_regulation of Binding of Prkaca 1 0.06 0 0.05
67 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
68 INT329996 Binding of SGCD and AKAP6 1 0.37 0.46 0
69 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
70 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
71 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
72 INT329995 Binding of KCNMA1 and AKAP6 1 0.40 0.48 0
73 INT247030 Prkaca Regulation of Positive_regulation of Cftr 1 0.05 0 0
74 INT74026 Negative_regulation of Prkaca Negative_regulation of Transcription of Penk 1 0.07 0.09 0
75 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
76 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
77 INT329992 Binding of SNRNP70 and AKAP6 1 0.03 0.95 0
78 INT247031 Npr1 Positive_regulation of Prkaca 1 0.00 0 0
79 INT192048 Binding of DSP and Ryr2 1 0.24 1.1 0
80 INT192042 Binding of Jup and Ryr2 1 0.17 1.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase A regulatory subunit binding. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase A regulatory subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
2 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
3 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
4 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
5 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
6 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
7 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05
8 INT89052 Positive_regulation of Phosphorylation of Prkaca 13 0.37 2.92 7.05
9 INT68466 Negative_regulation of Positive_regulation of Prkaca 6 0.57 2.29 6.83
10 INT85777 Regulation of Negative_regulation of Prkaca 7 0.46 1.85 5.76
11 INT71244 Binding of Prkaca 8 0.30 2.64 4.96
12 INT120742 Negative_regulation of Gene_expression of Prkaca 6 0.24 3.76 3.86
13 INT78969 Regulation of Positive_regulation of Prkaca 5 0.37 1.38 3.29
14 INT93341 Localization of Prkaca 7 0.59 2.04 2.28
15 INT103179 Regulation of Phosphorylation of Prkaca 6 0.45 0.79 2.15
16 INT186427 Negative_regulation of Negative_regulation of Prkaca 2 0.11 0.48 1.73
17 INT220732 Protein_catabolism of Prkaca 3 0.11 0.61 1.02
18 INT240463 Negative_regulation of Phosphorylation of Prkaca 2 0.23 0.59 0.99
19 INT93340 Negative_regulation of Localization of Prkaca 1 0.10 0 0.68
20 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
21 INT71245 Negative_regulation of Binding of Prkaca 2 0.21 0.06 0.4
22 INT104989 Positive_regulation of Negative_regulation of Prkaca 2 0.33 0.81 0.37
23 INT120216 Regulation of RYR2 2 0.28 1.03 0.22
24 INT139482 Regulation of Gene_expression of Prkaca 3 0.56 0.2 0.18
25 INT323165 Regulation of Akap5 1 0.10 0.08 0.14
26 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11
27 INT89806 Transcription of Prkaca 2 0.29 0.07 0.09
28 INT323163 Negative_regulation of Akap5 1 0.16 0.1 0.07
29 INT323162 Transcription of Akap5 1 0.19 0.1 0.07
30 INT329999 Binding of AKAP6 1 0.36 0.91 0.07
31 INT192016 Localization of RYR2 5 0.25 4.18 0.05
32 INT192012 Binding of RYR2 2 0.30 3.61 0.05
33 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05
34 INT89802 Positive_regulation of Transcription of Prkaca 1 0.21 0.07 0.05
35 INT287842 Negative_regulation of Regulation of Prkaca 1 0.11 0 0.04
36 INT192023 Negative_regulation of RYR2 1 0.15 1.86 0.04
37 INT275364 Positive_regulation of Localization of Prkaca 1 0.28 0.72 0.03
38 INT322462 Transcription of Ryr2 1 0.55 0.47 0.03
39 INT219581 Binding of Ryr2 2 0.27 4.54 0
40 INT219567 Phosphorylation of Ryr2 2 0.62 0.22 0
41 INT329998 Localization of AKAP6 1 0.72 0.26 0
42 INT219566 Localization of Ryr2 1 0.45 0.49 0
43 INT330002 Gene_expression of AKAP6 1 0.75 0.11 0
44 INT322461 Negative_regulation of Transcription of Ryr2 1 0.45 0 0
45 INT219582 Positive_regulation of Phosphorylation of Ryr2 1 0.30 0.22 0
46 INT192020 Regulation of Localization of RYR2 1 0.15 0.27 0
47 INT297204 Regulation of Ryr2 1 0.08 0.3 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox