GO:0034392

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Name negative regulation of smooth muscle cell apoptosis
Categary Process
Go Slim No
Go Link GO:0034392
Unique Molecular Interactions 420
Total Molecular Interactions 610
Total Single Events 4810
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of smooth muscle cell apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of smooth muscle cell apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
3 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
4 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
5 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
6 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
7 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
8 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
9 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
10 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
11 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
12 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
13 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
14 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
15 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
16 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
17 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
18 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
19 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
20 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
21 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
22 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
23 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
24 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
25 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
26 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
27 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
28 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
29 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
30 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
31 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
32 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
33 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
34 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
35 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
36 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
37 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
38 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
39 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
40 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
41 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
42 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
43 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
44 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
45 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
46 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
47 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
48 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
49 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
50 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
51 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
52 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
53 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
54 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
55 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
56 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
57 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
58 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
59 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
60 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
61 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
62 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
63 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
64 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
65 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
66 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
67 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
68 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
69 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
70 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
71 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
72 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
73 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
74 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
75 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
76 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
77 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
78 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
79 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
80 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
81 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
82 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
83 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
84 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
85 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
86 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
87 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
88 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
89 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
90 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
91 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
92 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
93 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
94 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
95 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
96 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
97 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
98 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
99 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
100 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
101 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
102 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
103 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
104 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
105 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
106 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
107 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
108 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
109 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
110 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
111 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
112 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
113 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
114 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
115 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
116 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
117 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
118 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
119 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
120 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
121 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
122 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
123 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
124 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
125 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
126 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
127 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
128 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
129 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
130 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
131 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
132 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
133 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
134 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
135 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
136 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
137 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
138 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
139 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
140 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
141 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
142 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
143 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
144 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
145 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
146 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
147 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
148 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
149 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
150 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
151 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
152 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
153 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
154 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
155 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
156 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
157 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
158 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
159 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
160 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
161 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
162 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
163 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
164 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
165 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
166 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
167 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
168 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
169 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
170 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
171 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
172 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
173 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
174 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
175 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
176 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
177 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
178 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
179 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
180 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
181 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
182 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
183 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
184 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
185 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
186 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
187 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
188 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
189 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
190 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
191 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
192 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
193 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
194 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
195 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
196 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
197 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
198 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
199 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
200 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of smooth muscle cell apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of smooth muscle cell apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
2 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
3 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
4 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
5 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
6 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
7 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
8 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
9 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
10 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
11 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
12 INT5048 Binding of Edn1 55 0.47 18.86 19.16
13 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
14 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
15 INT9191 Localization of EDN1 94 0.81 57.01 14.78
16 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
17 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
18 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
19 INT6365 Localization of Edn1 56 0.81 18.84 13.83
20 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
21 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
22 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
23 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
24 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
25 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
26 INT6361 Localization of Edn1 30 0.81 19.09 9.7
27 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
28 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
29 INT34777 Localization of IGF1 82 0.80 42.68 8.62
30 INT10237 Binding of EDN1 40 0.48 16 8.48
31 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
32 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
33 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
34 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
35 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
36 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
37 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
38 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
39 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
40 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
41 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
42 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
43 INT151032 Localization of Igf1 49 0.76 26.32 5.71
44 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
45 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
46 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
47 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
48 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
49 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
50 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
51 INT49360 Localization of Igf1 22 0.76 6.96 4.26
52 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
53 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
54 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
55 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
56 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
57 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
58 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
59 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
60 INT53374 Binding of Edn1 17 0.43 11.66 2.98
61 INT16130 Binding of IGF1 67 0.48 27.43 2.95
62 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
63 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
64 INT66544 Binding of Igf1 23 0.46 8.33 2.44
65 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
66 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
67 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
68 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
69 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
70 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
71 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
72 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
73 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
74 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
75 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
76 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
77 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
78 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
79 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
80 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
81 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
82 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
83 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
84 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
85 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
86 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
87 INT90491 Binding of Igf1 25 0.44 9.75 1.36
88 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
89 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
90 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
91 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
92 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
93 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
94 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
95 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
96 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
97 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
98 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
99 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
100 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
101 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
102 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
103 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
104 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
105 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
106 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
107 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
108 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
109 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
110 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
111 INT83194 Binding of APOH 4 0.17 3.92 0.66
112 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
113 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
114 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
115 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
116 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
117 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
118 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
119 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
120 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
121 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
122 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
123 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
124 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
125 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
126 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
127 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
128 INT133379 Negative_regulation of APOH 1 0.07 0.09 0.42
129 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
130 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
131 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
132 INT81221 Positive_regulation of APOH 1 0.02 1.24 0.36
133 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
134 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
135 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
136 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
137 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
138 INT130344 Gene_expression of APOH 3 0.34 2.87 0.32
139 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
140 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
141 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
142 INT83195 Regulation of Binding of APOH 1 0.13 0.88 0.31
143 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
144 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
145 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
146 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
147 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
148 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
149 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
150 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
151 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
152 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
153 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
154 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
155 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
156 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
157 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
158 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
159 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
160 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
161 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
162 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
163 INT48615 Positive_regulation of Binding of IGF1 5 0.50 0.54 0.11
164 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
165 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
166 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
167 INT119002 Regulation of APOH 1 0.01 0.43 0.09
168 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
169 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
170 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07
171 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
172 INT202238 Regulation of Transcription of IGF1 1 0.38 0 0.06
173 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
174 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
175 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
176 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
177 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0
178 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
179 INT202239 Negative_regulation of Negative_regulation of IGF1 2 0.39 0.53 0
180 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
181 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
182 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
183 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
184 INT161736 Negative_regulation of Gene_expression of Arrb2 1 0.50 0 0
185 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
186 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
187 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
188 INT274266 Regulation of Positive_regulation of IGF1 1 0.35 0.17 0
189 INT264308 Negative_regulation of Regulation of IGF1 1 0.39 0.23 0
190 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
191 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
192 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
193 INT112083 Negative_regulation of Negative_regulation of Igf1 1 0.31 0.22 0
194 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
195 INT246771 Negative_regulation of Phosphorylation of Igf1 1 0.09 0.37 0
196 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
197 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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