GO:0034405

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Name response to fluid shear stress
Categary Process
Go Slim No
Go Link GO:0034405
Unique Molecular Interactions 720
Total Molecular Interactions 985
Total Single Events 7549
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to fluid shear stress. They are ordered first by their pain relevance and then by number of times they were reported for response to fluid shear stress. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
5 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
6 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
7 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
8 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
9 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
10 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
11 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
12 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
13 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
14 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
15 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
16 INT155663 Positive_regulation of P2rx4 Positive_regulation of Localization of Bdnf 1 0.42 0.84 1.25
17 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
18 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
19 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
20 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
21 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
22 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
23 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
24 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
25 INT274899 Positive_regulation of P2rx4 Positive_regulation of Localization of Gtf3a 1 0.02 1.67 0.95
26 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
27 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
28 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
29 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
30 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
31 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
32 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
33 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
34 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
35 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
36 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
37 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
38 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
39 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
40 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
41 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
42 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
43 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
44 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
45 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
46 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
47 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
48 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
49 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
50 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
51 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
52 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
53 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
54 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
55 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
56 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
57 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
58 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
59 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
60 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
61 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
62 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
63 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
64 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
65 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
66 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
67 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
68 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
69 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
70 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
71 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
72 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
73 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
74 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
75 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
76 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
77 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
78 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
79 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
80 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
81 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
82 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
83 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
84 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
85 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
86 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
87 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
88 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
89 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
90 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
91 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
92 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
93 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
94 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
95 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
96 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
97 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
98 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
99 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
100 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
101 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
102 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
103 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
104 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
105 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
106 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
107 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
108 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
109 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
110 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
111 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
112 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
113 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
114 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
115 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
116 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
117 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
118 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
119 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
120 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
121 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
122 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
123 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
124 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
125 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
126 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
127 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
128 INT114809 Selp Positive_regulation of Gene_expression of F3 1 0.00 0.88 0.34
129 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
130 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
131 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
132 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
133 INT174266 TNF Regulation of Gene_expression of F3 1 0.00 3.2 0.33
134 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
135 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
136 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
137 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
138 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
139 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33
140 INT277011 CRP Positive_regulation of Gene_expression of F3 1 0.06 1.03 0.32
141 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
142 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
143 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
144 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
145 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
146 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
147 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
148 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
149 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
150 INT158708 Positive_regulation of P2RX4 Positive_regulation of Localization of Bdnf 1 0.09 0.48 0.3
151 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
152 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
153 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
154 INT158707 P2RX4 Positive_regulation of Localization of Bdnf 1 0.40 0.59 0.29
155 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
156 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
157 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
158 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
159 INT165171 Tpsab1 Positive_regulation of Gene_expression of P2RX4 1 0.02 0.47 0.28
160 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
161 INT191503 CD40LG Regulation of Gene_expression of F3 1 0.01 0.99 0.27
162 INT282647 IL6 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
163 INT282648 IL8 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
164 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
165 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
166 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
167 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
168 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
169 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
170 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
171 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
172 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
173 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
174 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
175 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
176 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
177 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
178 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
179 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
180 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
181 INT84522 IRF6 Positive_regulation of Gene_expression of F3 1 0.08 0.1 0.21
182 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
183 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
184 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
185 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
186 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
187 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
188 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
189 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
190 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
191 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
192 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
193 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
194 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
195 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
196 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
197 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
198 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
199 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
200 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to fluid shear stress. They are ordered first by their pain relevance and then by number of times they were reported in response to fluid shear stress. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
4 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
5 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
6 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
7 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
8 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
9 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68
10 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
11 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
12 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
13 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
14 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31
15 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
16 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
17 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
18 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
19 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
20 INT59870 Gene_expression of F3 51 0.65 51.83 14.01
21 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
22 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
23 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
24 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
25 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
26 INT122053 Positive_regulation of P2rx4 16 0.69 13.02 11.98
27 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
28 INT98329 Gene_expression of P2RX4 23 0.75 13.13 10.25
29 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
30 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
31 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
32 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57
33 INT168991 Negative_regulation of P2rx4 9 0.43 12.77 9.39
34 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
35 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
36 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
37 INT44003 Gene_expression of F3 40 0.75 27.92 8.29
38 INT136177 Gene_expression of P2rx4 8 0.75 6.74 8.05
39 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
40 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
41 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
42 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
43 INT112430 Negative_regulation of P2rx4 9 0.57 8.4 6.63
44 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
45 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
46 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21
47 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
48 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
49 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
50 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
51 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
52 INT215594 Negative_regulation of Gene_expression of P2rx4 7 0.48 6.46 5.22
53 INT145681 Regulation of P2rx4 4 0.61 3.41 5.09
54 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
55 INT134657 Localization of Akt1 37 0.68 11.58 4.62
56 INT158603 Positive_regulation of Gene_expression of P2RX4 7 0.55 5.85 4.56
57 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
58 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
59 INT136179 Positive_regulation of P2RX4 9 0.67 7.06 4.27
60 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
61 INT75136 Binding of Akt1 27 0.27 8.81 4.15
62 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
63 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
64 INT102515 Binding of Nos3 19 0.45 9.41 4.01
65 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
66 INT78493 Negative_regulation of F3 11 0.27 8.35 3.76
67 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
68 INT136692 Localization of Akt1 12 0.78 2.14 3.65
69 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
70 INT70958 Binding of NOS3 19 0.37 11.84 3.29
71 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
72 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
73 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
74 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
75 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
76 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
77 INT112429 Negative_regulation of Positive_regulation of P2rx4 4 0.57 4.03 2.94
78 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
79 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85
80 INT112431 Positive_regulation of Positive_regulation of P2rx4 2 0.49 3.52 2.81
81 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
82 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
83 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
84 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
85 INT122054 Positive_regulation of Positive_regulation of P2rx4 3 0.49 2.85 2.65
86 INT136176 Positive_regulation of Gene_expression of P2rx4 5 0.60 3.18 2.64
87 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
88 INT214355 Binding of Akt1 13 0.36 3.72 2.59
89 INT118791 Binding of AKT1 32 0.48 15.51 2.25
90 INT46088 Localization of F3 15 0.37 13.7 2.23
91 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
92 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
93 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
94 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
95 INT91594 Localization of NOS3 12 0.78 5.39 2.02
96 INT9106 Positive_regulation of F3 8 0.22 4.92 1.85
97 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
98 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
99 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
100 INT60999 Localization of Nos3 12 0.74 5.28 1.75
101 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
102 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
103 INT158602 Regulation of P2RX4 3 0.48 2.46 1.7
104 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
105 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
106 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
107 INT146941 Negative_regulation of Positive_regulation of P2rx4 2 0.37 1.36 1.47
108 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
109 INT304433 Localization of P2rx4 1 0.69 0 1.44
110 INT304444 Negative_regulation of Gene_expression of P2rx4 1 0.51 0.75 1.43
111 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
112 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
113 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
114 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
115 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
116 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
117 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
118 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
119 INT135556 Localization of AKT1 38 0.69 12.78 1.17
120 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
121 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
122 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
123 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
124 INT88820 Positive_regulation of Gene_expression of F3 8 0.67 5.48 1.08
125 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
126 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
127 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
128 INT44002 Negative_regulation of Gene_expression of F3 5 0.20 1.64 0.98
129 INT146616 Localization of P2RX4 3 0.68 1.65 0.96
130 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
131 INT126912 Localization of P2rx4 4 0.70 1.04 0.95
132 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
133 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
134 INT168989 Phosphorylation of P2rx4 1 0.13 1.15 0.88
135 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
136 INT304454 Negative_regulation of Localization of P2rx4 1 0.32 0 0.81
137 INT146277 Binding of P2RX4 5 0.45 1.1 0.79
138 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
139 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
140 INT216509 Negative_regulation of Positive_regulation of P2RX4 1 0.34 1.12 0.73
141 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
142 INT271590 Positive_regulation of Transcription of P2rx4 1 0.35 0.4 0.7
143 INT215816 Transcription of P2rx4 1 0.36 0.39 0.7
144 INT136594 Negative_regulation of P2RX4 1 0.57 1.16 0.7
145 INT46087 Regulation of F3 4 0.45 3.49 0.68
146 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
147 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
148 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
149 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
150 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
151 INT252418 Binding of P2rx4 2 0.32 0 0.64
152 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
153 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
154 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
155 INT215722 Regulation of P2rx4 2 0.20 0.89 0.6
156 INT67346 Regulation of Gene_expression of F3 2 0.13 1.42 0.6
157 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
158 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
159 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
160 INT304448 Negative_regulation of Regulation of P2rx4 1 0.37 0.09 0.55
161 INT82930 Localization of F3 3 0.26 2.07 0.54
162 INT174271 Binding of F3 6 0.15 6.85 0.53
163 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
164 INT215751 Regulation of Gene_expression of P2rx4 1 0.20 1.33 0.52
165 INT73485 Binding of F3 3 0.03 1.53 0.51
166 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
167 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
168 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
169 INT304441 Negative_regulation of Binding of P2rx4 1 0.37 0 0.49
170 INT278118 Positive_regulation of Positive_regulation of P2RX4 1 0.16 0.59 0.49
171 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
172 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
173 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
174 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
175 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
176 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
177 INT296724 Binding of P2rx4 1 0.29 0 0.35
178 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
179 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
180 INT174272 Negative_regulation of Gene_expression of F3 5 0.14 4.06 0.31
181 INT252656 Positive_regulation of Binding of F3 1 0.07 1.89 0.29
182 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
183 INT146279 Negative_regulation of Gene_expression of P2RX4 2 0.46 0.33 0.28
184 INT215497 Phosphorylation of P2rx4 1 0.11 0 0.28
185 INT210686 Regulation of F3 2 0.12 0.91 0.27
186 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
187 INT158704 Regulation of Localization of P2RX4 1 0.13 0.42 0.25
188 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24
189 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
190 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22
191 INT118276 Regulation of Positive_regulation of Nos3 1 0.09 0 0.21
192 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
193 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2
194 INT138506 Negative_regulation of F3 2 0.04 1.23 0.2
195 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
196 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
197 INT115160 Gene_expression of CITED2 1 0.04 0.45 0.2
198 INT115153 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
199 INT163997 Positive_regulation of Negative_regulation of Nos3 1 0.49 1.15 0.2
200 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
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