GO:0034447

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Name very-low-density lipoprotein particle clearance
Categary Process
Go Slim No
Go Link GO:0034447
Unique Molecular Interactions 116
Total Molecular Interactions 180
Total Single Events 1207
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for very-low-density lipoprotein particle clearance. They are ordered first by their pain relevance and then by number of times they were reported for very-low-density lipoprotein particle clearance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
2 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
3 INT335054 LPL Positive_regulation of Localization of VLDLR 1 0.04 1.48 0.67
4 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
5 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
6 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
7 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
8 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
9 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
10 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
11 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
12 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
13 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
14 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
15 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
16 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
17 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
18 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
19 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
20 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
21 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
22 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
23 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
24 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
25 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
26 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
27 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
28 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
29 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
30 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
31 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
32 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
33 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
34 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
35 INT21620 Binding of Ttpa and Vldlr 1 0.22 0.27 0.12
36 INT149792 Binding of Reln and Vldlr 3 0.51 0.35 0.11
37 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
38 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1
39 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
40 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
41 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
42 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07
43 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07
44 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
45 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
46 INT341019 Binding of VLDLR and Reln 1 0.01 0.1 0.05
47 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
48 INT340925 VLDLR Positive_regulation of Phosphorylation of DAB1 1 0.01 0.1 0.05
49 INT208356 Hdl1 Positive_regulation of Apoe 1 0.12 1.25 0.04
50 INT198922 Lrp8 Negative_regulation of Binding of Vldlr 1 0.19 0 0.04
51 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
52 INT149794 Binding of LRP8 and Vldlr 1 0.02 0.17 0.04
53 INT208357 Hdl1 Positive_regulation of Localization of Apoe 1 0.12 1.26 0.04
54 INT208350 Positive_regulation of Hdl1 Positive_regulation of Apoe 1 0.12 1.27 0.04
55 INT198930 Binding of Lrp8 and Vldlr 1 0.16 0 0.04
56 INT290181 Binding of APOE and PLTP 1 0.17 1.61 0.04
57 INT194483 Binding of Apoe and Chol1 1 0.24 0.51 0.03
58 INT208352 Apoe Regulation of Localization of Em 1 0.04 1.15 0.03
59 INT194481 Binding of Apoe and Apob 1 0.07 0.51 0.03
60 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03
61 INT341015 VLDLR Positive_regulation of Lrp8 1 0.02 0.06 0
62 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0
63 INT326065 APOE Positive_regulation of LCAT 1 0.53 0.84 0
64 INT352793 Binding of APOC1 and FGF21 1 0.01 2.76 0
65 INT209987 Binding of APOE and LDLR 1 0.24 0 0
66 INT208349 Regulation of Binding of Apoc3 and Apoe 1 0.01 0.38 0
67 INT90283 Binding of APOE and Il1a 1 0.01 0 0
68 INT340929 VLDLR Positive_regulation of PIK3CB 1 0.01 0.06 0
69 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
70 INT353802 Binding of APOE and Apob 1 0.05 0.83 0
71 INT211576 Vldlr Positive_regulation of Lpl 1 0.38 0.24 0
72 INT208355 Binding of Apoc3 and Apoe 1 0.01 0.76 0
73 INT198933 Binding of Apoe and App 1 0.33 0.19 0
74 INT353801 Binding of APOE and Cd320 1 0.22 0.83 0
75 INT341017 Binding of VLDLR and Lrp8 1 0.02 0 0
76 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
77 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
78 INT211577 Vldlr Regulation of Gene_expression of Lpin1 1 0.27 0.12 0
79 INT340923 VLDLR Positive_regulation of DAB1 1 0.01 0.06 0
80 INT353804 Binding of APOE and Ldlr 1 0.16 0.84 0
81 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0
82 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
83 INT341024 VLDLR Positive_regulation of Reln 1 0.02 0 0
84 INT284093 VWF Negative_regulation of APOE 1 0.40 2.32 0
85 INT312769 Binding of Apoe and Pon1 1 0.04 0.86 0
86 INT353803 Binding of APOE and Hdl1 1 0.01 0.83 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for very-low-density lipoprotein particle clearance. They are ordered first by their pain relevance and then by number of times they were reported in very-low-density lipoprotein particle clearance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
2 INT197493 Localization of Apoe 61 0.79 27.48 7.06
3 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
4 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
5 INT63042 Binding of Apoe 59 0.48 31.23 5.88
6 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
7 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
8 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
9 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
10 INT72141 Binding of Apoe 11 0.37 10.91 3.27
11 INT97710 Localization of Apoe 1 0.79 7.18 3.2
12 INT50080 Binding of APOE 38 0.45 29.61 2.67
13 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
14 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
15 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
16 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
17 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
18 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
19 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
20 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
21 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
22 INT198879 Localization of Vldlr 6 0.39 0.58 1.1
23 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
24 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
25 INT95561 Negative_regulation of Vldlr 9 0.53 2.59 0.84
26 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
27 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
28 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
29 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
30 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
31 INT198899 Regulation of Localization of Vldlr 1 0.24 0.17 0.67
32 INT175580 Localization of APOE 10 0.76 18.84 0.65
33 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
34 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
35 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
36 INT8638 Regulation of Vldlr 3 0.44 1.57 0.51
37 INT10862 Positive_regulation of Vldlr 4 0.15 2.96 0.49
38 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
39 INT198884 Gene_expression of Vldlr 13 0.70 2.41 0.44
40 INT96816 Regulation of APOE 8 0.45 6.62 0.44
41 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
42 INT159311 Gene_expression of Vldlr 2 0.65 0.89 0.34
43 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
44 INT335105 Localization of VLDLR 1 0.21 0.71 0.33
45 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
46 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
47 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
48 INT10861 Negative_regulation of Vldlr 5 0.11 3.22 0.27
49 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
50 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
51 INT268222 Negative_regulation of Localization of Vldlr 1 0.02 0.26 0.23
52 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
53 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
54 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
55 INT75874 Positive_regulation of Regulation of Vldlr 1 0.11 0.42 0.2
56 INT212383 Gene_expression of VLDLR 4 0.28 1.19 0.18
57 INT198874 Binding of Vldlr 3 0.32 0.73 0.18
58 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
59 INT198868 Regulation of Vldlr 1 0.14 0.73 0.16
60 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
61 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
62 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
63 INT126804 Gene_expression of APOC1 1 0.75 1.06 0.14
64 INT335121 Positive_regulation of Gene_expression of VLDLR 1 0.15 0.35 0.13
65 INT198900 Positive_regulation of Vldlr 3 0.26 1.44 0.12
66 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
67 INT215137 Regulation of Gene_expression of Vldlr 1 0.04 0.55 0.12
68 INT17084 Binding of Vldlr 1 0.29 0.42 0.11
69 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
70 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
71 INT198876 Protein_catabolism of Vldlr 1 0.34 0 0.09
72 INT268708 Phosphorylation of APOC1 1 0.38 1.02 0.09
73 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
74 INT57557 Negative_regulation of VLDLR 2 0.19 1.23 0.08
75 INT205147 Regulation of Phosphorylation of APOE 1 0.06 0.34 0.07
76 INT97709 Positive_regulation of Localization of Apoe 1 0.68 1.02 0.07
77 INT340996 Phosphorylation of VLDLR 1 0.14 0.1 0.05
78 INT208336 Positive_regulation of Binding of Apoe 1 0.48 0.7 0.05
79 INT208333 Positive_regulation of Positive_regulation of Apoe 1 0.48 0.65 0.05
80 INT211531 Negative_regulation of Gene_expression of Vldlr 1 0.38 0.21 0.04
81 INT246581 Negative_regulation of Gene_expression of VLDLR 1 0.11 0.22 0.04
82 INT199220 Negative_regulation of APOC1 1 0.02 1.89 0.03
83 INT326070 Regulation of Localization of APOE 1 0.58 1.21 0.03
84 INT191285 Positive_regulation of Localization of APOE 3 0.66 3.06 0
85 INT326073 Transcription of APOE 2 0.51 1.94 0
86 INT50081 Positive_regulation of Positive_regulation of APOE 2 0.49 0.18 0
87 INT353783 Positive_regulation of Gene_expression of Vldlr 1 0.28 0.51 0
88 INT340983 Positive_regulation of Positive_regulation of VLDLR 1 0.08 0.14 0
89 INT340997 Negative_regulation of Binding of VLDLR 1 0.07 0 0
90 INT340994 Binding of VLDLR 1 0.06 0 0
91 INT326524 Negative_regulation of Transcription of APOE 1 0.30 1.71 0
92 INT340987 Negative_regulation of Positive_regulation of VLDLR 1 0.07 0.08 0
93 INT340991 Positive_regulation of VLDLR 1 0.08 0.2 0
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