GO:0034504

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Name protein localization to nucleus
Categary Process
Go Slim No
Go Link GO:0034504
Unique Molecular Interactions 309
Total Molecular Interactions 418
Total Single Events 3144
Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein localization to nucleus. They are ordered first by their pain relevance and then by number of times they were reported for protein localization to nucleus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
2 INT189017 Binding of Pax3 and Lmna 1 0.14 0.42 1.16
3 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
4 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
5 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
6 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
7 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
8 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
9 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
10 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
11 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
12 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
13 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
14 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
15 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
16 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
17 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
18 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
19 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
20 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
21 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
22 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
23 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
24 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
25 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
26 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
27 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
28 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
29 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
30 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
31 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
32 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
33 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
34 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
35 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
36 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
37 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
38 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
39 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
40 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
41 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
42 INT225099 ZNF630 Positive_regulation of Gene_expression of COL1A1 1 0.00 0.17 0.2
43 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
44 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
45 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
46 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
47 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
48 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
49 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
50 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
51 INT295336 Binding of Grb7 and Xpo1 1 0.09 0.31 0.15
52 INT295342 Binding of Hua and Xpo1 1 0.06 0.31 0.15
53 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
54 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
55 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
56 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
57 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
58 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
59 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
60 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
61 INT246844 Binding of Irs1 and Myl7 1 0.05 0.43 0.11
62 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1
63 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
64 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
65 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
66 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
67 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
68 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
69 INT58630 Calca Negative_regulation of Positive_regulation of COL1A1 1 0.02 0.23 0.08
70 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
71 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
72 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
73 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
74 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
75 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08
76 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
77 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
78 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
79 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
80 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
81 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08
82 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
83 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08
84 INT246839 Binding of Irs1 and Gopc 1 0.16 0.15 0.08
85 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
86 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
87 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
88 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
89 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
90 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
91 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
92 INT246842 Binding of Ins1 and Irs1 1 0.16 0.63 0.06
93 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
94 INT240873 Ins1 Positive_regulation of Phosphorylation of Irs1 1 0.05 0 0.05
95 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
96 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05
97 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05
98 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05
99 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
100 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
101 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
102 INT240893 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Irs1 1 0.08 0.36 0.04
103 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
104 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
105 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
106 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
107 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
108 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
109 INT222980 TNF Positive_regulation of Localization of COL1A1 1 0.01 0.56 0.04
110 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
111 INT199526 Ceacam1 Negative_regulation of Col1a1 1 0.01 0.06 0.03
112 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
113 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
114 INT207555 GH1 Negative_regulation of Phosphorylation of IRS1 1 0.10 0.28 0.03
115 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
116 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
117 INT222977 Positive_regulation of COL1A1 Positive_regulation of MMP1 1 0.01 0.61 0.03
118 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03
119 INT222987 Positive_regulation of COL1A1 Positive_regulation of Protein_catabolism of MMP1 1 0.01 0.61 0.03
120 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
121 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
122 INT179949 Binding of Ins1 and Irs1 1 0.31 0.32 0.03
123 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
124 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
125 INT170329 Binding of Col4a1 and Col1a1 1 0.03 0.14 0.03
126 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03
127 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03
128 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
129 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
130 INT170331 Binding of Col7a1 and Col1a1 1 0.00 0.14 0.03
131 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
132 INT252820 ELANE Positive_regulation of Gene_expression of COL1A1 1 0.01 0.58 0
133 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
134 INT295338 Ptpn11 Regulation of Binding of Xpo1 1 0.02 0 0
135 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
136 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
137 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0
138 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
139 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
140 INT295344 Regulation of Binding of Hua and Xpo1 1 0.05 0 0
141 INT342358 Binding of Irs1 and Erap1 1 0.37 0 0
142 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
143 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0
144 INT295408 Binding of Oprk1 and Xpo1 1 0.00 0 0
145 INT252796 ELANE Regulation of COL1A1 1 0.01 0.57 0
146 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
147 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
148 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
149 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
150 INT335705 Binding of ITGA4 and Calr 1 0.01 0.43 0
151 INT321722 Negative_regulation of Binding of Irs1 and Ppp1r13b 1 0.20 0.07 0
152 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
153 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
154 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
155 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
156 INT180847 Binding of COL1A1 and NID2 1 0.05 0.91 0
157 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
158 INT321715 Regulation of Binding of Irs1 and Ppp1r13b 1 0.15 0.05 0
159 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
160 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
161 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
162 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0
163 INT240880 Mapk8 Positive_regulation of Protein_catabolism of Irs1 1 0.21 0.14 0
164 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
165 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
166 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
167 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
168 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
169 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
170 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
171 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
172 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
173 INT312214 INPP5K Regulation of Gene_expression of COL1A1 1 0.08 0 0
174 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
175 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
176 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
177 INT328906 Binding of LMNA and CSAD 1 0.11 0 0
178 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 1 0.03 0.1 0
179 INT304347 INS Positive_regulation of Phosphorylation of IRS1 1 0.09 0.77 0
180 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
181 INT252773 ROS1 Positive_regulation of COL1A1 1 0.05 0.57 0
182 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
183 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
184 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
185 INT252800 ROS1 Regulation of COL1A1 1 0.05 0.57 0
186 INT295410 Positive_regulation of Binding of Oprk1 and Xpo1 1 0.00 0 0
187 INT252813 ELANE Positive_regulation of COL1A1 1 0.01 0.57 0
188 INT118660 Binding of COL1A1 and GAPDH 1 0.16 0.09 0
189 INT342360 Binding of H2-K1 and Irs1 1 0.10 0 0
190 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
191 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
192 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
193 INT240900 Negative_regulation of Ros1 Positive_regulation of Gene_expression of Irs1 1 0.08 0.13 0
194 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
195 INT294523 Binding of MDM2 and PDB1 1 0.40 0.1 0
196 INT96782 FAM176C Regulation of Gene_expression of COL1A1 1 0.32 0.05 0
197 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 1 0.09 0 0
198 INT180859 Binding of COL1A1 and NID1 1 0.01 0.9 0
199 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
200 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein localization to nucleus. They are ordered first by their pain relevance and then by number of times they were reported in protein localization to nucleus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
2 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
3 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
4 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
5 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
6 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
7 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
8 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
9 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
10 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
11 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
12 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
13 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
14 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
15 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
16 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
17 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
18 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
19 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
20 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
21 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
22 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01
23 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
24 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
25 INT70526 Binding of CALR 11 0.35 7.09 1.97
26 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
27 INT21941 Regulation of CALR 7 0.53 3.88 1.96
28 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
29 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
30 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
31 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
32 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
33 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59
34 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
35 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
36 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
37 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
38 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
39 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
40 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
41 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
42 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
43 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
44 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
45 INT66118 Binding of Calr 4 0.46 1.46 1.26
46 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
47 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
48 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
49 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
50 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
51 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
52 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
53 INT250453 Gene_expression of Lmna 3 0.65 0.48 1.13
54 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
55 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
56 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
57 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
58 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
59 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
60 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
61 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
62 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
63 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83
64 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
65 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
66 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
67 INT270447 Binding of Smo 2 0.07 2.61 0.78
68 INT141150 Localization of BMP7 4 0.56 2.84 0.76
69 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
70 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
71 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
72 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66
73 INT242655 Binding of Irs1 1 0.29 1.45 0.66
74 INT75043 Binding of Msx1 6 0.35 2.36 0.65
75 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
76 INT177557 Positive_regulation of Calr 12 0.48 5.47 0.61
77 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
78 INT162801 Localization of CALR 7 0.73 8.69 0.6
79 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
80 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
81 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
82 INT250455 Localization of Lmna 1 0.68 0.08 0.58
83 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
84 INT100065 Negative_regulation of LMNA 12 0.49 0.12 0.56
85 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
86 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
87 INT247258 Positive_regulation of Lmna 1 0.45 0.53 0.55
88 INT68092 Negative_regulation of Localization of COL1A1 1 0.48 0 0.53
89 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
90 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
91 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
92 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
93 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
94 INT8886 Regulation of Transcription of Col1a1 1 0.04 0 0.5
95 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
96 INT206484 Localization of Shh 2 0.75 1.14 0.46
97 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
98 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
99 INT246828 Binding of Irs1 9 0.37 2.68 0.42
100 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
101 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
102 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
103 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
104 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
105 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
106 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
107 INT320812 Positive_regulation of Localization of COL1A1 1 0.05 1.04 0.4
108 INT250456 Regulation of Lmna 1 0.44 0 0.4
109 INT250454 Regulation of Regulation of Lmna 1 0.44 0 0.4
110 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
111 INT163709 Regulation of Negative_regulation of COL1A1 1 0.29 0.93 0.34
112 INT250452 Positive_regulation of Gene_expression of Lmna 1 0.49 0 0.33
113 INT158521 Positive_regulation of Negative_regulation of Irs1 1 0.02 0.57 0.33
114 INT214842 Positive_regulation of LMNA 14 0.45 2.98 0.31
115 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
116 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
117 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
118 INT254811 Localization of Col1a1 3 0.29 1.39 0.3
119 INT356400 Transcription of Smo 1 0.02 0.05 0.3
120 INT291615 Negative_regulation of Localization of Col1a1 1 0.06 1.28 0.3
121 INT287931 Positive_regulation of Gene_expression of DVL1 2 0.09 0.08 0.29
122 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
123 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
124 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
125 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
126 INT126512 Negative_regulation of Gene_expression of Col1a1 3 0.39 2.2 0.27
127 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
128 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26
129 INT240830 Positive_regulation of Protein_catabolism of Irs1 2 0.69 0.82 0.26
130 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
131 INT176464 Protein_catabolism of Col1a1 1 0.19 0.83 0.26
132 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
133 INT271432 Positive_regulation of Regulation of Col1a1 1 0.10 0.61 0.24
134 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
135 INT246817 Positive_regulation of Binding of Irs1 1 0.50 0.37 0.23
136 INT225109 Regulation of Localization of COL1A1 1 0.05 0.41 0.23
137 INT240818 Protein_catabolism of Irs1 3 0.98 1 0.22
138 INT222087 Regulation of Calr 3 0.42 0.56 0.22
139 INT279230 Regulation of Gene_expression of LMNA 1 0.02 0.22 0.22
140 INT89406 Negative_regulation of Positive_regulation of IRS1 1 0.22 0.93 0.22
141 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
142 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
143 INT218694 Binding of Col1a1 2 0.21 1.52 0.21
144 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
145 INT136488 Regulation of LMNA 13 0.60 3.53 0.2
146 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
147 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
148 INT335675 Localization of Calr 1 0.63 1.23 0.2
149 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
150 INT188239 Binding of LMNA 20 0.47 6.58 0.18
151 INT120859 Positive_regulation of Localization of Col1a1 1 0.16 0.05 0.18
152 INT246824 Negative_regulation of Irs1 6 0.43 2.13 0.17
153 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
154 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
155 INT289128 Negative_regulation of Gene_expression of DVL1 1 0.07 0.31 0.17
156 INT187816 Positive_regulation of Transcription of Col1a1 1 0.06 0.82 0.17
157 INT289117 Negative_regulation of DVL1 1 0.07 0.31 0.17
158 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
159 INT177555 Regulation of Gene_expression of Calr 3 0.28 0.82 0.16
160 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
161 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
162 INT284323 Regulation of IRS1 2 0.45 1.6 0.16
163 INT113346 Binding of MDM2 10 0.35 5.73 0.15
164 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
165 INT240841 Regulation of Gene_expression of Irs1 3 0.45 0.75 0.15
166 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
167 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
168 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
169 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
170 INT120962 Negative_regulation of Negative_regulation of Irs1 1 0.25 0.38 0.15
171 INT130000 Positive_regulation of Protein_catabolism of Col1a1 1 0.49 1.15 0.15
172 INT187815 Transcription of Col1a1 1 0.09 0.76 0.15
173 INT301563 Positive_regulation of Positive_regulation of Irs1 1 0.16 1.32 0.15
174 INT177554 Positive_regulation of Gene_expression of Calr 3 0.37 1.08 0.14
175 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
176 INT73297 Positive_regulation of Transcription of Col1a1 2 0.32 3.12 0.14
177 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
178 INT257290 Negative_regulation of Transcription of COL1A1 3 0.27 1.64 0.13
179 INT230807 Regulation of Phosphorylation of Irs1 3 0.45 1.59 0.13
180 INT253190 Localization of Shh 2 0.77 1.06 0.13
181 INT214127 Localization of Msx1 1 0.06 0.21 0.13
182 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
183 INT287922 Phosphorylation of DVL1 4 0.20 1.21 0.12
184 INT335686 Regulation of Localization of Calr 1 0.48 0.12 0.12
185 INT246818 Negative_regulation of Gene_expression of Irs1 3 0.42 1.25 0.1
186 INT304385 Protein_catabolism of IRS1 2 0.42 1.8 0.1
187 INT287912 Localization of BMP4 1 0.18 1.13 0.1
188 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
189 INT240850 Regulation of Irs1 2 0.47 0.64 0.09
190 INT246825 Regulation of Positive_regulation of Irs1 1 0.45 0.47 0.09
191 INT270442 Transcription of Shh 1 0.53 0.25 0.09
192 INT213515 Binding of Shh 8 0.37 1.92 0.08
193 INT192855 Transcription of Calr 1 0.11 0.99 0.08
194 INT270453 Regulation of Shh 1 0.27 0.83 0.08
195 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
196 INT316570 Binding of BMP7 3 0.37 0.95 0.07
197 INT205973 Binding of SHH 3 0.35 1.03 0.07
198 INT246819 Negative_regulation of Binding of Irs1 3 0.42 0.62 0.07
199 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
200 INT297181 Negative_regulation of Ppp3r1 1 0.52 2.3 0.07
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