GO:0034612

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Name response to tumor necrosis factor
Categary Process
Go Slim No
Go Link GO:0034612
Unique Molecular Interactions 774
Total Molecular Interactions 1100
Total Single Events 11608
Pain Genes Associated 41

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to tumor necrosis factor. They are ordered first by their pain relevance and then by number of times they were reported for response to tumor necrosis factor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
5 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
6 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
7 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
8 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
9 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
10 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
11 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
12 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
13 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
14 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
15 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
16 INT338691 Binding of Trpv1 and Aff3 1 0.24 1.21 1.88
17 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
18 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
19 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
20 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
21 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
22 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
23 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
24 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
25 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
26 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
27 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
28 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
29 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
30 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
31 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
32 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
33 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
34 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
35 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
36 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
37 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
38 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
39 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
40 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
41 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
42 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
43 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95
44 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
45 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
46 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
47 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
48 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
49 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
50 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
51 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
52 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
53 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
54 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
55 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
56 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
57 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
58 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
59 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
60 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
61 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
62 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
63 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
64 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
65 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
66 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
67 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78
68 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
69 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
70 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
71 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
72 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
73 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
74 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
75 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
76 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
77 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
78 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
79 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
80 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
81 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
82 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 0.06 0.27 0.7
83 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7
84 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
85 INT338693 Aff3 Positive_regulation of Localization of CAP1 1 0.01 0.39 0.69
86 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
87 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
88 INT338690 Aff3 Positive_regulation of Trpv1 1 0.39 0.4 0.67
89 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
90 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
91 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
92 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
93 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
94 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
95 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
96 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
97 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
98 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
99 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
100 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64
101 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
102 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
103 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
104 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
105 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
106 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
107 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
108 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
109 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
110 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
111 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
112 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
113 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
114 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
115 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
116 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
117 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
118 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6
119 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
120 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
121 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
122 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
123 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
124 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
125 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
126 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
127 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58
128 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
129 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
130 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
131 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
132 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
133 INT254637 Bdkrb2 Regulation of Gene_expression of Ccl5 1 0.17 1.22 0.56
134 INT203105 MMP3 Negative_regulation of Gene_expression of IL10 1 0.06 0.69 0.56
135 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
136 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
137 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56
138 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
139 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
140 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
141 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
142 INT176340 CHI3L1 Positive_regulation of Localization of CSF2 1 0.11 1.86 0.55
143 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
144 INT176343 CHI3L1 Positive_regulation of Localization of CSF1 1 0.23 1.86 0.55
145 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
146 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
147 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
148 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
149 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
150 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
151 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
152 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
153 INT196524 Binding of MMP1 and MMP9 1 0.31 0.74 0.51
154 INT196519 Positive_regulation of Binding of MMP1 and MMP9 1 0.42 0.74 0.51
155 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
156 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
157 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
158 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
159 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
160 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
161 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
162 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
163 INT203104 MMP3 Positive_regulation of Gene_expression of IFN1@ 1 0.25 0.33 0.48
164 INT127664 Negative_regulation of PDE4A Negative_regulation of MMP9 1 0.37 0.76 0.48
165 INT127665 Negative_regulation of PDE4A Negative_regulation of Transcription of MMP9 1 0.37 0.76 0.48
166 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
167 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
168 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
169 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
170 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
171 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
172 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
173 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
174 INT250858 Mmp3 Regulation of Protein_catabolism of Ecm1 1 0.01 1.11 0.47
175 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
176 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47
177 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
178 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
179 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
180 INT138159 IL6 Positive_regulation of Gene_expression of Mmp3 1 0.00 0.23 0.46
181 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
182 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
183 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
184 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
185 INT138160 IL1B Positive_regulation of Gene_expression of Mmp3 1 0.03 0.23 0.46
186 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
187 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
188 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
189 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
190 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
191 INT338692 CAP1 Negative_regulation of Positive_regulation of Aff3 1 0.01 0.2 0.44
192 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
193 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
194 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
195 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
196 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
197 INT226070 Binding of CRP and MMP9 1 0.51 1.13 0.42
198 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
199 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
200 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to tumor necrosis factor. They are ordered first by their pain relevance and then by number of times they were reported in response to tumor necrosis factor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
3 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
4 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
5 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
6 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
7 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
8 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
9 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
10 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
11 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
12 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
13 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
14 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
15 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
16 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
17 INT99610 Localization of MMP9 126 0.79 48.46 32.67
18 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
19 INT8691 Localization of Insr 85 0.80 9.27 30.32
20 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
21 INT5300 Regulation of Insr 54 0.60 11.33 29.26
22 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
23 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
24 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
25 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
26 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
27 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
28 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
29 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92
30 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
31 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
32 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
33 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
34 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
35 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
36 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
37 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
38 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
39 INT81486 Localization of MMP3 31 0.81 12.94 15.21
40 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
41 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
42 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
43 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
44 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
45 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
46 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
47 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
48 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
49 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
50 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
51 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
52 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
53 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
54 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
55 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
56 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
57 INT102987 Regulation of MMP3 23 0.60 9.35 9.54
58 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
59 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
60 INT116605 Binding of Nos2 28 0.37 16.88 8.18
61 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
62 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88
63 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
64 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
65 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
66 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
67 INT152347 Binding of GCH1 8 0.37 6.13 7.36
68 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
69 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
70 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
71 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18
72 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
73 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
74 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
75 INT181348 Localization of Ccl5 24 0.65 19.55 6.8
76 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
77 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
78 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
79 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
80 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08
81 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
82 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
83 INT329292 Gene_expression of Aff3 3 0.54 3.24 5.87
84 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
85 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
86 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
87 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47
88 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36
89 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28
90 INT62525 Positive_regulation of SELE 38 0.70 46 5.25
91 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12
92 INT107242 Binding of MMP3 14 0.47 12.06 5.11
93 INT181363 Regulation of Ccl5 16 0.46 13.65 5.09
94 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
95 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
96 INT73608 Localization of Nos2 21 0.75 9.58 5.05
97 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97
98 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
99 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96
100 INT82887 Positive_regulation of Ccl5 10 0.40 3.4 4.91
101 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
102 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
103 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
104 INT176614 Positive_regulation of Gene_expression of Ccl5 20 0.59 16.2 4.81
105 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
106 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
107 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71
108 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67
109 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64
110 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
111 INT181042 Binding of Ccl5 18 0.41 9.34 4.51
112 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43
113 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
114 INT51084 Binding of Insr 13 0.30 4.25 4.23
115 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19
116 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
117 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
118 INT99608 Transcription of MMP9 18 0.65 9.67 4.11
119 INT83035 Binding of INSR 16 0.47 9.29 4.11
120 INT144302 Protein_catabolism of MMP3 7 0.86 7.43 3.98
121 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
122 INT338681 Positive_regulation of Aff3 1 0.56 1.22 3.91
123 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
124 INT133312 Binding of MMP9 25 0.42 16.79 3.83
125 INT123883 Positive_regulation of Gene_expression of Mmp3 16 0.60 4.42 3.74
126 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
127 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
128 INT173849 Positive_regulation of Localization of MMP3 7 0.49 4.6 3.65
129 INT89592 Localization of Ccl5 10 0.61 7.65 3.62
130 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
131 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59
132 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
133 INT10116 Localization of INSR 11 0.57 5.43 3.48
134 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
135 INT122997 Phosphorylation of Rps6kb1 46 0.72 9.92 3.43
136 INT181418 Regulation of Gene_expression of Ccl5 11 0.52 9.86 3.37
137 INT68974 Localization of Mmp9 10 0.80 4.84 3.35
138 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
139 INT172689 Localization of Mmp3 15 0.68 5.52 3.32
140 INT135815 Transcription of Gch1 1 0.60 0 3.32
141 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
142 INT126223 Binding of Nos2 17 0.37 6 3.22
143 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17
144 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
145 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
146 INT115617 Binding of Ccl5 5 0.33 0.58 3.11
147 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
148 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
149 INT228677 Negative_regulation of Phosphorylation of Rps6kb1 24 0.51 3.88 2.97
150 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9
151 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
152 INT123139 Binding of Mmp3 7 0.37 1.98 2.84
153 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
154 INT123910 Gene_expression of CXCL16 5 0.49 3.81 2.82
155 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
156 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73
157 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
158 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
159 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64
160 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
161 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
162 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
163 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
164 INT89852 Localization of Nos2 22 0.78 14.89 2.56
165 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
166 INT151309 Positive_regulation of Positive_regulation of MMP3 5 0.60 2.62 2.5
167 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
168 INT183810 Positive_regulation of Positive_regulation of MMP9 9 0.52 4.15 2.46
169 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
170 INT113339 Binding of JAK2 6 0.40 5.31 2.4
171 INT338117 Negative_regulation of Transcription of Mmp3 1 0.09 1.01 2.4
172 INT120124 Transcription of MMP3 9 0.69 2.15 2.38
173 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
174 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
175 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
176 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
177 INT173850 Negative_regulation of Localization of MMP3 3 0.48 3.32 2.25
178 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
179 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
180 INT109970 Negative_regulation of Casp8 5 0.52 9.34 2.19
181 INT121706 Negative_regulation of Positive_regulation of MMP3 4 0.38 2.68 2.19
182 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
183 INT153406 Gene_expression of Cxcl16 18 0.72 6.16 2.16
184 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
185 INT152286 Regulation of Gene_expression of Mmp9 5 0.36 3.95 2.15
186 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
187 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13
188 INT93718 Protein_catabolism of Mmp3 9 0.73 4.32 2.11
189 INT125246 Negative_regulation of Positive_regulation of Mmp9 5 0.27 5.34 2.09
190 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
191 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
192 INT115616 Positive_regulation of Binding of Ccl5 3 0.25 0.59 2.04
193 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
194 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
195 INT103244 Protein_catabolism of MMP9 12 0.72 11.81 2.01
196 INT5279 Localization of Ggt1 9 0.81 2.8 1.99
197 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
198 INT158022 Binding of CHI3L1 10 0.43 14.18 1.94
199 INT102158 Protein_catabolism of Mmp9 7 0.65 5.43 1.91
200 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9
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