GO:0034617

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Name tetrahydrobiopterin binding
Categary Function
Go Slim No
Go Link GO:0034617
Unique Molecular Interactions 428
Total Molecular Interactions 567
Total Single Events 9917
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tetrahydrobiopterin binding. They are ordered first by their pain relevance and then by number of times they were reported for tetrahydrobiopterin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
2 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
3 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
4 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
5 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
6 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
7 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
8 INT40887 Penk Regulation of Th 1 0.04 0 1.53
9 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
10 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
11 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
12 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
13 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
14 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
15 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
16 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
17 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
18 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
19 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
20 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
21 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
22 INT31547 Binding of Th and Vip 1 0.31 0 1.08
23 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
24 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
25 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
26 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
27 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
28 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
29 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
30 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
31 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
32 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
33 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
34 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
35 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
36 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
37 INT184916 Binding of da and Th 1 0.09 1.22 0.87
38 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
39 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
40 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
41 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
42 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
43 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
44 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
45 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
46 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
47 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
48 INT235087 NOS1 Positive_regulation of Localization of ABAT 1 0.02 0.61 0.81
49 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
50 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
51 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
52 INT96501 Il11 Regulation of Gene_expression of NOS2 1 0.00 1.04 0.8
53 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
54 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
55 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
56 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
57 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
58 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77
59 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
60 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
61 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
62 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
63 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
64 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
65 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
66 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
67 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
68 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
69 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
70 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
71 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
72 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
73 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
74 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
75 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
76 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63
77 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
78 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
79 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
80 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
81 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
82 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59
83 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
84 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
85 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
86 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
87 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
88 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
89 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
90 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
91 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
92 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
93 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
94 INT121081 Negative_regulation of NOS1 Negative_regulation of Slep1 1 0.00 0 0.52
95 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
96 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
97 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
98 INT90131 NOS1 Regulation of Fos 1 0.00 0.25 0.49
99 INT235090 Positive_regulation of GRIN1 Positive_regulation of NOS1 1 0.42 0.81 0.49
100 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
101 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
102 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49
103 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
104 INT191950 NFKB2 Regulation of Gene_expression of NOS2 1 0.08 1 0.47
105 INT72928 Magel2 Negative_regulation of Positive_regulation of NOS1 1 0.01 0 0.47
106 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
107 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
108 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
109 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46
110 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
111 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46
112 INT95276 Obfc2a Negative_regulation of Nos3 1 0.02 1.02 0.46
113 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46
114 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
115 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
116 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
117 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
118 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
119 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
120 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
121 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
122 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
123 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
124 INT135972 Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.41
125 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
126 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
127 INT97789 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Nos2 1 0.12 0.23 0.4
128 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
129 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
130 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
131 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
132 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
133 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38
134 INT109683 NOS1 Positive_regulation of Positive_regulation of ISYNA1 1 0.01 0.11 0.38
135 INT235091 CALM1 Positive_regulation of NOS1 1 0.02 0.63 0.37
136 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36
137 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36
138 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
139 INT152240 Nfasc Regulation of Gene_expression of Nos2 1 0.06 0.19 0.36
140 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36
141 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
142 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
143 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
144 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
145 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34
146 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
147 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
148 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
149 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
150 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
151 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
152 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
153 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
154 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
155 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
156 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
157 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33
158 INT333158 asa Positive_regulation of Nos3 1 0.11 0.18 0.32
159 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
160 INT333166 Tlx2 Positive_regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
161 INT344036 Binding of NOS1 and SPTB 1 0.01 0.31 0.32
162 INT333155 Tlx2 Regulation of Gene_expression of Nos3 1 0.08 0.18 0.32
163 INT333152 Tlx2 Positive_regulation of Nos3 1 0.08 0.18 0.32
164 INT333169 asa Positive_regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
165 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
166 INT333164 asa Regulation of Nos3 1 0.11 0.18 0.32
167 INT333149 asa Regulation of Gene_expression of Nos3 1 0.11 0.18 0.32
168 INT333167 Tlx2 Regulation of Nos3 1 0.08 0.18 0.32
169 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
170 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
171 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
172 INT191949 NFKB2 Positive_regulation of NOS2 1 0.05 1.16 0.31
173 INT313740 Negative_regulation of NOS1 Positive_regulation of Gene_expression of Ccl2 1 0.02 0.38 0.3
174 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
175 INT55404 Binding of ENG and Th 1 0.02 0 0.3
176 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3
177 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
178 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
179 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
180 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28
181 INT141871 Binding of Nos3 and Slc2a4 1 0.25 0.51 0.28
182 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
183 INT156440 Cpox Positive_regulation of NOS1 1 0.01 0.52 0.28
184 INT78484 Binding of DBH and TH 1 0.09 0 0.28
185 INT349506 S100a8 Positive_regulation of Gene_expression of Nos2 1 0.02 0.67 0.28
186 INT278971 IL1B Positive_regulation of Gene_expression of NOS2 1 0.14 0.79 0.27
187 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
188 INT314305 Ptger2 Positive_regulation of Nos2 1 0.00 0.07 0.26
189 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
190 INT278954 MST1 Regulation of Gene_expression of NOS2 1 0.01 0.41 0.25
191 INT278945 NOS2 Regulation of Gene_expression of CPOX 1 0.02 0.41 0.25
192 INT278963 IL6 Regulation of Gene_expression of NOS2 1 0.12 0.41 0.25
193 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
194 INT127101 Memo1 Negative_regulation of Gene_expression of Nos2 1 0.10 0.55 0.24
195 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24
196 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24
197 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
198 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
199 INT273055 Plat Positive_regulation of Gene_expression of Nos2 1 0.01 1.34 0.23
200 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for tetrahydrobiopterin binding. They are ordered first by their pain relevance and then by number of times they were reported in tetrahydrobiopterin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
3 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
4 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
5 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
6 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85
7 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71
8 INT7327 Regulation of Th 164 0.62 29.67 110.14
9 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
10 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
11 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
12 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
13 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
14 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
15 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
16 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
17 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
18 INT350 Localization of Th 79 0.80 10.26 41.17
19 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
20 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
21 INT7326 Transcription of Th 83 0.72 13.5 35.33
22 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84
23 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
24 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
25 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72
26 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
27 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
28 INT48766 Regulation of NOS1 73 0.61 37.01 24.59
29 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
30 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
31 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
32 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96
33 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
34 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72
35 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
36 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
37 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
38 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
39 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
40 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
41 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
42 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
43 INT13716 Positive_regulation of TH 33 0.68 19.11 16
44 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
45 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
46 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
47 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
48 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
49 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47
50 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
51 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
52 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37
53 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
54 INT141 Binding of Th 21 0.48 3.53 11.04
55 INT48912 Localization of NOS1 52 0.77 24.14 10.92
56 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
57 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42
58 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
59 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71
60 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
61 INT48908 Transcription of NOS1 27 0.55 13.46 8.39
62 INT109265 Transcription of Th 18 0.68 4.5 8.21
63 INT116605 Binding of Nos2 28 0.37 16.88 8.18
64 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
65 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
66 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
67 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
68 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
69 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
70 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
71 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
72 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
73 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
74 INT66987 Regulation of Th 23 0.61 7.86 6.8
75 INT3506 Localization of TH 12 0.81 0.78 6.66
76 INT89131 Negative_regulation of NOS2 20 0.58 9.68 6.56
77 INT83712 Transcription of Nos3 19 0.69 13.09 6.31
78 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
79 INT48911 Binding of NOS1 24 0.40 11.21 5.89
80 INT94428 Negative_regulation of Gene_expression of NOS2 20 0.47 11.61 5.62
81 INT30317 Regulation of TH 14 0.43 7.27 5.38
82 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2
83 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
84 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
85 INT73608 Localization of Nos2 21 0.75 9.58 5.05
86 INT89132 Regulation of NOS2 9 0.61 7.34 4.95
87 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
88 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
89 INT37151 Localization of Th 13 0.57 3.11 4.82
90 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
91 INT76581 Regulation of Negative_regulation of NOS1 14 0.45 7.49 4.4
92 INT94427 Positive_regulation of Positive_regulation of NOS2 14 0.47 11.15 4.3
93 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
94 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
95 INT83991 Regulation of Nos3 25 0.44 9.89 4.06
96 INT102515 Binding of Nos3 19 0.45 9.41 4.01
97 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
98 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
99 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
100 INT70958 Binding of NOS3 19 0.37 11.84 3.29
101 INT126223 Binding of Nos2 17 0.37 6 3.22
102 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
103 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
104 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
105 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
106 INT89133 Transcription of NOS2 13 0.71 6.84 2.93
107 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
108 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
109 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73
110 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7
111 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
112 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
113 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
114 INT97523 Phosphorylation of NOS1 3 0.46 0.59 2.58
115 INT89852 Localization of Nos2 22 0.78 14.89 2.56
116 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
117 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
118 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
119 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
120 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
121 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
122 INT76094 Localization of NOS2 8 0.72 2.76 2.34
123 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
124 INT132669 Positive_regulation of Transcription of NOS1 7 0.44 4.43 2.19
125 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
126 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
127 INT104263 Regulation of Positive_regulation of NOS1 5 0.28 3.15 2.15
128 INT89130 Positive_regulation of Transcription of NOS2 7 0.50 3.32 2.14
129 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
130 INT91594 Localization of NOS3 12 0.78 5.39 2.02
131 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
132 INT76532 Binding of Nos3 13 0.37 9.32 1.87
133 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
134 INT3505 Binding of TH 5 0.39 2.6 1.8
135 INT60999 Localization of Nos3 12 0.74 5.28 1.75
136 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
137 INT79063 Regulation of Gene_expression of NOS2 6 0.43 3.68 1.7
138 INT145545 Transcription of TH 3 0.67 1.48 1.64
139 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
140 INT96047 Positive_regulation of Localization of NOS1 6 0.38 4.24 1.47
141 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
142 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
143 INT83713 Positive_regulation of Transcription of Nos3 3 0.67 2.92 1.38
144 INT89785 Regulation of Transcription of Nos3 1 0.32 0.85 1.36
145 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
146 INT136612 Positive_regulation of Positive_regulation of Nos3 5 0.43 4.22 1.26
147 INT61395 Negative_regulation of Negative_regulation of NOS1 5 0.30 1.83 1.25
148 INT144392 Negative_regulation of Negative_regulation of Nos2 2 0.42 1.83 1.24
149 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23
150 INT97869 Negative_regulation of Positive_regulation of Th 3 0.25 0.79 1.23
151 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
152 INT50267 Negative_regulation of Negative_regulation of Th 3 0.42 1.57 1.12
153 INT121052 Binding of NOS2 3 0.35 3.12 1.12
154 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
155 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
156 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
157 INT89288 Positive_regulation of Negative_regulation of NOS1 5 0.40 4.84 0.96
158 INT132667 Regulation of Transcription of NOS1 1 0.30 2.58 0.95
159 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
160 INT198953 Regulation of Regulation of Th 1 0.01 0.1 0.93
161 INT89856 Positive_regulation of Localization of Nos2 6 0.49 1.79 0.9
162 INT24242 Negative_regulation of Phosphorylation of Th 3 0.38 1.44 0.9
163 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
164 INT50266 Regulation of Negative_regulation of Th 1 0.42 0.94 0.88
165 INT132668 Negative_regulation of Transcription of NOS1 3 0.18 1.72 0.87
166 INT92836 Regulation of Transcription of Nos2 3 0.58 1.79 0.85
167 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
168 INT147138 Positive_regulation of Phosphorylation of NOS1 1 0.12 0.45 0.8
169 INT122572 Phosphorylation of Nos3 37 0.65 25.23 0.75
170 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
171 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68
172 INT85855 Negative_regulation of Binding of NOS1 6 0.37 3.4 0.66
173 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63
174 INT110019 Negative_regulation of Phosphorylation of NOS1 1 0.08 0 0.62
175 INT181576 Phosphorylation of Nos3 7 0.59 1.35 0.6
176 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
177 INT13929 Protein_catabolism of Th 3 1.00 0 0.58
178 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56
179 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56
180 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54
181 INT117882 Regulation of Positive_regulation of NOS2 1 0.45 0.43 0.54
182 INT278983 Regulation of Negative_regulation of NOS2 1 0.17 1.71 0.53
183 INT95368 Negative_regulation of Positive_regulation of NOS2 4 0.37 0.89 0.52
184 INT96037 Positive_regulation of Localization of Nos2 2 0.49 0.78 0.52
185 INT349037 Regulation of Phosphorylation of Nos2 1 0.39 1.02 0.51
186 INT229773 Positive_regulation of Regulation of Nos2 3 0.41 2.97 0.5
187 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
188 INT145100 Regulation of Transcription of Nos3 4 0.44 2.05 0.46
189 INT108735 Regulation of Localization of Nos2 3 0.42 0.52 0.46
190 INT111304 Regulation of Gene_expression of TH 2 0.17 0.57 0.44
191 INT144095 Localization of Nos3 8 0.57 4.5 0.43
192 INT186288 Negative_regulation of Binding of Nos2 3 0.35 1.08 0.42
193 INT149650 Protein_catabolism of Nos2 3 0.55 0.79 0.42
194 INT208368 Negative_regulation of Regulation of Nos2 1 0.42 0.35 0.42
195 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
196 INT193491 Negative_regulation of Positive_regulation of Nos3 2 0.36 1.67 0.4
197 INT235457 Negative_regulation of Regulation of Nos2 3 0.42 1.55 0.39
198 INT90640 Positive_regulation of Negative_regulation of Th 2 0.40 0.58 0.39
199 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38
200 INT95273 Regulation of Negative_regulation of Nos3 2 0.20 0.85 0.37
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