GO:0034641

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Name cellular nitrogen compound metabolic process
Categary Process
Go Slim Yes
Go Link GO:0034641
Unique Molecular Interactions 691
Total Molecular Interactions 995
Total Single Events 10839
Pain Genes Associated 73

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular nitrogen compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for cellular nitrogen compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
5 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
6 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
7 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
8 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
9 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
10 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
11 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
12 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
13 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
14 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
15 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
16 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
17 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
18 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
19 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
20 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
21 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
22 INT57249 GNRH1 Regulation of Regulation of CGA 1 0.20 0 1.74
23 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
24 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
25 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
26 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57
27 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
28 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
29 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
30 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
31 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
32 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
33 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
34 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
35 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
36 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
37 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
38 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
39 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
40 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
41 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
42 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
43 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
44 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33
45 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
46 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
47 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
48 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
49 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
50 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
51 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
52 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 0.58 0.81 1.23
53 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
54 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
55 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
56 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 0.45 0 1.19
57 INT142075 IL4 Negative_regulation of Binding of IDO1 1 0.02 2.07 1.19
58 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
59 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
60 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
61 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
62 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
63 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
64 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
65 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
66 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
67 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
68 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
69 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
70 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02
71 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
72 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
73 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
74 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
75 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
76 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
77 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
78 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94
79 INT20888 POMC Positive_regulation of Localization of PDYN 1 0.40 0 0.92
80 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
81 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
82 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
83 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
84 INT264944 Binding of POMC and BOC 1 0.07 0.44 0.89
85 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
86 INT59497 Adh1 Regulation of POMC 1 0.03 0 0.86
87 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
88 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
89 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
90 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
91 INT110236 Hk1 Regulation of CSAD 1 0.01 1.57 0.84
92 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
93 INT1582 Binding of PENK and POMC 1 0.16 0 0.83
94 INT79617 Htr1a Positive_regulation of Localization of POMC 1 0.38 0 0.83
95 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
96 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
97 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
98 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77
99 INT18099 POMC Positive_regulation of Binding of Prl 1 0.00 0 0.76
100 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
101 INT32163 Binding of CALM1 and POMC 4 0.46 0 0.75
102 INT164055 POMC Regulation of Agrp 1 0.29 0.3 0.75
103 INT164057 POMC Regulation of Pomc 1 0.09 0.3 0.75
104 INT124404 Binding of POMC and Oprm1 1 0.00 0.25 0.75
105 INT164056 Agrp Regulation of POMC 1 0.29 0.3 0.75
106 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
107 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
108 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
109 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
110 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73
111 INT26872 ABAT Positive_regulation of Localization of POMC 1 0.03 0 0.71
112 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
113 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 0.31 0 0.7
114 INT12711 POMC Regulation of Prl 1 0.04 1.25 0.7
115 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
116 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
117 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69
118 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
119 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68
120 INT40471 GH1 Positive_regulation of POMC 1 0.25 0 0.67
121 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 0.01 0.1 0.67
122 INT151252 CSAD Positive_regulation of Positive_regulation of Ltp 1 0.06 0.81 0.67
123 INT61798 Binding of NDP and POMC 2 0.22 0 0.66
124 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66
125 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
126 INT151251 CSAD Regulation of Positive_regulation of Ltp 1 0.04 0.82 0.65
127 INT28080 POMC Negative_regulation of Gene_expression of ITGAM 1 0.00 0.16 0.65
128 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
129 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
130 INT72146 POMC Positive_regulation of Phosphorylation of MYOT 1 0.00 0.25 0.65
131 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
132 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
133 INT23555 POMC Positive_regulation of Penk 1 0.56 0 0.63
134 INT23554 POMC Positive_regulation of Localization of Penk 1 0.56 0 0.63
135 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62
136 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
137 INT152766 TAT Positive_regulation of Positive_regulation of MYLK 1 0.44 0.67 0.61
138 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
139 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
140 INT42269 POMC Negative_regulation of Localization of AVP 1 0.09 0 0.61
141 INT47461 PDYN Regulation of POMC 1 0.01 0 0.6
142 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
143 INT152765 TAT Regulation of Positive_regulation of MYLK 1 0.40 0.66 0.6
144 INT13238 POMC Regulation of Gene_expression of IL2 1 0.09 0.26 0.59
145 INT130288 POMC Regulation of Gene_expression of VTCN1 1 0.01 0.1 0.59
146 INT34311 Regulation of CRH Positive_regulation of POMC 1 0.24 0 0.59
147 INT60538 Gnrh1 Positive_regulation of Localization of LHB 1 0.00 0.19 0.59
148 INT130287 POMC Regulation of Localization of IL10 1 0.12 0.1 0.59
149 INT37035 PLAT Negative_regulation of ODC1 1 0.45 0.15 0.58
150 INT62034 POMC Regulation of Positive_regulation of IL4 1 0.44 0 0.58
151 INT35181 Binding of STT3A and POMC 1 0.29 0.75 0.57
152 INT93541 Ntsr1 Regulation of POMC 1 0.00 0 0.57
153 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
154 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54
155 INT102422 POMC Regulation of Gene_expression of Sst 1 0.14 0.24 0.54
156 INT23486 HBE1 Positive_regulation of Localization of FSHB 1 0.03 0 0.54
157 INT56733 Ddc Positive_regulation of Localization of GLUL 1 0.00 0 0.54
158 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 0.27 0 0.53
159 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
160 INT70244 POMC Positive_regulation of Localization of PLOD1 1 0.21 0 0.53
161 INT23483 HBE1 Positive_regulation of FSHB 1 0.01 0 0.53
162 INT56390 CCK Positive_regulation of Localization of POMC 1 0.14 0.06 0.52
163 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
164 INT119030 Binding of POMC and Ighg1 1 0.06 0 0.52
165 INT18248 Binding of CGA and GNRH1 1 0.15 0.92 0.52
166 INT33505 Oprd1 Regulation of Localization of CGA 1 0.00 0 0.52
167 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52
168 INT261498 CBS Positive_regulation of DSE 1 0.00 0 0.5
169 INT55323 GNRH1 Regulation of POMC 1 0.35 0 0.49
170 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
171 INT48114 GHRH Positive_regulation of Localization of CGB 1 0.05 0 0.48
172 INT90252 Binding of PPBP and TAT 1 0.39 5.55 0.48
173 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48
174 INT92802 Binding of PPIG and GRHPR 1 0.03 0.11 0.47
175 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
176 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
177 INT177784 PDCD2 Positive_regulation of ASNS 1 0.04 0.76 0.46
178 INT72088 IL10 Positive_regulation of POMC 1 0.15 0 0.46
179 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
180 INT72087 IL4 Positive_regulation of POMC 1 0.16 0 0.46
181 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
182 INT28081 POMC Regulation of Gene_expression of VIM 1 0.13 0.09 0.46
183 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
184 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
185 INT32662 Hps1 Negative_regulation of Localization of CGB 1 0.00 0 0.46
186 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 0.06 0 0.45
187 INT69873 ASIP Negative_regulation of Binding of POMC 1 0.35 0 0.45
188 INT28082 POMC Regulation of PDYN 1 0.04 0.09 0.45
189 INT80053 Negative_regulation of Binding of ACAT1 and NA 1 0.01 0.25 0.45
190 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
191 INT56132 CALCA Positive_regulation of Localization of POMC 1 0.51 0.16 0.44
192 INT80052 Binding of ACAT1 and NA 1 0.01 0.24 0.44
193 INT100282 TXN Negative_regulation of Transcription of POMC 1 0.54 0.39 0.43
194 INT23481 POMC Regulation of Localization of PLOD1 1 0.20 0 0.42
195 INT128287 POMC Positive_regulation of RTCA 1 0.04 0.13 0.42
196 INT76153 Binding of NCOR2 and Negative_regulation of Localization of LHB 1 0.00 0 0.42
197 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
198 INT47595 Binding of POMC and Pomc 1 0.02 0 0.41
199 INT250975 Binding of FMOD and CSAD 1 0.01 0.86 0.41
200 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular nitrogen compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in cellular nitrogen compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT738 Regulation of POMC 459 0.62 111.19 243.74
5 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
6 INT695 Binding of POMC 304 0.48 56.66 126.85
7 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
8 INT1793 Localization of CGA 379 0.81 67.38 114.69
9 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
10 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
11 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
12 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
13 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98
14 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
15 INT7035 Regulation of CGA 87 0.45 29.04 28.45
16 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
17 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
18 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68
19 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
20 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
21 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
22 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
23 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
24 INT5372 Localization of LHB 55 0.68 9.47 19
25 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
26 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
27 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
28 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
29 INT13716 Positive_regulation of TH 33 0.68 19.11 16
30 INT1416 Transcription of POMC 40 0.72 10.71 15.38
31 INT11918 Localization of CGB 35 0.51 8.21 15.01
32 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94
33 INT180497 Binding of MRI1 45 0.42 28.35 14.77
34 INT70265 Regulation of MRI1 42 0.39 30.95 14.18
35 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
36 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
37 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
38 INT9946 Regulation of Localization of LHB 27 0.52 2.47 11.08
39 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
40 INT31780 Binding of DIO2 17 0.36 10.07 10
41 INT1648 Regulation of LHB 21 0.61 3.32 9.6
42 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96
43 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
44 INT156827 Localization of MRI1 25 0.65 16.06 8.33
45 INT13346 Regulation of Localization of CGB 18 0.30 1.29 8.32
46 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07
47 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
48 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
49 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47
50 INT261511 Localization of CBS 1 0.02 5.06 7.27
51 INT321907 Negative_regulation of DAO 1 0.51 9.08 7.07
52 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
53 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
54 INT3506 Localization of TH 12 0.81 0.78 6.66
55 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33
56 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
57 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
58 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
59 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6
60 INT8866 Positive_regulation of TAT 30 0.67 18.06 5.57
61 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47
62 INT30317 Regulation of TH 14 0.43 7.27 5.38
63 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
64 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
65 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28
66 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
67 INT94095 Negative_regulation of BCAT1 9 0.49 0.97 4.91
68 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81
69 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8
70 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
71 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
72 INT9729 Negative_regulation of LHB 14 0.42 1.86 4.63
73 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
74 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
75 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
76 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
77 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42
78 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
79 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06
80 INT11370 Positive_regulation of LHB 15 0.28 5.45 4.01
81 INT504 Gene_expression of GPT 42 0.75 27.54 3.99
82 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
83 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88
84 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81
85 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66
86 INT200385 Negative_regulation of ADC 19 0.18 16.56 3.6
87 INT4632 Regulation of CGB 9 0.38 1.81 3.53
88 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42
89 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
90 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
91 INT124569 Transcription of HPD 6 0.15 1.25 3.32
92 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23
93 INT35009 Binding of CSAD 12 0.41 10.74 3.21
94 INT15837 Binding of CGA 31 0.41 12.06 3.17
95 INT15253 Binding of DBH 7 0.36 3.21 3.17
96 INT9110 Binding of PAH 32 0.41 42.1 3.1
97 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09
98 INT109411 Gene_expression of SAT1 61 0.77 67.99 3.08
99 INT124570 Gene_expression of HPD 14 0.78 6.76 3.07
100 INT30077 Positive_regulation of Localization of CGB 5 0.34 0.42 3.07
101 INT12796 Binding of DLD 20 0.36 6.71 3.02
102 INT137301 Negative_regulation of Gene_expression of TPH1 5 0.12 1.49 2.98
103 INT202577 Localization of DIO2 9 0.56 1.3 2.97
104 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
105 INT11371 Positive_regulation of Localization of LHB 8 0.47 1.4 2.93
106 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
107 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
108 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91
109 INT16015 Negative_regulation of Localization of LHB 10 0.37 2.95 2.9
110 INT4147 Gene_expression of LHB 8 0.49 3.94 2.88
111 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84
112 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78
113 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
114 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76
115 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71
116 INT7976 Regulation of Gene_expression of CGA 8 0.19 1.09 2.71
117 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61
118 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
119 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
120 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
121 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53
122 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53
123 INT15606 Localization of FSHB 24 0.78 9.16 2.49
124 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48
125 INT2695 Regulation of DBH 5 0.45 1.09 2.48
126 INT200217 Localization of PAH 10 0.36 15.51 2.46
127 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45
128 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44
129 INT200384 Regulation of ADC 12 0.25 5.46 2.41
130 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35
131 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33
132 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
133 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
134 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
135 INT7034 Regulation of Regulation of CGA 5 0.16 0.17 2.29
136 INT27315 Positive_regulation of TPO 17 0.45 9.84 2.28
137 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
138 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16
139 INT281928 Gene_expression of ARG2 3 0.77 63.17 2.14
140 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12
141 INT49723 Localization of GLUL 5 0.27 0.67 2.1
142 INT61011 Regulation of TPH1 4 0.22 1.17 2.09
143 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02
144 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99
145 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
146 INT66082 Regulation of CSAD 5 0.27 4.72 1.99
147 INT42497 Regulation of Negative_regulation of POMC 4 0.44 0.63 1.99
148 INT243846 Localization of DDC 3 0.63 0.66 1.99
149 INT25952 Negative_regulation of Regulation of POMC 4 0.36 0.76 1.96
150 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
151 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9
152 INT37041 Positive_regulation of ODC1 8 0.70 4.04 1.9
153 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
154 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84
155 INT77523 Positive_regulation of ADC 14 0.63 13.81 1.81
156 INT3505 Binding of TH 5 0.39 2.6 1.8
157 INT321910 Positive_regulation of DAO 1 0.60 3.96 1.8
158 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79
159 INT41580 Negative_regulation of Negative_regulation of POMC 5 0.50 0.46 1.79
160 INT8556 Positive_regulation of NQO1 12 0.70 5.11 1.78
161 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
162 INT191342 Positive_regulation of Gene_expression of IDO1 4 0.36 3.5 1.75
163 INT142081 Binding of IDO1 4 0.21 2.55 1.73
164 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
165 INT6130 Positive_regulation of Regulation of POMC 6 0.69 3.57 1.7
166 INT145545 Transcription of TH 3 0.67 1.48 1.64
167 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
168 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61
169 INT53451 Regulation of TAT 6 0.44 3.07 1.61
170 INT76633 Regulation of BCAT1 2 0.04 0.79 1.61
171 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59
172 INT40453 Regulation of ODC1 7 0.45 1.08 1.58
173 INT99720 Positive_regulation of SAT1 21 0.69 26.55 1.56
174 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
175 INT43019 Regulation of PHGDH 4 0.26 2.46 1.53
176 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46
177 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46
178 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
179 INT146303 Binding of PHGDH 7 0.36 4.7 1.42
180 INT4486 Regulation of TSHB 5 0.28 0.99 1.42
181 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
182 INT333291 Positive_regulation of Gene_expression of DDC 1 0.49 0.13 1.35
183 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
184 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32
185 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32
186 INT76596 Gene_expression of BCAT1 5 0.58 0.73 1.32
187 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32
188 INT40102 Positive_regulation of Phosphorylation of POMC 3 0.44 0.57 1.3
189 INT9040 Negative_regulation of CGB 9 0.51 2.71 1.29
190 INT110838 Regulation of AGXT 5 0.46 2.21 1.28
191 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
192 INT36330 Positive_regulation of Positive_regulation of GOT1 4 0.32 4.42 1.26
193 INT142078 Negative_regulation of IDO1 3 0.14 2.59 1.23
194 INT31317 Positive_regulation of PHGDH 6 0.49 4.45 1.22
195 INT17099 Regulation of GPT 9 0.44 5.5 1.2
196 INT122745 Negative_regulation of TPH1 6 0.59 2.94 1.2
197 INT9730 Binding of LHB 4 0.35 2.38 1.19
198 INT122894 Transcription of DIO3 1 0.52 0.71 1.19
199 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18
200 INT105425 Binding of BCAT1 5 0.42 0.78 1.17
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