GO:0034713

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Name type I transforming growth factor beta receptor binding
Categary Function
Go Slim No
Go Link GO:0034713
Unique Molecular Interactions 189
Total Molecular Interactions 236
Total Single Events 1573
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for type I transforming growth factor beta receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for type I transforming growth factor beta receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
8 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
9 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
10 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
11 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
12 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
13 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
14 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
15 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
16 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
17 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
18 INT32719 ENG Regulation of LH 2 0.00 0 0.64
19 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
20 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
21 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
22 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
23 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
24 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
25 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
26 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
27 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
28 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
29 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
30 INT102213 Binding of ENG and HP 1 0.01 0 0.47
31 INT169478 TGFB3 Positive_regulation of Tgfa 1 0.01 0.9 0.44
32 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
33 INT169465 TGFB3 Positive_regulation of MTG1 1 0.03 0.89 0.43
34 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
35 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
36 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
37 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
38 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
39 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
40 INT55404 Binding of ENG and Th 1 0.02 0 0.3
41 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
42 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
43 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
44 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
45 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
46 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
47 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
48 INT14869 Binding of EGF and TGFB3 1 0.14 0.69 0.19
49 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
50 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
51 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
52 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
53 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
54 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
55 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
56 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
57 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
58 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
59 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
60 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
61 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
62 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
63 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
64 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
65 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
66 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
67 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
68 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
69 INT207760 Fkbp1a Regulation of MSMB 1 0.12 0.69 0.04
70 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
71 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
72 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
73 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
74 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
75 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
76 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
77 INT311909 Gene_expression of Smad6 Negative_regulation of Gene_expression of Col10a1 1 0.02 0.54 0.04
78 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
79 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
80 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
81 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
82 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
83 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
84 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
85 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
86 INT120077 Gene_expression of Smad7 Negative_regulation of Positive_regulation of Itk 1 0.02 0.27 0
87 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
88 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
89 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0
90 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
91 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
92 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
93 INT32148 POMC Regulation of ENG 1 0.24 0 0
94 INT218663 Olr811 Positive_regulation of Gene_expression of Smad7 1 0.01 0.45 0
95 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
96 INT134836 Binding of SMAD7 and YAP1 1 0.53 0.89 0
97 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
98 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
99 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
100 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
101 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
102 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
103 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0
104 INT347155 Mirlet7a-1 Negative_regulation of Smad7 1 0.10 0 0
105 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
106 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
107 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
108 INT137933 TGFB3 Regulation of Tgfb1 1 0.00 0 0
109 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
110 INT314870 Binding of Ltbp3 and Tgfb3 1 0.24 0.52 0
111 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
112 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0
113 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
114 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
115 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
116 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
117 INT137935 Tgfb1 Regulation of TGFB3 1 0.00 0 0
118 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0
119 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0
120 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
121 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0
122 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0
123 INT218670 Olr811 Regulation of Phosphorylation of Smad2 1 0.00 0.33 0
124 INT269938 Smad2 Positive_regulation of Tpt1 1 0.14 0.07 0
125 INT137929 IGF1 Regulation of TGFB3 1 0.00 0 0
126 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
127 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
128 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0
129 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for type I transforming growth factor beta receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in type I transforming growth factor beta receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT10799 Localization of ENG 63 0.78 18.67 27.28
4 INT7674 Regulation of ENG 42 0.30 11.41 14.44
5 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
6 INT23375 Binding of ENG 17 0.47 6.02 6.46
7 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
8 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
9 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
10 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
11 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
12 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96
13 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
14 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
15 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
16 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
17 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
18 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
19 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
20 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
21 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
22 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
23 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
24 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
25 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
26 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
27 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
28 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
29 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
30 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
31 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
32 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
33 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
34 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
35 INT14871 Binding of TGFB3 3 0.13 1.2 0.78
36 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
37 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
38 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
39 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
40 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
41 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
42 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
43 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
44 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
45 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
46 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
47 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
48 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
49 INT27659 Localization of TGFB3 3 0.29 0.52 0.4
50 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
51 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34
52 INT207065 Localization of Fkbp1a 1 0.36 0.82 0.33
53 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
54 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
55 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
56 INT184716 Binding of Smad7 2 0.34 0.91 0.29
57 INT14873 Positive_regulation of Gene_expression of TGFB3 2 0.25 1.14 0.29
58 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
59 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
60 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28
61 INT202802 Regulation of Fkbp1a 4 0.26 0.96 0.28
62 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
63 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
64 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
65 INT147840 Gene_expression of Tgfb3 1 0.03 0 0.22
66 INT147841 Positive_regulation of Gene_expression of Tgfb3 1 0.02 0 0.22
67 INT265311 Localization of Smad2 5 0.50 1.57 0.21
68 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
69 INT61823 Positive_regulation of TGFB3 2 0.01 1.64 0.2
70 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
71 INT272889 Negative_regulation of Smad6 2 0.20 1.31 0.19
72 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
73 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
74 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
75 INT135490 Localization of Smad2 1 0.51 0.08 0.14
76 INT90940 Binding of Eng 5 0.35 1.92 0.13
77 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
78 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
79 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
80 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
81 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1
82 INT81940 Regulation of TGFB3 3 0.14 0.45 0.1
83 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
84 INT299319 Localization of FKBP1A 1 0.44 0 0.09
85 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
86 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
87 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
88 INT128091 Binding of TGFBR2 1 0.02 0.08 0.08
89 INT265338 Regulation of Eng 2 0.42 0.94 0.05
90 INT347149 Localization of Smad7 1 0.67 0 0.05
91 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
92 INT268389 Positive_regulation of TGFBR2 1 0.39 0.62 0.05
93 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
94 INT337908 Binding of Smad2 3 0.24 1.06 0.04
95 INT172971 Gene_expression of Smad6 2 0.37 1.77 0.04
96 INT311898 Positive_regulation of Gene_expression of Smad6 1 0.33 0.53 0.04
97 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
98 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
99 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
100 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
101 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
102 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
103 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
104 INT245858 Positive_regulation of Gene_expression of Eng 1 0.12 0 0.03
105 INT289876 Localization of Eng 3 0.44 0.59 0
106 INT190471 Transcription of ENG 3 0.21 1.76 0
107 INT268378 Positive_regulation of Phosphorylation of SMAD2 3 0.67 1.22 0
108 INT271411 Positive_regulation of Positive_regulation of Smad2 2 0.45 0.9 0
109 INT265314 Regulation of Gene_expression of Eng 2 0.42 0.68 0
110 INT265324 Negative_regulation of Gene_expression of Eng 2 0.40 0.9 0
111 INT347148 Regulation of Smad7 1 0.26 0 0
112 INT197394 Protein_catabolism of Eng 1 0.07 0.13 0
113 INT296615 Positive_regulation of Smad2 1 0.50 1.51 0
114 INT218701 Negative_regulation of Binding of Smad7 1 0.14 0.15 0
115 INT166121 Binding of SMAD7 1 0.30 0.39 0
116 INT314827 Binding of Tgfb3 1 0.36 0.51 0
117 INT353273 Negative_regulation of Phosphorylation of Smad7 1 0.25 0 0
118 INT310177 Binding of Tgfbr2 1 0.24 0 0
119 INT310171 Phosphorylation of Eng 1 0.24 0.5 0
120 INT347145 Transcription of Smad7 1 0.68 0 0
121 INT83122 Transcription of TGFBR2 1 0.09 0 0
122 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0
123 INT295579 Negative_regulation of Phosphorylation of SMAD2 1 0.42 0.08 0
124 INT239992 Negative_regulation of Tgfbr2 1 0.06 0 0
125 INT260145 Positive_regulation of Gene_expression of TGFBR2 1 0.45 1.04 0
126 INT218685 Binding of Smad7 1 0.13 0.15 0
127 INT310173 Binding of Smad6 1 0.05 0 0
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